In this episode of the Onc Now Podcast, host Jonathan Sackier is joined by Sebastian Stintzing, Head of Department of Medicine, Division of Hematology, Oncology, and Cancer Immunology, Charité - Universitäetsmedizin Berlin, Germany. They discuss the most promising developments in gastrointestinal oncology, with particular focus on the role of personalised medicine in metastatic colorectal cancer treatment. 

Timestamps:   

00:00 – Introduction 

03:04 – Impactful developments in gastrointestinal oncology 

08:53 – Issues with funding clinical trials 

14:17 – Designing trials and the importance of patient advocacy  

17:11 – Translational biomarker programs 

19:58 – Treatment strategies for RAS wild-type tumours 

22:28 – The FIRE-4.5 study on mutant metastatic colorectal cancer 

29:50 – Genetic profiling and epigenomics 

33:12 – Precision medicine and immune oncology in GI cancers 

34:52 – Colorectal cancer in younger adults 

34:54 – Raising awareness for early screening of GI cancers