Talk Python To Me

Michael Kennedy

Talk Python to Me is a weekly podcast hosted by developer and entrepreneur Michael Kennedy. We dive deep into the popular packages and software developers, data scientists, and incredible hobbyists doing amazing things with Python. If you're new to Python, you'll quickly learn the ins and outs of the community by hearing from the leaders. And if you've been Pythoning for years, you'll learn about your favorite packages and the hot new ones coming out of open source.

  1. 5時間前

    Marimo Pair - A Canvas for Agent + Developers Collaboration

    Coding agents have gotten really good at one kind of work. You scope a feature, edit some files, run the tests, ship it. It all happens on disk. But that is not how data work feels. You load something, you look at it, you run a cell, you watch how it responds, and you decide the next move from whatever is sitting in memory. And until now, your agent couldn't see any of that. It only saw the files. Never the live state. This episode, that wall comes down. marimo pair drops a coding agent right inside a running notebook, with full access to every variable Python is holding in memory. The notebook becomes a shared canvas. You point, it runs the code. You tell it to zoom in on the Picasso paintings, and the chart just updates. No MCP tools to wire up, no schema to describe. Just Python, and an agent that can finally see what you see. Trevor Manz is back to walk us through it. Episode sponsors Sentry Error Monitoring, Code talkpython26 Talk Python Courses Links from the show marimo pair: marimo.io/pair Course transcripts announcement: talkpython.fm/blog anywidget: Jupyter Widgets made easy: talkpython.fm marimo: marimo.io blog: marimo.io GitHub: github.com given this: martinalderson.com llms.txt: talkpython.fm mcp: talkpython.fm cli: talkpython.fm open issues: github.com Discord: marimo.io Marimo Pair: marimo.io OpenCode: opencode.ai AI Tooling for Software Engineers in 2026: newsletter.pragmaticengineer.com Watch this episode on YouTube: youtube.com Episode #555 deep-dive: talkpython.fm/555 Episode transcripts: talkpython.fm Theme Song: Developer Rap 🥁 Served in a Flask 🎸: talkpython.fm/flasksong ---== Don't be a stranger ==--- YouTube: youtube.com/@talkpython Bluesky: @talkpython.fm Mastodon: @talkpython@fosstodon.org X.com: @talkpython Michael on Bluesky: @mkennedy.codes Michael on Mastodon: @mkennedy@fosstodon.org Michael on X.com: @mkennedy

    1時間5分
  2. 3日前

    Trustworthy AI in Healthcare and Longevity

    You ask an AI a question and it answers with total confidence. Most of the time, a confidently wrong answer is just an annoyance. But what if the question is medical, and there's a real patient on the other end? In that world, a hallucination isn't a bug, it's a patient-safety event. Sumit Gundawar is a London-based software engineer who builds the clinical platform for a UK longevity and aesthetic-medicine clinic, and his whole argument is that in high-stakes AI, the model is the easy part. Earning trust is the real engineering. We dig into grounding, refusal logic, human-in-the-loop design, and the messy frontier of longevity and biohacking, plus a live demo of an assistant that refuses to answer when it can't back up the claim. Let's get into it. Episode sponsors Six Feet Up Talk Python Courses Links from the show Guest Sumit Gundawar: linkedin.com Course transcripts announcement: talkpython.fm/blog Sumit Gundawar - JAX London Speaker: jaxlondon.com Anthropic: anthropic.com OpenAI Platform: platform.openai.com Anthropic: anthropic.com LangChain: langchain.com OWASP: owasp.org Pydantic: pydantic.dev EU AI Act - Regulatory Framework: digital-strategy.ec.europa.eu HIPAA - HHS: www.hhs.gov NHS: www.nhs.uk Llama: llama.com Qwen - QwenLM on GitHub: github.com OpenAI Platform: platform.openai.com Hugging Face: huggingface.co Llama: llama.com Granola: www.granola.ai HIPAA - HHS: www.hhs.gov CodeRabbit: www.coderabbit.ai Cursor Origin: cursor.com GitHub Status: www.githubstatus.com Midjourney Medical: www.midjourney.com Neko Health: www.nekohealth.com CERN: home.cern ATLAS Experiment: atlas.cern Watch this episode on YouTube: youtube.com Episode #554 deep-dive: talkpython.fm/554 Episode transcripts: talkpython.fm Theme Song: Developer Rap 🥁 Served in a Flask 🎸: talkpython.fm/flasksong ---== Don't be a stranger ==--- YouTube: youtube.com/@talkpython Bluesky: @talkpython.fm Mastodon: @talkpython@fosstodon.org X.com: @talkpython Michael on Bluesky: @mkennedy.codes Michael on Mastodon: @mkennedy@fosstodon.org Michael on X.com: @mkennedy

