One Thing with Dr. Adam Rinde Dr. Adam Rinde

Episode 100 of the One Thing Podcast with Dr. Adam Rinde did not disappoint

First, some goodies to mention. To order the Jona test we talk about this episode... go to https://jona.health and enter ONETHING100 to receive $100 off the test

In this episode I welcome on the CEO of Jona, Leo Grady, PhD and the Director of Business Development and GTM strategy , Jaclyn Kawwas. We are discussing a revolutionary stool microbiome test called Jona that uses AI to analyze gut microbiome data and connect it to health outcomes:

Jona, developed an AI system to analyze microbiome data obtained through shotgun metagenomic sequencing.



The AI system is able to:
1. Read and interpret existing research on the microbiome
2. Match patterns in an individual's microbiome data to relevant studies.
3. Generate personalized recommendations for dietary changes, lifestyle modifications, and supplements based on an individual's health goals

The gut microbiome is highly individualized and influenced by various factors: We highlight how the gut microbiome is highly personalized, with limited overlap between individuals. Factors contributing to microbiome variability include:

Diet: Processed foods, artificial sweeteners, emulsifiers, preservatives, fiber intake
Lifestyle: Exercise, travel, pet ownership
Medications: Antibiotics, chemotherapy, opioids
Infections: Salmonella poisoning, C. difficile infection, long COVID, PANDAS/PANS



Some highlights to our discussion:


We discuss hwo stool testing technology has evolved
We discuss metabolomics and how it provides additional insight into gut health:
We discuss how the field of microbiome research is rapidly evolving:
We discuss personalized recommendations that Jona makes.


About our guests:

Leo Grady, PhD

Leo is internationally recognized for his work to deliver AI in healthcare for 20 years at pioneering bay area startups (HeartFlow), multinational medical companies (Siemens) and, most recently, as CEO of Paige.ai. As CEO of Paige, Leo led the company to become an industry leader, internationally launching groundbreaking products and receiving the first-ever FDA approval for an AI product in pathology. Leo authored two books on AI, over 100 peer-reviewed scientific papers and is an inventor on over 300 patents. Winner of the Edison Patent Award, he was inducted as Fellow in the American Institute for Medical and Biological Engineering. Leo earned a Ph.D. in Cognitive and Neural Systems from BU. Leo is CEO in Residence with Breyer Capital and the Founder and CEO of Jona.

Jaclyn Kawwas, MBA

Jaclyn has dedicated her career to advancing medical and health technology, striving to combat the growing challenges of chronic illness. During her tenure at Medtronic, she contributed to the design and development of cutting-edge cardiovascular devices, including one that garnered FDA approval for hypertension treatment. Her solutions have earned her multiple patents in cardiovascular disease management.

Currently serving as the Head of Business Development and GTM Strategy at Jona, a health tech AI company specializing in the gut microbiome, Jaclyn continues to sit at the intersection of technology and healthcare. Prior to her role at Jona, she held positions in business development and growth strategy at Viz.ai and Thirty Madison which focus on chronic conditions from both a provider and consumer lens.

Jaclyn received her B.S.E. in biomedical engineering from the University of Michigan and an MBA in Healthcare Management from The Wharton School at the University of Pennsylvania. She remains committed to leveraging technology to make a positive impact on preventive health and patient care.



Show notes available at : https://onethingpod/jona


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The guest in this episode is Dr. Andrea McBeth, the CEO of Thaena , who talks about postbiotics and their role in addressing health imbalances. The podcast emphasizes the importance of consulting with a healthcare provider before making any changes to one's health routine. Dr. McBeth has dedicated this episode to Lesbians Who Tech https://lesbianswhotech.org/about/ and if we reach 300 plays in the first 30 days of launch a donation will be made in honor of Dr. McBeth to Lesbians Who tech. http://www.lesbianswhotech.org


In this episode we discuss:

- 💡 The concept of postbiotics, which are small molecules and metabolites produced by bacteria, is an emerging field of study in the microbiome space.
- 💡 Thaena a postbiotic supplement developed by Dr. Andrea McBeth's company, takes a unique approach by using sterilized stool as a source to create a complex mixture of postbiotics.
- 💡 Donor selection for postbiotic supplements is crucial, and Thaena has strict criteria in place to ensure the health and safety of their donors.
- 💡 Postbiotics have shown potential in addressing various health imbalances, including gut health, brain health, and immune function.
- 💡 Thaena is focused on gathering data and feedback from users to better understand the effects and potential applications of postbiotics.
- 💡 Individualized approaches to healthcare are important, as the microbiome and its response to interventions can vary greatly between individuals.
- 💡 The study of postbiotics and their impact on health is still in its early stages, but the potential for their use in supporting overall health and wellness is promising.

