Genefitletics Sushant Kumar

Chronic Kidney Disease is a global health problem. The biggest issue lies in its late diagnosis during the progression of disease. The clinical manifestation & plasma level indications such as eGFR that can indicate kidney health are reduced only at advanced stages of disease development.

However the fact is the changes in biology & chemistry at molecular level takes place years before the nitrogenous substances such as urea & creatinine accumulates in the blood.

Unfortunately, up till now, we had no models in place to detect the early signs of chronic kidney disease. Even some of the companies are tracking certain vital parameters such as weight monitoring, sleep, water tracking, nutrition & more but these practices are just focussed on managing kidney disease.

It is no brainer that increased risk of type 2 diabetes or high blood glucose level could damage blood vessels of kidneys & increase risk /trigger chronic kidney disease. However, research & empirical evidence has now found that functions of oral & gut microbiome have a role to play in early onset of chronic kidney diseases & could be used as early indication & offer preventative solutions

-Halitosis(bad breath) via oral microbial metabolites such as oral H2S, ammonia, polyamines & urease pathways is an early sign.
-Secretion of gut microbial derived metabolites & uremic toxins such as p-cresol, Indoxyl Sulphate, TMAO & LPS could impact kidney function.High circulatory level of these toxins could lead to oxidative stress.

Here comes a very important aspect which is missed by the current healthcare system.

Oxidative stress leads to oxidation of certain metals on protein & enzymes, thereby making cells dysfunctional & disrupting nitric oxide. This establishes a clear correlation that chronic kidney disease could increase risk of type 2 diabetes & cardiovascular diseases as well.

Our today’s podcast episode discusses this in detail

It has been found that 33% of adult female population suffer from depression, while 1 in 5 men would have this growing mental health issue.

Stress is rampant while millions of people deal with dementia & Parkinson's.

While there are solution such as drugs & antidepressants to manage these growing mental health conditions, we have not seen any application of science to carve out preventive solution for growing mental health issues.

We all know the role of gut microbiome in our brain health via the gut-brain axis. Gut microbes not only produce neurotransmitters but also secrete certain toxic metabolites which could travel to brain & trigger inflammation.

But research has now found that the second largest coloniser of microbes in the body- mouth has a vital role to play not only in our oral health but a range of systemic health issues such as type 2 diabetes, heart diseases, arthritis, IBD, colon cancer & more.

Improper nutrition & bad oral hygiene could lead to trigger oral microbial dysbiosis which over activates immune response & leads to chronic inflammation. This prolonged inflammation creates a situation of leaky gum which allows certain oral microbes such as streptococcus mutans & P Ginagavalis translocate from mouth into bloodstream & brain where it could secrete toxin metabolites & directly trigger onset & progression of brain health issues such as dementia. Specifically P. Gingivalis could secrete neurotoxic protease-Gingipain which could lead to creation of Amyloid Beta Protein Plague which is associated with dementia.

It has also been found that people suffering from Chronic Periodontal disease & also experience neuro inflammation.

Besides, Oral microbial dysbiosis is also connected with loss of dopamine production neurons, the hallmark of motor dysfunction & parkinsons disease.

Our today’s talk opens pandorabox on oral microbiome- brain health connection.

We are the only company in India that analyses oral microbiome functions to translate early pre-disease signals into unique molecular insights & carve our precision nutrition interventions to bring back your body back into homeostasis. More details here :https://genefitletics.com/orahyg/

We have become a protein obsessed nation! Have you ever wondered why?

We are told we are deficient in protein! But does this apply to everyone? Is the entire adult population protein deficient? What is the basis of the claim ? How do we calculate deficiency?

If you are recommended some X grams / kg of body weight to meet your protein requirement, you are misguided.

These recommendations are based on population studies which considers you as an average healthy individual & metabolising food/protein in the same way others metabolise? These are wrong claims as our biology is as unique as our fingerprint.

We need protein for various cellular processes, brain functioning, energy & more but how much each individual needs & which ones is & should be driven by his/her unique biochemical profile.

There are multiple factors at play when it comes to protein consumption & absorption which includes digestive enzymes. Your microbes could tell you if you are digesting protein efficiently via activating certain pathways such as Protein Fermentation & digestive efficiency. If you are not digestive protein efficiently or eating excess protein, it may land up in your large intestine where certain microbes- Proteobacteria interact with amino acid & produce harmful metabolites such as Ammonia, methane, H2S,p-Cresol, Putrescine, PAG, TMAO & more which could range of chronic health conditions including autoimmune disorders, cardiovascular diseases & more.

Research has found that excess production of p-cresol could suppress GLP-1 production which is said to cause obesity even typ3 2 diabetes.

Even when it comes to type 2 diabetes, do not fall for a high protein diet as a solution for type 2 diabetes.Understand your unique biology- Certain polyphenols such as walnuts, Pomegranate, Strawberry & more when converted by your microbiome into Urolithin A improve your hypoglycemic response & pancreatic B Cell function.

Do not fall for these generic recommendations, your biology is unique, you deserve nutrition choices aligned with your biochemical individuality.


Our today’s talk deep dives into role of protein in detail

Metabolic disease is taking a giant leap forward with the number of people developing obesity, type 2 diabetes & more is increasing.

Although we have all resources & tech in place, still we do not have any preventative solutions to stop these diseases from developing in the first place.

