Outperform Cancer Marybeth Gilliam

Is high-dose vitamin C the game-changer in cancer treatment that it's touted to be? Get the latest insights straight from the forefront of clinical research with the leading expert in the field. In this episode, we sit down with Dr. Joseph Cullen, a distinguished Professor of Surgery at the University of Iowa Carver College of Medicine. Dr. Cullen's groundbreaking clinical investigations center on the integration of high-dose vitamin C, also referred to as ascorbate or intravenous vitamin C (IVC), alongside conventional cancer therapies.

Drawing from his extensive experience, Dr. Cullen shared insights from several phase 1 and phase 2 clinical trials he has conducted. Notably, he discussed the groundbreaking results from the first-ever randomized IVC clinical trial which was conducted amongst pancreatic cancer patients. The trial's success was so remarkable that it was halted early, as it was deemed unethical not to offer IVC to all patients alongside standard care medications. These compelling findings have been submitted for publication in the prestigious Journal of Clinical Oncology.

During our conversation, Dr. Cullen also shed light on similar clinical trials being conducted by him and his colleagues at the University of Iowa, targeting glioblastoma, non-small cell lung, and rectal cancers. These trials signify the growing recognition of IVC's potential as an adjunctive therapy in cancer treatment.

Delving into the science behind the efficacy of IVC, Dr. Cullen explained its mechanism of action and why it holds such promise in cancer therapy. His laboratory's research focuses on pharmacological ascorbate (P-AscH-, high dose, intravenous vitamin C) as an adjuvant to standard treatments, particularly for pancreatic cancer but he also addresses its potential for breast and prostate cancers.

With an impressive track record comprising 162 peer-reviewed papers and 32 book chapters, Dr. Cullen is at the forefront of advancing our understanding of IVC's role in cancer care. As the principal investigator of multiple clinical trials utilizing pharmacological ascorbate, he continues to spearhead innovative approaches to enhance cancer therapy through the manipulation of redox metabolism.

Get inspired by Dr. Kathryn Schmitz, a pioneering figure in the field of exercise oncology and a strong advocate for cancer patients worldwide. In this compelling episode, Dr. Schmitz, a Professor at the University of Pittsburgh School of Medicine and past president of the American College of Sports Medicine, shares groundbreaking insights from her extensive research on the transformative power of exercise in cancer care. 

Learn about the compelling statistics that reveal how regular exercise can dramatically reduce the risk of cancer recurrence by an astonishing 30-50%—a figure that rivals the efficacy of some popular cancer drugs. 

Listen as Dr. Schmitz delves into the fascinating mechanisms behind exercise's ability to combat cancer, from activating tumor suppressor genes to boosting immune function. She also sheds light on the latest research, including the surprising benefits of short, intense bursts of exercise.

Don't miss critical insights from this multi-award winning scientist.
1. The Distinguished Scientist Award from the Society of Behavioral Medicine
2. The Clinical Research Professorship from the American Cancer Society.

Learn how exercise can be a powerful ally in the fight against cancer, and get empowered to take an active role in their health and recovery. 

We're thrilled to welcome Prof. Dr. Connie Jimenez, a leading figure in the field of OncoProteomics, to discuss high-dose intravenous vitamin C (IVC) as an anti-cancer strategy.

Dr. Jimenez is the Founder and Head of the OncoProteomics Laboratory and Professor of “Translational OncoProteomics” at the VU University Medical Center in Amsterdam. The focus of our conversation is her comprehensive 2021 research summary, “High-dose intravenous vitamin C, a promising multi-targeting agent in the treatment of cancer,” published in the Journal of Experimental & Clinical Cancer Research. This pivotal work delves into an array of studies, encompassing in vivo and in vitro research, omic studies, and clinical trials, providing a detailed look into the efficacy of high-dose intravenous vitamin C (IVC) in cancer treatment. Significantly, the summary offers tumor site-specific information, making it an invaluable resource for patients seeking relevant and personalized insights.

