Dr. Kara Fitzgerald | New Frontiers in Functional Medicine, Longevity, Epigenetics

Dr. Kara Fitzgerald
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Podden: Dr. Kara Fitzgerald | New Frontiers in Functional Medicine, Longevity, Epigenetics

Welcome to New Frontiers in Functional Medicine, Longevity & Epigenetics™ where I interview the best minds in functional medicine to discuss the science and research behind medicine, longevity, epigenetics, and so much more. Expect thought-provoking ideas, new research, lots of clinical pearls for practitioners, and step-change information for clinicians and patients. Join us! ~DrKF Copyright © 2023 by KF Education and Consulting, LLC All Rights Reserved

  1. Addressing the Gut-Skin Axis: A Root Cause Approach to Chronic Skin Conditions

    9 SEP.

    Addressing the Gut-Skin Axis: A Root Cause Approach to Chronic Skin Conditions

    In this episode of New Frontiers, Dr. Kara Fitzgerald sits down with Dr. Valerie Gershenhorn, a leading expert in functional dermatology and a Clinical Team Member for Diagnostic Solutions Laboratory, to explore the profound impact of the gut-skin axis and autonomic nervous system on chronic skin conditions like acne, eczema, and more. Dr. Gershenhorn shares her comprehensive approach, including the use of functional testing, targeted nutrition, and specific supplements to address the root causes of skin issues. Clinicians will gain valuable insights into how gut health influences skin conditions and practical strategies for discovering imbalances with GI-MAP testing, and how to correct these findings in clinical practice. This episode is a must-listen for those looking to deepen their understanding of the connection between gut and skin health. ~DrKF Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources. GUEST DETAILS Valerie Gershenhorn, DO, is a Clinical Team Member for Diagnostic Solutions Laboratory. She attended the New York College of Osteopathic Medicine, where she graduated in the top 5% of her class. Dr. Gershenhorn then went on to complete an internal medicine residency at Mount Sinai Beth Israel in New York where she became chief resident. After staying on for a chief residency year, Dr. Gershenhorn earned board certification in internal medicine. Dr. Gershenhorn completed her dermatology residency at Lehigh Valley Hospital and earned board certification in dermatology. She has been practicing dermatology since 2006. Dr. Gershenhorn feels aligned with integrative dermatology because she believes that the skin is a “check engine light” for what is happening within the body. WellEnci https://wellenci.org/about-us Email valerie.gershenhorn@diagnosticsolutionslab.com/ THANKS TO OUR SPONSOR Diagnostic Solutions Laboratory: Website New Frontiers Listeners, elevate your patient care - download the GI-MAP Gut Skin Handout. https://tinyurl.com/5dedxavw SHOW NOTES GI-MAP by DSL https://bit.ly/2IEhVrS GI-MAP Sample Report https://tinyurl.com/3jxa9d8z OAp - Organic Acids Profile https://tinyurl.com/463ny5r2 OAp - Sample Report https://tinyurl.com/3puz5u9e Study: High levels of Helicobacter pylori antigens and antibodies in patients with severe acne vulgaris https://tinyurl.com/wmhnwvpu Dr. Julie Greenberg https://tinyurl.com/4tjcsb8n Study: Filaggrin and beyond… (Includes filaggrin schematic) https://tinyurl.com/mudfumuv CONNECT WITH DrKF on: YouTube: https://tinyurl.com/hjpc8daz Instagram: https://www.instagram.com/drkarafitzgerald/

