250 episodes

Expert insight on health, performance, longevity, critical thinking, and pursuing excellence. Dr. Peter Attia (Stanford/Hopkins/NIH-trained MD) talks with leaders in their fields.

The Peter Attia Drive Peter Attia, MD

    • Health & Fitness
    • 4.1 • 8 Ratings

Expert insight on health, performance, longevity, critical thinking, and pursuing excellence. Dr. Peter Attia (Stanford/Hopkins/NIH-trained MD) talks with leaders in their fields.

    Earning the gift of life | Ric Elias (#79 rebroadcast)

    Earning the gift of life | Ric Elias (#79 rebroadcast)

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    In this episode, Ric Elias, founder of Red Ventures, opens up about the fateful day he knew for certain that he was going to die as a passenger on US Airways Flight 1549. Ric dives deep into how that day impacted his life, greatly changed his perspective, and improved his relationship with his family and the broader community. We also talk about his incredible role as CEO of an enormous company, his remarkable work in philanthropy, and all the wisdom he has acquired in his extraordinary life.
    We discuss: 
    Ric’s life leading up to the day of the plane crash [2:15]; The plane crash—What it’s like knowing you’re about to die, feelings of regret and sadness [8:00];
    The improbable plane landing in the Hudson River [15:45];
    Emotions after the safe landing (and a story he’s never told before) [22:15];
    A powerful story about Captain Sully [26:15];
    Earning his second chance at life, and playing the “infinite game” [35:15];
    Why time is the ultimate currency, and how (and why) to say “no” [43:00];
    Raising kids in an achievement culture, Ric’s definition of life success, and what Ric wants to instill in his kids [49:45];
    What Ric believes is actually worth getting upset about, and the organizations that are taking steps to help people [1:05:45];
    The core principles of Red Ventures (Ric’s company) [1:16:00];
    Ric’s tips for developing business acumen and negotiation skills [1:26:15];
    What qualities does Ric look for in people he wants to work with? [1:29:15];
    What is the next big problem that Ric wants to solve? [1:32:15];
    What is the most challenging part of your business today? [1:34:15];
    If Ric could go back and talk to himself in the morning before getting on that plane, what would he say? [1:36:00]; and
    More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

    • 1 hr 39 min
    The neuroscience of obesity | Stephan Guyenet, Ph.D.

    The neuroscience of obesity | Stephan Guyenet, Ph.D.

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    Stephan Guyenet is a neuroscientist focused on the neuroscience of obesity and energy homeostasis.  He is the author of the book, The Hungry Brain and founder/director of Red Pen Reviews. In this episode, Stephan explains how obesity has changed phenotypically over the course of human history as well as what might explain the dramatic increase in prevalence of obesity in the last few decades. He talks in depth about the role of genetics, the brain, and hormones like leptin play in the regulation of fat mass. He dives deep into two common theories of obesity—the carbohydrate-insulin model and the energy balance model and provides his take on which theory has stronger evidence. Additionally, he provides insights on how we’re hard-wired to think about food and the consequences of modern foods designed for maximal pleasure. Finally, he goes through the factors that affect body weight, set points, and provides takeaways for people wanting to take advantage of what we know about the brain’s role in regulating our body weight.
    We discuss:
    Stephan’s neuroscience background and his focus on the nuances of obesity [2:15]; How obesity has changed for humans throughout history [8:00]; The association between obesity and adverse health outcomes, the “obesity paradox,” and confounders when relating BMI to longevity [14:00]; The sharp increase in obesity across demographics [23:30]; The hypothalamus and its role in obesity [30:00];  The role of the hormone leptin in obesity [40:00]; The genetic component of obesity [46:30]; Understanding the tendency of humans to store fat through an evolutionary lens [57:00];   The hedonic aspect of food, and how the brain reacts to modern, highly-rewarding foods [1:03:30]; How we are hard-wired to think about food [1:14:30]; A review of the “Carnivore diet” [1:21:45]; The energy balance model, carbohydrate-insulin model, and unifying the theories around adiposity [1:34:15]; Body weight set points: a hypothetical comparison of two individuals [1:41:45]; Takeaways for people who want to lose weight and keep it off [1:48:30]; Evidence that favors the energy balance model of weight gain [1:56:00]; The synergistic effect of fat and carbohydrates and observations that a low-fat diet or a low-carb diet can cause weight loss [2:04:30]; Red Pen Reviews [2:11:00]; More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

