IDEA Collider: Innovation & Asymmetric Learning in Pharma

IDEA Pharma, SAI MedPartners
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IDEA Collider explores how asymmetric learning drives bold innovation in the pharmaceutical and life sciences industries. Hosted by Mike Rea, CEO of IDEA Pharma & Head of Strategy and Thought Leadership at SAI MedPartners, the podcast features conversations with top thinkers, scientists, and strategists who challenge the status quo to spark real progress in drug development, biotech, and healthcare. Each episode dives into how organizations can make smarter decisions earlier, reimagine R&D, and unlock competitive advantage through differentiated thinking. Questions We Explore * What is asymmetric learning, and how does it fuel pharma innovation? * Why do some organizations outpace others—and what can we learn from them? * How can we overcome barriers to meaningful progress in healthcare? * What’s broken in traditional innovation models—and how do we fix it? 🎧 Listen and subscribe on all major platforms.

  1. Dr. Christian Rommel on Oncology Innovations and Modern Drug Development at Bayer

    -6 DIAS

    Dr. Christian Rommel on Oncology Innovations and Modern Drug Development at Bayer

    In this episode of Idea Collider, host Mike Rea interviews Dr. Christian Rommel from Bayer. Dr. Rommel discusses his journey in molecular oncology from the Max Planck Institute, through roles at Roche, to overseeing global R&D at Bayer. He shares insights on turning scientific discovery into novel medicines, collaboration between scientists and commercial teams, and the importance of maintaining scientific integrity. Dr. Rommel also delves into the impact of AI in drug development, the potential of genetic medicines, and the complexities of launching new medicines on a global scale. The conversation also touches on embracing failure, internal and external partnerships, and the evolving landscape of clinical translation.   00:00 Introduction and Guest Welcome 00:25 Christian Rommel's Journey in Oncology 03:02 The Importance of Collaboration in Innovation 05:16 Balancing Risk and Reward in Drug Development 18:07 The Role of AI and Data in Modern R&D 22:33 Partnerships and External Learning 26:16 Balancing Legacy and Innovation in Biotech 27:18 Global Expansion and Leadership Diversity 27:27 Courage in Biotech Management 27:54 Inspiration from Roche Genentech 30:26 Commitment to Product Supply and Market Readiness 32:23 Challenges of Global Launches 35:53 Emerging Trends in Pharma: AI and Genetic Medicines 42:20 Decision-Making in Pharma 47:30 Reflections on Academic and Professional Journey   Don't forget to Like, Share, Subscribe, Rate, and Review!   Keep up with Christian Rommel; LinkedIn: https://www.linkedin.com/in/christian-rommel/ Website: https://www.bayer.com/en/innovation/science-research-and-innovation   Follow Mike Rea On; Website: https://www.ideapharma.com/ X: https://x.com/ideapharma LinkedIn: https://www.linkedin.com/in/bigidea/   Listen to more fantastic podcast episodes: https://podcast.ideapharma.com/

    50 min
  2. Bold Science, Bigger Bets: Mathai Mammen on Visionary R&D and Transforming Biopharma

    9/07

    Bold Science, Bigger Bets: Mathai Mammen on Visionary R&D and Transforming Biopharma

    In this insightful episode of IDEA Collider, Mike welcomes Mathai Mammen, Chairman and CEO of Parabilis Medicines. Mathai shares his extensive journey through academia, MD PhD program at Harvard, co-founding Theravance, and leadership roles at Merck and J&J. They delve into Mathai's innovative approach to creating transformative medicines, navigating the biotech industry, and the unique challenges of targeting 'undruggable' proteins. They also discuss the role of AI in drug discovery, the importance of strategic risk, and fostering team resilience and spirit in both large and small pharma companies.   00:00 Introduction and Guest Background 00:56 Founding Thebans and Career Highlights 01:43 Leadership at Merck and J&J 02:18 Innovative Approaches at Parabilis Medicines 04:09 Defining and Tackling Undruggable Targets 09:27 Multivalent Drug Design and Bispecifics 13:53 AI and Data Science in Drug Development 19:28 Building and Leading World-Class Teams 25:41 The Importance of Holding Conviction as an Entrepreneur 26:25 Learning from Setbacks in the Biotech Industry 30:10 Challenges and Innovations in Drug Development 32:28 Navigating the Ups and Downs of the Biotech Industry 36:02 The Mission and Future of Parabilis 40:35 Personal Reflections and Advice for Entrepreneurs 46:46 Book Recommendations and Closing Thoughts   Don't forget to Like, Share, Subscribe, Rate, and Review!   Keep up with Mathai Mammen; LinkedIn: https://www.linkedin.com/in/mathai-mammen/ Website: https://parabilismed.com/   Follow Mike Rea On; Website: https://www.ideapharma.com/ X: https://x.com/ideapharma LinkedIn: https://www.linkedin.com/in/bigidea/   Listen to more fantastic podcast episodes: https://podcast.ideapharma.com/

