Podovirus

Jessica Sacher and Joseph Campbell
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Phages (bacteriophages) are viruses that kill bacteria with sniper-like precision. They can be incredibly useful for treating life-threatening infections ('phage therapy'), and can help us reduce our dependence on antibiotics. They've been known for 100 years... so WHY do we still not see them on the shelves? Jessica Sacher, PhD (Staff Scientist at Stanford and cofounder of Phage Directory) and Joseph Campbell, PhD (former NIAID program officer) talk to phage therapy practitioners, researchers and entrepreneurs to understand one question: why don't we have phage therapy yet?

集數

  1. 8月15日

    How to get successful outcomes with phage therapy: Saima Aslam, MD, MS

    "When I first started, I was treating anything and everything in terms of ‘this is highly drug resistant and it's failed’. But I think I have a clearer idea now, at least clinically, where I think phage would be beneficial, rather than all comers.” What does it take to achieve an 85% success rate with phage therapy? We talk to Dr. Saima Aslam, MD, MS, a Professor of Medicine at UC San Diego and the clinical lead of IPATH (Center for Innovative Phage Applications and Therapeutics), about her strategies for successful phage treatment.  Since 2017, Dr. Aslam has treated many patients with phages, and learned crucial lessons about patient selection, trial design, and the importance of collaboration between clinicians and phage researchers. We explore how her approach has evolved from "treating anything and everything" to targeted strategies, why early clinical trials struggled, and her exciting NIH-funded placebo-controlled trial for recurrent UTIs in kidney transplant patients.  The conversation covers practical implementation challenges and lessons for phage therapy practitioners, and discusses her vision for a centralized US phage repository and manufacturing center to reduce the current 6-12 month delays in accessing treatment. Here's a taste of what we covered: 1. 🧫 Why patient selection is crucial: not all infections benefit equally from phage therapy 2. 🏥 Why phage scientists and clinicians must work together from day one 3. 🧪 Learning from early studies to create pragmatic, enrollable protocols 4. ⌛ The challenge of long-established biofilms in chronic infections like LVAD bacteremia 5. 💉 Why recurrent UTIs in transplant patients represent the "lowest hanging fruit" 6. 🔬 How Dr. Aslam designed her NIH-funded clinical trial for recurrent UTIs in kidney transplant patients 7. 🌐 The urgent need for centralized phage production in the US to reduce treatment delays Chapters: 00:00 Introduction to Phage Therapy and Dr. Saima Aslam 02:11 Early Experiences and Lessons in Phage Therapy 05:27 Criteria for Patient Selection in Phage Therapy 09:14 Challenges in Phage Therapy: Availability and Effectiveness 12:31 Collaboration and Research in Phage Therapy 24:08 Bottlenecks in Phage Therapy Development 36:07 Future Directions and Hopes for Phage Therapy Learn more: Saima’s team is now enrolling for their kidney transplant phage clinical trial! (https://clinicaltrials.gov/study/NCT06409819) A recent paper by Saima and her team: Phage Therapy in Lung Transplantation: Current Status and Future Possibilities (https://pubmed.ncbi.nlm.nih.gov/37932113/)

    54 分鐘

  2. 6月27日

    Dr. Marisa Azad, MD, PhD: Behind Canada's first prosthetic joint treatment with phage therapy

