Paul Saladino MD podcast

Paul Saladino, MD
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Paul Saladino MD podcast

Throughout my training and practice as a physician I have come to one very disappointing conclusion: Western medicine isn’t helping people lead better lives. Now that I’ve realized this, I’ve become obsessed with understanding what makes us healthy or ill. I want to live the best life I can and I want to be able to share this knowledge with others so that they can do the same. This podcast is the result of my relentless search to understand the roots of chronic disease. I hope you’ll join me on this journey.

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    252. The Root Cause of Metabolic Dysfunction w/ Dr. Casey Means

    In this podcast, I had the pleasure of sitting down with Casey Means to discuss the importance of removing processed foods and prioritizing unprocessed animal and plant foods in our diets… Casey and her brother Calley Means are leading the fight against processed food companies and have done a remarkable job in educating Americans about the importance of a whole-food diet that prioritizes unprocessed animal and plant foods… 00:00 Intro 01:42 Podcast begins 02:09 Casey’s story 13:24 The dark side of pharmaceutical companies 21:12 The root cause of most chronic diseases today 23:09 How to correct metabolic dysfunction 36:17 How processed foods break our metabolisms 48:16 What food should you eat? 57:06 Are seed oils healthy? 01:06:59 What about fruit? 01:30:13 The importance of sleep & sunlight Disclaimer: Dr. Paul Saladino received his medical degree from the University of Arizona Medical School.  His use of “doctor” or “Dr.” in relation to himself solely refers to that degree.  Dr. Saladino is a licensed physician in California, but he no longer practices in any state and does not see patients so he can focus on educating people as a full time activity. This video is for general informational purposes only.  It should not be used to self-diagnose and it is not a substitute for a medical exam, cure, treatment, diagnosis, and prescription or recommendation.  It does not create a doctor-patient relationship between Dr. Saladino and you.  You should not make any change in your health regimen or diet before first consulting a physician and obtaining a medical exam, diagnosis, and recommendation.  Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. ‌

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    251. Why Americans Are Sicker Than Ever w/ Alex Clark

    In this podcast, Paul had the pleasure of sitting down with Alex Clark to talk about health, processed foods, the flaws of western medicine, and dating advice for men… 00:00 Intro 02:11 Podcast begins 03:14 Roundtable hearing against processed foods 21:05 American cereals are toxic 26:49 How Alex overcame her health issues 43:43 Flaws of Western Medicine 49:49 Dating advice for men

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    250. When You Should Worry About LDL Cholesterol with Mike Fave

    Today, Paul and Mike unpack their opinions about lipids. They talk about true risk for cardiovascular disease, primary versus secondary prevention, lipid lowering drugs, and share their thoughts on a recent podcast episode with Peter Attia. *Produced by Mountain Valley Media 00:06:08 Blood markers & imaging techniques of metabolic function  00:14:38 Gene mutations 00:20:28 LDL & Plaque burden 00:27:23 Money in statins 00:31:38 Downsides of lowering LDL 01:21:23 The downsides of popular cholesterol lowering drugs 01:41:07 Should we fear heart attacks? 01:45:23 PCSK9 Inhibitors 01:52:43 Risk profile of Statins  01:53:02 Risk vs. reward of Ezetimibe 02:04:02 Primary vs. secondary prevention Resources: Debunking Sugar Claims: What Dr. Lustig Got Wrong On The Huberman Podcast: https://www.youtube.com/watch?v=JcEmSgbMfco&t=2933s Work With Mike: https://mikefave.com/

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    249. Bloodwork Review: April 2024

