Developments and Challenges in the Therapeutic Landscape of Chronic Myeloid Leukemia

Drs Michael J. Mauro and Jorge E. Cortes discuss developments in the therapeutic landscape of chronic myeloid leukemia, complexities of resistance, and the potential for treatment-free remission.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/989026). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Chronic Myelogenous Leukemia (CML) https://emedicine.medscape.com/article/199425-overview

Tyrosine Kinase Inhibitors https://www.ncbi.nlm.nih.gov/books/NBK563322/

Chronic Myelogenous Leukemia (CML) Treatment Protocols https://emedicine.medscape.com/article/2005453-overview

Monitoring Molecular Response in Chronic Myeloid Leukemia https://pubmed.ncbi.nlm.nih.gov/20960522/

Accelerated Phase Chronic Myelogenous Leukemia https://www.cancer.gov/publications/dictionaries/cancer-terms/def/accelerated-phase-chronic-myelogenous-leukemia

The 5th Edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms https://pubmed.ncbi.nlm.nih.gov/35732831/

International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: Integrating Morphologic, Clinical, and Genomic Data https://pubmed.ncbi.nlm.nih.gov/35767897/

International Chronic Myeloid Leukemia Foundation https://www.cml-foundation.org/

Sokal Score for CML https://reference.medscape.com/calculator/559/sokal-score-for-cml

Treatment-Free Remission: The New Goal in CML Therapy https://pubmed.ncbi.nlm.nih.gov/34618317/

Hematopoietic Stem Cell Transplantation (HSCT) https://emedicine.medscape.com/article/208954-overview

Imatinib (Rx) https://reference.medscape.com/drug/gleevec-imatinib-342239

BCR-ABL Fusion Gene https://www.cancer.gov/publications/dictionaries/cancer-terms/def/bcr-abl-fusion-gene

Ph-like Acute Lymphoblastic Leukemia https://pubmed.ncbi.nlm.nih.gov/28972016/

Next-Generation Sequencing for BCR-ABL1 Kinase Domain Mutation Testing in Patients With Chronic Myeloid Leukemia: A Position Paper https://pubmed.ncbi.nlm.nih.gov/31801582/

ASXL1 Gene https://medlineplus.gov/genetics/gene/asxl1/

Asciminib https://reference.medscape.com/drug/scemblix-asciminib-4000255

The Specificity of Asciminib, a Potential Treatment for Chronic Myeloid Leukemia, as a Myristate-Pocket Binding ABL Inhibitor and Analysis of Its Interactions With Mutant Forms of BCR-ABL1 Kinase https://pubmed.ncbi.nlm.nih.gov/33096322/

ATP-Competitive Inhibitors Modulate the Substrate Binding Cooperativity of a Kinase by Altering Its Conformational Entropy https://pubmed.ncbi.nlm.nih.gov/35905186/

Ponatinib (Rx) https://reference.medscape.com/drug/iclusig-ponatinib-999800