    "It's unacceptable to just tell this poor patient, there's nothing I can do to help you... That's when I thought, okay, well, what about kind of pushing the boundaries a bit here and thinking about phage therapy?" - Dr. Marisa Azad Join us for an inspiring conversation with Dr. Marisa Azad, a clinician-scientist at The Ottawa Hospital who is pioneering the treatment of chronic infections using phage therapy. Dr. Azad shares her journey from microbiology PhD to orthopedic infectious disease specialist, and how a desperate patient case led her to become the first in Canada to use phage therapy for prosthetic joint infections. Here's a taste of what we covered: 1. 🦠 The challenges of treating orthopedic infections, and how the problem is typically being dealt with in Canada (hint: MULTIPLE repeated surgeries for years is normal) 2. 🧪 How Dr. Azad navigated regulatory hurdles to bring phage therapy to Canada, and what it was like working with Health Canada (Canada's FDA) to get approval 3. 💉 Insights on phage administration and patient immune responses: what she's learned and what barriers she sees 4. 🔬 The importance of collaboration in advancing phage therapy research, and what's left for researchers to figure out 5. 👩‍🔬 How crucial it is to support women in science and medicine, still in 2025, especially in innovative fields that require taking steps your field isn't taking (which require extra bravery and support systems!) 6. 🏥 Bridging the gap between basic science and clinical practice: how Dr. Azad weaves together both ways of thinking, all with patient benefit as her central driver You can also watch the episode on YouTube: https://youtu.be/5TKhgFplvfU Want to learn more? - CBC (Canada's national news outlet)'s coverage of Dr. Azad's successful case, and how patient Thea Turcotte recovered - Dr. Azad's recent publication on phage therapy for PJI (an n-of-1 clinical trial) - Our recent Podovirus interview with Cytophage CEO Steven Theriault, whose Winnipeg-based company prepared the phages for Dr. Azad's patient, and who is partnering with her as the phage manufacturer for future cases - Since Dr. Azad's success last year, Health Canada is beginning to enable more phage therapy: a PJI phage treatment has just taken place in Calgary by a separate group — watch the news segment here

    49 分鐘

  3. 6月2日

    How to navigate regulatory limbo: a Canadian phage therapy CEO's playbook

    "Phages are not drugs. Every time they say, 'Did you go through regulatory?' I say, 'I can do regulatory, but I'm not a drug.' There's 145 components of the regulatory requirements that I don't fit in." When your health innovation doesn't fit existing regulatory boxes, how do you build a business? Steven Theriault, CEO of Cytophage, has spent 9 years learning to navigate Canada's regulatory maze for phage therapy. From being told "we don't know" by government officials to raising $24M and treating patients, Steven shares his hard-won playbook for building in uncharted regulatory territory. In this episode of the Podovirus Podcast, Jessica Sacher and Joe Campbell talk to Steven Theriault about what he's tried, accomplished and learned in the last ~decade building a phage biotech company in Canada: 🎯 The pivot strategy: When hospitals won't buy your innovation, find another market (Steven turned to chicken farmers when Clorox contracts blocked hospital sales)  🏛️ Educating regulators: How to teach government officials about your technology when they've never heard of it (Steven went from 10 officials with no idea what a phage was, to regular advisory calls to shape Canada's approach to regulating phage therapy) 📋 Creating your own framework: Why Steven argues phages need different GMP guidelines than traditional drugs, and how to advocate for biological variability  💰 Funding the unfundable: How Cytophage raised $24M for technology that doesn't fit traditional pharma investment models 🔄 The workaround approach: Building revenue streams (agriculture) to fund your real mission (human health) when direct paths are blocked 🌐 International advantage: Why Steven has more regulatory traction in the US than Canada, and how to leverage global progress domestically Learn more: Cytophage website: https://cytophage.com/ Steven's 2024 TEDx talk on the future of phage therapy: https://www.youtube.com/watch?v=OyfbKOLNlWg The CBC News story on Cytophage's first patient treatment: Thea's success story: https://www.cbc.ca/news/canada/manitoba/phage-therapy-infection-1.7156333

    1 小時

  4. 5月9日

    Why can't patients access phage therapy? Does FDA need to change, or do patients just need a voice?

