Distillations | Science History Institute Science History Institute

In 1973 a bombshell study appeared in the premier scientific journal Science. It was called “On Being Sane in Insane Places.” Its author, a Stanford psychology professor named David Rosenhan, claimed that by faking their way into psychiatric hospitals, he and eight other pseudo-patients had proven that psychiatrists were unable to diagnose mental illness accurately.

Psychiatrists panicked, and, as a result, re-wrote what’s known as “psychiatry’s bible”—the Diagnostic and Statistical Manual of Mental Disorders, or DSM. The study and the subsequent overhaul of the DSM changed the field forever. So it was a surprise when, decades later, a journalist reopened Rosenhan’s files and discovered that the study was full of inconsistencies and even blatant fraud. So should we throw out everything it revealed? Or can something based on a lie still contain any truths?

Credits
Host: Alexis Pedrick
Senior Producer: Mariel Carr
Producer: Rigoberto Hernandez
Associate Producer: Sarah Kaplan
Audio Engineer: Jonathan Pfeffer
“Color Theme” composed by Jonathan Pfeffer. Additional music by Blue Dot Sessions

 

For more than 100 years, biologists who suggested that some cancers may be caused by viruses were the pariahs of genetics. However, they persevered and incrementally built their knowledge, leading to the discovery of retroviruses, the development of a test to diagnose HIV, and the creation of the HPV vaccine. Join us as we interview Gregory J. Morgan about his book Cancer Virus Hunters: A History of Tumor Virology.
Credits Host: Alexis Pedrick
Senior Producer: Mariel Carr
Producer: Rigoberto Hernandez
Associate Producer: Sarah Kaplan
Audio Engineer: Jonathan Pfeffer
“Color Theme” composed by Jonathan Pfeffer. Additional music by Blue Dot Sessions
Note to Our Listeners We are aware of an issue with certain podcast players displaying the incorrect length for the episode. We're looking into it and hope to have the matter resolved soon. In the meantime, the actual run time of the episode is the length displayed in the feed before pressing play. We apologize for the inconvenience. 

In 1973 biochemist Bruce Ames created a simple test that showed if chemicals had the potential to cause cancer. The Ames test made him a hero of the emerging environmental movement. But then he completely changed course and said concerns about chemicals were overblown. So what happened? Did Ames change? Or did our understanding of what causes cancer change?
Featured Oral History Bruce N. Ames, "Bruce N. Ames: The Marriage of Biochemistry and Genetics at Caltech, the NIH, UC Berkeley, and CHORI, 1954–2018" conducted by Paul Burnett in 2019 and 2020, Oral History Center, The Bancroft Library, University of California, Berkeley, 2021.
Credits Host: Alexis Pedrick
Senior Producer: Mariel Carr
Producer: Rigoberto Hernandez
Associate Producer: Sarah Kaplan
Audio Engineer: Jonathan Pfeffer
“Color Theme” composed by Jonathan Pfeffer. Additional music by Blue Dot Sessions
Note to Our Listeners We are aware of an issue with certain podcast players displaying the incorrect length for the episode. We're looking into it and hope to have the matter resolved soon. In the meantime, the actual run time of the episode is the length displayed in the feed before pressing play. We apologize for the inconvenience. 

Ozempic and others in this family of drugs are nothing short of miraculous. Meant to treat Type 2 Diabetes, the drug exploded in popularity after researchers found that patients were reporting losing 15-21% of their body weight in clinical trials. There were some side effects, but none so severe that it raised concerns. Doctors began prescribing it to people who weren't diabetic but could benefit from weight loss, and now, our only problem seems to be getting enough of it for all the people who need it. It all seems magical, but is it too good to be true? Join us as we dive into the history of weight loss drugs, drug manufacturing regulations, and the role we think medicine should play in our lives.
Credits Host: Alexis Pedrick
Senior Producer: Mariel Carr
Producer: Rigoberto Hernandez
Associate Producer: Sarah Kaplan
Audio Engineer: Jonathan Pfeffer
“Color Theme” composed by Jonathan Pfeffer. Additional music by Blue Dot Sessions
Note to Our Listeners We are aware of an issue with certain podcast players displaying the incorrect length for the episode. We're looking into it and hope to have the matter resolved soon. In the meantime, the actual run time of the episode is the length displayed in the feed before pressing play. We apologize for the inconvenience. 

The impact of cars on wildlife extends beyond roadkill, affecting species that never venture near roads. Car noise disrupts bird communication and behavior, and tire and brake dust from pollutes waterways with microplastics. In this wide-ranging interview, we talk to the author of Traffication: How Cars Destroy Nature and What We Can Do About It, Paul Donald about how he coined the term "traffication," the history of road ecology, and what we can do about the problem.
Credits Host: Alexis Pedrick
Senior Producer: Mariel Carr
Producer: Rigoberto Hernandez
Associate Producer: Sarah Kaplan
Audio Engineer: Jonathan Pfeffer
“Color Theme” composed by Jonathan Pfeffer. Additional music by Blue Dot Sessions
Note to Our Listeners We are aware of an issue with certain podcast players displaying the incorrect length for the episode. We're looking into it and hope to have the matter resolved soon. In the meantime, the actual run time of the episode is the length displayed in the feed before pressing play. We apologize for the inconvenience. 

In 1856, Henry Perkin's attempt to synthesize quinine led to something very different: a vibrant purple dye. Perkin’s mauve revolutionized the fashion industry when Queen Victoria wore a dress of the color to her daughter's wedding. And in an ironic twist, synthetic fabric dyes ultimately led to synthetic drugs, including the first antipsychotic. This drug, known by its trade name Thorazine, was a gamechanger. “Nobody thought there could be a drug that would treat schizophrenia effectively,” says sociologist Andrew Scull, “and then suddenly there was.” In this episode we explore the enduring relationship between dyes and drugs, and the role that mistakes and serendipity still play in drug development.
Credits
Host: Alexis Pedrick
Executive Producer: Mariel Carr
Producer: Rigoberto Hernandez
Associate Producer: Sarah Kaplan
Audio Engineer: Jonathan Pfeffer
“Color Theme” composed by Jonathan Pfeffer. Additional music by Blue Dot Sessions.
Note to Our Listeners We are aware of an issue with certain podcast players displaying the incorrect length for the episode. We're looking into it and hope to have the matter resolved soon. In the meantime, the actual run time of the episode is the length displayed in the feed before pressing play. We apologize for the inconvenience.