1 hr 21 min

NR vs NMN is Dated, Boosting NAD+ to New Levels – EP21: Nichola Conlon (Nuchido‪)‬ Quantified Health, Wellness & Aging

    • Health & Fitness

In this twenty-first episode, Nichola Conlon provides a scientific background, introducing sirtuins and NAD. She then explains why popular NAD+ boosters, NR and NMN, are first-gen products.



Read the transcript



She details how Nuchido formulated the first second-gen product by taking a novel whole systems approach. Lots of NAD, anti-aging, and nutraceutical discussion along the way.

Topics we discussed in this episode



Recent personal experience with COVID-19

Her molecular biology PhD focus

Systems pharmacology

Help from Aubrey de Gray

Disillusioned with drug development

Founding Nuchido

What are Sirtuins? What is NAD?

Importance of NAD. Why Boost NAD Levels?

Inefficiency of First-Gen NAD Supplements: NR and NMN

Three ingredients to boost NAD

Pure NAD limitations

Nicotinamide Riboside (NR)

Nicotinamide Mononucleotide (NMN)

60% increase in NAD "only"

Second-gen, demonstrated it can be done much better if you take a whole systems approach

Importance of NAD salvage pathway

PARP enzymes

Inability to power sustained high-levels because of salvage pathway deterioration

First-gen may not be great for epigenetics

Increases expression of the enzymes in the salvage pathway that are known to decline with age

Ingredients that reduce the expression of other processes that are actually wasting NAD

Enzyme called CD38

Inflammatory levels - CD38 just chews up NAD

Multiple things that you can do to fix the cell before you even need to put precursors in.

NAD decreases with age

Do we Need NAD Supplements?

Sirtuins and mitochondrial biogenesis

Boosting your NAD levels, improves mitochondrial function.

Multiple reasons that are causing the NAD to decline, boosting as with first-gen only the amount of raw material that your cell has is quite naïve

Second-gen helps fixe your body's natural ability to make and recycle its own NAD

Nuchido TIME+ boosts NAD on average by 242%, four times more than the 60% widely cited for first-gen

ChromaDex vs Elyisum Health

Terms B3, niacin, nicotinamide, nicotinic acid, NR

Abram Hoffer and orthomolecular medicine

Nicotinamide is not likely to be a sirtuin inhibitor,

How to measure NAD levels

Nuchido TIME+ ingredients

Alpha lipoic acid (ALA) and effects on AMPK

Conversion of NADH to NAD+

Drift more towards having more NADH in your cell with age

Pathway called NQO1, converts NADH back to NAD+

ALA is a really powerful antioxidant, activates NRF2

ALA vs ALA-R

Sophora Japonica Extract Rutin, senolytic

NAMP

Aging is an inflicted cascade disorder



Show links



Nuchido (Company Website)

ChromaDex (Company Website)

Elysium Health (Company Website)

Elysium Health, Inc. Loses Appeal of Patent Challenge Decision (Press Release)

Orthomolecular Medicine (Wikipedia Entry)

Abram Hoffer (Wikipedia Entry)

Niacin: The Real Story: Learn about the Wonderful Healing Properties of Niacin (Amazon, Book)

Orthomolecular Medicine for Everyone (Amazon, Book)

GlycanAge (Company Website)

In this twenty-first episode, Nichola Conlon provides a scientific background, introducing sirtuins and NAD. She then explains why popular NAD+ boosters, NR and NMN, are first-gen products.



Read the transcript



She details how Nuchido formulated the first second-gen product by taking a novel whole systems approach. Lots of NAD, anti-aging, and nutraceutical discussion along the way.

Topics we discussed in this episode



Recent personal experience with COVID-19

Her molecular biology PhD focus

Systems pharmacology

Help from Aubrey de Gray

Disillusioned with drug development

Founding Nuchido

What are Sirtuins? What is NAD?

Importance of NAD. Why Boost NAD Levels?

Inefficiency of First-Gen NAD Supplements: NR and NMN

Three ingredients to boost NAD

Pure NAD limitations

Nicotinamide Riboside (NR)

Nicotinamide Mononucleotide (NMN)

60% increase in NAD "only"

Second-gen, demonstrated it can be done much better if you take a whole systems approach

Importance of NAD salvage pathway

PARP enzymes

Inability to power sustained high-levels because of salvage pathway deterioration

First-gen may not be great for epigenetics

Increases expression of the enzymes in the salvage pathway that are known to decline with age

Ingredients that reduce the expression of other processes that are actually wasting NAD

Enzyme called CD38

Inflammatory levels - CD38 just chews up NAD

Multiple things that you can do to fix the cell before you even need to put precursors in.

NAD decreases with age

Do we Need NAD Supplements?

Sirtuins and mitochondrial biogenesis

Boosting your NAD levels, improves mitochondrial function.

Multiple reasons that are causing the NAD to decline, boosting as with first-gen only the amount of raw material that your cell has is quite naïve

Second-gen helps fixe your body's natural ability to make and recycle its own NAD

Nuchido TIME+ boosts NAD on average by 242%, four times more than the 60% widely cited for first-gen

ChromaDex vs Elyisum Health

Terms B3, niacin, nicotinamide, nicotinic acid, NR

Abram Hoffer and orthomolecular medicine

Nicotinamide is not likely to be a sirtuin inhibitor,

How to measure NAD levels

Nuchido TIME+ ingredients

Alpha lipoic acid (ALA) and effects on AMPK

Conversion of NADH to NAD+

Drift more towards having more NADH in your cell with age

Pathway called NQO1, converts NADH back to NAD+

ALA is a really powerful antioxidant, activates NRF2

ALA vs ALA-R

Sophora Japonica Extract Rutin, senolytic

NAMP

Aging is an inflicted cascade disorder



Show links



Nuchido (Company Website)

ChromaDex (Company Website)

Elysium Health (Company Website)

Elysium Health, Inc. Loses Appeal of Patent Challenge Decision (Press Release)

Orthomolecular Medicine (Wikipedia Entry)

Abram Hoffer (Wikipedia Entry)

Niacin: The Real Story: Learn about the Wonderful Healing Properties of Niacin (Amazon, Book)

Orthomolecular Medicine for Everyone (Amazon, Book)

GlycanAge (Company Website)

1 hr 21 min

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