    1 tim 7 min
  2. You Are Only As Young As Your Immune System with Dr. Greg Fahy

    22 AUG.

    You Are Only As Young As Your Immune System with Dr. Greg Fahy

    Your thymus isn't talked about much, but this small organ in your upper chest is a key component of your immune system that is solely responsible for the essential "education" of the immune cells that protect your body from invaders. Through this action it also affects levels of inflammation (an immune-mediated process). It's also interesting to note that most of us end up dying of an immune-related dysfunction - even cardiovascular disease, as Dr. Greg Fahy points out in this New Frontiers podcast, is often caused by atherosclerosis driven by underlying chronic inflammation. I was thrilled to finally sit down with Dr. Fahy, whose groundbreaking work in aging has reshaped our understanding of what’s possible. His 2019 TRIIM study, showing clear epigenetic age reversal through thymus regeneration, was an absolute game-changer. The thinking prior to that was that epigenetic age reversal was not possible! It was exciting to read his publication as we were in the midst of our own original clinical trial. I'm sure you'll enjoy his recounting of that adventure and just how he's rejuvenating thymic function, the rationale for targeting immune rejuvenation, and the trial extensions he's currently working on now. ~ DrKF Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources. GUEST DETAILS Greg Fahy, PhD https://tinyurl.com/3f4jww7j Chief Scientific Officer, Co-founder Intervene Immune fahy@interveneimmune.com Dr. Greg Fahy received his Ph.D. in Pharmacology and Cryobiology from the Medical College of Georgia in 1977. A world-renowned cryobiologist, Dr. Fahy is the chief science officer and co-founder of Intervene Immune, where he leads groundbreaking research on thymus regeneration and combating age-related immune decline. He designed and led the TRIIM trial, the first to demonstrate both thymus rejuvenation and the reversal of human epigenetic age. His work has been pivotal in advancing aging research, resulting in successful follow-up trials like TRIIM-XA, and further planned studies aimed at refining and expanding these innovative treatments. THANKS TO OUR SPONSORS DIAMOND Rupa Health: https://tinyurl.com/4anbz7b3 Biotics Research: https://www.bioticsresearch.com/ Integrative Therapeutics: https://tinyurl.com/4emwj48z GOLD TimeLine Nutrition: https://tinyurl.com/bdzx2xms OneSkin: https://tinyurl.com/ycxtw4zt MIDROLL DUTCH: Learn more about DUTCH testing https://tinyurl.com/2y24st67 ONESKIN: Try OneSkin for yourself with coupon code DRKARA15 to receive 15% off your first purchase at https://tinyurl.com/ycxvz5we SHOW NOTES Intervene Immune https://interveneimmune.com/ Reversal of epigenetic aging and immunosenescent trends in humans https://tinyurl.com/55dhx453 TRIIM-X Trial: Thymus Regeneration, Immunorestoration, and Insulin Mitigation Extension Trial https://tinyurl.com/y65cu33p The Future of Aging: Pathways to Human Life Extension https://tinyurl.com/3hmbx29c/

    1 tim 2 min
  3. Innovative Approaches to Cardiovascular Care: A Deep Dive with Dr. Mark Houston

    12 AUG.

    Innovative Approaches to Cardiovascular Care: A Deep Dive with Dr. Mark Houston

    Cardiovascular disease might be the leading cause of death, but after my conversation with Dr. Mark Houston, I'm more convinced than ever that we have the power to change that narrative. We delved into the power of diet and lifestyle changes, the essential role of nitric oxide and the impressive results of innovative supplements like Vascanox HP by Calroy Health Sciences in managing blood pressure and cardiovascular disease risk. Dr. Houston's passion for prevention and the practical tips he shared made me feel hopeful and empowered. From understanding key tests to making everyday changes, this episode is all about giving you the tools to protect your heart health. Let's dive in and explore how we can all live longer, healthier lives. ~DrKF Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources. GUEST DETAILS Dr. Mark Houston, MD https://tinyurl.com/27thhcpr" Dr. Mark Houston is a Clinical Instructor at George Washington University. He is also Director of the Hypertension Institute and Vascular Biology and Medical Director of the division of Human Nutrition at St. Thomas Medical Group, St. Thomas Hospital and Health Services in Nashville, TN. He is on the faculty of A4M, for the FAARM and the Metabolic Medicine Institute (MMI) and George Washington University, and directs the Cardiovascular modules. He has also published seven best-selling books on vascular function. Dr. Houston has an active clinical practice, teaches, and does clinical research at St. Thomas Medical Group and Hospital. He founded the Hypertension Institute in 2000. THANKS TO OUR SPONSOR Calroy Health Sciences: Website New Frontiers Listeners, get your exclusive discount and resources from Calroy at http://calroy.com/drkf SHOW NOTES Hypertension Institute https://tinyurl.com/mr46hsph Metabolic Medicine Institute (MMI) https://tinyurl.com/2s39ryym Dr. Houston’s Study: Effects of S-Allylcysteine-Rich Garlic Extract and Dietary Inorganic Nitrate Formula on Blood Pressure and Salivary Nitric Oxide… https://tinyurl.com/4y5ndbjn About Vascanox HP https://tinyurl.com/543tamcj About Arterosil HP https://tinyurl.com/4fr6nbtc Ovationlab Vascular Support Protocol https://tinyurl.com/ynpdphmy Prevalence and Factors Associated With Circadian Blood Pressure Patterns in Hypertensive Patients https://tinyurl.com/2c7xvwz2 Heart Disease and Stroke Statistics—2023 Update: A Report From the American Heart Association https://tinyurl.com/55shva8p CONNECT WITH DrKF on: YouTube: https://tinyurl.com/hjpc8daz Instagram: https://www.instagram.com/drkarafitzgerald/

