Inside GRAPPA GRAPPA Network

Today on Inside GRAPPA, host Fabian Proft is joined by Professor Elaine Husni and Professor Stefan Siebert to discuss the management of conditions related to psoriatic arthritis (PSA), particularly inflammatory bowel disease (IBD) and uveitis.
In this episode, we discuss treatment modalities, the importance of early diagnosis, and the implications for clinical practice. The experts also delve into future directions for PSA treatment, highlighting the evolving field of biologics and interdisciplinary approaches. This episode offers a comprehensive exploration of managing associated conditions in PSA, emphasizing the importance of personalized treatment strategies.
What's inside this episode?
Understanding Psoriatic Arthritis: Insights into managing associated conditions like IBD and uveitis.Expert Discussions: Professors Husni and Siebert share their experiences and approaches in treating these complex cases.Future of Treatment: An overview of emerging therapies and the importance of interdisciplinary collaboration in PSA management.Clinical Perspectives: Exploring the impact of early diagnosis and treatment personalization on patient outcomes.
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In this insightful episode, our host and moderator Dr. Charlotte Gollins dives deep into the complexities and nuances of the 2022 GRAPPA Treatment Recommendations for the skin psoriasis domain, alongside experts Dr. Kristina Duffin and Dr. Joseph Merola.
What's inside this episode?
Behind the Scenes: Get an exclusive look into the rigorous process of developing the GRAPPA treatment recommendations.Challenges and Innovations: Explore the unique challenges faced in formulating guidelines for a complex disease like psoriatic arthritis.Expert Insights: Hear from Dr. Duffin and Dr. Merola as they share their experiences and the key focus areas in the development process of the skin domain.Future Directions: Learn about the aspirations for future updates to these crucial guidelines and how they aim to continuously evolve to meet patient needs.
Join us for a deep dive into:
The multifaceted approach to treating psoriasis.Balancing evidence-based guidelines with practical clinical application.The ongoing journey to refine and improve treatment recommendations.
Why listen?
Educational Insight: Understand the latest advancements in psoriasis treatment.Expert Opinions: Gain valuable knowledge from leading experts in the field.Global Impact: Discover how these guidelines are shaping psoriatic arthritis care worldwide.
Stay Connected:
For more intriguing insights and episodes, visit our website. Don't forget to subscribe to Inside GRAPPA for more episodes like this. Share with your colleagues and friends who might benefit from this episode!
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Explore the realm of enthesitis and its treatment advancements in this informative episode of Inside GRAPPA. With renowned experts, Philip Mease (USA) and Dr. Lihi Eder (Canada), we journey through the intricacies of these diseases, emphasizing the manuscript "Management of Enthesitis in Patients with Psoriatic Arthritis." Discover the essence of Enthesitis, the challenges in its diagnosis, and the promising horizon of treatments. Stay curious as we unravel the complexities of this intriguing topic together!
Key Highlights:
Manuscript Spotlight: 
"Management of Enthesitis in Patients with Psoriatic Arthritis" - A comprehensive paper spotlighting the advancements and current insights on psoriatic arthritis and enthesitis.
Understanding Enthesitis:
The essence and impact of Enthesitis in the medical landscape. The diagnostic challenges and the role of ultrasound in offering a game-changing solution.
Journey through Treatments:
Historical insights into enthesitis and the tools, like the Leeds Enthesitis Index and SPARC, that have transformed our understanding over the last 25 years.The evolution of treatments, what the present offers, and a sneak peek into the future of psoriatic arthritis treatment.
Unveiling the Future:
The burning questions surrounding the pathophysiology of Enthesitis and the unmet needs in its management. The promising direction of current research and what it aims to achieve.
Resources and Links:
Manuscript: Management of Enthesitis in Patients with Psoriatic Arthritis. Organizations: CorEvitas Cohort - Delve deeper into the studies that shape our understanding of enthesitis.