    "This feels just like the early days of the HIV crisis. People are dying, you're not hearing about it. We need a group like ACT UP to bring this to the public. We're not going to get phage therapy until people start demanding we have it."  On this episode, we talk to phage therapy patient advocate Chris Shaffer about how he fought for access to phage therapy to save his own life, and how it's led him to advocate on behalf of other patients being told there's "nothing left" for their infections.  He draws parallels between phage advocacy and 1980s AIDS activism, while sharing his successful treatment journey to Tbilisi, Georgia for phage therapy. He shares his vision for a patient-centered future where anyone, not just the well-connected or the lucky, can access phage therapy if it could help them.  Here's a taste of what we covered: 1. 🦠 Chris's battle with a drug-resistant infection that antibiotics couldn't cure, and how after two years of suffering, he was completely cured in just four months with phage therapy 2. 🧪 The major obstacles to phage therapy access in the US: lack of awareness among doctors, patient trust issues, and difficulty finding phages that match specific infections 3. 🏥 The striking cost difference: Chris's complete phage treatment at Eliava (including doctor visits, tests, and therapy) cost $4,600 vs. $10,000+ for just a single round of IV antibiotics in the US 4. 🔬 How the FDA actually considers phages safe enough that they don't require the same safety testing as antibiotics - but this information isn't reaching patients or doctors 5. 📢 Why Chris believes we need more vocal advocacy similar to the HIV/AIDS movement in the 1980s-90s to push for greater phage therapy access 6. 📱 Practical ideas for improving access through non-profit phage centers, better education for medical students, and targeted communication strategies Learn more: - Chris Shaffer's book about his phage therapy journey: https://www.amazon.com/FINDING-PHAGE-Partnered-Bacterial-Superinfection/dp/1733418296 - Chris’ website: https://phagetherapyusa.com/ - Case study on Chris’ case, published in the International Journal of Clinical Virology: https://www.clinvirologyjournal.com/articles/ijcv-aid1059.php - Eliava Phage Therapy Center in Tbilisi, Georgia: https://eliavaphagetherapy.com/  - 2021 FDA-NIAID Workshop on Phage Therapy transcripts mentioned during the conversation: https://www.fda.gov/media/159401/download - Pranav Johri's case study that helped Chris trust phage therapy: https://pubmed.ncbi.nlm.nih.gov/37790805/ - An youtube interview we did with Pranav about his story: https://www.youtube.com/watch?v=V-Qso4q52CY - An interview we published in Capsid & Tail on Pranav's story: https://phage.directory/capsid/phage-therapy-access-india#article - The PASTEUR Act, which Chris mentions: a bill in US congress (still has not passed) on changing how antimicrobials can be paid for by the government: https://www.contagionlive.com/view/an-update-on-the-pasteur-act

    1 小時 12 分鐘

  5. 5月2日

    Finally, phase 2 data! Inside BiomX's successful phage therapy trial with CEO Jonathan Solomon

    "Finally, finally we have Phase 2 data. We put a dent in the theory that phage therapy doesn't work. Maybe it does work. Maybe it's worth taking a risk." Jonathan Solomon joins Jessica Sacher and Joe Campbell on the Podovirus Podcast to discuss BiomX's exciting Phase 2 clinical trial results, where they used bacteriophages to treat diabetic foot osteomyelitis (DFO). With 40% of DFO patients facing amputation, this is an area of massive unmet need. Jonathan shares how their trial was designed (he credits the team at Adaptive Phage Therapeutics, which began the trial prior to its merge with BiomX), and how it achieved what many of us have almost given up on: positive, statistically significant clinical efficacy data for a phage therapy treatment*. Here's a taste of what we covered: 1. 🔬 The "Head of the Snake" theory – why many diabetic foot ID docs believe targeting Staph aureus alone works even in polymicrobial infections 2. 💉 Their phage delivery approach: combining IV "debulking" with topical phage application to help break down biofilms 3. 🏥 How 12 out of 13 phage-treated patients with bone-deep ulcers showed significant tissue rebuilding vs. only 5 of 9 in the placebo group 4. 💰 The commercial viability challenge: "If you're not seeing a 30% improvement, no one would pay for an expensive phage therapy" 5. 🧪 How personalized medicine meets practicality – the decision to use just one optimized phage per patient 6. 🔭 BiomX's dual-program approach with both DFO and cystic fibrosis trials showing promising results Learn more! 1. BiomX Positive Phase 2 Diabetic Foot Osteomyelitis Results 2. The details of BiomX/Adaptive Phage Therapeutics’ DANCE trial 3. Recent key opinion leader discussion of Diabetic foot osteomyelitis results 4. BiomX Positive Part 2 Phase1b/2a trial of Cystic Fibrosis results 5. BiomX (NYSE: PHGE) website *Added context Timestamp ~22:50: Technophage (a biotech company in Portugal) did run a prior Phase 1/2a trial for diabetic foot infections. While the study showed their TP-102 phage cocktail was well tolerated and safe, and reported improved outcomes, the authors report it was underpowered to determine the superiority of TP-102 over placebo, as it ended before reaching the final target of 18 patients due to slow recruitment. Technophage is currently running a larger version of this study.  Of note, there has been one other successful phase 2 phage trial: the Wright et al. ear infection trial published in 2009. This clinical program would have moved to phase 3, but corporate priorities shifted around the time of the ‘08 crash, and it was dropped (check out this interview with trial lead David Harper to learn more). Phage companies have been trying to re-reach this milestone ever since. Finally, it’s been reached.