    50 min
  3. Bridging Clinical Practice and Biotech: Paul Peter Tak's Transformative Journey

    22/06

    Bridging Clinical Practice and Biotech: Paul Peter Tak's Transformative Journey

    In this episode of Idea Collider, host Mike Rea interviews Paul Peter Tak, CEO of Candel Therapeutics, discussing his remarkable journey from a clinician in Amsterdam to leading cutting-edge biotech companies. Paul shares pivotal moments in his career, the challenges of transitioning from academia to big pharma, and the innovative principles he applied. He dives deep into Candel’s promising work in viral immunotherapies for cancers and the unique leadership and management philosophies that have guided his journey. Additionally, Paul Peter touches on his passion for leveraging collective intelligence and his unconventional hobbies that keep him grounded and creative.   00:00 Introduction and Guest Welcome 00:59 Early Career and Passion for Medicine 02:09 Transition to Industry and GSK Experience 04:50 Building Successful Organizations 07:42 Innovative Models in Pharma 19:03 Joining Candel Therapeutics and Vision for the Future 25:15 Transforming Cancer Treatment 27:24 Challenges in Biotech Market 28:45 Strategic Decisions and Prioritization 31:39 Collaborations and External Partnerships 33:07 Innovative Approaches and Future Prospects 44:23 Leadership and Personal Insights   Don't forget to Like, Share, Subscribe, Rate, and Review!   Keep up with Paul Peter Tak; LinkedIn: https://www.linkedin.com/in/paul-peter-tak-md-phd-fmedsci-1b44749/   Follow Mike Rea On; Website: https://www.ideapharma.com/ X: https://x.com/ideapharma LinkedIn: https://www.linkedin.com/in/bigidea/   Listen to more fantastic podcast episodes: https://podcast.ideapharma.com/

    50 min
  4. Creating Breakthroughs in Oncology: A Conversation with Susan Galbraith of AstraZeneca

    25/05

    Creating Breakthroughs in Oncology: A Conversation with Susan Galbraith of AstraZeneca

    In this episode of Idea Collider, we sit down with Susan Galbraith from AstraZeneca, a leading figure in oncology R&D. Susan shares her journey from medical training in Manchester and Cambridge to spearheading transformative cancer treatments at AstraZeneca. She discusses pivotal moments in her career, AstraZeneca's vision for eliminating cancer as a cause of death, the role of patient stories in motivating R&D efforts, and the integration of emerging technologies like AI and digital health tools.    With a focus on collaboration and continuous learning, Susan provides insights into how successful oncology drugs are developed and the importance of equitable representation in clinical trials. Stay tuned for an engaging conversation that highlights the future of personalized cancer therapies and the collaborative efforts driving innovations in oncology. Chapter Summaries; 00:00 Introduction and Guest Welcome 00:27 Susan Galbraith's Career Journey 02:37 Defining Success in Oncology R&D 05:01 Early Phase Drug Development 07:09 Digital Health and Patient Experience 12:37 Global Collaboration and Innovation 15:05 AI and Future of Oncology 28:08 Diversity and Inclusion in Clinical Trials 33:46 Mentorship and Career Advice 37:45 Challenges and Future Outlook in Oncology 42:06 Closing Remarks and Call to Action   Don't forget to Like, Share, Subscribe, Rate, and Review!   Keep up with Susan Gabraith; LinkedIn: https://www.linkedin.com/in/susan-galbraith-584a195/?originalSubdomain=uk  Follow Mike Rea On; Website: https://www.ideapharma.com/X: https://x.com/ideapharmaLinkedIn: https://www.linkedin.com/in/bigidea/  Listen to more fantastic podcast episodes: https://podcast.ideapharma.com/

