Behind Biotech

Jingyi Liu, Eric Dai
Behind Biotech

From mRNA vaccines to gene and cell therapies, biotech is changing the world. But who are the leaders behind these and other biotech innovations and what makes them so passionate about what they do? In the Behind Biotech Podcast, we’re exploring not only disruptive trends in biotechnology, but also the stories of the ‌founders,‌ ‌researchers, executives,‌ ‌patients,‌ ‌investors,‌ ‌and‌ ‌other‌ ‌leaders‌ ‌who‌ ‌dedicate‌ ‌their‌ ‌lives‌ ‌to‌ ‌improve healthcare through biotech.

  1. 2022. 08. 03.

    Season 2| China: Hong Tang on Traditional Chinese Medicine and Targeted Cancer Supportive Therapy

    Hong Tang Biography Dr. Hong Tang is Chief Medical Officer, and co-founder of OnQuality Pharmaceuticals. Hong is a Board-certified internal medicine physician with more than 15 years’ experience in both drug development and medical affairs, and conducted all phases of clinical trials. She served as VP, Executive Medical Director, Medical Director, and Medical Officer in Dendreon, Juno, Astellas, BMS and NIH. OnQuality Pharmaceuticals is designing targeted cancer supportive care treatments aimed at preventing and treating the intolerable side effects caused by specific cancer drugs. Their mission is to make fighting cancer easier by alleviating the side effects of anti-cancer therapy, so the patients can continue cancer treatment and live with a better quality of life. OnQuality is based in Seattle and Shanghai. She received her medical degree in Traditional Chinese Medicine in Hefei, China, pursued her graduate study in Western medicine in Guangzhou, China, and at the University of Texas in San Antonio. She is also board certified in internal medicine and practiced as an internist in Indiana for almost 7 years. In this episode of Behind Biotech, we spoke with Hong about: Starting her career in Traditional Chinese Medicine, and how this education on holistic patient care influenced her career path The need for more targeted cancer supportive therapy, such as IL-6 inhibitors for CAR-T OnQuality’s current pipeline in oncodermatology and oncogastroenterology

    32분
  2. 2022. 06. 29.

    Season 2 | China: George Chen on Building a "In China, for Global" Biotech

    George Chen Biography George Chen, MD MBA, is an oncologist by training with a successful track record in the world of global pharmaceutical companies.  Prior to founding D3 Bio, Dr. Chen held senior global positions in research, drug development and management at leading institutions, such as the National Institutes of Health, and multinational pharmaceutical companies, such as Eli Lilly, GlaxoSmithKline, Johnson & Johnson, BeiGene, and Astra Zeneca.  At these organizations he led development and regulatory registrations of blockbuster drugs into the U.S. and Chinese markets, directing more than 70 IND approvals and more than 30 NDAs.  His medical degree is from the Shanghai Medical College of Fudan University and his MBA is from the Wharton School of Business at the University of Pennsylvania. D3 Bio D3 Bio, Inc is an “in China, for global” biotech company aiming to become a world-class biotherapeutic company to develop and register the First/best-in-class medicines for cancer and autoimmune disease patients in large unmet medical needs through a continuously progressing cycle of using the insight of Development to guide Discovery and back to Development process. The company has launched 6 pre-clinical portfolio projects with first and best in class potential and recently received IND clearance from the FDA to initiate Phase 1 trial for D3S-001. D3 Bio is backed by a syndicate of world-class investors whose support underscores their belief in the promise of the Company. Major investors include Boyu Capital, Matrix Partners China, Sequoia Capital China, Temasek, and WuXi AppTec's Corporate Venture Fund. In this episode of Behind Biotech, we spoke with George about: Training as an oncologist in China in the 80s and his motivation to come to the US to learn about immunotherapy His experience of building the foundation of BeiGene as the company’s first Chief Medical Officer The success story of and lessons learned from developing Tagrisso, an EGFR-TKI for NSCLC, at Astrazeneca China D3 Bio’s plans after launching with a $200M Series A-the second largest Series A in 2020 of any biotech company

    36분
  3. Season 2| China: Bing Yuan on Global Outlicensing of Chinese Biotech

    2022. 06. 02.

