Pharmacology is one of the most challenge topics you will encounter as a healthcare professional, but it can be the most rewarding with a good understanding. Whether you are preparing to be a nurse, physician, physician assistant, pharmacist, dentist, nurse practitioner, pharmacy technician, pharmacologist, or other healthcare professional, this podcast will help you better understand pharmacology. In addition to giving you the basics like mechanism of action, side effects, drug interactions, etc., you will also be exposed to how medications actually impact patients in real life. In the Real Life Pharmacology podcast, Eric Christianson, PharmD shares his real world experiences about how a medication's mechanism of action, pharmacokinetics, adverse effects, and drug interactions can actually impact patients in both a positive and a potentially negative way. Eric Christianson PharmD is the author of the popular clinical pharmacy blog Meded101.com. People who are passionate about nursing, medicine, or pharmacy will find this podcast beneficial in helping them prepare for passing exams. This podcast is for educational purposes only and is not medical advice or intended to be a substitute for medical advice. Please seek advice from your pharmacist or primary care provider if you have questions about medications that you are taking.
On this episode of the Real Life Pharmacology podcast, I explore doxycycline pharmacology, adverse effects, and drug interactions.
Doxycycline can be bound by numerous minerals like calcium, magnesium, and iron. Coadministration can lead to reduced concentrations.
Sun sensitivity is a really important adverse effect that can be caused by doxycycline. Be sure to educate your patients.
Doxycycline can be used as an alternative to beta-lactams and macrolides in the management of community-acquired pneumonia.
On this episode, I discuss tolterodine pharmacology, adverse effects, and drug interactions.
Tolterodine (Detrol) is an anticholinergic medication used to manage the symptoms of overactive bladder.
Tolterodine's anticholinergic activity can lead to a significant number of adverse effects like dry mouth, dry eyes, constipation, and urinary retention.
Elderly patients may be at greater risk for anticholinergic adverse effects from tolterodine compared to younger patients.
Tolterodine can have additive effects from other anticholinergics like diphenhydramine or TCAs which enhance its potential for side effects.
On this episode, I discuss clarithromycin pharmacology, adverse effects, and drug interactions.
Clarithromycin is a macrolide antibiotic that can be used for many similar indications as azithromycin.
Clarithromycin has numerous drug interactions as it can inhibit CYP3A4. This limits its use in practice.
Clarithromycin can be used in the treatment of H. pylori in combination with other antibiotics and a PPI.
On this episode, I discuss azathioprine pharmacology, adverse effects, monitoring parameters, and drug interactions.
Azathioprine is classified as an immunosuppressive agent so it is naturally going to be used for autoimmune type disorders and transplantation.
Azathioprine has a boxed warning for myelosuppression. I talk more about this in the episode.
Genetic testing is recommended by the AGA prior to the use of azathioprine. I discuss which tests might be helpful to reduce the risk of toxicity.
On this episode, I discuss amitriptyline pharmacology, adverse effects, and drug interactions.
Grapefruit Juice Interactions
On this episode of the podcast, I discuss my approach and strategies to handle grapefruit juice interactions.
Grapefruit juice causes drug interactions by inhibiting the CYP enzyme system. More specifically, it inhibits CYP3A4 which is responsible for the breakdown of many medications.
Quantity is always an important consideration when assessing grapefruit juice interactions. The more that is taken, typically, the more drug concentrations will be affected.
It is important to assess the use of grapefruit juice when your patient has a history of cardiovascular disease, cardiac conditions, pain, mental health disease, or gout as some medications used to treat these diseases can interact with grapefruit juice.
If you are looking for more content on drug food interactions, be sure to check out my book in the links below.
Informative and concise
Short abs sweet bit to the point, I enjoy that they’re only 15-20 mins for easy listening. Doesn’t feel like a lecture but gives good concise info. Gives tips and pointers to remember and despite being American translates well to UK clinical therapy
Great Podcast for me as a community and clinical pharmacist. I find it concise and easy to follow to take all in.
Thank you from the UK.
Really enjoy this podcast and it’s not too big to take it all in. Explains the medication in a very succinct way and how to apply to everyday practice.
It’s been a very useful tool while developing my non medical portfolio