Medical Rewrites Meghan Jeffres

The rewrite today is for Trainwreck. The deep dive is about drug-drug interactions between alcohol and antibiotics. Movie suggestion form: https://tinyurl.com/8pa8svey
References used in this episode
Fact versus Fiction: a Review of the Evidence behind Alcohol and Antibiotic Interactions https://pubmed.ncbi.nlm.nih.gov/31871085/ 

Doxycycline PK after whiskey or wine https://pubmed.ncbi.nlm.nih.gov/7113712/  

Doxycycline + rifampin for Brucellosis infection in rats fed alcohol https://pubmed.ncbi.nlm.nih.gov/16323439/  

Doxycycline + rifampin PK changes in human Brucellosis infections https://www.ncbi.nlm.nih.gov/pmc/articles/PMC188288/     

Long-term alcohol consumption and half-life of erythromycin and doxycycline https://pubmed.ncbi.nlm.nih.gov/1002368/  

Tyramine concentrations in alcohol https://pubmed.ncbi.nlm.nih.gov/28824206/, https://pubmed.ncbi.nlm.nih.gov/34655830/  

Linezolid and tyramine and increase in SBP https://pubmed.ncbi.nlm.nih.gov/11361052/                    

Cephalosporin induced disulfiram-like reaction: a retrospective review of 78 cases. https://pubmed.ncbi.nlm.nih.gov/24670024/  

Cephalosporin induced hypoprothrombinemia due to side chains of N-methylthiotetrazole (latamoxef, cefmenoxime, cefoperazone, cefotetan, cefamandole) https://pubmed.ncbi.nlm.nih.gov/3350995/   

Metronidazole plus alcohol in rats https://pubmed.ncbi.nlm.nih.gov/10798595/ 

RCT metronidazole plus alcohol in humans https://pubmed.ncbi.nlm.nih.gov/12022894/ 

Retro case-control of pts admitted after ethanol who received metronidazole https://pubmed.ncbi.nlm.nih.gov/37494646/  

Z-drugs adverse reactions https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8077048/ 

Zolpidem plus alcohol and ICU admission https://pubmed.ncbi.nlm.nih.gov/20458214/ 

The rewrite today is for Knives Out. The deep dive is about pain management of musculoskeletal injuries.
Movie suggestion form: https://tinyurl.com/8pa8svey

References used in this episode 

Clinical Practice Guidelines for Pain Management in Acute Musculoskeletal Injury by the Orthopaedic Trauma Association Musculoskeletal Pain Task Force https://pubmed.ncbi.nlm.nih.gov/30681429/ 

Nonpharmacologic and Pharmacologic Management of Acute Pain From Non-Low Back, Musculoskeletal Injuries in Adults: A Clinical Guideline From the American College of Physicians and American Academy of Family Physicians INFOGRAPHIC INCLUDED https://pubmed.ncbi.nlm.nih.gov/32805126/ 

Oxycodone vs ibuprofen vs. combo tx for the treatment of pain after abdominal or pelvic surgery in women RCT https://pubmed.ncbi.nlm.nih.gov/15763605/ 

RCT topical diclofenac/menthol vs. placebo for ankle sprain pain https://pubmed.ncbi.nlm.nih.gov/28345425/ 

RCT topical diclofenac gel, ibuprofen gel, and ibuprofen gel with levomenthol for musculoskeletal injuries https://pubmed.ncbi.nlm.nih.gov/31353997/ 

RCT: ketorolac 60 mg IM vs ibuprofen 800 mg PO for acute musculoskeletal pain https://pubmed.ncbi.nlm.nih.gov/7618770/ 

RCT: ketorolac 60 mg vs 15 mg for acute musculoskeletal pain https://pubmed.ncbi.nlm.nih.gov/34365063/ 

Post-market surveillance study of ketorolac and GI bleeds https://pubmed.ncbi.nlm.nih.gov/8569017/ 

Nested-case control for NSAID-associated heart failure admissions https://pubmed.ncbi.nlm.nih.gov/27682515/ 

Drug Information summary about ketorolac duration by Christie Denton, PharmD, BCPS https://dig.pharmacy.uic.edu/faqs/2022-2/september-2022-faqs/what-evidence-is-there-for-the-5-day-maximum-with-the-use-of-ketorolac/

Our medical rewrite today will be for Knocked Up. The deep dive will be about flatulence and conjunctivitis.
Movie suggestion form: https://tinyurl.com/8pa8svey

References used in this episode 

Frequency of eye-related problems see in primary care https://pubmed.ncbi.nlm.nih.gov/1936738/ 

Microbiology of conjunctivitis
https://pubmed.ncbi.nlm.nih.gov/24150468/
https://pubmed.ncbi.nlm.nih.gov/28535396/
https://pubmed.ncbi.nlm.nih.gov/1936738/
https://pubmed.ncbi.nlm.nih.gov/28499285/ 

Systematic review of signs and symptoms between viral and bacterial conjunctivitis https://pubmed.ncbi.nlm.nih.gov/35699701/ 

Research about gaseous components of farts
https://pubmed.ncbi.nlm.nih.gov/18128419/
https://pubmed.ncbi.nlm.nih.gov/32900799/
https://pubmed.ncbi.nlm.nih.gov/31520080/
https://pubmed.ncbi.nlm.nih.gov/24150797/ 

