5 episodes
The Translational Mixer Andy Marshall
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- Science
Two lapsed Nature editors, Andy Marshall and Juan-Carlos Lopez, have a conversation and a cocktail with experts in translational research and biomedicine
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Episode 5: Nathan Price on scientific wellness and a Mojito
Nathan Price, currently on leave from the Institute for Systems Biology in Seattle and Chief Scientific Officer at Thorne HealthTech, talks to JC and Andy about his data-driven approach to understanding health and predicting personal trajectories into disease as we age.03:24 What is scientific wellness?06:53 Correlates of scientific wellness15:45. Generating hypotheses18:40 Multimodal over unimodal data22:04. Biomarkers and individual disease trajectories28:00 How to intervene to maintain wel...
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Episode 4: Dan Kaufman on off-the-shelf cell therapy and Manhattans
UCSD's Dan Kaufman, an innovator in the field of induced pluripotent cell (iPSC)-derived natural killer cell therapies, talks to Andy and JC about the latest in allogeneic and autologous immune and regenerative cell therapies at the 2024 Keystone symposium on Emerging Cell Therapies. 02:55 Sourcing and expanding NK cells 05:59 Off-the-shelf versus self09:26. Clinical trials and manufacturing13:40. Stealth, immune cloaking and protein manufacture16:51. Safety, cost, availabil...
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Episode 3: Kiran Musunuru, gene and base editors hit the clinic and a Bloody Mary mix
UPenn's Kiran Musunuru, a human geneticist and practicing cardiologist who has pioneered the translation of gene- and base-editing approaches, talks to JC and Andy about the latest clinical results and modalities discussed at the 2024 Keystone symposium on Precision Genome Engineering. 4:07 Impacting patients6:44 In vivo editing in different liver diseases11:37 The FDA stance on programmable therapy19:41 Base-editors march into the clinic25:54 Multiplexing with base editors2...
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Episode 2: Eric Topol, multimodal AI models in medicine, and a glass of Merlot
Scripps' Eric Topol is a visionary in the application of artificial intelligence to medicine. He has a wide-ranging conversation with JC and Andy about : 02:52 Multimodal AI is coming06:44 FDA-approved AI software10:02 How to validate AI models?12:50 Synthetic doctor’s notes and other early applications15:38 Thinking about the model and its training19:28 Dealing with hallucination and GPT524:13 Low-to-middle income countries 27:40 Uptake by the medical community29:15 Open or p...
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Episode 1: Pete Kirkpatrick, mRNA therapeutics and Espresso Martinis
Pete Kirkpatrick, Chief Editor of Nature Reviews Drug Discovery, gives Andy and JC the lowdown on a Nature Conference on RNA therapeutics and what innovations he is seeing in the field of mRNA therapies.01:44 Nature conference on RNA therapies08:11 Differences between mRNA therapeutics and mRNA vaccines14:24 mRNA chemistries18:08 mRNA manufacturing22:05 mRNA delivery27:21 Delivering LNPs to organs other than liver34:25 Targeting RNA with s...