    54 min
  4. Latest Research Data on Diet & Other Interventions for Multiple Sclerosis with Dr. Terry Wahls

    19 JULI

    Latest Research Data on Diet & Other Interventions for Multiple Sclerosis with Dr. Terry Wahls

    What a tour de force conversation with Dr. Terry Wahls, who is, with her groundbreaking research, changing both conventional and functional medicine's approach to multiple sclerosis and ultimately patient care. I'm very excited to see the findings of her ongoing clinical trials, which evaluate the use of several popular dietary patterns, using MRIs to measure brain volume loss, microbiome data, metabolomics, and more. And folks, if you want to be a research participant there's still time - register your interest on Dr. Wahls' website here. In the podcast we also dive into long COVID, mental health challenges, autoimmunity, and explore treatments in the longevity and biohacking space, such as therapeutic plasma exchange, stem cells, and exosomes. Dr. Wahls has her finger on the pulse of what’s happening in the MS community, and you’re definitely going to want to listen to this one. Enjoy! ~DrKF Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources. GUEST DETAILS Dr. Terry Wahls https://tinyurl.com/2ztnxbda Dr. Terry Wahls is an IFM Certified Practitioner and conducts clinical trials in the setting of Multiple Sclerosis. In 2018 she was awarded the Institute for Functional Medicine’s Linus Pauling Award for her contributions in research, clinical care, and patient advocacy. She is the author of The Wahls Protocol: A Radical New Way to Treat AllChronic Autoimmune Conditions Using Paleo Principles, and the cookbook, The WahlsProtocol Cooking for Life. Get involved in the clinical trial https://terrywahls.com/trials/ THANKS TO OUR SPONSORS DIAMOND Rupa Health: https://tinyurl.com/4anbz7b3 Biotics Research: https://www.bioticsresearch.com/ Integrative Therapeutics: https://tinyurl.com/4emwj48z GOLD TimeLine Nutrition: https://tinyurl.com/bdzx2xms OneSkin: https://tinyurl.com/ycxtw4zt Try OneSkin for yourself with coupon code DRKARA15 to receive 15% off your first purchase. MIDROLL DUTCH: Learn more about DUTCH testing https://tinyurl.com/2y24st67 ONESKIN: Try OneSkin for yourself with coupon code DRKARA15 to receive 15% off your first purchase at https://tinyurl.com/ycxvz5we SHOW NOTES WahlsTM Diet Cheat Sheet http://www.terrywahls.com/diet The Wahls Behavior Change Model for Complex Chronic Diseases: A Clinician’s Guide https://tinyurl.com/mv47ww9k The Wahls Protocol: A Radical New Way to Treat All Chronic Autoimmune Conditions Using Paleo Principles https://tinyurl.com/2p9rn82j Efficacy of Diet on Fatigue and Quality of Life in Multiple Sclerosis: A Systematic Review and Network Meta-analysis of Randomized Trials https://tinyurl.com/y5ahbn5s The WAVES randomized parallel-arm clinical trial https://tinyurl.com/5c2rkufb