    58 分鐘

  6. 4月9日

    Does every scientist need an AI co-scientist? How two professors solved a years-long viral mystery

    "I was so biased. I knew too much and that's why we couldn't see the obvious answer that was right in front of us for years." In this episode of the Podovirus Podcast, we explore the intersection of AI and phage biology with Professors José Penadés and Tiago Costa from Imperial College London. They share their recent discovery about phage-inducible chromosomal islands (PICIs) and how Google's new (not-yet-released) AI co-scientist tool independently reached the same conclusions they had spent years working toward—revealing how tailless phage capsids can bind with different phage tails to expand their host range. Here's a taste of what we discussed: 1. 🧬 First, the biology: José and Tiago discovered that sometimes the end product of a viral lifecycle isn't infectious (yet). It might instead float around as a half-virus (a 'tail-less capsid'), and even mix and match with halves (tails) of other viruses floating around, enabling it to get into a vast array of totally different cells with one simple genetic code. This is the story of PICIs (phage-inducible chromosomal islands).  2. 🤖 How Google's AI co-scientist tool—without access to their unpublished data on this project—accurately proposed the hypotheses and experiments it took them years to come up with (because they seemed to go against dogma in the field) 3. 🔬 Why 'knowing too much' can be an obstacle to discovery in science, the beauty of an unbiased companion, piecing apart what they would have done differently if they'd had AI all along, and how José and Tiago will be using AI tools going forward Chapters 00:00 Introduction: AI + phage research, and why we wanted to talk to José and Tiago! 02:10 First, the biology background: exploring PICIs (phage-inducible chromosomal islands) and their significance 10:13 The role of AI in hypothesis generation 19:08 Interpreting data and overcoming bias 28:40 Future implications of AI in phage therapy 37:25 Experimental evidence and hypotheses validation 40:46 AI tools and their effectiveness 44:38 Interpreting AI outputs and experimental design 51:30 The role of AI in scientific discovery 57:30 Future of AI in research and collaboration Papers discussed: 1. José and Tiago's new preprint on the science of PICIs: https://www.biorxiv.org/content/10.1101/2025.02.11.637232v1.full 2. Their companion preprint on exactly how they worked with the AI co-scientist (+ benchmarking against other AI tools!): https://www.biorxiv.org/content/10.1101/2025.02.19.639094v1  More info about Google's AI co-scientist: https://research.google/blog/accelerating-scientific-breakthroughs-with-an-ai-co-scientist/ More info about their research:  José's lab: https://profiles.imperial.ac.uk/j.penades/about Tiago's lab: https://profiles.imperial.ac.uk/t.costa Want to learn more about phage satellites? Check out this new Nature Reviews Microbiology by José's team: https://www.nature.com/articles/s41579-025-01156-z

    1 小時 9 分鐘

  7. 2月21日

    What's the business case for phage therapy?

