Pharmacy to Dose: The Critical Care Podcast Nick Peters

ANNEXa-I Deep Dive Part II
Special Guests: Scott Dietrich, PharmD, BCCCP
Brian Gilbert, PharmD, MBA, BCCCP, FCCM, FNCS
Todd Miano, PharmD, PhD, FCCM
 
03:13 – Safety/thrombotic findings
21:50 – Questions that remain
26:50 – Practical considerations
41:40 – P&T elevator pitch
 
Reference List: https://pharmacytodose.com/wp-content/uploads/2024/06/annexai-deep-dive-part-ii-references.pdf
 
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ANNEXa-I Deep Dive Part I
Special Guests: Scott Dietrich, PharmD, BCCCP
Brian Gilbert, PharmD, MBA, BCCCP, FCCM, FNCS
Todd Miano, PharmD, PhD, FCCM
 
05:40 – Brief ANNEXa-I study overview
20:40 –Primary composite outcome
26:40 – Anti-FXa levels
30:45 – Statistics/methodology questions
 
Reference List: https://pharmacytodose.com/wp-content/uploads/2024/06/annexai-deep-dive-part-i-references.pdf
 
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Literature Review Series
January 2024
Special Guests: Haley Torr, PharmD
Nick Tran, PharmD
 
06:55 – Featured Articles
32:55 – PAD-IS articles
37:10 – Cardiology articles
46:00 – Heme articles
51:40 – Potpourri articles
60:05 – Pharmacist-featured articles
67:30 – Sweet Emotion articles
 
Reference List: https://pharmacytodose.com/wp-content/uploads/2024/06/jan-2024-lrs-references.pdf
 
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Trial of the Week: PROWESS-SHOCK
Special Guest: Paul Szumita, PharmD, FCCM, FASHP, BCCCP, BCPS @paulszumita
 
03:30 – Background studies/Setting the scene
30:25 – PROWESS-SHOCK discussion/Where are we now
 
Paul Szumita joins to highlight a June Trial of the Week “Drotrecogin alfa (activated) in adults with septic shock” published in the New England Journal of Medicine in 2012.
To fully understand the discussion regarding drotrecogin alfa, Paul and I review the mechanism of action and its proposed action in the treatment of sepsis. Then we review earlier studies and the controversy behind the FDA approval process. Finally, we go into detail on what Clinical Pharmacists were tasked with doing at the time based on treatment protocols or hospital restrictions.
Then we dive into the Trial of the Week, discussing the study design and results. What was the mood in ICUs and Pharmacy Departments after this publication? How much did our sepsis care improve from PROWESS to PROWESS-SHOCK? What lessons did we learn with the Xigris FDA approval process? Is there a patient population that could still benefit from drotrecogin alfa treatment? Plus, trial fun facts, issues with calculating APACHE II scores, and so much more.
Reference list: https://pharmacytodose.com/wp-content/uploads/2024/06/prowess-shock-trial-of-the-week-references.pdf
 
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Literature Review Series
2023 Year-In-Review
Special Guests: Jacquelyn Crawford, PharmD @jacuronium
Kathleen Hartman, PharmD @HartKate8
 
04:30 – Neurology
11:05 – Cardiology
18:50 – Cardiac Arrest
26:30 – Pulmonary
35:00 – Sepsis
44:05 – Endocrine/Renal
52:30 – Trauma
61:05 – Infectious Diseases
 
Reference List: https://pharmacytodose.com/wp-content/uploads/2024/06/yir-2023-lrs-references.pdf
 
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Trial of the Week: Ketamine for EM Agitation
Special Guest: Justin Lin, PharmD, BCPS, BCCCP @jjlinpharmd
 
Justin Lin joins to review the May Trial of the Week “Efficacy of ketamine for initial control of acute agitation in the emergency department: a randomized study” published in the American Journal of Emergency Medicine in 2021.
We set the scene by discussing how this research idea started, review the classic agitation presentation at his institution, and highlight evidence comparing pharmacotherapy treatment options prior to this study. Then we dive into the Trial of the Week, discussing the study design and results. What was the biggest pushback from providers or the IRB? Any unique education strategies? Would results stay the same with increased IV push administration? What would the comparator arm be if this study was replicated today? Plus, the most challenging part of this project, Justin’s favorite agent, and so much more.
 
Reference list: https://pharmacytodose.com/wp-content/uploads/2024/05/ketamine-for-em-agitation-trial-of-the-week-references.pdf
 
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