Gradient Dissent: Conversations on AI

Lukas Biewald
Gradient Dissent: Conversations on AI

Join Lukas Biewald on Gradient Dissent, an AI-focused podcast brought to you by Weights & Biases. Dive into fascinating conversations with industry giants from NVIDIA, Meta, Google, Lyft, OpenAI, and more. Explore the cutting-edge of AI and learn the intricacies of bringing models into production.

  1. GitHub CEO Thomas Dohmke on Copilot and the Future of Software Development

    JUN 10

    GitHub CEO Thomas Dohmke on Copilot and the Future of Software Development

    In this episode of Gradient Dissent, Lukas Biewald sits down with Thomas Dohmke, CEO of GitHub, to talk about the future of software engineering in the age of AI. They discuss how GitHub Copilot was built, why agents are reshaping developer workflows, and what it takes to make tools that are not only powerful but also fun. Thomas shares his experience leading GitHub through its $7.5B acquisition by Microsoft, the unexpected ways it accelerated innovation, and why developer happiness is crucial to productivity. They explore what still makes human engineers irreplaceable and how the next generation of developers might grow up coding alongside AI. Follow Thomas Dohmke: https://www.linkedin.com/in/ashtom/ Follow Weights & Biases: https://twitter.com/weights_biases https://www.linkedin.com/company/wandb

    1h 10m
  2. From Pharma to AGI Hype, and Developing AI in Finance: Martin Shkreli’s Journey

    MAY 20

    From Pharma to AGI Hype, and Developing AI in Finance: Martin Shkreli’s Journey

    In this episode of Gradient Dissent, Lukas Biewald talks with Martin Shkreli — the infamous "pharma bro" turned founder — about his path from hedge fund manager and pharma CEO to convicted felon and now software entrepreneur. Shkreli shares his side of the drug pricing controversy, reflects on his prison experience, and explains how he rebuilt his life and business after being "canceled." They dive deep into AI and drug discovery, where Shkreli delivers a strong critique of mainstream approaches. He also talks about his latest venture in finance software, building Godel Terminal “a Vim for traders", and why he thinks the AI hype cycle is just beginning. It's a wide-ranging and candid conversation with one of the most controversial figures in tech and biotech. Follow Martin Shkreli on Twitter Godel Terminal: https://godelterminal.com/ Follow Weights & Biases on Twitter https://www.linkedin.com/company/wandb   Join the Weights & Biases Discord Server: https://discord.gg/CkZKRNnaf3

    1h 30m
  3. Inside Cursor: The future of AI coding with Co-founder Sualeh Asif

    APR 29

    Inside Cursor: The future of AI coding with Co-founder Sualeh Asif

    In this episode of Gradient Dissent, host Lukas Biewald talks with Sualeh Asif, the CPO and co-founder of Cursor, one of the fastest-growing and most loved AI-powered coding platforms. Sualeh shares the story behind Cursor’s creation, the technical and design decisions that set it apart, and how AI models are changing the way we build software. They dive deep into infrastructure challenges, the importance of speed and user experience, and how emerging trends in agents and reasoning models are reshaping the developer workflow. Sualeh also discusses scaling AI inference to support hundreds of millions of requests per day, building trust through product quality, and his vision for how programming will evolve in the next few years. ⏳Timestamps: 00:00 How Cursor got started and why it took off 04:50 Switching from Vim to VS Code and the rise of CoPilot 08:10 Why Cursor won among competitors: product philosophy and execution 10:30 How user data and feedback loops drive Cursor’s improvements 12:20 Iterating on AI agents: what made Cursor hold back and wait 13:30 Competitive coding background: advantage or challenge? 16:30 Making coding fun again: latency, flow, and model choices 19:10 Building Cursor’s infrastructure: from GPUs to indexing billions of files 26:00 How Cursor prioritizes compute allocation for indexing 30:00 Running massive ML infrastructure: surprises and scaling lessons 34:50 Why Cursor chose DeepSeek models early 36:00 Where AI agents are heading next 40:07 Debugging and evaluating complex AI agents 42:00 How coding workflows will change over the next 2–3 years 46:20 Dream future projects: AI for reading codebases and papers 🎙 Get our podcasts on these platforms: Apple Podcasts: https://wandb.me/apple-podcastsSpotify: https://wandb.me/spotifyYouTube: https://wandb.me/youtube Follow Weights & Biases: https://x.com/weights_biaseshttps://www.linkedin.com/company/wandb

    50 min
  4. Inside the Dark Web, AI and Cybersecurity with Christopher Ahlberg CEO of Recorded Future

    APR 8

    Inside the Dark Web, AI and Cybersecurity with Christopher Ahlberg CEO of Recorded Future

    In this episode of Gradient Dissent, host Lukas Biewald talks with Christopher Ahlberg, CEO of Recorded Future, a pioneering cybersecurity company leveraging AI to provide intelligence insights. Christopher shares his fascinating journey from founding data visualization startup Spotfire to building Recorded Future into an industry leader, eventually leading to its acquisition by Mastercard. They dive into gripping stories of cyber espionage, including how Recorded Future intercepted a hacker selling access to the U.S. Electoral Assistance Commission. Christopher also explains why the criminal underworld has shifted to platforms like Telegram, how AI is transforming both cyber threats and defenses, and the real-world implications of becoming an "undesirable enemy" of the Russian state. This episode offers unique insights into cybersecurity, AI-driven intelligence, entrepreneurship lessons from a two-time founder, and what happens when geopolitical tensions intersect with cutting-edge technology. A must-listen for anyone interested in cybersecurity, artificial intelligence, or the complex dynamics shaping global security. 🎙 Get our podcasts on these platforms: Apple Podcasts: https://wandb.me/apple-podcasts Spotify: https://wandb.me/spotify YouTube: https://wandb.me/youtube Follow Weights & Biases: https://twitter.com/weights_biases  https://www.linkedin.com/company/wandb