    43 min
  5. Biotech Innovations & Leadership with John Maraganore

    18/05

    Biotech Innovations & Leadership with John Maraganore

    In this episode of IDEA Collider, we dive into the world of biotech innovation with John Maraganore, former CEO of Alnylam Pharmaceuticals. Recognized as a trailblazer, John transformed RNA interference from a scientific concept into a revolutionary class of medicines, leading the development of five life-changing drugs.  Join us as we explore John's journey from a first-generation American with Greek immigrant parents to a key figure in biomedicine. We'll discuss his education at the University of Chicago, his leadership role at Alnylam, drug delivery challenges for RNAi therapeutics, and the importance of strategic pharmaceutical alliances. John also shares his take on the current biotech environment, the impact of policy and regulation, and the promising future of genetic medicines and AI in drug discovery.   Chapter Summaries; 00:00 Introduction to John Maraganore: Biotech Trailblazer 01:11 John's Early Life and Education 03:09 Joining Alnylam and the RNAi Revolution 04:56 Challenges and Successes at Alnylam 06:47 Current Biotech Funding Environment 08:17 Global Competition and US Leadership in Biotech 10:25 The Importance of In-Person Collaboration 12:01 Overcoming Drug Delivery Hurdles 15:21 Maintaining an Entrepreneurial Spirit in Biotech 17:00 Balancing Science and Business in Decision Making 20:27 Strategic Partnerships in Biotech 23:36 The Role of Biotech in Global Challenges 26:25 Advocating for Policy Changes in Biotech 30:41 Mentoring the Next Generation of Biotech Leaders 32:35 Future Frontiers in Biotech Innovation 36:08 John's Vision for the Future of Biomedicine 37:18 Communicating Innovation and Leadership Don't forget to Like, Share, Subscribe, Rate, and Review!   Keep up with John Maraganore; LinkedIn: https://www.linkedin.com/in/john-maraganore/  Follow Mike Rea On; Website: https://www.ideapharma.com/X: https://x.com/ideapharmaLinkedIn: https://www.linkedin.com/in/bigidea/  Listen to more fantastic podcast episodes: https://podcast.ideapharma.com/

    39 min
  6. IDEA Collider- with IDEA Pharma COO Jacqueline Barendregt and Exploristics Founder & CEO Aiden Flynn

    08/05/2024

    IDEA Collider- with IDEA Pharma COO Jacqueline Barendregt and Exploristics Founder & CEO Aiden Flynn

    We are excited to tell you more about the IDEA Pharma and Exploristics partnership. IDEA’s COO, Jacqui Barendregt, asked Exploristics Founder and CEO Aiden Flynn five key questions about the innovative service model and, most importantly, the value to the pharmaceutical industry this newly formed partnership will bring.

    19 min

  7. 14/06/2023

    Embracing Innovation and Collaboration in the Pharma Industry with Dr. Nedim Pipic

    Welcome to another episode of Idea Collider with your host, Mike Rea.  In this engaging conversation, we delve into the world of pharmaceutical innovation and collaboration. Our guest, Dr. Nedim Pipic, a pharmaceutical expert specializing in mental and retinal health, shares his journey and passion for making a difference. Join us as we explore the unmet needs in these areas, the power of hybrid approaches and precision psychiatry, and the integration of digital therapeutics.  Discover how the industry is transforming lives through innovation while remaining patient-centric. With insights into measuring development quality, the advantages of being a private company, and the importance of collaboration, this episode will inspire you to embrace change and drive positive outcomes in the pharmaceutical landscape.  Tune in to Idea Collider today and be part of the movement toward a healthier, sustainable, and equitable future.  Chapter Summaries  [0:00:21] Introduction to today's guest, Dr. Nedim Pipic  [0:04:23] Discussion on Innovation and Growth Mindset  [0:06:44] Innovation and Patient Benefit in the Pharmaceutical Industry: A Discussion on the Importance of Return on Invention and Understanding Unmet Needs in Mental Health  [0:08:25] Innovating Mental Health: A Discussion on Precision Psychiatry and Unmet Patient Needs  [0:14:39] A Discussion on Precision Medicine and the Importance of Understanding Neurobiology in Addressing Symptoms  [0:16:39] Driving Innovation in Pharma: Importance of Early Research Collaborations and Agile Culture  [0:18:52] Discussion on Innovation and R&D in Pharmaceutical Industry  [0:20:22] Driving Innovation and Culture in a Private Pharmaceutical Company  [0:23:41] Insights on Innovation and Transformation  [0:25:46] The Importance of Seeking Inspiration Outside of the Pharma Industry: A Conversation on AI and Agile Transformation  [0:27:04] A Discussion on the Intersection of Medicine and Business in Pharmaceutical Innovation  [0:33:28] Discussion on the Future of the Pharma and Biotech Industry and the Importance of Innovation and Collaboration  [0:36:06] The Future of the Pharma Industry: Collaboration, Patient Empowerment, and Sustainability  [0:37:39] Closing Remarks  Don't forget to Like, Share, Subscribe, Rate, and Review!  Keep up with Dr. Nedim Pipic;  ● LinkedIn: https://www.linkedin.com/in/nedim-pip...  ● Website: http://www.boehringer-ingelheim.com  Follow Mike Rea On;  ● Website: https://www.ideapharma.com/  ● Twitter: https://twitter.com/ideapharma  ● LinkedIn: https://www.linkedin.com/in/bigidea/  Listen to more fantastic podcast episodes: https://podcast.ideapharma.com/  Don’t forget to Subscribe, Rate, Review, Like, and Share!  To listen to more fantastic podcast episodes: https://podcast.ideapharma.com/