    1 tim 3 min
  5. Targeting Cellular Senescence for Healthier, More Youthful Skin With Dr. Alessandra Zonari

    9 JULI

    Targeting Cellular Senescence for Healthier, More Youthful Skin With Dr. Alessandra Zonari

    *Save the date! Join me and Dr. Alessandra Zonari for a free webinar on July 25th 2024 and get your questions answered on all things OS-01 peptide and biological aging. Register at https://www.drkarafitzgerald.com/webinars/ I'm thrilled to be joined by Dr. Alessandra Zonari to take a deep dive into a breakthrough in skincare science that has caught my attention—OneSkin's OS-01 peptide. This episode explores how OS-01 targets cellular senescence, the core of aging, potentially transforming skin health - preserving function, not just aesthetics. I'm particularly impressed by OneSkin's commitment to rigorous research and evidence-based results. Their approach rejuvenates skin function in addition to enhancing its natural radiance, elasticity, and even its microbiome. This could be a significant advancement for individuals managing aging skin or conditions like atopic dermatitis. Throughout our discussion, we explore the scientific foundation behind OS-01 and its clinical implications and uncover how this peptide may redefine skincare protocols, offering new possibilities for healthier, more radiant skin. Whether you're a practitioner seeking innovative solutions for patients for ultrasensitive skin or dermatitis, or someone passionate about maintaining skin health, this episode promises insights that could reshape your approach to skincare. And if you’re using OneSkin, I'd be curious to hear from you. You can post a comment wherever you're listening to this or email me directly at DrKaraFitzgerald.com. ~DrKF Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources. GUEST DETAILS Alessandra Zonari, PhD OneSkin co-founder and Chief Scientific Officer, Alessandra Zonari, PhD joined the early team in 2017 dedicating her time to understanding the underlying mechanism of the aging process and developing solutions to reverse skin’s biological age. Zonari is the co-inventor of five patents and has published more than 20 peer-reviewed papers in scientific journals. Email: alessandra@oneskin.co THANKS TO OUR SPONSOR OneSkin: Website PROMO Try OneSkin for yourself with coupon code DRKARA15 to receive 15% off your first purchase at Website SHOW NOTES Animated science video explaining how OS-01 works Another Study Website Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models Study Website In vitro and in vivo toxicity assessment of the senotherapeutic Peptide 14 Study Website Highly accurate skin-specific methylome analysis algorithm as a platform to screen and validate therapeutics for healthy aging Another Study Website MolClock: Estimate DNA methylation age of Skin Tissues Study Website Double-blind, vehicle-controlled clinical investigation of peptide OS-01 for skin rejuvenation Another Study Website Senotherapeutics, Senolytics, and Senomorphics -- What are they and what is OS-01? Study Website

    58 min
  6. Resolving Chronic Inflammation using SPMs: A Two-Phase Approach with Ashley Koff RD

    25 JUNI

    Resolving Chronic Inflammation using SPMs: A Two-Phase Approach with Ashley Koff RD

