Touching Base Genetic Engineering & Biotechnology News (GEN)

Episode 19 (April 26, 2024): This week, the GEN editors celebrated DNA Day by sharing some stories about their favorite observations and applications of DNA research.
 
Featuring Kevin Davies, PhD (Editorial Director, GEN), John Sterling (Editor in Chief, GEN), Uduak Thomas (Senior Editor, GEN), Alex Philippidis (Senior Business Editor, GEN), Fay Lin, PhD (Senior Editor, GEN Biotechnology), Jonathan Grinstein, PhD (Senior Editor, GEN), and moderated by Corinna Singleman, PhD (Managing Editor, GEN and IPM).
 
Listed below are key references to the GEN stories, media, and other items discussed in this episode of Touching Base:
 
The Life and Times of Rosalind Franklin
GEN Webinar presented by Matthew Cobb, PhD, Oct 16, 2020.
 
"Life Story"
BBC film (1987).
 
Nobel Winner Svante Pӓӓbo Discovered the Neandertal in Our Genes
By Daniela Mocker, Scientific American, Oct 4, 2022.
 
“Svante Pӓӓbo, reader of the Neanderthal genome”
Wielgus, Danielewski, and Walkowiak, Acta Physiol, Nov 23, 2022.
 
Colossal’s Woolly Mammoth Project Advances as Elephant iPSCs Clear Milestones
GEN, Mar 7, 2024.
 
The State of Omics 2024
GEN Summit.
 
“Genetic Ancestry Testing What is it and Why is it Important?”
Jorde and Bamshad, JAMA, Mar 27, 2020.
 
A Leading Cause of Autism Spectrum Disorders May Be Prevented by Novel Approach
GEN, May 21, 2023.
 
AI Finds Autism-Causing Mutations in “Junk” DNA
GEN, May 28, 2024.
 
Pollution and Stress Alter Brain Development and Social Behavior in Male Mice
GEN, Aug 3, 2022.
 
“Mechanistic Basis of Resistance to PCBs in Atlantic Tomcod from the Hudson River”
Wirgin, et al., Science, Mar 11, 2011.

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Episode 18 (April 19, 2024):  
  
Biology’s exploding data streams continue to leverage artificial intelligence (AI) tools to streamline drug development. How do we define AI in drug discovery? Who are notable players in the space? How do humans fit into these growing computational pipelines?  
 
This week, Jonathan Grinstein, PhD (Senior Editor, GEN) and Fay Lin, PhD (Senior Editor, GEN Biotechnology) unpack one of the fastest growing topics in the biotech field, AI in drug discovery. 
 
Listed below are key references to the GEN stories, media, and other items discussed in this episode of Touching Base: 
 
The Difference Is the Data: Drug Discovery’s AI Revolution 
By Fay Lin, PhD, GEN Biotechnology, April 18, 2024 
 
Archimedes’ Box: Diagonal Therapeutics Raises $128 Million to Discover Agonist Antibodies 
By Jonathan Grinstein, PhD, GEN Edge, April 3, 2024 
 
Generate:Biomedicines Raises Largest Biotech Series C of 2023 
By Jonathan Grinstein, PhD, GEN Edge, September 14, 2023 
 
Alex Zhavoronkov Aims to Take Over the Drug Development World with AI 
By Jonathan Grinstein, PhD, GEN Edge, June 20, 2023 
 
Diffusion Evolution: New Artificial intelligence Models Break Barriers in Protein Design
By Fay Lin, PhD, GEN Biotechnology, October 16, 2023

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Episode 17 (April 12, 2024):  
  
This week, the GEN editors discuss the launch of Nvelop Therapeutics, a new start-up leveraging approaches developed by gene editing pioneers David Liu, PhD, and J. Keith Joung, MD, PhD, to advance delivery of genetic cargo. The GEN editors also recap highlights from the American Association for Cancer Research (AACR) annual meeting held in San Diego, California. 
 
Featuring Uduak Thomas (Senior Editor, GEN), Alex Philippidis (Senior Business Editor, GEN), Julianna LeMieux, PhD (Deputy Editor-in-Chief, GEN), and Jonathan Grinstein, PhD (Senior Editor, GEN), and moderated by Fay Lin, PhD (Senior Editor, GEN Biotechnology) 
 
Listed below are key references to the GEN stories, media, and other items discussed in this episode of Touching Base: 
  
The State of Omics 2024 Registration 
GEN Summit 
  
Cloaking Device: Liu, Joung Launch $100M Nvelop Therapeutics to Advance Delivery of Genetic Cargo 
By Alex Philippidis, GEN Edge, April 9, 2024 
 