    1時間1分
  3. 6月26日

    All of our tools

    This episode is a fun crossover from our Python news and tips podcast, Python Bytes. We have had some big changes over there. Brian Okken has moved on and Calvin Hendryx-Parker has joined the show as the new co-host. To kick off this new era, we decided to do a longer and more personal episode called "All Our Tools". The idea is both of us talk about some of our most useful day-to-day developer and business owner tools that we think you all would find useful. It was so well received, that I'm bringing it to you all as a crossover episode. Enjoy and we hope you find something new and awesome to help you with your software and data science day to day. Episode sponsors Sentry Error Monitoring, Code talkpython26 Python in Production Talk Python Courses Links from the show @calvinhp@sixfeetup.social: sixfeetup.social @calvinhp.com: bsky.app calvinhp.com: calvinhp.com Original airing on Python Bytes: pythonbytes.fm pi: pi.dev superpowers: github.com Warp.dev: Warp.dev OhMyZSH: ohmyz.sh Commandbookapp.com: Commandbookapp.com Blink: blink.sh kitty: sw.kovidgoyal.net mosh: mosh.org tmux: github.com Claude code: www.anthropic.com Claude.md: Claude.md MacWhisper: goodsnooze.gumroad.com Handy: handy.computer Tailscale: tailscale.com Talk Python episode with Alex: talkpython.fm Telescopo: www.telescopo.app Typora markdown: typora.io formal documentation for many of my open source packages: mkennedy.codes Great Docs: posit-dev.github.io Statement on the US government directive to suspend access to Fable 5 and Mythos 5: www.anthropic.com No second date: x.com Watch this episode on YouTube: youtube.com Episode #553 deep-dive: talkpython.fm/553 Episode transcripts: talkpython.fm Theme Song: Developer Rap 🥁 Served in a Flask 🎸: talkpython.fm/flasksong ---== Don't be a stranger ==--- YouTube: youtube.com/@talkpython Bluesky: @talkpython.fm Mastodon: @talkpython@fosstodon.org X.com: @talkpython Michael on Bluesky: @mkennedy.codes Michael on Mastodon: @mkennedy@fosstodon.org Michael on X.com: @mkennedy

    55分
  4. 6月11日

    Stroll Down Startup Lane - 2026

    If you've ever been to PyCon, you know one of the best parts of the expo hall is Startup Row, a stretch of booths where early-stage companies built on Python show off what they're creating. But only attendees get to walk that lane, so let's bring it to everyone. In this episode, we stroll down Startup Row together. We kick things off with the organizers, Jason and Shay, who share the program's origin story going back to Paul Graham and the PSF, plus some surprising stats, including two unicorns among the alumni. Then we meet five startups: Tetrix, bringing AI to institutional investing in private markets. Arcjet, security that lives inside your app as an SDK. Phemeral.dev, serverless hosting built for Python web apps. CapiscIO, an identity and authority layer for AI agents. And Pixeltable, a multimodal database from Marcel Kornacker, co-creator of Apache Parquet. See if you can spot the theme running through them all. Let's go for a walk. Episode sponsors AgentField AI Talk Python Courses Links from the show Guests Naunidh Bhalla: linkedin.com Grant Gittes: linkedin.com Marcel Kornacker: linkedin.com Beon de Nood: linkedin.com Chinmaya Joshi: linkedin.com David Mytton: linkedin.com Shea Tate-Di Donna: linkedin.com Jason Rowley: linkedin.com Azul Garza: github.com Renée Rosillo: linkedin.com Tetrix: tetrix.co Tetrix Jobs: tetrix.co Arcjet: arcjet.com Pixeltable: pixeltable.com Phemeral.dev: phemeral.dev CapiscIO: capisc.io Episode #551 deep-dive: talkpython.fm/551 Episode transcripts: talkpython.fm Theme Song: Developer Rap 🥁 Served in a Flask 🎸: talkpython.fm/flasksong ---== Don't be a stranger ==--- YouTube: youtube.com/@talkpython Bluesky: @talkpython.fm Mastodon: @talkpython@fosstodon.org X.com: @talkpython Michael on Bluesky: @mkennedy.codes Michael on Mastodon: @mkennedy@fosstodon.org Michael on X.com: @mkennedy