Time stamps:
00:00 Welcome to the One Thing Podcast
00:43 Introducing Dr. Andrea Macbeth: A Deep Dive into Postbiotics
01:09 The Revolutionary World of Thaena Biotic
01:30 Exploring the Science and Impact of Postbiotics
04:35 The Journey from Scientist to Naturopathic Doctor
07:32 The Unique Approach of Thaena to Postbiotics
12:42 Understanding the Microbiome and Postbiotics
16:36 Personalizing Gut Health: Prebiotics, Probiotics, and Postbiotics
28:35 Finding and Qualifying Donors for Thaena
45:35 Final Thoughts and How to Access Thaena Products


About Dr. McBeth
Andrea McBeth, ND, is a naturopathic doctor, entrepreneur and activist dedicated to building products that reduce suffering while also challenging healthcare systems to reimagine what it means to heal. The CEO and co-founder of Thaena®, Andrea views wellness through the lens of the microbiota, emphasizing the relationship between gut health and overall health.

Thaena®, pronounced | thay-nah |, is a female-founded, Pacific Northwest-based company and the proud creators of ThaenaBiotic®, the world's first stool-derived postbiotic supplement. Our mission is simple: To use science, radical innovation, and the microbiome to help people feel better. We believe in using the innate wisdom of the human body to shift the paradigms of medicine by expanding access to microbiome supports and putting postbiotics on the map.

Special Links Mentioned In the Episode https://thaena.com/Rinde

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Much emphasis is being placed on the gut microbiome to look for therapeutic derivatives that provide health and medicinal benefit. And in addition, we have another natural source of compounds from human breast milk that provides a wide range of therapeutic and medicinal properties. Everybody knows about colostrum; however, this range of health constituents in breast milk goes much further. Properties of human breast milk have been linked to helping health conditions related to gut health, skin health, and musculoskeletal health. While researching a health solution for a patient of mine; I was introduced to Maya. Ashkenazi Otmazin, B.SC, M.E. and her company Maolac.

Maya is an experienced entrepreneur in the field of R&D with a proven professional track record in the health and wellness industries and Israel’s Food Tech community. Maya has an M.E. and a B.Sc in Biomedical Engineering and Pharmaceutical Engineering. She was listed in the Forbes 30 under 30 Class of 2020 .

Maya has an engineering background with a degree in pharmaceutical engineering and another one in biomedical engineering. Throughout her career, she has created new products for different industries and worked in a pharmaceutical company where she created products from concept through production and scale-up. She is the CEO and Co-founder of Maolac. Maolac is an Israeli food tech company that develops biofunctional proteins (BFPs) from animal and non-animal sources to make human milk proteins accessible to everyone. The company uses AI technology to identify proteins in bovine colostrum that are similar to those found in human milk. Maolac's first products, Maolactin for Gut Health and Maolactin for Anti-Inflammatory Activity, are bio-functional protein mixtures that are designed to have similar benefits to breast milk

Here are some highlights from our discussion:
🥛 Breast milk is a complex matrix that contains over 1,500 proteins, many of which are essential for human health. Maolac focuses on analyzing the proteomic composition of breast milk and developing biosimilar proteins for use in nutraceuticals. –
🧪 Maolac utilizes AI technology and the Maolactin AI platform to predict the best combination of proteins for specific indications. This allows for a more precise approach to developing nutraceuticals and ensures high bio-similarity to human proteins. –
🌱 Maolactin's products are derived from natural sources such as colostrum, algae, fungi, and yeast. They undergo rigorous testing in ex-vivo, in-vivo, and clinical trials to validate their efficacy and safety. –
🏋️‍♀️ Maolac's products have potential applications in various areas, including leaky gut, muscle recovery, and healthy aging. By targeting specific biological needs, they offer a more effective and natural approach to improving health. –
🧠 The use of AI technology in the development of nutraceuticals allows for faster and more efficient analysis of scientific data. This enables researchers to identify new bioactive molecules and bring innovative solutions to market more quickly. –
💡 Maolac's approach to developing nutraceuticals demonstrates the potential of integrating AI technology with natural sources to create effective and safe products. By focusing on the proteomic composition of breast milk and other natural substances, they are able to harness the power of nature to improve human health. –
🌍 Maolac's mission is to bring innovative biological molecules to the nutraceutical space. By leveraging AI technology, they aim to revolutionize the industry and provide tailored solutions for various populations, including those with specific health conditions and athletes.


