1 hr
Your Future Self Will Thank You | Connectomics Part II Neurotech Pub
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- Technology
We’re back with Part II of our two-part series on Connectomics! In part one we speculated on the legal and ethical implications of emerging technologies in the connectomics field. In part two, we don our lab coats and take a deep dive into the latest research tools, from fixation protocols for the preservation of neural tissue, to multimodal imaging techniques, to the machine intelligence designed to interpret massive data sets and reconstruct the vast neural circuits that make up the connectome. Our guests are:
Kenneth Hayworth, PhD, President and Co-Founder of the Brain Preservation Foundation, Senior Scientist at the Howard Hughes Medical Institute’s Janelia Farm Research Campus (JFRC)
Robert McIntyre, CEO at Nectome
Jeremy Maitin-Shepard, PhD, Software Engineer–Connectomics at Google
In this episode, Ken and Robert from part one return to the pub, and we are also joined by Jeremy Maitin-Shepard, an engineer and researcher at Google, who shares insights into some of the machine intelligence modalities being used to decode previously uncharted neural networks. Check out Jeremy’s recent paper on BioRxiv, as well as his published work at Google. If you missed part one, you can listen and explore the show notes here. Cheers!Show Notes: 0:00 | Intro1:03 | Kenneth Hayworth, PhD1:12 | Robert McKintyre, CEO, Nectome1:17 | Jeremy Maitin-Shepard, PhD1:51 | Setting the record straight 3:09 | The nucleotide sequence of bacteriophage φX1744:22 | Frozen Zoo at San Diego Zoo12:01| Glutaraldehyde and reduction techniques for immunolabeling 17:39 | SWITCH Framework19:14 | Population Responses in V1 Encode Different Figures by Response Amplitude Enhanced mirror neuron network activity and effective connectivity during live interaction among female subjects Permeabilization-free en bloc immunohistochemistry for correlative microscopy 19:57 | Synaptic Signaling in Learning and Memory Structure and function of a neocortical synapse Engineering a memory with LTD and LTP Synapse-specific representation of the identity of overlapping memory engrams 20:28 | Ultrastructure of Dendritic SpinesStructure–stability–function relationships of dendritic spines 24:25 | Reconstructing the connectome 24:32 | Connectomics Research Team at Google 24:55 | Google x HHMI: Releasing the Drosophila Hemibrain Connectome 28:38 | Serial Block-Face Scanning Electron Microscopy 29:22 | Automated Serial Sections to Tape29:45 | Mapping connections in mouse neocortex30:59 | A connectome and analysis of the adult Drosophila central brain 32:14 | Expansion Microscopy34:37 | The future of connectomics 45:13 | Contribution of apical and basal dendrites to orientation encoding in mouse V1 L2/3 pyramidal neurons49:49 | Mice and rats achieve similar levels of performance in an adaptive decision-making task Want More?Follow Neurotech Pub on TwitterFollow Paradromics on Twitter, LinkedIn, and InstagramFollow Matt on LinkedIn and Twitter
We’re back with Part II of our two-part series on Connectomics! In part one we speculated on the legal and ethical implications of emerging technologies in the connectomics field. In part two, we don our lab coats and take a deep dive into the latest research tools, from fixation protocols for the preservation of neural tissue, to multimodal imaging techniques, to the machine intelligence designed to interpret massive data sets and reconstruct the vast neural circuits that make up the connectome. Our guests are:
Kenneth Hayworth, PhD, President and Co-Founder of the Brain Preservation Foundation, Senior Scientist at the Howard Hughes Medical Institute’s Janelia Farm Research Campus (JFRC)
Robert McIntyre, CEO at Nectome
Jeremy Maitin-Shepard, PhD, Software Engineer–Connectomics at Google
In this episode, Ken and Robert from part one return to the pub, and we are also joined by Jeremy Maitin-Shepard, an engineer and researcher at Google, who shares insights into some of the machine intelligence modalities being used to decode previously uncharted neural networks. Check out Jeremy’s recent paper on BioRxiv, as well as his published work at Google. If you missed part one, you can listen and explore the show notes here. Cheers!Show Notes: 0:00 | Intro1:03 | Kenneth Hayworth, PhD1:12 | Robert McKintyre, CEO, Nectome1:17 | Jeremy Maitin-Shepard, PhD1:51 | Setting the record straight 3:09 | The nucleotide sequence of bacteriophage φX1744:22 | Frozen Zoo at San Diego Zoo12:01| Glutaraldehyde and reduction techniques for immunolabeling 17:39 | SWITCH Framework19:14 | Population Responses in V1 Encode Different Figures by Response Amplitude Enhanced mirror neuron network activity and effective connectivity during live interaction among female subjects Permeabilization-free en bloc immunohistochemistry for correlative microscopy 19:57 | Synaptic Signaling in Learning and Memory Structure and function of a neocortical synapse Engineering a memory with LTD and LTP Synapse-specific representation of the identity of overlapping memory engrams 20:28 | Ultrastructure of Dendritic SpinesStructure–stability–function relationships of dendritic spines 24:25 | Reconstructing the connectome 24:32 | Connectomics Research Team at Google 24:55 | Google x HHMI: Releasing the Drosophila Hemibrain Connectome 28:38 | Serial Block-Face Scanning Electron Microscopy 29:22 | Automated Serial Sections to Tape29:45 | Mapping connections in mouse neocortex30:59 | A connectome and analysis of the adult Drosophila central brain 32:14 | Expansion Microscopy34:37 | The future of connectomics 45:13 | Contribution of apical and basal dendrites to orientation encoding in mouse V1 L2/3 pyramidal neurons49:49 | Mice and rats achieve similar levels of performance in an adaptive decision-making task Want More?Follow Neurotech Pub on TwitterFollow Paradromics on Twitter, LinkedIn, and InstagramFollow Matt on LinkedIn and Twitter
1 hr