Ongoing Genetic Research with Tourettic Mice

In this episode, I'm joined by the brilliant Drs. Jay and Max Tischfield, father and son renowned Tourette researchers at Rutgers University. They share their fascinating journey into the world of Tourette Syndrome research, discussing how they use genetic data to create groundbreaking mouse models that mimic the human condition. We delve into the intricacies of gene mutations, the challenges of studying tics in mice, and the potential for these models to lead to effective treatments.

You'll hear about the Tischfields' unique father-son dynamic in the lab, their collaborative work with the NJCTS Sharing Repository, and the exciting prospects of using AI and advanced genetic editing to further understand and treat Tourette Syndrome. This episode offers a peek into the cutting-edge science that's pushing the boundaries of what we know about TS.

Episode Highlights:

[02:06] Jay's unexpected journey into TS research, sparked by a passionate advocate.

[05:35] Max's fascination with using gene editing to create Tourette-like mouse models.

[07:58] The promise of using these models to test potential treatments.

[13:23] Exploring the complexities of identifying tics in mice.

[16:49] How human studies guide mouse model research and the role of sensory motor gating.

[24:42] Discussing the genetic landscape of Tourette Syndrome.

[28:30] The future of drug testing on TS mouse models.

[37:11] Cognitive Behavioral Intervention Therapy (CBIT) and its role in treating tics.

[43:02] How listeners can contribute to the NJCTS Sharing Repository.

Links & Resources:

New Jersey Center for Tourette Syndrome: https://njcts.org/ 

Dr. Max Tischfield’s Website: http://www.maxtischfieldlab.org/ 

Remember, each story shared on this podcast brings light and understanding to the diverse experiences within the Tourette's community. Your journey is your own, and it's filled with potential and promise. If this episode resonated with you, I encourage you to like, share, and leave a review to help us connect with more listeners.

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