    1時間49分
  5. 5月30日

    AI Contributions and Maintainer Load in Open Source

    You wake up, brew the coffee, open GitHub, and there it is. Another pull request on your open source project. Thirteen thousand lines added. No issue filed first. No discussion. Just "here, please review this for me." Over the past year, GitHub activity has spiked roughly twelve times in a few short months, and a huge chunk of that signal is landing on the same small group of maintainers who were already stretched thin. The curl bug bounty got buried under AI-generated noise. Jazzband, the home of Django classics like pip-tools and the Django debug toolbar, hit what its maintainer called an "apocalypse" and started sunsetting. Even CPython just shipped fresh guidelines on AI-assisted contributions this week. So what does all of this actually look like from the receiving end of the pull request? On this episode, Paolo Melchiorre joins us to tell that story from inside the maintainer's chair. Paolo is a director of the Django Software Foundation, an organizer of PyCon Italy, a Django Girls coach, and he has spent the past year carefully collecting examples of how AI is reshaping open source contributions. The good, the bad, and the extra fingers. We dig into his PyCon US talk on AI-assisted contributions and maintainer load, why AI is best understood as an amplifier rather than a new kind of contributor, the wildly different policies across 86 open source foundations, whether projects banning AI today are reacting to last year's models. Episode sponsors AgentField AI Talk Python Courses Links from the show Guest Paolo Melchiorre: github.com DSF: www.djangoproject.com djangonaut-space: djangonaut.space PyCon Italia: 2026.pycon.it uDjango: github.com My PyCon US 2026 post: www.paulox.net AI-Assisted Contributions and Maintainer Load: www.paulox.net Senior Engineer Tries Vibe Coding: www.youtube.com Code Rabbit AI PR Reviews: www.coderabbit.ai GitHub Usage Graphs: github.blog Update on CPython's AI Policies: fosstodon.org High-Quality Chaos from Curl: daniel.haxx.se The Generative AI Policy Landscape in Open Source: redmonk.com Watch this episode on YouTube: youtube.com Episode #550 deep-dive: talkpython.fm/550 Episode transcripts: talkpython.fm Theme Song: Developer Rap 🥁 Served in a Flask 🎸: talkpython.fm/flasksong ---== Don't be a stranger ==--- YouTube: youtube.com/@talkpython Bluesky: @talkpython.fm Mastodon: @talkpython@fosstodon.org X.com: @talkpython Michael on Bluesky: @mkennedy.codes Michael on Mastodon: @mkennedy@fosstodon.org Michael on X.com: @mkennedy