    Practitioners, if specialized pro-resolving lipid mediators (SPMs) aren't already on your radar, you'll be a convert by the end of this New Frontiers episode. In functional medicine, we excel at addressing inflammation through nutrition and lifestyle. However, brilliant researchers like Dr. Charles Serhan from Harvard have shown us that resolving inflammation requires a two-phase approach. We need to shift gears, rally the cleanup crew, start the repair process, and turn down the volume on the immune system. This transition from inflammation to resolution is exactly what our guest, Ashley Koff, RD, will discuss. We'll explore why SPMs, discovered by Dr. Serhan, are crucial for healthy inflammation resolution and how Metagenics has developed a product using the patented Serhan method that has numerous clinical applications, from managing inflammation and pain to addressing neurodegenerative conditions, autoimmunity, and even infertility. We'll also delve into factors that influence our ability to convert omega-3 and -6 fatty acids into these superstar molecules, such as diet, genetics, inflammatory bias, and poor vagal tone. This conversation is packed with clinical pearls for your practice and personal use. Enjoy. ~DrKF Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources. GUEST INFORMATION Ashley Koff, RD is a 25+ year award-winning practitioner, founder of The Better Nutrition Program (est. 2019), and fractional Chief Nutrition Officer for entities like Vitaboom. Ashley Koff, RD | The Better Nutrition Program Phone: 323-251-7537 | Email: ashley@thebetternutritionprogram.com GUEST DETAILS Ashley Koff, RD: https://tinyurl.com/2drp29ky Founder - The Better Nutrition Program: https://thebetternutritionprogram.com/ Phone: 323-251-7537 Email: ashley@thebetternutritionprogram.com THANKS TO OUR SPONSOR: Metagenics: Website PROMO Get 15% off Metagenics SPM Active Supplement with Code SPMW624US (US) or SPMW624CAN (Canada) at checkout. https://tinyurl.com/4jc9np3y (Offer expires 7/15/24. Max order value $500. For consumer purchases only.) SHOW NOTES Metagenics Institute Study Website NFFM Podcast: Specialized Pro-Resolving Mediators (SPMs): As Close to a Panpharmacon as We Can Get? Another Study Website Latest Updates on Specialized Pro-Resolving Mediator (SPM) Science by Charles Serhan, PhD, DSc Another Study Website CONNECT WITH DrKF on: YouTube: https://tinyurl.com/hjpc8daz Instagram: https://www.instagram.com/drkarafitzgerald/

    59 min
  7. Towards Predicting Autism in Utero with Dr. Janine LaSalle

    12 JUNI

    Towards Predicting Autism in Utero with Dr. Janine LaSalle

    What if we could actually identify and even correct significant autism risk factors in utero, before a baby is born? This is the promise of the game-changing research of Dr. Janine LaSalle, epigeneticist extraordinaire from UC Davis. With autism rates continuing to increase at alarming rates (the latest data from the CDC, released in 2023, is 1 in 36 children in the US, an increase from the prior 1 in 44), new ways to prevent and treat this condition are of utmost importance. Dr. LaSalle is on a mission to change that, by investigating something you probably haven't heard much about yet - the placental methylome. Methylation signatures in the maternal placenta are yielding information both for predicting autism in children and for intervention targets to prevent the development of the disease. It's just incredibly exciting. In our conversation, you'll also learn how placental methylation behaves differently to DNA methylation in other tissues, and how the placental methylome may also help us better understand cancer as well as mechanisms that restore more youthful epigenetic patterns. Hold onto your hats folks - yes this is deep science, but it's also actionable even now. You'll hear how methylation support specifically in the early pregnancy window is key and how it's also protective against insults from environmental toxicants. You’re in for a treat with this fascinating conversation that has far-reaching implications for you and your patients. ~DrKF Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources. Guest Information Janine LaSalle, Ph.D. Professor, Medical Microbiology and Immunology, School of Medicine University of California, Davis jmlasalle@ucdavis.edu The LaSalle Lab at University of California, Davis Thank you to our sponsors Diamond Rupa Health: https://tinyurl.com/4anbz7b3 Biotics Research: https://www.bioticsresearch.com/ Integrative Therapeutics: https://tinyurl.com/4emwj48z Gold TimeLine Nutrition: https://tinyurl.com/bdzx2xms OneSkin: https://tinyurl.com/ycxtw4zt Try OneSkin for yourself with coupon code DRKARA15 to receive 15% off your first purchase. Midroll Practice Better: https://tinyurl.com/28mmab99 Start your free trial and save 20% for 4 months on any paid plan with code KF20 Show Notes Perinatal Origins of Disparities Center: https://pod.ucdavis.edu/ Environmental Health Sciences Center: https://environmentalhealth.ucdavis.edu/ MIND Institute: https://health.ucdavis.edu/mindinstitute/ Article: Too Much Folate in Pregnant Women Increases Risk for Autism, Study Suggests: https://tinyurl.com/bdf9ez6k The human placental methylome: https://tinyurl.com/7zz8dz55 Markers of Autism Risk in Babies (MARBLES): https://tinyurl.com/49phe22r