    “Getting our foot through the door to any VC... As soon as they hear we're infectious disease, their eyes kind of get big. And then they hear we're antibacterial, their eyes get bigger. And then they hear we're not small molecule, it's like all the alarm bells are ringing.” In this episode, we sit down with Amanda Burkardt (CEO) and Mayukh Das (COO) of Phiogen Pharmaceuticals, a new entrant in the phage therapy space, to tackle one of the field's most pressing questions: can phage therapy succeed as a business where antibiotics have struggled? Drawing from their experience building a phage company from scratch, and recent discussions with Medicare, they share how they're thinking about drug pricing, reimbursement strategies, and how they’re navigating investor skepticism in antimicrobial development. Takeaways: - Starting with clear differentiation is crucial - Phiogen's directed evolution platform allows them to enhance desired phage properties - The antibiotics market's poor track record has created significant barriers for phage therapy companies seeking investment - Unforeseen post-approval monitoring costs contributed to Achaogen’s bankruptcy, and must be factored into business planning - Recent approvals of Live Biologic Products (LBPs) for recurrent C. diff provide a potential pathway for phage therapy pricing (~$10,000 per treatment) - CMS (Medicare/Medicaid) engagement early in development is critical for establishing reimbursement strategies — they are happy to talk to startups! - The UK's subscription model for antimicrobials could provide significant value (~$100M over 3 years) for qualifying companies - Phage companies must demonstrate value beyond one-time treatment to justify higher price points - Infrastructure development, like standardized susceptibility testing, remains a critical need - The field needs both fixed cocktails for mainstream use and flexibility for personalized approaches - Success requires alignment between unmet medical need, pricing strategy, and reimbursement policies Chapters: 00:00 Introduction to Phiogen and business challenges in phage therapy 08:10 Phiogen's technology platform and differentiation strategy 15:13 Navigating investor skepticism in antimicrobials 27:29 Reimbursement strategies and pricing models 35:04 Learning from Live Biologic Product approvals 43:59 The Pasteur Act and subscription models 47:27 Five and fifteen year outlook for phage therapy Key Quotes: “Getting our foot through the door to any VC... As soon as they hear we're infectious disease, their eyes kind of get big. And then they hear we're antibacterial, their eyes get bigger. And then they hear we're not small molecule, it's like all the alarm bells are ringing.” "As long as people are dying and there are unmet medical needs, it is doable. Getting the business model to support that is going to be more challenging, but it is a real problem. There are people dying and there are people suffering. And so as long as that will be the case, there is a need.” "By utilizing some high throughput methods, we could actually train phages in a way that hadn't been done before. And we're able to utilize this machine to enhance whatever antibacterial capabilities we want.” Learn more: - John Rex’s financial post-mortem on antibiotic company Achaogen: https://amr.solutions/2024/10/14/plazomicin-achaogen-financial-post-mortem-passpasteur/ - UK subscription model for antimicrobials: https://www.england.nhs.uk/publication/antimicrobial-products-subscription-model-guidance-on-commercial-arrangements/ - Pasteur Act information: https://www.congress.gov/bill/118th-congress/senate-bill/1355 - A blog post Amanda wrote last year for Capsid & Tail on Phiogen's approach to phage therapy: https://phage.directory/capsid/phiogen-missing-middle-ground#article: "The Missing Middle Ground of Phage Therapy: Effective Phage Therapeutics that Bridge Economy, Regulation, and Unprecedented Functionality"

    51 分鐘

  8. 2024/12/19

    How to bring phages to market: Intralytix's food-to-pharma strategy

    "Somebody's father, friend, husband just passed away in the most developed country in the world... from a simple infection that probably could have been treated in Georgia." In this episode, we sit down with Dr. Alexander (Sandro) Sulakvelidze to explore his journey in growing a phage therapy company from scratch, from food to human therapy. Growing up in the Republic of Georgia, phage therapy was a normal thing for Sandro; when he came to the US and saw people dying of preventable infections, he founded Intralytix. This was 26 years ago. Takeaways: - Starting with food safety applications proved crucial for Intralytix's survival and success as one of the few profitable phage companies - The field has transformed from complete skepticism to active engagement, with hundreds attending phage conferences and multiple clinical trials underway - Current regulatory concerns about transducing phages may be disproportionate given natural background levels in the human gut - Personalized, customized phage cocktails consistently show better results than "mainstream" fixed cocktails - Modern healthcare lacks the infrastructure for phage therapy - there's no equivalent to antibiotic susceptibility testing - AI and machine learning are revolutionizing phage manufacturing, Intralytix is seeing 100% success in predicting optimal production conditions - The next 5 years may see limited adoption through personalized medicine and nutraceuticals, while mainstream adoption could take 15+ years - Phage therapy's future may extend beyond infectious disease to microbiome modulation for conditions like obesity and neurological disorders - Proof of efficacy in rigorous clinical trials remains the critical barrier to widespread adoption and insurance coverage - The field needs both mainstream products and the flexibility to customize treatments for individual patients Chapters: 00:00 Introduction to Phage Therapy and Background 06:01 Evolution of Phage Therapy and Regulatory Changes 11:51 Skepticism and Acceptance of Phage Therapy in the West 20:11 Challenges in FDA Approval and Transduction Concerns 26:09 Personalized Medicine and Future of Phage Therapy 35:36 Navigating Regulatory Challenges in Phage Therapy 38:31 Research Gaps and Future Directions 41:45 Infrastructure and Logistical Hurdles 44:31 The Need for Standardization in Phage Testing 46:15 Cross-Pollination Between Food Safety and Human Health 50:38 Future Outlook: Phage Therapy in 5 to 15 Years 57:07 Challenges Ahead: Efficacy and Regulatory Concerns Key Quotes: "Deep in my heart, there is no doubt this works. There's just too many successful stories." "My experience with FDA has been very good... The people we've dealt with have been reasonable." "The variables you have to examine are mind boggling... We use artificial intelligence to learn what creates the best conditions to grow each phage." "We are one of the very few phage companies today that actually has sales revenues... If you ignore the very long time, we're probably the only phage company that has some profit." "The customized cocktail always worked better... scientifically and technically, it has a better chance of working." Learn more about Intralytix: https://www.intralytix.com/

