14 episodes

In this show, I break down barriers between scientific-thinking and modern-day actions to teach you about the future of healthcare and how biotechnology works.

Think Like a Scientist Reema AlYousef

    • Science

In this show, I break down barriers between scientific-thinking and modern-day actions to teach you about the future of healthcare and how biotechnology works.

    5 Powerful Insights I Learned in 2021

    5 Powerful Insights I Learned in 2021

    Lessons and insights I learned the last year. 

    • 10 min
    Engineering a 3D Tumour Microenvironment to Personalize Cancer Treatments

    Engineering a 3D Tumour Microenvironment to Personalize Cancer Treatments

    We've known that tumour heterogeneity plays a key role in cancer drug resistance. So, how can we engineer a 3D cancer tumour microenvironment in vitro that portrays the physiological relevance and cell-to-cell interactions of a tumour composition? In this episode I go over research from the McGuigan Lab at the University of Toronto and their development of the TRACER model which will come to revolutionize how we detect, diagnose, and treat cancer patients—and as well as accelerate the drug discovery process. I discuss the importance of tissue-engineering in developing a model that allows us to spatially map the dynamic interactions and composition of a tumour microenvironment. I also discuss significant findings from these research papers such as transcription factors that play a role in tumour progression and tumour cell metabolism which create immunosuppressive environments, and how we could use this information to personalize treatments that could to better patient outcomes. 

    Research Papers: 
    A three-dimensional engineered tumour for spatial snapshot analysis of cell metabolism and phenotype in hypoxic gradients
    Tissue-engineered 3D cancer microenvironment for screening therapeutics

    • 24 min
    Mapping the Human Proteoform: The Future of Cancer Therapy

    Mapping the Human Proteoform: The Future of Cancer Therapy

    What will be the future of cancer therapy? In this episode I discuss the major key takeaways from the recently published paper and established project: "The Human Proteoform Project: Defining the human proteome." 

    Ranging from stories of a six year old girl, among many, who was cured from childhood cancer using immunotherapy. We've known that strategies like chemotherapy and immune-supression like insulin have only been partially successful. What have we been missing this whole time? I discuss how the emerging field of precision medicine takes into account the other half of what has been missed—which will increase the efficacy and aid the development of novel therapeutics that are both preventative and curative. 



    The Human Proteoform Project: Defining the human proteome: 

    https://doi.org/10.1126/sciadv.abk0734



    Differences between germline genomes of monozygotic twins:

    https://www.nature.com/articles/s41588-020-00755-1

    • 25 min
    What happens when your DNA is damaged?

    What happens when your DNA is damaged?

    Did you know that thousands of mutations occur on our DNA every second? In this episode I discuss what happens when our DNA is damaged, and more specifically, what happens when our body fails to repair mutations on our DNA, leading to disease. I talk about how mutations on our DNA can either cause disease or increase our chances of survival. I talk about what makes someone genetically prone to a disease and what it means for someone to be genetically prone to a certain disease. I talk about how mutations can be beneficial and detrimental simultaneously, which is what is seen in sickle cell disease. I discuss how advances in healthcare allows us to examine which diseases we are genetically prone to, like breast cancer, and how these tests allow us to take steps to prevent the disease from being expressed. I also talk about the promise of genetic engineering and CRISPR technology and how they can be applied and implemented to potentially cure diseases like sickle cell disease and muscular dystrophy.

    • 26 min
    Dr. Austin Perlmutter on Brain Health and Chronic Disease

    Dr. Austin Perlmutter on Brain Health and Chronic Disease

    Do you respond or react to your biology? In this episode, we welcome our guest Dr. Austin Perlmutter, an internal medicine physician, New York Times Bestselling author of Brain Wash, and researcher. We had an amazing conversation on the root of preventing chronic disease. The focal point of our conversation was on how our cognition affects the quality of our decisions which then drives behaviours that affect the quality of our life.

    Dr. Austin Perlmutter is an internal medicine physician, New York times Bestselling author of Brain Wash, and researcher. He focuses on the interconnection between our immune system pathways, neurochemistry, and cognition. He has published various articles in the medical literature connecting inflammation, the gut microbiota, depression, diet, COVID-19, sleep, and immunity. His recent article is an extensive review on the COVID-19 pandemic and depression: https://www.frontiersin.org/articles/10.3389/fneur.2021.657004/full 

    Often times we react to our biology rather than respond to our biology. Often times we let our psychological state drive our behaviours. Dr. Austin Perlmutter talked about how to gain control of our actions by paying attention to how our brain works. Many tools were discussed throughout the episode to optimize our brain health and increase quality of life. 

    • 59 min
    How Food Influences Our Emotions

    How Food Influences Our Emotions

    This episode discusses the gut-brain connection. I discuss the key aspects of the nervous system—more specifically, the peripheral and enteric nervous system for serotonin and dopamine synthesis. I talk about how the gut microbiome is initially developed via vertical transmission of the amniotic fluid, placenta and meconium. I talk about the different ways our gut microbiome is affected before and during childbirth. Many tools are discussed related to plant-based diets, fermented foods and Omega-3 supplements. I go over various studies regarding the effects of probiotics, artificial sweeteners, Omega-3 fatty acids, SCFAs and their potential beneficial and detrimental effects on the gut microbiome, brain and body. 



    Artificial Sweeteners and Gut Microbiome:

    https://pubmed.ncbi.nlm.nih.gov/25231862/

    https://pubmed.ncbi.nlm.nih.gov/25231865/

    Anti-Depressive Effects of EPAs:

    https://pubmed.ncbi.nlm.nih.gov/18247193/

    Effects of L-Dopa on Parkinson's Patients:

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197852/

    SCFAs on Colonic Serotonin Secretion: 

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396604/

    • 30 min

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