    • 2 hrs 24 min
    AMA #36: Fruits & vegetables—everything you need to know

    AMA #36: Fruits & vegetables—everything you need to know

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    In this “Ask Me Anything” (AMA) episode, Peter discusses the nutritional profiles of various fruits and vegetables as a means of assessing their relative value. He explains the difference between eating them vs. drinking them, how processing fruits and vegetables can change their properties, and how one’s current state of health affects nutrition strategy when it comes to fruits and vegetable consumption. Additionally, Peter explains the potential benefits and negative effects of certain phytochemicals found in produce and concludes with a discussion of supplementing with green powders, multivitamins, and more.
    If you’re not a subscriber and listening on a podcast player, you’ll only be able to hear a preview of the AMA. If you’re a subscriber, you can now listen to this full episode on your private RSS feed or on our website at the AMA #36 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here.
    We discuss:
    The limitations of nutritional data and challenges of making broad recommendations [2:00]; How one’s current state of health impacts their “optimal” diet [11:30]; Defining “metabolic health” [14:45]; The wide-ranging nutrition profiles of various fruits and vegetables [16:30]; The benefits of fiber [20:45]; Eating whole fruits vs. drinking fruit juice or smoothies [22:30]; Drinking alcohol: metabolic effects, calories in alcohol, and more [28:30]; Can excess fruit consumption lead to insulin resistance? [30:30]; Glycemic impact of different fruits, using CGM data to assist decision making, and how fruit is fundamentally different from what we evolved to eat [31:30]; Dietary approaches for people with a carbohydrate tolerance disorder (TD2, NAFLD, etc.), and when it makes sense to restrict fruit consumption [34:30]; Nutrition profile of select vegetables: sugar content, micronutrients, and more [40:00]; Phytochemicals in produce: potential positive health impacts on inflammation, cardiovascular (CV) risk, and cancer [44:30]; Phytochemicals with potential negative health impacts [50:45]; Nightshades and inflammation [53:15]; How important is it to eat organic foods? [56:00]; How necessary is it to wash fruits and vegetables? [1:00:45]; How does food preparation change the nutritional composition? [1:03:45]; Considerations when eating canned and frozen food, and paying attention to processed food additives [1:04:45]; Supplementing vitamins and nutrients as an alternative to eating whole fruits and vegetables [1:06:15]; Green powder supplements [1:11:15]; Important takeaways [1:16:00]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

    • 20 min
    Lp(a) and its impact on heart disease | Benoît Arsenault, Ph.D.

    Lp(a) and its impact on heart disease | Benoît Arsenault, Ph.D.

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    Benoît Arsenault is a research scientist focused on understanding how lifestyle and genetic factors contribute to cardiovascular disease risk. In this episode, the discussion casts a spotlight on Lp(a)—the single most important genetically-inherited trait when it comes to atherosclerotic cardiovascular disease (ASCVD) risk. Benoît explains the biology of Lp(a), how it’s inherited, the importance of measuring Lp(a) levels, and the diseases most associated with high Lp(a). He dives into data on the possible treatments for lowering Lp(a) such niacin, statins, and PCSK9 inhibitors, as well as the most exciting new potential therapeutic—antisense oligonucleotides.
    We discuss:
    How Benoît came to study Lp(a)—a new marker for cardiovascular risk [3:15]; The relationship between Lp(a) and CVD risk [6:45]; What genome-wide association studies (GWAS) revealed about Lp(a) [16:00]; Clinical tests to measure Lp(a) [22:00]; The biology of Lp(a) [25:45]; How statins lower LDL-cholesterol and why this doesn't work for an Lp(a) [29:15]; The structure of LDL-p and Lp(a) and what makes Lp(a) more atherogenic than an equivalent LDL particle [34:00]; The role of Lp(a) in aortic valve disease [42:45]; How greater numbers of Lp(a) particles are associated with increased risk of disease [48:00]; The genetics and inheritance of Lp(a) and how and when to measure Lp(a) levels [52:00]; Niacin and other proposed therapies to lower Lp(a), apoB, and CVD risk [1:00:45]; Why awareness of Lp(a) among physicians remains low despite the importance of managing risk factors for ASCVD [1:14:00]; The variability of disease in patients with high Lp(a) [1:19:00]; Diseases most associated with high Lp(a) [1:26:30]; The biology of PCSK9 protein, familial hypercholesterolemia, and the case for inhibiting PCSK9 [1:35:00]; The variability in PCSK9 inhibitors’ ability to lower Lp(a) and why we need more research on individuals with high levels of Lp(a) [1:50:30]; Peter’s approach to managing patients with high Lp(a), and Benoît’s personal approach to managing his risk [1:54:45]; Antisense oligonucleotides—a potential new therapeutic for Lp(a) [1:57:15]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

    • 2 hrs 7 min
    Medical mistakes, patient safety, and the RaDonda Vaught case | Marty Makary, M.D., M.P.H.