Listeners will gain an in-depth understanding of the optimal dose levels of IVC used in research studies, crucial for achieving effective cancer cell eradication. Moreover, Dr. Jimenez elucidates the fascinating mechanisms of action of IVC, including its ability to reactivate tumor suppressor genes, which play a critical role in cancer prevention and treatment.

A particularly intriguing aspect of IVC's mechanism, as discussed by Dr. Jimenez, is its 'Trojan horse' effect, which allows it to penetrate and target tumor cells, even showing promise for cancers with challenging mutations, such as KRAS mutations, which have traditionally been difficult to treat.

Additionally, our conversation sheds light on the secondary benefits of IVC, particularly in alleviating the side effects of chemotherapy. This dual role of IVC, both as a direct combatant against cancer cells and as a mitigator of chemotherapy's adverse effects, underscores its potential as a multifaceted treatment option.

Don't miss this episode as we explore these groundbreaking insights with Prof. Dr. Connie Jimenez, offering hope and new perspectives in the ongoing battle against cancer.

Welcome to Episode 1 of the Outperform Cancer Podcast. I’m your host, Marybeth Gilliam, and I’m on a mission to bring life-changing research discoveries directly to you, bypassing the staggering 15-year average wait for them to enter clinical practice. For countless cancer warriors, like myself, that wait is too long.

In this kickoff episode, I explain my dedication to unveiling actionable, evidence-based strategies to outperform cancer. Together, we’ll bridge the formidable gap between world-leading researchers and cancer patients, ensuring that cutting-edge discoveries translate into actionable steps for prevention, management, and triumph over this disease.

The cruel reality is that most cancer patients will never benefit from numerous clinical research discoveries due to the prolonged journey from the lab to the bedside. The Outperform Cancer Podcast is conceived with an unwavering commitment to change this narrative. We connect you directly with esteemed researchers, bringing their pioneering discoveries to the forefront. No waiting. No barriers. Just real-time insights for real-world impact.

Actionable Insights: Every discovery we explore is immediately actionable. If you’re surrounded by a sea of breakthrough science news yet stranded without a lifeline of “what now,” you’ve found your sanctuary. We delve into pragmatic strategies for those aiming to evade cancer, prevent its recurrence, or conquer active cancer.

Our Promise: In each enriching episode, we engage in enlightening conversations with well-regarded, peer-reviewed, and published researchers. We acknowledge the infancy of some research, often supported by early clinical or pre-clinical data. Yet, together, we will assess the volume and methodologies of studies, meticulously evaluating the strengths and weaknesses to unveil potential pathways to improved cancer outcomes.

Join me in this empowering journey. Every episode is a step closer to a world where the latest anti-cancer strategies are not just known but are accessible and actionable for all. Together, we will outperform cancer.

Subscribe Now: Join us in this pivotal movement towards a cancer-free world. Subscribe, and let’s transform cutting-edge research into real-life victories.

In this eye-opening episode of the @OutperformCancerPodcast, we are honored to have Dr. Jed Fahey, a renowned expert in the field of phytochemicals, as our guest. Dr. Fahey dives deep into the remarkable properties of sulforaphane, a potent phytochemical found abundantly in broccoli sprouts. You'll learn how sulforaphane helps to prevent the onset of cancer, kill active cancer cells, and eliminate the cancer stem cells that chemotherapy can’t kill.

Chemopreventative Power of Sulforaphane: Discover how this unique phytochemical can help in preventing the onset of cancer.

Antiproliferative Capabilities: Understand how sulforaphane can slow down or even stop the growth of cancer cells.

Cancer Stem Cell Elimination: Perhaps one of the most striking features of sulforaphane is its ability to kill cancer stem cells—a feat that even chemotherapy often fails to achieve.

The information Dr. Fahey shares in this video has profound implications for the future of cancer treatment and prevention. As a naturally occurring compound, sulforaphane offers a range of benefits with minimal side effects, making it a subject of intense scientific investigation.