The Joe Cohen Show SelfDecode

In this episode, Joe tackles a controversial new study that suggests even 25 milligrams of niacin could potentially increase the risk of heart disease. 

Delving deep into the world of niacin supplementation, Joe discusses how, despite these concerns, niacin offers numerous health benefits, including enhanced cognitive function, better mood, and increased energy levels.

Joe draws on personal experiences to compare the negatives against the significant positives of niacin, as he explores niacin's biochemical effects, particularly its interaction with proteins such as 2PY, 4PY, and VCAM1, all linked to cardiovascular health. 

Throughout the episode, Joe examines the importance of dosage, sharing insights into the varying effects of low versus high doses of niacin. 

Join Joe as he navigates the complexities of niacin use, advocating for a well-informed, nuanced approach to its benefits and risks.

If you're interested in learning more about how your DNA and genetics affect your health:

- Check out SelfDecode: https://selfdecode.com/

- Join Joe’s online community: https://thejoecohenshow.com/ 

In this episode, we explore the complex interplay between the CNR1 gene, cannabinoid receptors, and cannabis. 

Discover the role of the endocannabinoid system in maintaining bodily balance, particularly in brain function, mood regulation, and inflammation response. 

We delve deep into how genetic variations in the CNR1 gene can influence the CB1 receptors, and the implications of CB1 receptor function in managing stress, anxiety, and cognitive processes such as memory and decision-making. 

Whether you're curious about the science behind getting high or looking for ways to optimize your cannabinoid system through diet and supplements like CBD oil, this episode has something for everyone. 

If you're interested in learning more about how your DNA and genetics affect your health:

- Check out SelfDecode: https://selfdecode.com/

- Join Joe’s online community: https://thejoecohenshow.com/ 

In this episode, we explore the crucial role of serotonin in managing anxiety and enhancing mental wellbeing. 

Discover how serotonin not only influences mood but also plays a pivotal role in anxiety regulation and mental health. 

Learn about the HTR1A and HTR2A genes, which act like switches, controlling the serotonin levels in the brain. 

Understanding the SNPs in these genes can provide personal insights into your serotonin activity, offering potential strategies to alleviate anxiety, depression, and other mental health disorders. 

The episode further discusses how various serotonin receptors, affected by genetic differences, impact numerous physiological and psychological functions. 

Gain practical advice on how to balance your serotonin levels through diet, lifestyle choices, and supplements tailored to your genetic makeup, and see how this can significantly improve your mood and reduce anxiety. 

If you're interested in learning more about how your DNA and genetics affect your health:

- Check out SelfDecode: https://selfdecode.com/- Join Joe’s online community: https://thejoecohenshow.com/

In this episode, Joe takes questions from SelfDecode members, answering questions like:


What makes SelfDecode different from other DNA companies?


How does the recommendations engine work?


Can you find out if a certain supplement is right for you?



Plus, he shares some of his genetic predispositions and how they correlate with his lab levels!

- Check out SelfDecode: https://selfdecode.com/

- Join Joe’s online community: https://thejoecohenshow.com/ 

In this episode, we delve into the critical process of methylation, highlighting its significant impact on health issues ranging from heart disease to mental health and focusing on a lesser known methylation gene - MTHFD1.

We focus on the MTHFD1 gene and choline's significance beyond methylfolate and Vitamin B12 for undermethylators. 

Discover how MTHFD1 impacts methylation by metabolizing tetrahydrofolate and how choline is important in supplying methyl groups. 

We highlight the impact of a negative MTHFD1 variant on choline usage and the potential consequences of choline deficiency, while also stressing the importance of considering other genes involved in methylation, not just MTHFR and MTHFD1.

If you're interested in learning more about how your DNA and genetics affect your health, you can:

- Check out SelfDecode: https://selfdecode.com/

- Join Joe’s online community: https://thejoecohenshow.com/ 

This episode was originally published on April 12, 2015.

Dr. Jack Kruse and Joe explore unconventional approaches to health through the lens of physics and biochemistry. 

They cover topics like the critical roles of mitochondrial function, environmental factors such as EMFs, blue light, and dietary choices on our well-being, and challenge common health paradigms, emphasizing the importance of circadian biology, the effects of cold exposure, water quality, and the necessity of questioning mainstream nutritional advice. 

Next, they focus on aligning with nature's design through sunlight exposure, understanding electron flow, optimizing DHA intake, and reducing exposure to non-native EMFs. 

These conversations aim to encourage curiosity over conforming, urging listeners to consider the interconnectedness of their biology with their environment in the pursuit of optimal health.

- Check out SelfDecode: https://selfdecode.com/

- Join Joe’s online community: https://thejoecohenshow.com/