NR vs NMN is Dated, Boosting NAD+ to New Levels – EP21: Nichola Conlon (Nuchido)

In this twenty-first episode, Nichola Conlon provides a scientific background, introducing sirtuins and NAD. She then explains why popular NAD+ boosters, NR and NMN, are first-gen products.

Read the transcript

She details how Nuchido formulated the first second-gen product by taking a novel whole systems approach. Lots of NAD, anti-aging, and nutraceutical discussion along the way.

Topics we discussed in this episode

• Recent personal experience with COVID-19
• Her molecular biology PhD focus
• Systems pharmacology
• Help from Aubrey de Gray
• Disillusioned with drug development
• Founding Nuchido
• What are Sirtuins? What is NAD?
• Importance of NAD. Why Boost NAD Levels?
• Inefficiency of First-Gen NAD Supplements: NR and NMN
• Three ingredients to boost NAD
• Pure NAD limitations
• Nicotinamide Riboside (NR)
• Nicotinamide Mononucleotide (NMN)
• 60% increase in NAD “only”
• Second-gen, demonstrated it can be done much better if you take a whole systems approach
• Importance of NAD salvage pathway
• PARP enzymes
• Inability to power sustained high-levels because of salvage pathway deterioration
• First-gen may not be great for epigenetics
• Increases expression of the enzymes in the salvage pathway that are known to decline with age
• Ingredients that reduce the expression of other processes that are actually wasting NAD
• Enzyme called CD38
• Inflammatory levels – CD38 just chews up NAD
• Multiple things that you can do to fix the cell before you even need to put precursors in.
• NAD decreases with age
• Do we Need NAD Supplements?
• Sirtuins and mitochondrial biogenesis
• Boosting your NAD levels, improves mitochondrial function.
• Multiple reasons that are causing the NAD to decline, boosting as with first-gen only the amount of raw material that your cell has is quite naïve
• Second-gen helps fixe your body’s natural ability to make and recycle its own NAD
• Nuchido TIME+ boosts NAD on average by 242%, four times more than the 60% widely cited for first-gen
• ChromaDex vs Elyisum Health
• Terms B3, niacin, nicotinamide, nicotinic acid, NR
• Abram Hoffer and orthomolecular medicine
• Nicotinamide is not likely to be a sirtuin inhibitor,
• How to measure NAD levels
• Nuchido TIME+ ingredients
• Alpha lipoic acid (ALA) and effects on AMPK
• Conversion of NADH to NAD+
• Drift more towards having more NADH in your cell with age
• Pathway called NQO1, converts NADH back to NAD+
• ALA is a really powerful antioxidant, activates NRF2
• ALA vs ALA-R
• Sophora Japonica Extract Rutin, senolytic
• NAMP
• Aging is an inflicted cascade disorder

Show links

• Nuchido (Company Website)
• ChromaDex (Company Website)
• Elysium Health (Company Website)
• Elysium Health, Inc. Loses Appeal of Patent Challenge Decision (Press Release)
• Orthomolecular Medicine (Wikipedia Entry)
• Abram Hoffer (Wikipedia Entry)
• Niacin: The Real Story: Learn about the Wonderful Healing Properties of Niacin (Amazon, Book)
• Orthomolecular Medicine for Everyone