Big Picture Medicine Dr Mustafa Sultan

0:00 Intro

0:18 Ali Parsa's Immigrant Story

1:57 Picking a Problem That Was Too Big

4:15 The Supply Induced Demand Problem

5:55 The Unit Economics Problem

7:37 The Misaligned Incentives Problem

10:11 The Friction Problem

12:06 The First Mover Disadvantage

13:30 Raising Too Much Money

14:55 The SPAC Problem

17:40 The Pig With Lipstick Problem

22:07 Should Founders be Liberal with the Truth?

26:06 What Will the Next Health Unicorn Be?


Articles Mentioned

Babylon shareholders wiped out in restructuring deal: https://www.ft.com/content/ce42bcb7-d9ee-4667-910a-b6c7a419449b


Podcast Links

YouTube: https://www.youtube.com/@bigpicturemedicineApple: https://podcasts.apple.com/gb/podcast/big-picture-medicine/id1500446262

Spotify: https://open.spotify.com/show/5707RPmWOJkVZyUHNRSUfS?si=96c7fff6bccb456a



People

Dr Imran Mahmud: https://www.imranmahmud.com/

Dr Adam Bataineh: https://twitter.com/DrAdamBat / https://numenor.health

Dr Mustafa Sultan: https://www.musty.io/

0:00 Intro

0:38 VC Dirty Money (LP Sources)

8:30 Power Dynamics Founder vs VC

12:56 Trillion $ Alzheimer's Opportunity

14:26 Eli Lily's New Alzheimer's Blockbuster (?) Donanemab

19:01 More Issues with Donanemab Phase III Results

21:48 Will Anyone Pay for Donanemab?

24:13 Donanemab Side Effects

27:15 Startup Opportunities in Alzheimer's 

31:34 Outro



Articles Mentioned

Founders need to take a stand against VC's 'dirty money’: https://sifted.eu/articles/founders-vc-dirty-money

Eli Lily Donanemab Phase III Press Release: https://investor.lilly.com/news-releases/news-release-details/lillys-donanemab-significantly-slowed-cognitive-and-functional

Cost Effectiveness of Donanemab: https://pubmed.ncbi.nlm.nih.gov/35344024/



Podcast Links

YouTube: https://www.youtube.com/@bigpicturemedicine

Apple: https://podcasts.apple.com/gb/podcast/big-picture-medicine/id1500446262

Spotify: https://open.spotify.com/show/5707RPmWOJkVZyUHNRSUfS?si=96c7fff6bccb456a



People

Dr Imran Mahmud: https://www.imranmahmud.com/

Dr Adam Bataineh: https://twitter.com/DrAdamBat?s=20

Dr Mustafa Sultan: https://www.musty.io/

Papers Mentioned—

ChatGPT better + more empathetic than human doctors (JAMA Int Med Paper): https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2804309

Detecting eye disease using AI (Nature Biomedical Engineering): https://www.nature.com/articles/s41551-022-00867-5

Predicting dementia using LLMs (PLOS Digital Health): https://pubmed.ncbi.nlm.nih.gov/36812634/

AI recognises race from black and white X rays (Lancet Digital Health): https://www.thelancet.com/journals/landig/article/PIIS2589-7500(22)00063-2/fulltext

VC dirty money article: https://sifted.eu/articles/founders-vc-dirty-money



0:00 Intro
0:30 ChatGPT vs Doctors (JAMA Paper)
15:57 AI Better at Diagnosis than Doctors
30:57 Dirty VC Money
32:02 Audience Feedback

Joined by:
Dr Adam Bataineh: Longevity doctor and Co-founder Span Health (acquired by EightSleep).
Dr Imran Mahmud: Investor, Oxford-trained doctor, ex-Mckinsey and Co-founder of NYE Health.
Dr Mustafa Sultan: Creator of Big Picture Medicine and Doctor.

0:00 Intro

0:32 Why are VCs so unhappy?

2:18 What’s hard about being a VC?

3:56 Hustle culture, FOMO, always-on culture in VC

9:54 Is it ever easy to become rich?

12:22 It’s time to build in healthcare

15:31 Why is healthcare so hard for big tech?

17:31 Reasons why healthcare is easier than you think

21:04 Imposter syndrome for tech people entering healthcare

24:03 Would you build another healthcare startup?

25:12 Outro



Joined by:

Dr Imran Mahmud: Investor, Oxford-trained doctor, ex-Mckinsey and Co-founder of NYE Health. 

Dr Mustafa Sultan: Creator of Big Picture Medicine and Doctor.

Martin Shkreli is an American Investor, Pharmaceutical Executive and Hedge Fund Manager who became the most hated man in America in 2015 when he obtained the drug Daraprim and increased its price from $13.50 a pill, to $750 overnight.



0:00 Intro

1:56 The Big Short

8:04 How to price a drug

20:01 Should we price drugs like iPhones

25:36 Pharma's dirty secret with R&D spend

34:12 Why are we not discovering more drugs? Eroom's Law

43:59 Marting's new AI Doctor — Dr Gupta

51:08 What's the FDA going to say?

53:26 Problems with GPT-4; hallucinations and sources

1:00:00 Mental health impact of being the most hated man in America

1:02:30 How rich are you?

1:08:00 Outro



Daraprim is used to treat or prevent parasitic diseases, commonly in patients with HIV or AIDS.

He defended the move by saying “If there was a company that was selling an Aston Martin at the price of a bicycle, and we buy that company and we ask to charge Toyota prices, I don't think that that should be a crime.”

Unrelated to the Daraprim scandal, in 2017 he was charged with securities fraud and sentenced to seven years in prison and fined a total of over $70M dollars.

Martin comes from humble beginnings, his parents are Albanian immigrants — but he quickly ascended the world and became a multimillionaire polymath. And despite having no formal training in Medical Sciences — he has a penchant for consuming medical literature from PubMed, and making novel insights.

We talk about how Martin does this, his philosophy around drug pricing — and whether we should think about pricing drugs in the same way we price iPhones, we talk about whether blowing more money into pharma research & development actually leads to more exciting drugs, Martin’s new AI doctor that he just launched and the mental health impact of being the world’s most hated man.



You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Dr Ben Maruthappu is the the Co-founder and CEO of Cera Care; a digitally-enabled social care company which has raised over $400M dollars. He was made a Member of the Order of the British Empire in 2020.


0:00 Intro

0:47 Ben's story

6:10 How to have good ideas, at the right time

12:14 Good decisions Ben made with Cera to scale

21:07 Is the US greener pastures?

28:10 What healthtech can learn from fintech, ridesharing and food delivery

30:17 Anti-lessons from other industries

33:53 How do you stop driving becoming toxic

36:13 Are founders olympic athletes who don't deserve work-life balance?

38:31 Are you full of sh*t? What are your real motives?

41:19 Are successful founders happy people?

43:30 Mo money mo problems

46:51 The power of vulnerability vs the magnetism of certainty

52:21 Networking advice


You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io