Social Links:
https://www.Maolac.com
https://www.linkedin.com/in/maya-ashkenazi-otmazgin/




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Nutritional therapy plays a significant role in managing inflammatory bowel disease (IBD), but it is often overlooked in traditional medical care.

Exclusive enteral nutrition is effective in inducing remission, while therapeutic diets like the IBD-Anti-Inflammatory Diet and the Specific Carbohydrate Diet have shown positive results.

Monitoring nutrient deficiencies and biometric measurements like grip strength are essential for optimal management of IBD.

To help develop a framework for this topic I welcomed on the Kim Beall, Pharm.D., who is the Cofounder and Managing Director of Nutritional Therapy for IBD, http://www.nutritionaltherapyforibd.org a non-profit dedicated to establishing evidence-based nutritional therapy as a foundational part of IBD care to improve the well-being and health outcomes of those living with Crohn’s disease and ulcerative colitis. Kim and I met related to a mutual colleague the late Trina Seligman, ND who had a courageous life long battle with Crohns/Colitis . We share a strong bond with Trina.



Here are some of the timestamps of the conversations.

00:00 - 🎙️ Introduction to the One Thing Podcast and the guest, Kim Beall, Pharm.D, who is a pharmacist and the co-founder of Nutritional Therapy for IBD, a nonprofit dedicated to incorporating evidence-based nutrition into IBD care.

02:45 - 💔 Discussion about the passing of Dr. Trina Seligman, a mentor and advocate for IBD patients, and her impact on the IBD community.

05:23 - 🏥 The importance of nutrition in managing IBD and the role of exclusive enteral nutrition (EEN) in inducing remission and mucosal healing.

08:32 - 💡 Dr. Beall's personal journey with IBD and her son's diagnosis with Crohn's disease, which led her to advocate for nutrition as a foundational part of IBD care.

12:15 - 🤝 The need for earlier intervention and education on nutrition for IBD patients and the importance of collaboration between patients and healthcare providers.

16:10 - 🤔 The confusion surrounding dietary recommendations for IBD and the lack of official guidelines, leading to the need for ongoing research and evidence-based approaches.

19:05 - ⚖️ The importance of avoiding blame and shame when discussing the role of diet in IBD and the complexity of factors contributing to the development of the disease.

21:20 - 📊 The significance of biometric evaluations, such as grip strength and body mass, in assessing nutritional status and overall health in IBD patients.

24:20 - 🌱 The current evidence for routine nutrient monitoring in IBD patients, including the importance of micronutrients like zinc, magnesium, and vitamins.

27:10 - 🍽️ The different dietary strategies and therapeutic diets for IBD, including exclusive enteral nutrition, the anti-inflammatory diet, autoimmune protocol, and specific carbohydrate diet.

32:00 - 🔍 Ongoing research on the microbiome and its potential role in IBD management, along with the need for personalized nutrition approaches based on an individual's microbiome and metabolic profile.

35:05 - 💪 The potential benefits of partial enteral nutrition and its underutilization in IBD care, including its role in maintaining remission and reducing surgical recurrence.

38:40 - 🌟 The importance of raising awareness about the efficacy of nutritional therapy in IBD and advocating for insurance coverage of nutrition-related treatments.

Here is the link to Nutritional Therapy For IBD
Links : http://www.nutritionaltherapyforibd.org

#IBD #crohns #colitis


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Claire Hall, a researcher at Mindset Health, joins us on episode 96 discusses menopause and the effectiveness of hypnotherapy in treating hot flashes.



