EP 151: Understanding cell ageing and its role in disease with Marco Quarta Co-founder and CEO of Rubedo Life Sciences

0:00 Intro to The Genetics Podcast
01:00 Welcome to Marco
02:00 The areas Marco focused on during his academic career and what motivated him to found his first company
03:18 How our understanding of ageing has changed over the past two decades and some of the current big questions in ageing biology
06:01 How to get a clearer picture of the ageing process within a tissue or cell and if new technologies like single cell genomics can aid this process
11:08 Catalyst or cause? Understanding the role of cellular senescence in disease and how it impacts treatment pathways
12:54 The challenges of building a company that addresses an area of biology which sits at the core of so many diseases and disease types
16:17 Deciding on which therapeutic modality to target when using a platform biology approach
17:57 Identifying the most effective stage at which to intervene in the senescence process and if this changes dependent upon organ system or disease area
24:33 How another company founded by Marco, Turnbio, uses a different approach by focusing on turning back the biological clock rather than understanding the ageing process and intervening
31:08 Addressing if both preventative and intervention approaches are required to comprehensively treat or cure a disease
35:39 Whether there is potential to develop core therapeutics which can have a system-wide effect and address all-cause ageing
40:12 Why ‘biohacking’ therapies can present a risk to the field of ageing biology as a whole, as well as to individuals
41:18 The developing area of science or technology Marco is most excited about and which he believes is going to have a significant impact in the coming years 43:23 Closing remarks

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