    50 min
  5. AI, autonomy, and the future of naval warfare with Captain Jon Haase, United States Navy

    MAR 25

    AI, autonomy, and the future of naval warfare with Captain Jon Haase, United States Navy

    In this episode of Gradient Dissent, host Lukas Biewald speaks with Captain Jon Haase, United States Navy about real-world applications of AI and autonomy in defense. From underwater mine detection with autonomous vehicles to the ethics of lethal AI systems, this conversation dives into how the U.S. military is integrating AI into mission-critical operations — and why humans will always be at the center of warfighting. They explore the challenges of underwater autonomy, multi-agent collaboration, cybersecurity, and the growing role of large language models like Gemini and Claude in the defense space. Essential listening for anyone curious about military AI, defense tech, and the future of autonomous systems. ✅ *Subscribe to Weights & Biases* → https://bit.ly/45BCkYz 🎙 Get our podcasts on these platforms: Apple Podcasts: http://wandb.me/apple-podcasts Spotify: http://wandb.me/spotify Google: http://wandb.me/gd_google YouTube: http://wandb.me/youtube Follow Weights & Biases: https://twitter.com/weights_biases https://www.linkedin.com/company/wandb Join the Weights & Biases Discord Server: https://discord.gg/CkZKRNnaf3

    1h 2m
  6. The rise of AI agents

    FEB 25

    The rise of AI agents

    In this episode of Gradient Dissent, host Lukas Biewald sits down with João Moura, CEO & Founder of CrewAI, one of the leading platforms enabling AI agents for enterprise applications. Joe shares insights into how AI agents are being successfully deployed in over 40% of Fortune 500 companies, what tools these agents rely on, and how software companies are adapting to an agentic world. They also discuss: What defines a true AI agent versus simple automationHow AI agents are transforming business processes in industries like finance, insurance, and softwareThe evolving business models for APIs as AI agents become the dominant software usersWhat the next breakthroughs in agentic AI might look like in 2025 and beyond If you're curious about the cutting edge of AI automation, enterprise AI adoption, and the real impact of multi-agent systems, this episode is packed with essential insights.

    49 min
  7. R1, OpenAI’s o3, and the ARC-AGI Benchmark: Insights from Mike Knoop

    FEB 4

    R1, OpenAI’s o3, and the ARC-AGI Benchmark: Insights from Mike Knoop

    In this episode of Gradient Dissent, host Lukas Biewald sits down with Mike Knoop, Co-founder and CEO of Ndea, a cutting-edge AI research lab. Mike shares his journey from building Zapier into a major automation platform to diving into the frontiers of AI research. They discuss DeepSeek’s R1, OpenAI’s O-series models, and the ARC Prize, a competition aimed at advancing AI’s reasoning capabilities. Mike explains how program synthesis and deep learning must merge to create true AGI, and why he believes AI reliability is the biggest hurdle for automation adoption. This conversation covers AGI timelines, research breakthroughs, and the future of intelligent systems, making it essential listening for AI enthusiasts, researchers, and entrepreneurs. Mentioned Show Notes: https://ndea.com https://arcprize.org/blog/r1-zero-r1-results-analysis https://arcprize.org/blog/oai-o3-pub-breakthrough 🎙 Get our podcasts on these platforms: Apple Podcasts: http://wandb.me/apple-podcasts Spotify: http://wandb.me/spotify Google: http://wandb.me/gd_google YouTube: http://wandb.me/youtube Connect with Mike Knoop" @mikeknoop Follow Weights & Biases: https://twitter.com/weights_biases https://www.linkedin.com/company/wandb Join the Weights & Biases Discord Server: https://discord.gg/CkZKRNnaf3

    1h 12m
  8. DeepSeek, Stargate and AI's $600 Billion Question with Sequoia's David Cahn

    JAN 28

    DeepSeek, Stargate and AI's $600 Billion Question with Sequoia's David Cahn

    In this episode of Gradient Dissent, host Lukas Biewald sits down with David Cahn, partner at Sequoia Capital, for a compelling discussion on the dynamic world of AI investments. They dive into recent developments, including DeepSeek and Stargate, exploring their implications for the AI industry. Drawing from his articles, "AI's $200 Billion Question" and "AI's $600 Billion Question," David unpacks the financial challenges and opportunities surrounding AI infrastructure spending and the staggering revenue required to sustain these investments. Together, they examine the competitive strategies of cloud providers, the transformative impact of AI on business models, and predictions for the next wave of AI-driven growth. This episode offers an in-depth look at the crossroads of AI innovation and financial strategy. Mentioned Articles: AI’s $200B Question AI’s $600B Question 🎙 Get our podcasts on these platforms: Apple Podcasts: http://wandb.me/apple-podcasts Spotify: http://wandb.me/spotify Google: http://wandb.me/gd_google YouTube: http://wandb.me/youtube Connect with David Cahn: @DavidCahn6 Follow Weights & Biases: https://twitter.com/weights_biases  https://www.linkedin.com/company/wandb   Join the Weights & Biases Discord Server: https://discord.gg/CkZKRNnaf3

    58 min
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4.8
out of 5
67 Ratings

About

Join Lukas Biewald on Gradient Dissent, an AI-focused podcast brought to you by Weights & Biases. Dive into fascinating conversations with industry giants from NVIDIA, Meta, Google, Lyft, OpenAI, and more. Explore the cutting-edge of AI and learn the intricacies of bringing models into production.

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