Through A Scientist's Eyes Chris Wynder

How do explore the question of how to make a brain? How did genomic sequencing and genetic manipulation change the nature and speed of the research. This episode goes through my journey as a brain scientist as the human genome project was just in its infancy.

There is an intimate relationship between gene expression, developmental biology and the environment. In this episode we will discuss how this plays out to shape humans using a thought experiment: getting the human species ready to survive on other planets.

It is the science behind an on-going SciFi short story that I have been writing for a few years now: Acchret's Children

How do you translate signals into action? How do you remember your actions? 

For the cell, similar to a computer, it is a series of additive changes- in this case to the packaging of DNA that make it either easier or more difficult for the DNA to be accessed by RNA polymerase, the ultimate control of gene expression.

When we discuss Genes, cells and disease- what does a scientist mean? This episode I will try and explain through what the experiments "did" to allow scientists to come up with a model- such as what you can see on the "Through Scientists Eyes" on Instagram or the blog (the link for the Podcast).

How did normal cell biology let scientists come up with mRNA vaccines "so fast"...about 80 years of research went into these overnight vaccines.

These brand new vaccines are built an enormous amount of data on vaccines here are a few of the ones I read:

https://www.sciencefriday.com/articles/the-origin-of-the-word-vaccine/https://www.immunology.org/celebrate-vaccines/public-engagement/guide-childhood-vaccinations/how-vaccines-work

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253346/

https://vk.ovg.ox.ac.uk/vk/how-do-vaccines-work

Video explanation of immunity and vaccines  and More detailed medical term one

NCBI- Pubmed findable science articles on the history of mRNA for vaccinces

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597572/

https://www.frontiersin.org/articles/10.3389/fimmu.2019.00594/full

https://www.nature.com/articles/s41541-020-0159-8

https://www.nejm.org/doi/full/10.1056/NEJMcibr2009737

CDC information on the current mRNA viruses for COVID19

https://www.cdc.gov/vaccines/covid-19/hcp/mrna-vaccine-basics.html

https://www.cdc.gov/vaccines/covid-19/info-by-product/pfizer/index.html

https://www.cdc.gov/vaccines/covid-19/info-by-product/moderna/index.html

How do we regulate a gene? In this episode I'll go through some of the experimental biology that lead us to understand the "Who, What, When and Why" of a gene. This will be a deep dive that takes the basic question of how do DNA, RNA and Protein relate and provide some "meat" on the bones.

Some related videos and sites that visualize some of these concepts:

"Strawberry Experiment"

"Biology4Kids.com: Cell Structure" 

Videos on Gene Expression

Sci Eyes Blog