37 min
16 B&D: CRISPR Babies Science for Progress
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- Science
At the end of November 2018, Chinese scientist He Jiankui announced that he had genetically modified human embryos which were then brought to term. The resulting twin sisters appear to be healthy. But this experiment was not greeted with enthusiasm by the scientific community.
The critique attacks every aspect of the experiment: the treatment’s medical necessity, the reasoning behind the treatment approach, the way it was conducted, the ethical implications, and it also wasn’t legal.
Listen to the Full Conversation on Patreon!
He Jiankui was aware that he was doing something the public and the scientific community would not agree with. In order to dampen the fall, He announced his experiments in a series of YouTube videos in which he also attempts an ethical justification. He addressed the public in this way before the scientific community could comment, to frame the following discussion in his favor. Possibly also to force Chinese authorities to act cautiously with the eyes of the world resting on He Jiankui.
After an appearance at a conference in Hong Kong, He Jiankui went missing, and it still seems to be unclear where he is. Some news outlets reported the Dr. He was put under house arrest.
In this episode, Bart Geurten (@BartGeurten) and I (Dennis Eckmeier, @DennisEckmeier) have a conversation about what we understand about what happened. (Recorded Dec 16th, 2018)
What Happened?
He Jiankui is a geneticist who works on genetic alteration of human embryos. In some countries, scientists can get permission to experiment on human embryos when the embryos are just a few cells big. Such embryos, however, may not be allowed to develop into full human beings. The goal of such experiments is, for example, to establish safer methods for gene therapies.
The embryos are created through in-vitro-fertilization, an established practice for couples who are having trouble having healthy babies. Eggs and sperms are brought together outside the woman’s body, and the growing embryos can be tested for possible gene defects. Healthy embryos can then be implanted in the becoming mother’s womb.
But He implanted genetically modified embryos in the womb of a woman, which the scientific community has many problems with. The two embryos have become babies and were born several months before the announcement.
What exactly did He Jiankui try to achieve?
He Jiankui wants to protect children of HIV infected parents from infection, AIDS, and social discrimination that comes with HIV infection.
The medical community, however, does not agree that gene modification would be an appropriate method to accomplish this. There are numerous ways to protect yourself from infection with HIV by following simple rules of caution.
He chose couples where the father is HIV positive, while the mother is not. To protect the mother, such couples can use in vitro fertilization, if they want a child. In the process of IVF, the HIV is removed.
Was the treatment well designed?
So there was no medical necessity for this treatment. But let’s say there would have been.
At the end of November 2018, Chinese scientist He Jiankui announced that he had genetically modified human embryos which were then brought to term. The resulting twin sisters appear to be healthy. But this experiment was not greeted with enthusiasm by the scientific community.
The critique attacks every aspect of the experiment: the treatment’s medical necessity, the reasoning behind the treatment approach, the way it was conducted, the ethical implications, and it also wasn’t legal.
Listen to the Full Conversation on Patreon!
He Jiankui was aware that he was doing something the public and the scientific community would not agree with. In order to dampen the fall, He announced his experiments in a series of YouTube videos in which he also attempts an ethical justification. He addressed the public in this way before the scientific community could comment, to frame the following discussion in his favor. Possibly also to force Chinese authorities to act cautiously with the eyes of the world resting on He Jiankui.
After an appearance at a conference in Hong Kong, He Jiankui went missing, and it still seems to be unclear where he is. Some news outlets reported the Dr. He was put under house arrest.
In this episode, Bart Geurten (@BartGeurten) and I (Dennis Eckmeier, @DennisEckmeier) have a conversation about what we understand about what happened. (Recorded Dec 16th, 2018)
What Happened?
He Jiankui is a geneticist who works on genetic alteration of human embryos. In some countries, scientists can get permission to experiment on human embryos when the embryos are just a few cells big. Such embryos, however, may not be allowed to develop into full human beings. The goal of such experiments is, for example, to establish safer methods for gene therapies.
The embryos are created through in-vitro-fertilization, an established practice for couples who are having trouble having healthy babies. Eggs and sperms are brought together outside the woman’s body, and the growing embryos can be tested for possible gene defects. Healthy embryos can then be implanted in the becoming mother’s womb.
But He implanted genetically modified embryos in the womb of a woman, which the scientific community has many problems with. The two embryos have become babies and were born several months before the announcement.
What exactly did He Jiankui try to achieve?
He Jiankui wants to protect children of HIV infected parents from infection, AIDS, and social discrimination that comes with HIV infection.
The medical community, however, does not agree that gene modification would be an appropriate method to accomplish this. There are numerous ways to protect yourself from infection with HIV by following simple rules of caution.
He chose couples where the father is HIV positive, while the mother is not. To protect the mother, such couples can use in vitro fertilization, if they want a child. In the process of IVF, the HIV is removed.
Was the treatment well designed?
So there was no medical necessity for this treatment. But let’s say there would have been.
37 min