100 episodes

Pharmacology is one of the most challenge topics you will encounter as a healthcare professional, but it can be the most rewarding with a good understanding. Whether you are preparing to be a nurse, physician, physician assistant, pharmacist, dentist, nurse practitioner, pharmacy technician, pharmacologist, or other healthcare professional, this podcast will help you better understand pharmacology. In addition to giving you the basics like mechanism of action, side effects, drug interactions, etc., you will also be exposed to how medications actually impact patients in real life. In the Real Life Pharmacology podcast, Eric Christianson, PharmD shares his real world experiences about how a medication's mechanism of action, pharmacokinetics, adverse effects, and drug interactions can actually impact patients in both a positive and a potentially negative way. Eric Christianson PharmD is the author of the popular clinical pharmacy blog Meded101.com. People who are passionate about nursing, medicine, or pharmacy will find this podcast beneficial in helping them prepare for passing exams. This podcast is for educational purposes only and is not medical advice or intended to be a substitute for medical advice. Please seek advice from your pharmacist or primary care provider if you have questions about medications that you are taking.

Real Life Pharmacology - Pharmacology Education for Health Care Professionals Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist

    • Medicine

Pharmacology is one of the most challenge topics you will encounter as a healthcare professional, but it can be the most rewarding with a good understanding. Whether you are preparing to be a nurse, physician, physician assistant, pharmacist, dentist, nurse practitioner, pharmacy technician, pharmacologist, or other healthcare professional, this podcast will help you better understand pharmacology. In addition to giving you the basics like mechanism of action, side effects, drug interactions, etc., you will also be exposed to how medications actually impact patients in real life. In the Real Life Pharmacology podcast, Eric Christianson, PharmD shares his real world experiences about how a medication's mechanism of action, pharmacokinetics, adverse effects, and drug interactions can actually impact patients in both a positive and a potentially negative way. Eric Christianson PharmD is the author of the popular clinical pharmacy blog Meded101.com. People who are passionate about nursing, medicine, or pharmacy will find this podcast beneficial in helping them prepare for passing exams. This podcast is for educational purposes only and is not medical advice or intended to be a substitute for medical advice. Please seek advice from your pharmacist or primary care provider if you have questions about medications that you are taking.

    Probenecid Pharmacology

    Probenecid Pharmacology

    Patients with G6PD deficiency who are taking probenecid are at increased risk for hemolytic anemia.







    In a patient taking probenecid, they need to have adequate kidney function for the drug to work.







    GI upset is likely the most common adverse effect of probenecid. It can be given with food.







    Probenecid can raise the concentrations of many common antibiotics like penicillins and cephalosporins.







    Remember that there are many medications that can oppose the beneficial effects of probenecid. Thiazides, niacin, and some immunosuppressants can raise uric acid.

    • 12 min
    Nicotine Patch Pharmacology

    Nicotine Patch Pharmacology

    Nicotine replacement therapy is an important tool in helping our patients quit smoking. There are lots of clinical pearls involving the pharmacology of nicotine patches and I explore them in this episode.







    Nicotine patches differ from the gum and other acute relief forms in that they are intended to provide a consistent level of nicotine in the body.







    The initial dosing of nicotine patches is dependent upon the number of cigarettes smoked by the patient. I discuss it further in the podcast.







    When applying nicotine patches, it is important to remember to utilize a clean, non-hairy area to ensure the patch adheres to the skin appropriately.

    • 16 min
    Doxepin Pharmacology

    Doxepin Pharmacology

    Doxepin is under the class of tricyclic antidepressants. It can inhibit the reuptake of serotonin and norepinephrine.







    In addition to the serotonin and norepinephrine reuptake inhibition mechanism, doxepin also has antihistamine type effects.







    Because of the anticholinergic activity of doxepin, it is recommended to avoid this medication in the elderly, particularly at high doses.







    Be aware that anticholinergics like doxepin can reduce the benefit of dementia medications.







    CYP2D6 is an important enzyme in the metabolism of doxepin and drugs like bupropion that inhibit CYP2D6 can increase the concentrations of doxepin.

    • 13 min
    Atomoxetine Pharmacology

    Atomoxetine Pharmacology

    Atomoxetine is a norepinephrine reuptake inhibitor that can be used in the management of ADHD.







    Atomoxetine is a non-controlled substance option for patients seeking this alternative to traditional stimulants.







    CYP2D6 is an important enzyme in the breakdown of atomoxetine.







    CYP2D6 inhibition or poor metabolizers via CYP2D6 can lead to higher concentrations of atomoxetine and put our patients at greater risk for adverse effects.

    • 10 min
    Fluoxetine Pharmacology

    Fluoxetine Pharmacology

    Fluoxetine is an SSRI used in the management of depression, anxiety, OCD, PTSD, and other psychiatric conditions.







    Fluoxetine has a very long half-life which can impact clinical management. I discuss how this matters in this podcast episode.







    Fluoxetine inhibits CYP2D6 which can alter the concentrations of many drugs.







    Prodrugs like codeine and tamoxifen can have their effects reduced because of fluoxetine. I explain this further in the episode.







    By inhibiting CYP2D6 concentrations of many drugs can be raised by the use of fluoxetine.

    • 12 min
    Metoprolol Pharmacology

    Metoprolol Pharmacology

    Metoprolol is a beta-blocker commonly used in the management of hypertension, heart failure, and atrial fibrillation.







    There is an extended release dosage form and immediate release dosage form with metoprolol. The advantage of the extended release product is that it doesn't require as frequent dosing.







    Metoprolol is selective for beta-1 receptors. It is less likely to interact with asthma medications.







    CYP2D6 plays an important role in breaking down metoprolol. Alterations in this enzyme's activity can alter concentrations of the drug.

    • 10 min

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