    1 小時

  9. 2024/11/08

    Gina Suh, MD: What it's really like to treat patients with phage therapy

    What's it like to be a doctor treating patients with phage therapy in the US today? Dr. Gina Suh, Mayo Clinic infectious disease physician, tells us: - How she established phage therapy as an option for her patients at Mayo - How phages have helped her patients - What's been hardest - Where she's hopeful - Where things have gotten worse - What's next This episode, I'm joined by my phage friend Joe Campbell (former NIH program officer)! This is part 1 of a series we'll be co-hosting together, digging into phage therapy from multiple perspectives, trying to answer our curiosities about what's holding phage therapy back in this country and beyond — stay tuned!  Chapters 00:00 Introduction to our new phage therapy series 01:23 Dr. Gina Suh's journey into phage therapy 06:01 How Gina has shifted how she selects patients for phage therapy 14:35 Challenges Gina has faced with phage therapy 17:46 Research needs: what the field should be studying 26:16 Infrastructure needs: Gina's wishlist 44:34 Gina's phage therapy aspirations 55:18 Why are there no support groups for antibiotic resistance? Watch this episode on YouTube: https://youtu.be/b2NBYn4jEUo Learn more:  Paper by Gina and team: Considerations for the use of phage therapy in clinical practice: https://pubmed.ncbi.nlm.nih.gov/35041506/ Video: Gina Suh and John Haverty talk about John's treatment with phages (2021): https://youtu.be/XZPLt6wkh5A?si=PxSZAYmOkn2KICLs

    1 小時 12 分鐘

  10. 2024/09/20

    Jesus Fernandez-Rodriguez: How Eligo Bioscience edits gut bacteria with phages

    Welcome to the Podovirus podcast, episode 3! In this episode, I talk with Jesus Fernandez-Rodriguez from Eligo Bioscience, a Paris-based biotech company pioneering microbiome editing using modified bacteriophages. We talk about Eligo’s recent Nature publication, “In situ targeted base editing of bacteria in the mouse gut”, how it works, and what the team is thinking of doing with it. 💡 Takeaways: - Eligo Biosciences has developed a base editing technology using modified phages to precisely modify populations of E. coli and Klebsiella in the mouse gut microbiome without killing them. - Microbiome hype is not over yet! - Beyond using the editing tool to kill bacteria for therapeutic reasons, this tool can be used to delete a gene or bacterium to probe what happens in vivo, which could help us figure out what to try to drug next - Not all targets need to be infectious disease-based: the gut-brain axis is an interesting area that this approach could be useful for (or any bacteria-causing disease or phenotype) - The Eligo team designed their base editing system using a PICI (phage-inducible chromosomal island) origin of replication, which lets them produce their therapeutic 'cosmid' (plasmid containing lambda phage packaging instructions plus their payload) in an E. coli strain expressing PICI primase, but prevents replication of the cosmid in target bacteria. 📕 Read: Eligo's In Situ Base Editing paper, published July 2024 in Nature: https://www.nature.com/articles/s41586-024-07681-w 💻 Check out Eligo Bioscience's website, especially their open roles! https://eligo.bio/ Chapters 00:00 Introduction to Eligo Biosciences and their work 02:22 History and evolution of Eligo Biosciences' technology 03:23 Transition from antimicrobial focus to microbiome editing 05:21 Base editing, killing bacteria, and modifying bacteria 06:11 The importance of understanding and targeting bacterial genes in human disease 11:30 Distinguishing base editing from CRISPR and its applications 13:27 Different tools for different modifications in bacteria 16:16 Engineering phage particles for high transduction efficiencies 21:33 Challenges and process of publishing the paper 23:29 The value of publishing and attracting talent 27:19 Eligo Biosciences' plans for clinical trials and future applications 28:43 The importance of bacterial genes in human disease and the new way of thinking 29:12 Microbiome Research and Gut-Brain Axis 31:34 Challenges in Identifying Microbes and Genes 34:48 The PICI System in Eligo's Technology 37:14 Multiplexing the Base Editing Approach 52:04 Complexity of Identifying Disease-Causing Genes 56:25 The Importance of Research and Collaboration

