Drug Safety Matters

Uppsala Monitoring Centre

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MEDICINE
EVERY TWO MONTHS

Drug Safety Matters brings you the best stories from the world of pharmacovigilance. Through in-depth interviews with our guests, we cover new research and trends, and explore the most pressing issues in medicines safety today. Produced by Uppsala Monitoring Centre, the WHO Collaborating Centre for International Drug Monitoring.

25 OCT

#32 Pharmacovigilance in older adults – Giovanni Furlan

Medication-related-harm (MRH) is especially prevalent in older adults due to changing physiology as the body ages, increased frailty, and the incidence of polypharmacy in this patient group. Giovanni Furlan, Worldwide Safety Site Lead for Thessaloniki of Pfizer discusses what makes this patient group so vulnerable to adverse drug reactions, how poor representation and using age alone to define older adults exacerbates this problem, and suggests ways forward in monitoring drug safety in older ...

48 min
30 SEPT

#31 A guide to reporting disproportionality analyses – Michele Fusaroli and Daniele Sartori

Disproportionality analyses are a mainstay of pharmacovigilance research, but without clear guidelines, they often lead to confusion and misinterpretation. Enter the READUS-PV statement: the first-ever guide for reporting disproportionality analyses that are replicable, reliable, and reproducible. Tune in to find out: The history of reporting guidelines in pharmacovigilance and why the READUS-PV guidelines were created Why there has been a spike in the publication of dispropor...

43 min
26 AUG

Uppsala Reports Long Reads – Weeding out duplicates to better detect side effects

Duplicate reports are a big problem when it comes to signal detection, but with the help of machine learning and new ways of comparing reports, we may more effectively detect them. This episode is part of the Uppsala Reports Long Reads series – the most topical stories from UMC’s pharmacovigilance news site, brought to you in audio format. Find the original article here.After the read, we speak to author Jim Barrett, Senior Data Scientist at UMC, to learn more about the duplicate detecti...

25 min
27 JUN

Uppsala Reports Long Reads – Ensuring trust in AI/ML when used in pharmacovigilance

Ensuring trust in AI is vital to fully reap the benefits of the technology in pharmacovigilance. Yet, how do we do so while grappling with its ever-growing complexity?This episode is part of the Uppsala Reports Long Reads series – the most topical stories from UMC’s pharmacovigilance news site, brought to you in audio format. Find the original article here.After the read, we speak to one of the authors of the article, Michael Glaser, to learn more about how AI and ML has been used in pharmaco...

30 min
15 MAY

#30 Preventing and reporting medication errors – Rabat CC & UMC

Look-alike medicines, unclear communication and distractions during administration – medication errors may occur for many different reasons. They all have in common that they are unintended mistakes in the drug treatment process that may or may not lead to patient harm. In this episode Ghita Benabdallah and Loubna Alj from the national pharmacovigilance centre of Morocco, and Alem Zekarias from Uppsala Monitoring Centre discuss how we can prevent medication errors from occurring – and, when t...

34 min
23 APR

#29 When medicines change our behaviour – Michele Fusaroli

Medicines can affect our personality in positive ways, but they may also lead to destructive behaviours that can damage our relationships, finances, and overall quality of life. Michele Fusaroli from the University of Bologna explains how to diagnose and treat drug-induced impulse control disorders.Tune in to find out:Which medicines may cause impulsivityWhat the ‘four knights’ of impulsivity areHow patient stories can help detect these conditionsWant to know more?This review by Daniel Weintr...

31 min
29 FEB

#28 Catching black swans – François Montastruc

Serious and unexpected adverse drug reactions – the ‘black swans’ of pharmacovigilance – can place enormous strain on safety monitoring systems. Drawing examples from the COVID-19 pandemic, François Montastruc from Toulouse University Hospital explains how we can get better at dealing with the unpredictable.Tune in to find out:What Nassim Nicholas Taleb’s ‘black swan’ theory has to do with pharmacovigilanceWhat makes an adverse drug reaction a black, white, or grey swan Why flexibility a...

27 min
1 FEB

#27 When drugs damage the liver – Rita Baião

The liver is the primary site for drug metabolism in the body, but it can be severely damaged by medicines or their toxic compounds. Rita Baião from the North Lisbon University Hospital Center reviews what pharmacovigilance professionals should know about drug-induced liver injury (DILI).Tune in to find out:Who is most at risk of developing DILIHow to diagnose the condition and control the damageHow to assess case reports of DILIWant to know more?This infographic in Nature Reviews nicely summ...

29 min

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Creator

Uppsala Monitoring Centre
Years Active

2020 - 2024
Episodes

49
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Clean
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Drug Safety Matters

#32 Pharmacovigilance in older adults – Giovanni Furlan

#31 A guide to reporting disproportionality analyses – Michele Fusaroli and Daniele Sartori

Uppsala Reports Long Reads – Weeding out duplicates to better detect side effects

Uppsala Reports Long Reads – Ensuring trust in AI/ML when used in pharmacovigilance

#30 Preventing and reporting medication errors – Rabat CC & UMC

#29 When medicines change our behaviour – Michele Fusaroli

#28 Catching black swans – François Montastruc

#27 When drugs damage the liver – Rita Baião

About

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Drug Safety Matters

Episodes

#32 Pharmacovigilance in older adults – Giovanni Furlan

#31 A guide to reporting disproportionality analyses – Michele Fusaroli and Daniele Sartori

Uppsala Reports Long Reads – Weeding out duplicates to better detect side effects

Uppsala Reports Long Reads – Ensuring trust in AI/ML when used in pharmacovigilance

#30 Preventing and reporting medication errors – Rabat CC & UMC

#29 When medicines change our behaviour – Michele Fusaroli

#28 Catching black swans – François Montastruc

#27 When drugs damage the liver – Rita Baião

About

Information

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