JAMA Clinical Reviews

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JAMA Clinical Reviews

Author interviews that explore the latest clinical reviews.

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Ovarian Aging

Ovarian aging is an important cause of infertility in women older than 35 years. Success rates of fertility treatment decline with age, most commonly due to declining ovarian function. Author Albert L. Hsu, MD, MS, of University of Cincinnati, Ohio, discusses this and more with JAMA Deputy Editor Kristin L. Walter, MD, MS. Related Content: Ovarian Aging and Fertility

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Mpox Treatment Strategies, Clinical Presentation, and Diagnostic Approaches

Mpox is an evolving global health threat, and clinicians should be aware of characteristic signs and symptoms to ensure timely diagnosis and appropriate management. Author Jason Zucker, MD, MS, of Columbia University Irving Medical Center speaks with JAMA Deputy Editor Preeti Malani, MD, MSJ, about the transmission, diagnosis, management, and prevention of mpox. Related Content: Mpox Clinical Presentation, Diagnostic Approaches, and Treatment Strategies The Resurgence of Mpox in Africa Decline of Mpox Antibody Responses After Modified Vaccinia Ankara–Bavarian Nordic Vaccination WHO Announces Mpox Global Plan, Appeals for Funding

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Calcific Aortic Stenosis: Symptoms, Diagnosis, and Treatment

Calcific aortic stenosis affects approximately 12% of people >75 years in the US and worldwide leads to more than 100 000 deaths each year. Catherine M. Otto, MD, PhD, of the University of Washington School of Medicine, Seattle, discusses the symptoms, diagnosis, and treatment of aortic stenosis with JAMA Deputy Editor Kristin L. Walter, MD, MS. Related Content: Calcific Aortic Stenosis

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CAR T Cells and T-Cell Therapies for Cancer

CAR T cells are genetically engineered to express a receptor that recognizes and kills tumor cells. CAR T-cell products are now FDA approved for 6 hematologic malignancies. Author Jennifer N. Brudno, MD, National Cancer Institute, joins JAMA Deputy Editor Mary McGrae McDermott, MD, to discuss "CAR T Cells and T-Cell Therapies for Cancer: A Translational Science Review.” Related Content: CAR T Cells and T-Cell Therapies for Cancer Translational Science Reviews—A New JAMA Review

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Diagnosis and Treatment of Peptic Ulcer Disease

Peptic ulcer disease affects approximately 1% of the population in the US, and H pylori is a common cause of peptic ulcer disease. Author Nimish Vakil, MD, a gastroenterologist from the University of Wisconsin, Madison, discusses current evidence regarding diagnosis and treatment of peptic ulcer disease with JAMA Deputy Editor Mary McGrae McDermott, MD. Related Content: Peptic Ulcer Disease

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Strategies for Helping Patients Navigate High Prescription Drug Costs

High prescription costs are a major barrier to the optimal treatment of many health conditions. Prescribers need tools to help patients find the lowest drug costs. Author Hussain S. Lalani, MD, MPH, MSc, of Brigham and Women's Hospital and Harvard Medical School joins JAMA Senior Editor Anne R. Cappola, MD, ScM, to discuss "Strategies to Help Patients Navigate High Prescription Drug Costs." Related Content: Strategies to Help Patients Navigate High Prescription Drug Costs Strategies to Help Patients Afford Their Medicines in the US

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Preexposure Prophylaxis (PrEP) Options for HIV

Even though highly effective medications are currently available to prevent HIV, there are about 1.3 million new infections worldwide each year. Monica Gandhi, MD, MPH, of the University of California San Francisco joins JAMA Senior Editor Karen E. Lasser, MD, MPH, to discuss preexposure prophylaxis (PrEP) for HIV. Related Content: Preexposure Prophylaxis (PrEP) for HIV What Is Doxycycline Postexposure Prophylaxis?

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Update on Over-the-Counter (OTC) Contraception

In July 2023, the US Food and Drug Administration (FDA) approved Opill, a daily progestin-only oral contraceptive for over-the-counter sale to people of all ages. Daniel Grossman, MD, discusses this and more with JAMA Associate Editor Melissa A. Simon, MD, MPH. Related Content: Over-the-Counter Oral Contraceptives Over-the-Counter Oral Contraceptive Pills Over-the-Counter Progestin-Only Oral Contraceptives

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Author interviews that explore the latest clinical reviews.

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