    1時間3分
  6. 5月25日

    Great Docs

    Your documentation has two audiences now - humans reading the rendered HTML, and AI agents trying to make sense of your library. Rich Iannone and Michael Chow from Posit are back on Talk Python with a brand new Python documentation tool called Great Docs that takes both seriously. Rich is the creator of Great Tables, and before that the R package GT, the man has a serious eye for design, and he's pointed that energy at the Python docs ecosystem. We'll talk about how Great Docs spins up a polished site in three commands, why every page ships as Markdown for your favorite LLM, how it leans on Quarto for executable code blocks and tabbed install sections, and where it lands against Sphinx, MkDocs, and Zensical. Plus, you'll meet Tablin. Here we go. Episode sponsors Sentry Error Monitoring, Code talkpython26 Temporal Talk Python Courses Links from the show Guests Michael Chow: github.com Rich lannone: github.com Python Web Security with OWASP Top 10 and Agentic AI Course: talkpython.fm Great Docs: posit-dev.github.io/great-docs Great Tables: posit-dev.github.io GT Episode: talkpython.fm Sphinx: www.sphinx-doc.org mkdocs: www.mkdocs.org Zensical: zensical.org Hugo: gohugo.io Ghost: ghost.org Rs pkgdown: pkgdown.r-lib.org Quarto: quarto.org quickstart: posit-dev.github.io llms.txt file: llmstxt.org llms.txt: talkpython.fm mcp: talkpython.fm cli: talkpython.fm Watch this episode on YouTube: youtube.com Episode #549 deep-dive: talkpython.fm/549 Episode transcripts: talkpython.fm Theme Song: Developer Rap 🥁 Served in a Flask 🎸: talkpython.fm/flasksong ---== Don't be a stranger ==--- YouTube: youtube.com/@talkpython Bluesky: @talkpython.fm Mastodon: @talkpython@fosstodon.org X.com: @talkpython Michael on Bluesky: @mkennedy.codes Michael on Mastodon: @mkennedy@fosstodon.org Michael on X.com: @mkennedy

    1時間7分
  7. 5月11日

    Event Sourcing Design Pattern

    What if your database worked more like Git? Every change captured as an immutable event you can replay, instead of a single mutating row that quietly forgets its own history. That's event sourcing, and Chris May is back on Talk Python, fresh off our Datastar panel, to walk us through what it actually looks like in Python. We'll cover the core patterns, the libraries to reach for, when not to use it, and why event sourcing turns out to be a surprisingly good fit for AI-assisted coding. Episode sponsors Sentry Error Monitoring, Code talkpython26 Temporal Talk Python Courses Links from the show Guest Chris May: everydaysuperpowers.dev Intro to event sourcing e-book: everydaysuperpowers.gumroad.com Domain-Driven Design: The Power of CQRS and Event Sourcing: How CQRS/ES Redefine Building Scalable System: ricofritzsche.me DDD: www.amazon.com Understanding Eventsourcing (Martin Dilger): www.amazon.com Event Sourcing Explained using Football Video: www.youtube.com Why I finally embraced event sourcing and why you should too article: everydaysuperpowers.dev valkey: valkey.io diskcache: talkpython.fm eventsourcing package: github.com eventsourcing docs: eventsourcing.readthedocs.io John Bywater: github.com Datastar: data-star.dev Microconf: microconf.com Event Modeling & Event Sourcing Podcast: podcast.eventmodeling.org Python Package Guides for AI Agents: github.com Iodine tablets AI joke: x.com KurrentDb: www.kurrent.io Watch this episode on YouTube: youtube.com Episode #548 deep-dive: talkpython.fm/548 Episode transcripts: talkpython.fm Theme Song: Developer Rap 🥁 Served in a Flask 🎸: talkpython.fm/flasksong ---== Don't be a stranger ==--- YouTube: youtube.com/@talkpython Bluesky: @talkpython.fm Mastodon: @talkpython@fosstodon.org X.com: @talkpython Michael on Bluesky: @mkennedy.codes Michael on Mastodon: @mkennedy@fosstodon.org Michael on X.com: @mkennedy

    1時間9分

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番組について

Talk Python to Me is a weekly podcast hosted by developer and entrepreneur Michael Kennedy. We dive deep into the popular packages and software developers, data scientists, and incredible hobbyists doing amazing things with Python. If you're new to Python, you'll quickly learn the ins and outs of the community by hearing from the leaders. And if you've been Pythoning for years, you'll learn about your favorite packages and the hot new ones coming out of open source.

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