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Dive deep into the intricate world of psoriasis and psoriatic arthritis with experts Prof. Dafna Gladman and Prof. Ennio Lubrano. This episode focuses on the latest research, insights, and breakthroughs, with an in-depth exploration of the manuscript "Management of Axial Disease in Patients with Psoriatic Arthritis." Join us as we navigate the nuances and challenges of axial psoriatic arthritis, its distinction from ankylosing spondylitis, and the complexities of treatment choices. Stay curious, and let's uncover the mysteries of this fascinating topic together!
Key Highlights:
Manuscript Spotlight: "Management of Actual Disease in Patients with Psoriatic Arthritis" -- a vital paper highlighting the advancements and current understanding of axial psoriatic arthritis.Axial PsA Exploration:Historical perspective of Axial PsA and its progression.Differences between psoriatic arthritis with axial disease and ankylosing spondylitis.Radiographic features, MRI in diagnosis, and the AXIS trial's significance.Treatment Landscape:The current treatments available and the challenges of determining the best treatment.Addressing similarities and differences in treatment approaches for axial psoriatic arthritis and axial spondyloarthritis.Future Perspectives:The need for further research and clarity in defining axial psoriatic arthritis.The anticipation around the STAR study results and their implications.
Resources and Links:
Organization: Spondyloarthritis Research Consortium Canada (SPARCC).Studies:AXIS trial (Axial Psoriatic Arthritis)The STAR studyPublication: Article on early stages of axial psoriatic arthritis published in the Annals.Stay Connected: Visit our official GRAPPA website for more resources and episodes.

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In this enlightening episode of Inside GRAPPA, we delve deep into the intricate world of peripheral arthritis in psoriatic disease. Today's host, Dr. Sebastian Herrera, is joined by the esteemed Dr. Katy Leung, and Professor Oliver Fitzgerald to discuss the significance, manifestation, and management of peripheral arthritis in patients with psoriatic disease.
Dr. Herrera is a rheumatologist at Clínica Las Américas Auna and ARTMEDICA in Medellín, Colombia and also an Associate Professor of Rheumatology at Universidad CES and a member of Young GRAPPA. 
Dr. Leung is an Associate Professor at Singapore General Hospital and Duke-NUS Medical School in Singapore. Dr. Leung has interest in clinical and translational research in PsA, is the co-chair of the GRAPPA-OMERACT Outcome Measure Working group, and is also a member of the GRAPPA Education Committee. Dr. Fitzgerald is based at University College Dublin and has a major interest in clinical and translational research in PsA. More recent studies have explored genetic factors and biomarker development. Dr. Fitzgerald has been involved for many years with GRAPPA and took up the office of co-President in July 2021. He has been advocating for grant application opportunities addressing critical unmet needs in PsA for some time and this has culminated in the award of the first, significant, joint EU/industry funded Innovative Medicines Initiative (IMI) grant in PsA, the HIPPOCRATES consortium.

🗝 Key Points & Highlights:   - Importance of Peripheral Arthritis:
A critical manifestation in psoriatic disease, contributing to morbidity and irreversible joint damage if uncontrolled.Early detection and treatment are paramount to prevent long-term disability.   - Symptoms and Manifestations:
Peripheral arthritis often presents as the first sign, leading to joint pain, swelling, and Arthralgia.Studies highlight its prevalence, with erosions noted in 47% of patients within two years of symptom onset.   - Risk Factors and Associations:
Family history of psoriatic arthritis, severity of psoriasis, and obesity are common risk factors.The presence of certain genetic markers and clinical features can help predict the development of psoriatic arthritis.   - Treatment Strategies & Recommendations:
The episode discusses the use of conventional DMARDs like methotrexate and the divergence in treatment preferences across continents.TNF blockers, IL-17 blockers, IL-23 blockers, and JAK inhibitors are strongly recommended, highlighting the need for more head-to-head studies to guide treatment choices.
📚 Resources and Studies Mentioned:TICOPA trial & PSA SIM trial: Examining the efficacy of conventional DMARDs in peripheral arthritis.Presto Study: Investigating predictive factors for the onset of psoriatic arthritis.Hippocrates Consortium: Conducting extensive research on various treatments focusing on methotrexate, TNF inhibitors, and JAK inhibitors.
🔗 Links and Social Media:Visit our Website for more information.Follow us on YouTube, Facebook, and Twitter.

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Welcome to the inaugural episode of Inside GRAPPA, where we delve into the latest research and development on psoriatic diseases.
This episode takes you behind the scenes of GRAPPA (Group for Research and Assessment of Psoriasis and Psoriatic Arthritis), sharing the meticulous process of creating these vital guidelines.
In our inaugural episode, we bring together experts Laura Coates, Artie Kavanaugh, and Enrique Soriano along with Moderator Fabian Proft. They provide their unique perspectives on the creation, implementation, and future of the GRAPPA guidelines. This comprehensive framework is changing lives by reducing disease activity and managing symptoms, and you'll get to hear firsthand how it's evolved.
 
Visit our website at grappanetwork.org to learn more.

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