Sapio with Buck Joffrey

Buck Joffrey
  • 5.0 (37)
  • 替代保健
Sapio with Buck Joffrey

The podcast that explores the world through the eyes of Buck Joffrey. Join us as we venture beyond the realm of finance and discover Buck’s passions for health, longevity, psychology, and more.

  1. 3天前

    110: Unique Framework for Nutrition and Longevity

    In this episode, Buck dives into the groundbreaking work of Dr. David Raubenheimer and Professor Stephen Simpson, renowned nutritional scientists from the University of Sydney. They unpack the "Geometric Framework for Nutrition," a holistic and visual approach that examines how nutrients interact to shape health and aging. From protein leverage to balancing macronutrients for longevity, this conversation challenges conventional calorie counting and offers profound insights into optimizing diet across the lifespan.

    38 分钟

  2. 11月11日

    109: Red Light in Mitochondrial Health

    Buck and Prof Glen Jeffery dive deep into the science of red light therapy, revealing how it boosts mitochondrial function and potentially slows aging. He shares groundbreaking insights from clinical trials, showing how red light can recharge cellular energy and improve vision health. We get into practical tips on using red light therapy—where to get it, when to use it, and what to watch out for in devices.

    38 分钟

  3. 11月4日

    108: Diving Deep on Lipids and Heart Disease

    Buck interviews Dr. Dennis Hughes, a concierge physician with a special interest in lipidology. They discuss the complexities of cholesterol, the importance of understanding lipid profiles, and the role of various lipoproteins in cardiovascular health. Dr. Hughes emphasizes the need for modern medicine to move beyond outdated notions of 'good' and 'bad' cholesterol, advocating for a more nuanced understanding of lipid management. The discussion also covers key lab tests, the significance of apolipoprotein B, and the future of pharmacotherapy in lipid management. 04:51 Understanding Cholesterol: Beyond Good and Bad   08:25 Key Lab Tests for Lipid Management   11:12 The Role of Apolipoprotein B in Cardiovascular Health   14:44 The Complexities of HDL and Its Functions   19:11 The Misconceptions Around LDL and HDL Ratios   34:42 Pharmacotherapy: Statins and Beyond

    47 分钟

  4. 10月28日

    Do You Have Your Longevity Roadmap?

    Sapio with Buck Joffrey

    4 分钟

  5. 10月28日

    107: Longevity Supplements - The Novos Approach

    Dr. Diogo Barardo, Director of Research and Development at Novos, joins Buck to discuss Novos’ innovative approach to longevity supplements, unpacking the differences between biological and epigenetic aging and the impact of the Drug Age database. He details how Novos evaluates compounds for safety and efficacy, the unique ingredients in their flagship NovoScore, and the promising roles of lithium microdoses and NAD precursors. Their conversation also delves into the latest in longevity science, from the controversies around resveratrol to mitophagy’s role in cellular health, the complexities of supplement dosages, and the potential of aging biomarkers and AI-driven research for consumer longevity solutions. Learn more about Dr. Barardo and NOVOS: https://novoslabs.com/ 00:00 Introduction to Longevity Research and Novos   02:04 Understanding Biological and Epigenetic Aging   09:20 The Drug Age Database and Its Significance   10:37 Longevity Compounds and Their Efficacy   20:58 The Role of Lithium and NAD Precursors   26:44 The Role of Mitochondria in Aging   36:14 Leveraging AI in Longevity Research

    45 分钟

  6. 10月21日

    106: Nitric Oxide - The X Factor in Longevity?

    Buck and Dr. Nathan Bryan delve into the pivotal role of nitric oxide in human physiology, with a particular focus on cardiovascular health and aging. Dr. Bryan breaks down the body’s nitric oxide production processes, how everyday lifestyle choices impact its levels, and what happens when there’s a deficiency. He also explores the surprising connection between oral hygiene and nitric oxide, the risks associated with proton pump inhibitors, and the promise of emerging products designed to boost nitric oxide levels. Additionally, Dr. Bryan addresses genetic factors such as MTHFR polymorphisms that can impact nitric oxide synthesis, shedding light on their broader implications for health and longevity. 00:00  The Role of Nitric Oxide in Human Physiology 02:54 Age-Related Decline of Nitric Oxide and Cardiovascular Health 05:49 Understanding Nitric Oxide Production Pathways 09:03 The Impact of Oral Health on Nitric Oxide Levels 12:11 Proton Pump Inhibitors and Their Effects on Nitric Oxide 15:12 Pharmaceutical Approaches to Increase Nitric Oxide 18:03 Innovations in Nitric Oxide Delivery Systems 21:25 The Role of Nitric Oxide as a Hormone 23:02 Nitric Oxide in COVID-19 Treatment 25:58 MTHFR Gene and Nitric Oxide Production 29:05 Cardiovascular Disease and Nitric Oxide 31:53 Safety and Regulation of Nitric Oxide 34:05 Cholesterol Myths and Nitric Oxide's Importance

    40 分钟

  7. 10月14日

    105: Understanding Heart Rate Variability

    Buck speaks to Dr. Torkil Færø, a Norwegian general practitioner, emergency physician, and seasoned traveler with Doctors Without Borders, to discuss the crucial relationship between stress, heart rate variability (HRV), and overall health. Dr. Færø delves into how HRV serves as a key indicator of our body’s autonomic nervous system balance, showing how lifestyle factors, particularly chronic stress, can undermine well-being. He highlights practical strategies, from breathwork to dietary adjustments, aimed at optimizing HRV and promoting long-term health. 00:12 What is Heart Rate Variability? 05:34 The Normal Range of HRV 08:39 Contributing Factors that Impact Your HRV 23:18 Tactics to Improve HRV

    38 分钟

  8. 10月7日

    104: The Real Science Behind Mitochondrial Health

    Buck discusses the implications of mitochondrial dysfunction on aging, and the unique genetics of mitochondrial DNA. He also explores innovative approaches to enhance mitochondrial health, including gene therapy and the use of specific pharmaceuticals and supplements. Buck emphasizes the importance of understanding mitochondrial function in the context of health and longevity, while also addressing the potential challenges posed by medications like statins and conditions such as long COVID. 02:07 What are Mitochondria? 05:05 Mitochondrial Dysfunction and Aging 12:13 Mitochondrial Genetics and Inheritance 14:54 Innovative Approaches to Mitochondrial Health 17:58 Pharmaceuticals and Supplements for Mitochondrial Support

    19 分钟
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The podcast that explores the world through the eyes of Buck Joffrey. Join us as we venture beyond the realm of finance and discover Buck’s passions for health, longevity, psychology, and more.

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