Sounds of Science

Charles River
  • 4.7 (13)
  • SCIENCE
  • UPDATED MONTHLY

Sounds of Science is a monthly podcast about beginnings: how a molecule becomes a drug, how a rodent elucidates a disease pathway, how a horseshoe crab morphs into an infection fighter. The podcast is produced by Eureka, the scientific blog of Charles River, a contract research organization for drug discovery and development. Tune in and begin the journey.

  1. 1D AGO

    Cancer Vaccines, Then and Now

    Did you know that the first attempt at a cancer vaccine was all the way back in the 1800s? I am joined by Charles River experts Louise Brackenbury, Dan Rocca, and Mike Templin to discuss the fascinating science behind therapeutic cancer vaccines.

    35 min

  2. MAR 18

    All About Spheroids

    Spheroids are three dimensional cell models that can mimic some organs, tumors, and other biological systems for drug testing. Like organoids and organs-on-a-chip, spheroids are breaking in to drug development as a promising alternative to animal models. I am joined by Madhu Lal Nag, MBS PhD from the 3D in vitro model company InSphero, to discuss the development and future potential of these tiny cellular machines.

    27 min

  3. MAR 4

    Ep. 89: Rethinking Toxicology: The Future of NAMs in Agrochemicals

    The agrochemical field has long relied on animal models to evaluate the safety and efficacy of substances, but there’s a growing demand to adopt new alternative methods (NAMs) that can further the industry while reducing the need for animal testing. However, questions remain as to their long-term viability.    Join Robert Landsiedel, Vice President of Experimental Toxicology and Ecology, and Susanne Kolle, Research Coordinator of Experimental Toxicology and Ecology at BASF, as they explain the benefits of NAMs, how they comply with the 3Rs principle, and the role collaboration is playing to push NAMs as a viable alternative to animals. Show Notes      Alternative Methods   AMAP Strategic Partnerships  Animals in Research   Modernizing Drug Development  Agrochemical Testing Service for Approvals  Chemical Testing Services  Charles River Laboratories Announces Development of Nonclinical Virtual Control Groups with Sanofi to Reduce the Use of Animals  Charles River Laboratories, in Collaboration with MatTek Corporation, Awarded Grant from the Foundation for Chemistry Research and Initiatives to Advance Research Alternatives

    28 min

  4. FEB 18

    Ep. 88: The Epidemiology of Cancer

    How can genetic, geographic, and social considerations effect outcomes for Black women with cancer? To answer this question, I am joined this week by Dr. Lauren E. McCullough, Associate Professor in the Department of Epidemiology at the Rollins School of Public Health, and Julia Schueler, Research Director Therapeutic Area Lead Oncology for Charles River. Dr. McCullough is also one of the lead researchers for the American Cancer Society’s VOICES of Black Women initiative, which will track the health of participants over several years to gain insight into health considerations for Black women. For more information on how to enroll, please visit voices.cancer.org.

    31 min

  5. FEB 4

    Ep. 87: Taking a Customized and Collaborative Approach to Therapeutic Development

    The N=1 Collaborative is changing the way we view drug development. Their specialty is creating customized therapies tailored to individual patients, paving the way for a unique approach that can leave long-lasting impacts on those with ultra-rare diseases.     Join us as Executive Director Hugh Hempel discusses the origins of N=1, the collaborative effort it takes to advance customized therapies down the pipeline, and what the future holds for the field of individualized medicine. Show Notes      n=1 Collaborative  Rare Disease | Charles River  Rare Disease Research for Drug Development  Repurposing Drugs for Rare Disease  S4 E07: Free For Life: The Story of N-Lorem Foundation

    29 min

  6. JAN 21

    Ep. 85: The Next Generation of Drug Development

    Artificial intelligence and machine learning are launching a new era in drug development. By integrating these technologies, researchers can get their life-saving therapies to patients faster thanks to more accurate data and efficient processes.     Join us as Brian Roche, General Manager of Charles River’s integrated toxicology site in Kansas, as he discusses the advantages of using these advanced technologies, how their being leveraged across multiple platforms, and what role they play in shaping the future. Show Notes New Integrated Toxicology Site  Kansas Site  Unlocking the Promise of Integrated Toxicology: A Tour Through the Lab of the Future  Meeting at the Intersection of Technology and Scientific Innovation

    26 min

  7. JAN 7

    Ep. 84: A Family's Fight Against Batten Disease

    David and Karen Kahn were overjoyed when they welcomed twins Amelia and Makenzie in 2010. However, it wasn't long before they realized their girls were different. Since getting their Batten disease diagnosis, they have worked tirelessly to find a treatment not only for their girls, but for kids around the world, with the help of researcher Dr. Michelle Hastings. Listen to their story now, and learn more about their mission at www.forebatten.org.

    34 min

  8. 12/17/2024

    Ep. 83: NAMs: The Future of Research?

    As researchers look for ways to reduce the need for animals in their studies, new alternative methods (NAMs) are an intriguing route to capture crucial safety data and help advance drug discovery and development – specifically, virtual control groups (VCGs).     Join Steve Bulera, CVP and Chief Scientific Officer for Safety Assessment and Toxicology at Charles River, as he discusses how VCGs can be a viable alternative to research models, what it would take for the industry to widely accept NAMs, and how they can revolutionize research for the future. Show Notes Virtual Control Groups   Sounds of Science E73: Virtual Control Groups  Modernizing Drug Development with Virtual Control Groups  Virtual Control Groups: A Data-Driven Novel Method  Revolutionizing the Future of Safety Studies  Charles River Laboratories Announces Development of Nonclinical Virtual Control Groups with Sanofi to Reduce the Use of Animals

    25 min
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4.7
out of 5
13 Ratings

About

Sounds of Science is a monthly podcast about beginnings: how a molecule becomes a drug, how a rodent elucidates a disease pathway, how a horseshoe crab morphs into an infection fighter. The podcast is produced by Eureka, the scientific blog of Charles River, a contract research organization for drug discovery and development. Tune in and begin the journey.

Information

  • Creator
    Charles River
  • Years Active
    2018 - 2025
  • Episodes
    91
  • Rating
    Clean
  • Copyright
    © 2025 Charles River
  • Show Website
    Sounds of Science

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