    This week, Paul shares his most recent set of bloodwork in totality. He shares what he decides to order and why, and what bloodwork you may consider getting yourself. He also unpacks the importance of cortisol to DHEA sulphate radio and his cholesterol results. 00:00:00 Podcast begins 00:01:40 Traditional bloodwork  00:05:40 MTHFR polymorphism: Does Paul take supplements? 00:10:10 Glucose & creatine 00:14:10 Electrolytes & insulin 00:23:10 Thyroid panel 00:26:18 Cortisol to DHEA sulphate ratio 00:32:20 Cholesterol panel 00:46:10 Hormones & Other results 00:50:20 Iron panel 00:52:40 What bloodwork should you get? References: July 2022 Bloodwork: https://www.youtube.com/watch?v=NuD9lWHMup8&t=669s August 2022 Bloodwork: https://www.youtube.com/watch?v=1br0cDkYv3Y December 2022 Bloodwork: https://www.youtube.com/watch?v=LQE3mrwaE8c March 2023 Bloodwork: https://www.youtube.com/watch?v=vonHW14TTdg DEXA scan reveals “side effects” of red meat: https://www.youtube.com/shorts/ZgRoz60ugnc Cortisol, DHEA sulphate, their ratio, and all-cause and cause-specific mortality in the Vietnam Experience Study: https://pubmed.ncbi.nlm.nih.gov/20498139/ Cholesterol, coconuts, and diet on Polynesian atolls: a natural experiment: the Pukapuka and Tokelau island studies: https://pubmed.ncbi.nlm.nih.gov/7270479/ Cardiovascular risk factors in a Melanesian population apparently free from stroke and ischaemic heart disease: the Kitava study: https://pubmed.ncbi.nlm.nih.gov/8077891/ The effect of HMG-CoA reductase inhibitors on cognition in patients with Alzheimer's dementia: a prospective withdrawal and rechallenge pilot study: https://pubmed.ncbi.nlm.nih.gov/22921881/ Lipid profile of term infants on exclusive breastfeeding and mixed feeding: a comparative study: https://pubmed.ncbi.nlm.nih.gov/17327867/ Total cholesterol and all-cause mortality by sex and age: a prospective cohort study among 12.8 million adults: https://www.nature.com/articles/s41598-018-38461-y Low-Density Lipoprotein Cholesterol Is Predominantly Associated With Atherosclerotic Cardiovascular Disease Events in Patients With Evidence of Coronary Atherosclerosis: The Western Denmark Heart Registry: https://pubmed.ncbi.nlm.nih.gov/36621817/ Get your bloodwork from ultalabs.com

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    248. Why I Built a Food Company with Anthony Gustin

    While the food industry continues to follow its convenience, profit, addiction business model Paul and Anthony explain the ethos behind and process of creating Lineage Provisions, a radically transparent food company determined to play their part in elevating and celebrating food quality. Check out Lineage Meat Sticks here: lineageprovisions.com/psmdyt *Produced by Mountain Valley Media 00:00:00 Podcast begins 00:03:00 The devaluation of food preparation in modern society 00:09:00 how supply chain issues contribute to poor food quality 00:17:50 Why it’s so hard to raise pork and chicken on their ancestral diet 00:28:47 Ads 00:45:21 Why most “grass-finished” beef isn’t what you think it is 01:05:09 Lineage Ad 01:13:21 Paul’s beef with seafood 01:21:20 Testing for PFAs 01:25:17 What to expect from Lineage Provisions 01:28:45 Answering FAQs about Lineage Provision’s meat sticks Buy Lineage Beef Sticks: https://lineageprovisions.com/products/classic-meat-sticks

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    247. Gary Brecka: Tap Water is Lowering Your IQ!

    Paul has Human Biologist and founder of 10X Health Systems Gary Brecka on the podcast this week. As a previous life insurance adjuster, he talks about longevity through the lens of maintenance, being nutritionally optimal, and biohacking. They touch on adequate water filtration, all things genes & methylation, and food sourcing in the US. *Produced by ⁠Mountain Valley Media 00:00:00 Podcast begins 00:01:23 What is fluoride and is it harmful? 00:07:30 How to filter your water 00:09:00 Western medicine & longevity 00:27:00 Food sourcing and big food 00:30:50 Cyanocobalamin 00:34:55 Folic acid 00:42:00 Gathering objective & subjective data 00:49:00 The importance of gene testing & methylation

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    246. Some things I'm experimenting with lately...