Summary of episode:


Hypnotherapy is an effective non-drug alternative for managing hot flashes, as it has been shown to reduce their frequency and severity. It has shown in trials that hypnotherapy can reduce Hot flash severity by up to 70% . It also seems to be helpful in reducing anxiety and depression and sleep disturbances related to menopause.

Mindset Health develops hypnotherapy-based apps to deliver evidence-based protocols for various conditions, including irritable bowel syndrome (Nerva app), menopausal hot flashes (Evia app), and smoking cessation (Finito app).


Menopause is often viewed negatively in society, but it is a natural life transition that involves hormonal changes leading to symptoms such as hot flashes.


Hypnotherapy works by guiding patients into a deeply relaxed state and then providing therapeutic suggestions that reinforce coolness and control over body temperature.


A study involving 10,000 Evia users found that 70% experienced a clinically significant improvement in vasomotor symptoms.


Mindset Health prioritizes publishing both clinical trial data and real-world user data to provide a comprehensive understanding of the effectiveness of their digital therapeutics.


Hypnotherapy may be more effective than traditional treatments for hot flashes. A study published in the journal Menopause found that women who used hypnotherapy to treat their hot flashes had a 70% reduction in symptoms, compared to a 20% reduction in women who used hormone therapy.


Hypnotherapy may help to reduce anxiety and depression during menopause. A study published in the journal Maturitas found that women who used hypnotherapy to treat their hot flashes experienced a significant reduction in anxiety and depression symptoms.


Hypnotherapy may help to improve sleep quality during menopause. A study published in the journal Sleep found that women who used hypnotherapy to treat their hot flashes experienced a significant improvement in their sleep quality.


Hypnotherapy is a safe and effective treatment for hot flashes that has no side effects. Unlike hormone therapy, hypnotherapy has no known side effects, making it a safe and effective option for women who are looking to relieve their hot flashes.

about Claire Hall

Claire is the Research Lead at Mindset Health, a digital therapeutic company that uses hypnotherapy based protocols to help people manage their health. Claire was on the founding team at Mindset Health and has helped grow the company into a model for how health tech companies should prioritize strong clinical research in the digital therapeutic world.


Links of Interest:

www.mindsethealth.com

Evia App for Menopause care


Snyder M, Elkins GR. Characteristics of Users of a Digital Hypnotherapy Intervention for Hot Flashes: Retrospective Study. JMIR Form Res. 2024 Mar 14;8:e53555. doi: 10.2196/53555. PMID: 38483465; PMCID: PMC10979336.






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Welcome to Episode 95: Cardiovascular endothelium health with Dr. Kristine Burke


podcast is dedicated to Alzheimer’s Prevention and Reversal Project Foundation. If we reach 500 listens within
the first 30 days, we will make a donation in honor of our guest Dr. Burke.



Episode 95: Cardiovascular endothelium health with Dr. Kristine Burke



In this episode we discuss:


The endothelial glycocalyx and its importance in cardiovascular health.
Vascular inflammation markers and their impact on cardiovascular health.
Using non-invasive tests to assess cardiovascular health.
Glycocalyx strengthening nutrients and compounds
Nutrition and supplements for vascular health.
Cardiovascular health and treatment options.

About Dr. Burke

Kristine Burke, MD is a triple board-certified Functional
Medicine Physician, Entrepreneur, Author, Educator, and Researcher. She is an
expert in the reversal and prevention of chronic diseases such as dementia,
diabetes, heart attacks and strokes. She has a special focus on mold-related
illness and its connection to many conditions including research into reversing
the cognitive decline of Alzheimer's Disease and Dementia. She teaches
Functional Medicine in her role as Asst Clinical Professor of Preventive
Medicine at Loma Linda University School of Medicine and has also had the
pleasure of being an educator for IFM. She is the Founder and Medical Director
of True Health Center for Precision Medicine in Northern California - a
multi-disciplinary practice that delivers personalized primary care with a
proprietary data-driven wellness plan that has successfully prevented any heart
attacks from occurring among its patients for over a decade. The center also
provides an array of specialized consultation services to define and address
the root causes of disease so that every day we can reverse chronic illness to
help people reclaim their health.


Social Links:


www.truehealthcfm.com

@truehealthcfm

@drkristineburke

@qlaritybreastimagingedh




























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