    1 tim 5 min
  8. Challenging Food Reactions? Addressing the Gut Microbiome and More with Dr. Thomas Fabian

    21 MAJ

    Challenging Food Reactions? Addressing the Gut Microbiome and More with Dr. Thomas Fabian

    Addressing adverse food reactions goes way beyond simply cutting out the culprits, so I’m thrilled to have Dr. Tom Fabian join us again on New Frontiers to highlight the interventions that will move the needle for our patients. We explore the mechanisms through which specific strains can either exacerbate or alleviate both immune-mediated and non-immune-mediated food reactions, and discuss the fascinating connection between circadian rhythms of mast cells and intestinal permeability, feeding times and increased susceptibility to food reactivity. We look at why some patients may be more sensitive to symptoms and how histamine-producing microbes may lead to visceral hypersensitivity. But we also talk strategy, with one pearl after another, such as the potential of Lactobacillus reuteri in attenuating immune-mediated food reactions, the role of butyrate and indole in stabilizing mast cells, and using specific polyphenols to calm the immune system and promote a health microbiome. For any practitioner or health-savvy individual grappling with these issues, this is an episode you won’t want to miss. ~DrKF Head over to https://www.drkarafitzgerald.com/fxmed-podcast/ for the transcript, a COMPLETE LIST OF SHOW NOTES and all the FxMed resources. GUEST INFORMATION Thomas Fabian, PhD, CNTP https://tinyurl.com/5ehysjp7 Dr. Fabian serves as a translational science consultant and science advisor with Diagnostic Solutions Laboratory and is a leading expert on the role of the microbiome in health, immune function, chronic disease, and aging. THANK YOU TO OUR SPONSOR Diagnostic Solutions Laboratory https://bit.ly/2IEhVrS *SPECIAL OFFER FOR FxMED LISTENERS* Download the GI-MAP Interpretive Guide at https://tinyurl.com/5ehysjp7 and use it to follow along with the episode. This practical guide from Diagnostic Solutions Laboratory can help you better understand and interpret test results for your patients. SHOW NOTES Understanding food allergy through neuroimmune interactions in the gastrointestinal tract https://tinyurl.com/2kstjrzp The intestinal neuro-immune axis: crosstalk between neurons, immune cells, and microbes https://tinyurl.com/5n7ymaj4 DSL Webinar: Neuroinflammation and the Gut-Brain Connection https://tinyurl.com/ykeeehnk Mechanisms Underlying Food-Triggered Symptoms in Disorders of Gut-Brain Interactions https://tinyurl.com/yhb5ddyc FxMED RESOURCES Gut Healing in Aging & Disease: Emerging Roles of the Microbiome and Diet in Intestinal Barrier Regeneration with Tom Fabian, PhD, CNTP https://tinyurl.com/h3rtumbs Hydrogen Sulfide in Health, Disease & Longevity with Dr. Tom Fabian https://tinyurl.com/25fmk83n Latest Insights into the Role of the Gut Microbiome in Healthy Aging with Dr. Tom Fabian https://tinyurl.com/bdz5u7vz CONNECT WITH DrKF Facebook: https://www.facebook.com/DrKaraFitzgerald/ YouTube: https://tinyurl.com/hjpc8daz Instagram: https://www.instagram.com/drkarafitzgerald/ DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb Bio Age Lab Test: https://tinyurl.com/b7bjmfj9 Bio Age Self Assessment Quiz: https://tinyurl.com/4z8f7ucc

    1 tim 11 min
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Welcome to New Frontiers in Functional Medicine, Longevity & Epigenetics™ where I interview the best minds in functional medicine to discuss the science and research behind medicine, longevity, epigenetics, and so much more. Expect thought-provoking ideas, new research, lots of clinical pearls for practitioners, and step-change information for clinicians and patients. Join us! ~DrKF Copyright © 2023 by KF Education and Consulting, LLC All Rights Reserved

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