    On today’s podcast, Paul shares some new things he’s been experimenting with lately including eating more heart, supplementing with creatine, attempting to incorporate white rice as a carb source, and most excitingly, the launch of his new company: Lineage. *Produced by ⁠Mountain Valley Media 00:00:00 The importance of heart & riboflavin 00:08:30 Pauls new company: Lineage 00:10:50 Thoughts on creatine 00:19:10 Paul’s experience with white rice & potatoes 00:24:45 Paul experimenting with supplements for methylation Check out Lineage Meat Sticks: https://lineageprovisions.com/password References: Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C-T polymorphism: https://pubmed.ncbi.nlm.nih.gov/16380544/

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    245. Debunking Sugar Claims: What Dr. Lustig Got Wrong On The Huberman Lab Podcast

    This week, Paul talks to Mike Fave, critical care RN, about all things sugar & fructose. They share their thoughts on a recent podcast with Andrew Huberman and Alex Lustig, and why they disagree with certain points made about insulin, fruit juice, and fructose. *Produced by ⁠Mountain Valley Media 00:00:00 Podcast begins 00:04:00 Mike’s background 00:05:15 Diving into fructose 00:13:00 Thoughts on honey and other carb sources 00:27:30 Robert Lustig rebuttal: is fructose addictive? 00:37:40 Fructose & fiber 00:47:00 How fructose affects the mitochondria 00:51:00 Clarifying hyperglycemia vs. a postprandial hyperglycemia 00:56:17 Is insulin the bad guy? 01:12:20 How insulin relates to diabetes, obesity, and insulin resistance 01:23:30 Balancing protein, fat and carbohydrates 01:30:00 Is fructose making us fat? 01:46:00 Final thoughts Connect with Mike: Mikefave.com https://m.youtube.com/@MikeFaveSimplified References: Review article: fructose malabsorption and the bigger picture: https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2006.03186.x A Relationship between Reduced Nucleus Accumbens Shell and Enhanced Lateral Hypothalamic Orexin Neuronal Activation in Long-Term Fructose Bingeing Behavior: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988143/ A High-Fat Meal, or Intraperitoneal Administration of a Fat Emulsion, Increases Extracellular Dopamine in the Nucleus Accumbens: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061790/ A Relationship between Reduced Nucleus Accumbens Shell and Enhanced Lateral Hypothalamic Orexin Neuronal Activation in Long-Term Fructose Bingeing Behavior: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988143/ The regulation of glucose metabolism: implications and considerations for the assessment of glucose homeostasis in rodents: https://journals.physiology.org/doi/full/10.1152/ajpendo.00165.2014?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org Consumption of Raw Orange, 100% Fresh Orange Juice, and Nectar- Sweetened Orange Juice—Effects on Blood Glucose and Insulin Levels on Healthy Subjects: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770506/ The Effects of Soluble Dietary Fibers on Glycemic Response: An Overview and Futures Perspectives: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736284/#B37-foods-11-03934 The Effects of Soluble Dietary Fibers on Glycemic Response: An Overview and Futures Perspectives: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736284/#B37-foods-11-03934 Formation of Fructose-Mediated Advanced Glycation End Products and Their Roles in Metabolic and Inflammatory Diseases: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5227984/ Altered glycolytic and oxidative capacities of skeletal muscle contribute to insulin resistance in NIDDM: https://pubmed.ncbi.nlm.nih.gov/9216960/ Glucagon and type 2 diabetes: the return of the alpha cell: https://pubmed.ncbi.nlm.nih.gov/25344790/ Insulin, growth hormone and sport: https://pubmed.ncbi.nlm.nih.gov/11431133/ Effect of Mild Physiologic Hyperglycemia on Insulin Secretion, Insulin Clearance, and Insulin Sensitivity in Healthy Glucose-Tolerant Subjects: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881846/ Fructose metabolism in humans – what isotopic tracer studies tell us: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533803/ Absorption capacity of fructose in healthy adults. Comparison with sucrose and its constituent monosaccharides: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1433856/ Review article: fructose malabsorption and the bigger picture: https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2006.03186.x Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice: https://pubmed.ncbi.nlm.nih.gov/19637282/ Fructose Promotes Leaky Gut, Endotoxemia and Liver Fibrosis through CYP2E1-Mediated Oxidative and Nitrative Stress: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783321/

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Throughout my training and practice as a physician I have come to one very disappointing conclusion: Western medicine isn’t helping people lead better lives. Now that I’ve realized this, I’ve become obsessed with understanding what makes us healthy or ill. I want to live the best life I can and I want to be able to share this knowledge with others so that they can do the same. This podcast is the result of my relentless search to understand the roots of chronic disease. I hope you’ll join me on this journey.

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    Paul Saladino, MD
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    Paul Saladino MD podcast

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