    Season 2| China: Bing Yuan on Global Outlicensing of Chinese Biotech

    Dr. Bing Yuan is an entrepreneur and a seasoned business executive in business development and licensing (BD&L), marketing and new product strategy. He has made significant contributions to 13 approved global oncology drugs at various stages of product life cycle, including blockbusters such as Keytruda and Glivec. Before founding OnCusp, he was Chief Strategy and Business Officer at CStone Pharmaceuticals. As a senior executive from the beginning, he helped to build the company from scratch to successful IPO and a fully integrated biopharma. At CStone, he established and managed over 10 departments, such as BD&L, public relations, R&D project management and commercial organization. He successfully reached close to 10 strategic partnerships with Pfizer, Bayer, Blueprint, Agios, EQRx, etc. Before joining CStone in November 2016, he spent 22 years in the USA. He was Executive Director and Global Lead of Oncology BD&L at Merck (MSD), Global Head of Life Cycle Strategy and Executive Director at Novartis Oncology, Global Oncology Marketing Lead at Eisai, and Product Manager at Thermo-Fisher. He successfully led or contributed to over 40 M&A, licensing and Keytruda clinical collaboration deals. As a core member of the global project team (GPT), he played a key role in designing development strategy for 5 oncology drugs. He used to lead Glivec and Afinitor brand life cycle strategy, and participated in global launch of Zykadia in ALK+ lung cancer. Dr. Yuan holds a Ph.D. in Molecular Biology from Columbia University, an MBA from Cornell University and B.S. of Biochemistry from Nanjing University. In this episode of Behind Biotech with Bing, we discussed: Bing's professional journey from China to the US and back to China Catalysts behind the striking growth of the Chinese Biotech industry starting in 2015 Pioneering new models of global outlicensing of Chinese Biotech with OnCusp Therapeutics

    31분
  4. Season 1|Penn: Hyun (Michel) Koo on the Need for Innovation in Oral Health

    2022. 01. 25.

    Season 1|Penn: Hyun (Michel) Koo on the Need for Innovation in Oral Health

    Hyun (Michel) Koo, DDS, MS, PhD obtained his DDS from The Sao Paulo State University, Brazil, and later obtained his MS in Food Engineering and PhD in Oral Biology from The University of Campinas, Brazil as well as the University of Rochester Medical Center. Michel joined the faculty at Penn in 2013, where he has led interdisciplinary research integrating oral, biomedical and engineering sciences, culminating with the launch of the Center for Innovation & Precision Dentistry (CiPD), uniting the dental and engineering schools at Penn. Michel has been recognized as an outstanding leader for his pioneering work on understanding and modulating the oral biofilms for better health. In this episode of Behind Biotech, we discussed: Michel’s unique upbringing as a German-born Korean-Brazilian who immigrated to the United States, and how that unusual background informs his approach as a mentor and an inventor. The need to find more effective and affordable approaches to tackle the global burden of oral disease, which disproportionately affects vulnerable populations. His work as the Director of the Penn Center for Innovation & Precision Dentistry, including driving initiatives to develop advanced functional materials for craniofacial tissue restoration and teeth protection, using AI to understand oral diseases, and studying the use of robotics, nanomaterials and biotechnology to diagnose, treat, and prevent oral diseases more effectively.

    30분

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From mRNA vaccines to gene and cell therapies, biotech is changing the world. But who are the leaders behind these and other biotech innovations and what makes them so passionate about what they do? In the Behind Biotech Podcast, we’re exploring not only disruptive trends in biotechnology, but also the stories of the ‌founders,‌ ‌researchers, executives,‌ ‌patients,‌ ‌investors,‌ ‌and‌ ‌other‌ ‌leaders‌ ‌who‌ ‌dedicate‌ ‌their‌ ‌lives‌ ‌to‌ ‌improve healthcare through biotech.

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