Twice monthly recap of the NephJC journal club
ACR, PCR and the urine dip stick
The filtrate welcome Drs. Morgan Grams and Talar Kharadjian to discuss the recent paper in Annals of Internal Medicine: Conversion of Urine Protein-Creatinine Ratio or Urine Dipstick Protein to Urine Albumin-Creatinine Ratio for Use in Chronic Kidney Disease Screening and Prognosis: An Individual Participant-Based Meta-analysis
When to initiate kidney replacement therapy in AKI, the STARRT Trial
Swapnil Hiremath COI: he was a sub-investigator on STARRT
And two special guests:
Dr. Jay Koyner of the University of Chicago and #NephBBQ fame.
Anitha Vijayan, professor of medicine at Wash U in St Louis
The STARRT-AKI trial acronym is: Standard versus Accelerated Initiation of Renal-Replacement Therapy in Acute Kidney Injury
Matt suggests STAKRT-AKI Standard versus Accelerated Initiation of Kikdney-Replacement Therapy in Acute Kidney Injury
Coverage at NephJC: Time to Stop Starting RRT Early in AKI
House of God by Samuel Shem. Contemporary Review in the New Yorker. Amazon
Ronco’s legendary dose of CRRT study. Lancet 2000.
AJKD Meta analysis on initiation of dialysis in AKI by VF Seabra.
Lead time bias
Timing of Initiation of Dialysis in Critically Ill Patients with Acute Kidney Injury Initiation of dialysis by BUN in the Picard trial by Dr. Kathleen Liu.
Immortal time bias
AKIKI and ELAIN trials as covered by NephJC
Issues surrounding informed consent in the ICU
The Chicago Way
Dr Palevsky’s ATN Study, AKA Intensity of Renal Support in Critically Ill Patients with Acute Kidney Injury
Is Irregardless A Word?
Debate at Kidney Week: Intensivist vs Nephrologist for Renal Replacement Therapy (RRT) in the ICU
Internal and External Validation of a Machine Learning Risk Score for Acute Kidney Injury
That sweet sweet NephJC pot of gold
Furosemide Stress Test and Biomarkers for the Prediction of AKI Severity
Thai study that used FST to randomize patients for early versus late start KRT: Early versus standard initiation of renal replacement therapy in furosemide stress test non-responsive acute kidney injury patients (the FST trial)
AKIKI 2 at clinical trials.gov
Swapnil’s Tubular secretion, the Twitter timeline of Oded Rechavi
Matt’s Tubular Secretion: #kidneydietchallenge
Anitha comes from the land of coconuts. Lots of potassium in coconut water.
The Skeleton Key Group on The Renal Fellow Network
Race and estimated GFR
And three special guests:
Carina Seah a second year MD PhD student Mt Sinai who led the initiative to remove race from the eGFR formulas
Poyan Mehr, founder of GlomCon and author of this post on the use of race in eGFR estimating formulas.
Deidra Crews Professor of Medicine and researcher in health disparities.
Petition for Removal of “Race Correction” in eGFR at Mount Sinai https://docs.google.com/document/d/1vJCwVndyzemWCx8RXZLvLm6JLuFN7NdgEFVCFaDnSOk/edit
Dr Murphy, Dean For Clinical Integration And Population Health. Professor And System Chair. https://icahn.mssm.edu/profiles/barbara-murphy
The Bowman Society at the University of Chicago. I can not find a recording of the webinar https://pritzker.uchicago.edu/resources/bowman-society
Social Determinants of Racial Disparities in CKD https://jasn.asnjournals.org/content/27/9/2576
Socioeconomic Disparities in Chronic Kidney Disease https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291541/
Shortcomings of the current GFR estimating equations https://pubs.glomcon.org/archives/1491
Alan S Go’s work on eGFR, hospitalization and death: https://www.nejm.org/doi/full/10.1056/nejmoa041031
Tangri Kidney Failure Risk Calculation https://kidneyfailurerisk.com
De-adjusting for body surface area: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756662/
2018 Nature Reviews Nephrology Porrini Estimated GFR: time for a critical appraisal https://www.nature.com/articles/s41581-018-0080-9
Estimating Glomerular Filtration Rate from Serum Creatinine and Cystatin C https://www.nejm.org/doi/full/10.1056/nejmoa1114248
Transdermal Measurement of Glomerular Filtration Rate in Mice https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235579/
Worldwide Frequencies of Apolipoprotein L1 Renal Risk Variants https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482949/
Health Affairs Blog about when and how to measure race in research: https://www.healthaffairs.org/do/10.1377/hblog20200630.939347/full/
ASN Kidney Stars https://www.asn-online.org/grants/travel/details.aspx?app=MSR
Allopurinol Fixes the Numbers and Little Else
The Freely Filtered team welcomes Katalin Susztak to talk about the recent pair of studies that examined the use of allopurinol to prevent the progression of CKD. It didn't work.
Hyperaldosteronism is everywhere
The Freely Filtered team welcome Susan Steigerwalt and Brian Byrd to talk about the recent study published in Annals of Internal Medicine that looks for hyperaldosteronism in patients with high salt intake and suppressed renin.
SGLT2i are diuretics
The Freely Filtered team welcome Paul Welling and Sadiya Kahn to talk about the recent study published in Circulation that does a careful and detailed analysis on the diuretic and the changes in the neural-hormonal effects of a two-week, placebo-controlled, cross-over trial of empagliflozen.