    57 分鐘

  11. 2024/08/08

    Getting phage research funded — Joe Campbell reflects on a career at NIAID

    Welcome to the Podovirus podcast, episode 2! In this episode, Jessica talks with Dr. Joe Campbell, who recently retired as a program officer at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH). Joe played a key role in shaping phage research funding and policy during his tenure at NIAID. He reflects on his career, the evolution of phage therapy research, and shares insights into the grant application process. Takeaways - Phage therapy funding at NIAID has evolved over time; it used to be lumped in with antibiotics, but Joe and his colleague Jane Knisely at NIAID eventually spearheaded the creation of phage-specific grants, which had phage people on their study sections! - Phage therapy centers, such as Phage Canada and Phage Australia, play a key role nowadays in providing personalized phage treatments for patients who don't fit the criteria for traditional clinical trials. - Rigorous clinical trials are essential for demonstrating the efficacy of phage therapies and gaining support from governments and healthcare systems. - Phage therapy has the potential to treat a wide range of infections, and Joe is optimistic that clinical trials will show positive results Chapters 00:00 Introduction 01:24 Reflections on a Career in the Phage Field 06:18 The Evolution of Phage Therapy Funding at NIAID 10:53 Taking Action to Support Phage Grants 14:09 The Impact of Phage Grants on Research and Funding 20:41 The Role of Phage Therapy Centers 22:47 Balancing Phage Therapy Centers and Biotech Companies 28:25 Challenges in Developing Phage Therapies in the US Healthcare System 30:41 The Importance of Rigorous Clinical Trials for Phage Therapies 33:38 NIAD's Preclinical Services for Phage Therapy Development 34:57 Pseudomonas Mouse Models and In Vitro Assays 37:09 The Role of NIAD Program Officers 38:46 Addressing the Economic Challenges of Phage Therapy

    46 分鐘

  12. 2024/05/03

    Why all phage researchers need to be in Australia this July

    This is a very special week. We’re launching the first episode of our Podovirus podcast! We started this on a whim (I wanted to explore this format, since I love talking to phage people and I love podcasts; and Jan came up with a punny name we couldn't pass up). Ok, episode 1! I'll be honest — I stayed in science because of how much I love conferences. My phage phriendships are some of my favourites in life, and annual conferences have always pushed my science forward more than anything else. It was so much fun to chat with Dr. Jeremy Barr, Associate Professor at Monash University, about the Viruses of Microbes (VoM) conference he's co-organizing in Cairns, Australia this July. We talk about what organizing has been like (take note, whoever applies to host the next VoM in 2026!), what Australia is like (fewer crocodiles than you might think, equally as many koalas), why VoM 2024 will be extra-special for early career researchers, and how to convince your PI to help you get there!

    37 分鐘
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簡介

Phages (bacteriophages) are viruses that kill bacteria with sniper-like precision. They can be incredibly useful for treating life-threatening infections ('phage therapy'), and can help us reduce our dependence on antibiotics. They've been known for 100 years... so WHY do we still not see them on the shelves? Jessica Sacher, PhD (Staff Scientist at Stanford and cofounder of Phage Directory) and Joseph Campbell, PhD (former NIAID program officer) talk to phage therapy practitioners, researchers and entrepreneurs to understand one question: why don't we have phage therapy yet?

資訊

  • 創作者
    Jessica Sacher and Joseph Campbell
  • 活躍年代
    2025年
  • 集數
    12
  • 年齡分級
    兒少適宜
  • 版權
    © Jessica Sacher and Joseph Campbell
  • 節目網站
    Podovirus