There is need to understand

-Food processing, farming practices & industrial practices to improve the shelf life: Although labels will show the same value, processed foods such as rolled oats or commercially grinded nuts would be processed differently. Besides, it is also important to decode the functions of your microbiome as 99% of biological functions are performed by them. The interaction between food & microbiome also determine how each food is processed, how much calories are extracted what byproducts is produced as a result

- Glycemic response to various foods: Over the last 2 years, we have seen a number of companies coming up with continuous glucose monitoring machines but there are multiple structure & functional issues associated with CGM.

CGM are not more that a guess work

-CGM measures your glycemic response to various foods post its consumption, does not predict glucose spike
-CGM measures response to a meal, not food, not specific molecules in food. We really need to understand how each of molecule contribute to our blood sugar response
-You may fix CGM for 2-3 weeks to make a list of food that is going to spike more than others & may consider it static for you. However, as you feed your microbiome, functional pathways & composition changes, glycemic response to food changes & therefore you need to track glycemic response every month, making you endlessly spend on CGM every month.
-CGM does not tell you why you have a glycemic response to specific foods as it does not decode the interaction between food you eat & your gut/oral microbiome.
- Rather than just tracking glycemic response using CGM, the focus is on understanding the level of production of nitric oxide(which is a signal that tells GLUT 4 to clear the glucose from the circulation, LPS Production, TMAO, P-cresol & more.

Our today’s talk discusses in detail

We at Genefitletics, based on functional pathways of gut & oral microbiome measure & quantify 17 pls microbial pathways to predict onset & progression of type 2 diabetes & even predict insulin response to 317 foods. More details here: www.genefitletics.com

Digitise your body before you put a fork inside your mouth!

If someone would have told you this 5 to 7 years ago, you would have told them you must be joking! Technology has taken leap & bounds over last few years still when it comes to nutrition as medicine, we get inclined towards that lucrative quick fix without understanding our unique biology & chemistry

“ Oh, have 25 grams of veggies daily! Which one is Broccoli? Tomatoes? Bell Pepper? Carrot?

Broccoli - really? What if my microbes producing hydrogen Sulphide are active? What if it could cause bad breath

YOur body needs a lot of antioxidants, take pomegranate! What if you do not right set of gut microbes to convert ellagic acid in Pomegranate into Urolithin A

We need to think good beyond calories. Food is an ecosystem of 25,000 plus molecules. When you put a fork inside your mouth, around 1,000 molecules are hitting your top & bottom of the digestive tube. Food ingredients & molecules are first available to your microbes who convert them into metabolites /by products which are made available to your body. How your microbe interacts with each of these food substrates is what matters.

One important case in point is PROTEIN.

“ Oh you need to lose 10 Kgs, please stop eating wheat, reduce your carbohydrates, eat lot of protein”

But did you know the excess protein you are ingesting lands up in your gut when a group of microbes called proteobacteria can synthesise some specific amino acids into harmful metabolites which are connected with onset & progression of type 2 diabetes, cardiovascular diseases, chronic kidney disease & more. Some of these metabolites include

P-cresol: byproduct of tyrosine implicated in pathogenesis of Chronic Kidney Disease, Cardiovascular disease, Obesity & type 2 diabetes( by suppressing GLP-1).
-Phenylacetylglutamine(PAG): byproduct of phenylalanine which is connected with increasing LDL production & heart failure
-TMAO-byproduct of lecithin, choline & L-carnitine which is said to cause plaque in arteries
-Indoxyl Sulphate-byproduct of Tryptophan which is said to cause chronic kidney disease & cardiovascular issues

& the list goes on

Think before you replace your carbohydrates with protein. When it comes to carbs, processed foods are complete no but it does not mean wheat or rice is bad. Our today’s talk deep dive into interaction between amino acids & gut microbiome in detail

Last few years have seen advancement in technology which has opened up flood gates to revisit how we measure our health. This has transformed the methods of collecting healthcare delivery data & point of care diagnostics with usage of Wearables- Smart rings, smart watches & CGM

However are the healthcare delivery data & plasma level indications really solving healthcare problems?

Some facts

1)Globally,41 million people die of chronic diseases every year
2)55 million+ people suffer from dementia worldwide
3)Global incidence of Non- Alcoholic Fatty Liver Disease(NAFLD) is 47 for every 1000 people
4)100 million plus Indians are either prediabetic or suffering from type 2 diabetes
5)13% of Indian population have high risk of cancer
6)10% of Indian population suffers from chronic kidney disease; Renal failure is detected at a late stage & most of the patients end up in dialysis with no curative solution
7)Diseases such as NAFLD, Oral & Throat Cancer & Dementia are hard to detect
& the list goes on
Still these new age technologies in the name of AI & ML are just helping us manage the symptoms of chronic diseases not finding or identifying asymptomatic signatures predictive of chronic diseases & biggest thing these models have missed out tracking 99% of biology

AI/ML is a system & we need to feed the right set of data sets to draw meaningful outcomes that could help us understand the pathogenic process involved in onset & progression of chronic diseases.

We need to focus not on plasma level biomarkers & DNA but on downstream functions via RNA & Metabolites

We need to collect a lot of molecular & biological data sets & apply AI/ML tools to deep dive on what is happening at molecular level & changes in chemistry before & during disease onset. This could help us identify molecular indications which are invisible & cannot be identified by POC diagnostics/Wearables & compute interventions to kill these molecules so that disease does not even develop in the first place.

Today we unveiled what data sets should be collected & analysed to eradicate epidemic of chronic diseases.



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