Sci•Care Robin Laird

Today we're going on a journey with Jelena Grozdanich, the founder of TheSecret.LA.
What I love about Jelena is how intuitive she is about healthy living. In this interview we hear about her personal experiences and I interject with some science-based reflections that can help us understand her experiences.
Enjoy!
Follow Jelena on Instagram: @thesecret.la
Follow us on Instagram: @science.of.selfcare

In this episode we discuss the drawbacks of high-protein diets and what this means for your health long-term.
Share your thoughts on Instagram: @science.of.selfcare
CITATIONS
Kitada, M., Ogura, Y., Monno, I., & Koya, D. (2019). The impact of dietary protein intake on longevity and metabolic health. EBioMedicine, 43, 632–640. https://doi.org/10.1016/j.ebiom.2019....
Levine, M. E., Suarez, J. A., Brandhorst, S., Balasubramanian, P., Cheng, C. W., Madia, F., Fontana, L., Mirisola, M. G., Guevara-Aguirre, J., Wan, J., Passarino, G., Kennedy, B. K., Wei, M., Cohen, P., Crimmins, E. M., & Longo, V. D. (2014). Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population. Cell metabolism, 19(3), 407–417. https://doi.org/10.1016/j.cmet.2014.0...
Papadopoli, D., Boulay, K., Kazak, L., Pollak, M., Mallette, F., Topisirovic, I., & Hulea, L. (2019). mTOR as a central regulator of lifespan and aging. F1000Research, 8, F1000 Faculty Rev-998. https://doi.org/10.12688/f1000researc...
Wahl, D., Solon-Biet, S. M., Wang, Q. P., Wali, J. A., Pulpitel, T., Clark, X., Raubenheimer, D., Senior, A. M., Sinclair, D. A., Cooney, G. J., de Cabo, R., Cogger, V. C., Simpson, S. J., & Le Couteur, D. G. (2018). Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice. Cell reports, 25(8), 2234–2243.e6. https://doi.org/10.1016/j.celrep.2018...
Weichhart T. (2018). mTOR as Regulator of Lifespan, Aging, and Cellular Senescence: A Mini-Review. Gerontology, 64(2), 127–134. https://doi.org/10.1159/000484629

In this episode, Robin discusses the importance of daily light exposure on your daily circadian rhythm, or sleep / wake cycle. Enjoy! And reach out on Instagram @science.of.selfcare.
*Editors note: SAD stands for seasonal affectIVE disorder
CITATIONS
Dautovich, N. D., Schreiber, D. R., Imel, J. L., Tighe, C. A., Shoji, K. D., Cyrus, J., Bryant, N., Lisech, A., O'Brien, C., & Dzierzewski, J. M. (2019). A systematic review of the amount and timing of light in association with objective and subjective sleep outcomes in community-dwelling adults. Sleep health, 5(1), 31–48. https://doi.org/10.1016/j.sleh.2018.09.006
Dharani R, Lee CF, Theng ZX, Drury VB, Ngo C, Sandar M, et al.. Comparison of measurements of time outdoors and light levels as risk factors for myopia in young Singapore children. Eye (Lond). 2012;26(7):911–8. Epub 2012/05/09. doi: 10.1038/eye.2012.49
Duffy, J. F., & Czeisler, C. A. (2009). Effect of Light on Human Circadian Physiology. Sleep medicine clinics, 4(2), 165–177. https://doi.org/10.1016/j.jsmc.2009.01.004

Vadnie, C. A., & McClung, C. A. (2017). Circadian Rhythm Disturbances in Mood Disorders: Insights into the Role of the Suprachiasmatic Nucleus. Neural plasticity, 2017, 1504507. https://doi.org/10.1155/2017/1504507

Walker, M. (2018). Why we sleep. Penguin Books.

Consider this your crash course on epigenetics with Dr. Peter W Laird.
Whether or not you've heard about epigenetics before, I guarantee you'll learn something new from this episode. This is the first of a series in which I'll be interviewing experts in health and science on their expertise, so if you have any specific topics you'd like us to cover, get in touch!
For any super curious nerds who want to go into a deeper dive on Epigenetics, here are a few interesting papers published by Dr. Laird and colleagues:
Knijnenburg, T. A., Wang, L., Zimmermann, M. T., Chambwe, N., Gao, G. F., Cherniack, A. D., Fan, H., Shen, H., Way, G. P., Greene, C. S., Liu, Y., Akbani, R., Feng, B., Donehower, L. A., Miller, C., Shen, Y., Karimi, M., Chen, H., Kim, P., Jia, P., … Wang, C. (2018). Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas. Cell reports, 23(1), 239–254.e6. https://doi.org/10.1016/j.celrep.2018.03.076
Shen, H., & Laird, P. W. (2013). Interplay between the cancer genome and epigenome. Cell, 153(1), 38–55. https://doi.org/10.1016/j.cell.2013.03.008
Shen, H., & Laird, P. W. (2012). In epigenetic therapy, less is more. Cell stem cell, 10(4), 353–354. https://doi.org/10.1016/j.stem.2012.03.012

In this episode, Robin discusses the difference between objective and subjective information, and how they relate to each other in the context of our health.
CITATIONS
Arias E, Heron M, Xu J. United States Life Tables, 2014. National vital statistics reports: from the Centers for Disease Control and Prevention, National Center for Health Statistics, National Vital Statistics System. 2017;66:1–64. [PubMed] [Google Scholar]
Oeppen J, Vaupel JW. Broken limits to life expectancy. Science. 2002;296:1029–1031. [PubMed] [Google Scholar]

In this episode, Robin talks about the power of asking questions and how they can be used to coach ourselves.
RESOURCES
Learn more about the five why's : https://www.adb.org/publications/five-whys-technique
CITATIONS
Kleinsinger F. (2018). The Unmet Challenge of Medication Nonadherence. The Permanente journal, 22, 18–033. https://doi.org/10.7812/TPP/18-033