Story about farting on a blood agar plate
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1121900/
https://www.abc.net.au/science/k2/homework/s312551.htm 

Rectal colonization of GAS by physician and post-partum outbreak https://pubmed.ncbi.nlm.nih.gov/1928189/ 

Virome review https://pubmed.ncbi.nlm.nih.gov/35753153/ 

Postulating about SARS-CoV-2 spread through farts https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7716952/

Our medical rewrite today will be for 28 Days. The deep dive will be about medical management of alcohol use disorder.
Movie suggestion form: https://tinyurl.com/8pa8svey

References used in this episode

Mechanisms of medications used for alcohol use disorder https://pubmed.ncbi.nlm.nih.gov/35133639/

LiverTox of disulfiram https://www.ncbi.nlm.nih.gov/books/NBK548103/

COMBINE study comparing naltrexone vs. acamprosate and medication management vs. cognitive behavior intervention https://pubmed.ncbi.nlm.nih.gov/16670409/

Meta-analysis of naltrexone and acamprosate for alcohol use disorder https://pubmed.ncbi.nlm.nih.gov/24825644/

Meta-analysis of long-acting naltrexone injection vs placebo https://pubmed.ncbi.nlm.nih.gov/34033183/

CYP2D6 Overview https://www.ncbi.nlm.nih.gov/books/NBK574601/

Hydrocodone pain control in CYP2D6 slow metabolizers https://pubmed.ncbi.nlm.nih.gov/34423496/

Systematic review of naltrexone efficacy in women with alcohol use disorder https://pubmed.ncbi.nlm.nih.gov/28247556/

Sex differences and opioid use https://pubmed.ncbi.nlm.nih.gov/24508560/

Review on sex/hormone differences and opioid effects https://pubmed.ncbi.nlm.nih.gov/34995646/

Acamprosate efficacy based on sex https://pubmed.ncbi.nlm.nih.gov/21895717/

Our medical rewrite today will be for CODA. The deep dives will be about Dermatophyte infections – aka ring worm.
Movie suggestion form: https://tinyurl.com/8pa8svey

References used in this episode 

Epidemiology and etiology of tinea infections· https://pubmed.ncbi.nlm.nih.gov/18478365/· https://pubmed.ncbi.nlm.nih.gov/33900539/· https://pubmed.ncbi.nlm.nih.gov/15097959/ 

Large case series of tinea scrotum https://pubmed.ncbi.nlm.nih.gov/37072674/ 

Effects of temperature and humidity on penetration of dermatophytes into human stratum https://pubmed.ncbi.nlm.nih.gov/14615792/ 

Tinea infections transmitted from sexual contact – MUST SEE PICTURES TO APPRECIATE SEVERITY· https://pubmed.ncbi.nlm.nih.gov/11913763/· https://pubmed.ncbi.nlm.nih.gov/26071391/· https://pubmed.ncbi.nlm.nih.gov/37347803/ 

British Association of Dermatologists' guidelines for the management of onychomycosis https://pubmed.ncbi.nlm.nih.gov/25409999/ 

UpToDate Dermatophyte infections https://www.uptodate.com/contents/dermatophyte-tinea-infections#H1217398057 

Cochrane review of topical antifungal treatments for tinea cruris and tinea corporis https://pubmed.ncbi.nlm.nih.gov/25090020/ 

Superficial fungal infection review out of Australia from 2019 https://pubmed.ncbi.nlm.nih.gov/31569324/

The medical rewrite today is for Wedding Crashers. The deep dives will be about tetrahydrozoline, an active ingredient in eye drops and sugar alcohols. Please note that this podcast discusses the poisoning found in the movie Wedding Crashers.
Movie suggestion form: https://tinyurl.com/8pa8svey

References 

Systemic absorption after topical administration of tetrahydrozoline https://pubmed.ncbi.nlm.nih.gov/21972870/ 

Alpha 2 agonism on the GI track https://pubmed.ncbi.nlm.nih.gov/6148675/ 

Absolutely wild toxicology study of tetrahydrozoline in 19 infants from 1956 https://pubmed.ncbi.nlm.nih.gov/13295960/ 

Case report and of CV toxicity after oral tetrahydrozoline https://pubmed.ncbi.nlm.nih.gov/15388224/ 

Tetrahydrozoline toxicity review of the literature https://pubmed.ncbi.nlm.nih.gov/24760708/ 

Use of tetrahydrozoline in sexual assault
· https://pubmed.ncbi.nlm.nih.gov/22554870/
· https://pubmed.ncbi.nlm.nih.gov/37278617/ 

Incredible reviews of Haribo Gummy Bears made with maltitol https://www.buzzfeednews.com/article/michaelrusch/haribo-gummy-bear-reviews-on-amazon-are-the-most-insane-thin 

Diarrhea dose finding study in adult males https://pubmed.ncbi.nlm.nih.gov/12548293/ 

Diarrhea dose finding study in adult females https://pubmed.ncbi.nlm.nih.gov/18797153/ 

Maltitol organic chemistry – making it a solution https://pubmed.ncbi.nlm.nih.gov/32698373/