    39 min
  8. Exploring the book “Quit: The Power of Knowing When to Walk Away” by Annie Duke

    28/12/2022

    Exploring the book “Quit: The Power of Knowing When to Walk Away” by Annie Duke

    Welcome to another incredible episode of the IDEA Collider│Pharma Book Club series with your host Mike Rea. Today, Annie Duke joins us on the show to discuss her latest book, “Quit: The Power of Knowing When to Walk Away.” Annie is an Author, Professional Speaker, Decision Strategist & co-founder of The Alliance for Decision Education, a non-profit whose mission is to improve lives by empowering students through decision skills education.  In the episode, Annie Duke delves into the motivation behind her latest book, “Quit,” when quitting is a valuable option rather than sticking around, grit versus willingness to quit, and Stewart’s Butterfield’s Quit story before founding Slack. In addition, Annie expounds on the fear of changing your mind and why most people worry about failing instead of winning.  Ultimately, she delves into the Monkey & Pedestal Model, three reasons behind building the pedestal, the kill criteria & why you should have a quitting coach!  Tune in for more!  During this episode, you will learn about;  [00:00:33] Introducing today’s guest  [00:01:37] What motivated Annie in writing her book Quit as opposed to Thinking in Bets that lead to decision making  [00:06:40] The difference between grit & willingness to quit  [00:09:27] Why eight times more people die on the descent of Mt. Everest than climbing  [00:18:53] Muhammad Ali is the embodiment of showing how in one circumstance, Grit can be a virtue & in the other circumstance, a downfall  [00:30:20] Stewart Butterfield’s story from one of the world’s greatest quitter to founding Slack  [00:39:37] The fear of changing your mind & failing [00:48:36] The monkey & pedestal model  [00:56:18] Three reasons behind building the pedestal  [01:02:38] The kill criteria  & the idea of having a quitting coach  [01:10:08] Does Annie act as a quitting coach?  [01:18:51] The Reverse Sicilian concept  [01:20:17] How to connect with Annie Duke   Don’t forget to Follow, Rate, Review, Like, and Share   Mentioned Books Thinking in Bets by Annie DukeQuit: The Power of Knowing When to Walk Away by Annie DukeGrit by Angela DuckworthInto Thin Air by Jon Krakauer  Let’s Connect!   Follow Alliance For Decision Education; Website: https://alliancefordecisioneducation.org/  Follow Annie Duke; Website: https://www.annieduke.com/Twitter: https://twitter.com/AnnieDukeLinkedIn: https://www.linkedin.com/in/annie-duke/  More Products Follow Mike Rea on; Website: https://www.ideapharma.com/Twitter: https://twitter.com/ideapharmaLinkedIn: https://www.linkedin.com/in/bigidea/  To listen to more amazing podcast episodes: https://podcast.ideapharma.com/

    1 h 22 min
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IDEA Collider explores how asymmetric learning drives bold innovation in the pharmaceutical and life sciences industries. Hosted by Mike Rea, CEO of IDEA Pharma & Head of Strategy and Thought Leadership at SAI MedPartners, the podcast features conversations with top thinkers, scientists, and strategists who challenge the status quo to spark real progress in drug development, biotech, and healthcare. Each episode dives into how organizations can make smarter decisions earlier, reimagine R&D, and unlock competitive advantage through differentiated thinking. Questions We Explore * What is asymmetric learning, and how does it fuel pharma innovation? * Why do some organizations outpace others—and what can we learn from them? * How can we overcome barriers to meaningful progress in healthcare? * What’s broken in traditional innovation models—and how do we fix it? 🎧 Listen and subscribe on all major platforms.

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