Bertozzi, Regev, and More Inspire During the Opening Plenary Session of AACR 
By Julianna LeMieux, PhD, GEN, April 8, 2024 
 
AACR 2024: Aviv Regev Shows How Single-Cell Atlases Foster New Axis to Genentech’s Drug Discovery 
By Jonathan Grinstein, PhD, GEN, April 8, 2024 
 
AACR 2024: A Video Update from San Diego 
By Julianna LeMieux, PhD, and Jonathan Grinstein, PhD, GEN, April 8, 2024 
 
A Video Update from Day Two of the AACR Meeting 
By Julianna LeMieux, PhD, and Jonathan Grinstein, PhD, GEN, April 9, 2024 
 
AACR 2024: EpiBiologics Advances Degraders of Membrane-Bound Proteins 
By Jonathan Grinstein, PhD, GEN, April 8, 2024 
 
Celebrating National Robotics Week
By Uduak Thomas, GEN, April 12, 2024

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Episode 16 (April 5, 2024): This week, the GEN editors discussed deep proteome profiling of home-sampled dried blood spots to assess the effects of SARS-CoV-2 in mildly symptomatic or asymptomatic, rapid liquid nitrogen treatment for converting tumor cells into carriers for gene editing tools that target cancer in vivo, Verve Therapeutics’ pausing of a clinical trial due to a serious adverse event, Iambic Therapeutics’ advancement of its first AI-designed candidate into the clinic, and the launch of Diagonal Therapeutics to find agonist antibodies for heteromeric receptor complexes.
 
Featuring Uduak Thomas (Senior Editor, GEN), Alex Philippidis (Senior Business Editor, GEN), Jonathan Grinstein, PhD, (Senior Editor, GEN), and moderated by Corinna Singleman, PhD, (Managing Editor, GEN and IPM)
 
Listed below are key references to the GEN stories, media, and other items discussed in this episode of Touching Base:
 
The State of Omics 2024 Registration
GEN Summit
 
COVID-19 Infections Detected in Dried Blood Spots via At-Home Proteomic Profiling
By GEN, April 2, 2024.
 
CRISPR-Cas9 Targets Lung Cancer Using Cryo-Shocked Tumor Cells
By GEN, March 31, 2024.
 
Iambic Rhythm: AI Drug Developer Enters the Clinic, Targeting HER2 Cancers
By Alex Philipidis, GEN, April 3, 2024.
 
Archimedes' Box: Diagonal Therapeutics Raises $128 Million to Discover Agonist Antibodies
By Jonathan D. Grinstein, PhD, GEN Edge, April 3, 2024.

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Episode 15 (March 29, 2024): From the expansion of Nvidia's generative artificial intelligence (AI) platform for drug discovery to AI notetakers that coach doctors to be more human, the GEN editors discuss the latest news in AI from two conferences in California: Nvidia GTC (San Jose) and Precision Med TRI-CON (San Diego).
 
Featuring Alex Philippidis (Senior Business Editor, GEN), Fay Lin, PhD (Senior Editor, GEN Biotechnology), Jonathan D. Grinstein, PhD (Senior Editor, GEN), moderated by Corinna Singleman, PhD (Managing Editor, GEN and IPM).
 
Listed below are key references to the GEN stories, media, and other items discussed in this episode of Touching Base:
 
GTC 2024: Nvidia Highlights AI ‘Revolution’ in Drug Discovery, Genomics
By Alex Philippidis, GEN, March 19, 2024.
 
GTC 2024: Nvidia’s Quantum Expansion Runs through the Cloud
By Alex Philippidis, GEN, March 20, 2024.
 
Machines Bring Efficiency…and Empathy? Eric Topol Talks AI in Precision Medicine
By Fay Lin, PhD, GEN Edge, March 28, 2024.

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Episode 14 (March 22, 2024): This week, the GEN editors cover identifying receptors and proteins for cellular uptake and intracellular processing of nanoparticles, and a new mRNA structure by adding multiple “tails” to the molecules that boosted mRNA activity levels in cells by 5 to 20 times. 
 
Featuring Jonathan D. Grinstein, PhD, (Senior Editor, GEN), Uduak Thomas (Senior Editor, GEN), and moderated by Fay Lin, PhD, (Senior Editor, GEN Biotechnology) 
 
  
Listed below are key references to the GEN stories, media, and other items discussed in this episode of Touching Base: 
  
Nanoparticle Uptake Screen Informs Nanomedicine Design 
By GEN, March 19, 2024. 
  
mRNA Therapeutics May Act Longer If Given Multiple Tails
By GEN, March 22, 2024 

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