    Medical mistakes, patient safety, and the RaDonda Vaught case | Marty Makary, M.D., M.P.H.

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    Marty Makary is a surgeon, public policy researcher, and author of the New York times best-sellers Unaccountable and The Price We Pay. In this episode, Marty dives deep into the topic of patient safety. He describes the risk of medical errors that patients face when they walk into the hospital and how those errors take place, and he highlights what amounts to an epidemic of medical mistakes. He explains how the culture of patient safety has advanced in recent decades, the specific improvements driven by a patient safety movement, and what’s holding back further progress. The second half of this episode discusses the high-profile case of RaDonda Vaught, a nurse at Vanderbilt Hospital convicted of negligent homicide after she mistakenly gave a patient the wrong medication in 2017. He discusses the fallout from this case and how it has in some ways unraveled decades of progress in patient safety. Furthermore, Marty provides insights in how to advocate for a loved one in the hospital, details the changes needed to meaningfully reduce the death rate from medical errors, and provides a hopeful vision for future improvements to patient safety.
    We discuss:
    Brief history of patient safety, preventable medical mistakes, and catalysts for major changes to patient safety protocols [0:12]; Advancements in patient safety and the dramatic reduction in central line infections [14:55]; A surgical safety checklist—a major milestone in patient safety [23:03]; A tragic case stimulates a culture of speaking up about concerns among surgical teams [25:19]; Studies showing the ubiquitous nature of medical mistakes leading to patient death [29:42]; The medical mistake of over-prescribing of opioids [33:48]; Other types of errors—electronic medical records, nosocomial infections, and more [35:43]; Importance of honesty from physicians and what really drives malpractice claims [40:26]; A high-profile medical mistake case involving nurse RaDonda Vaught [47:31]; Investigations leading to the arrest of RaDonda Vaught [59:48]; Vaught’s trial—a charge of “negligent homicide” [1:05:16]; A guilty charge and an outpouring of support for Vaught [1:12:09]; Concerns from the nursing profession over the RaDonda Vaught conviction [1:18:09]; How to advocate for a friend or family member in the hospital [1:20:22]; Changes needed for meaningful reduction in the death rate from medical errors [1:26:42]; Blind spots in our current national funding mechanism and the need for more research into patient safety [1:31:42]; Parting thoughts—where do we go from here? [1:35:48]; More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

    • 1 hr 45 min
    The Art of Stability | Beth Lewis (Ep. #131 Rebroadcast)

    The Art of Stability | Beth Lewis (Ep. #131 Rebroadcast)

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    Beth Lewis is a former professional dancer and a self-described “educator of movement” who has an unmatched ability to assimilate information and customize training plans from multiple training systems. In this episode, Beth describes how she identifies problematic movement patterns and postures to help individuals relieve pain, avoid injury, and move better within all types of exercise. She explains how movement is a trainable skill and provides suggestions for ways that people can modify or supplement their exercise routine to benefit their health and longevity.
    We discuss:
    Beth’s “way of no way” training philosophy [2:15] Beth’s background in dancing and how she ended up in New York City [5:00] Beth’s transition to fitness coaching and how her training philosophy has evolved [10:15]; Functional Range Conditioning and scapular mobility [19:20]; An overview of the Postural Restoration Institute, and Peter’s squat assessment [33:00]; The important connection between the ribs and breathing [37:15]; The role of sitting and external stress in chronic muscular tension [40:00]; The important role of your toes, minimalist footwear, and toe yoga [42:00]; Dynamic Neuromuscular Stabilization (DNS) [46:00]; A different view on knee valgus [50:15]; Is there such a thing as “bad posture”? [54:00]; How Beth identifies an issue, addresses it, and keeps clients motivated [56:15]; Lifting weights, the Centenarian Olympics, and dancing into old age [1:08:30]; The importance of the hamstrings versus abs [1:18:45]; Benefits of rowing, and why everyone should add it to their exercise regimen [1:24:45] Different roles of concentric versus eccentric strength [1:32:45]; Flexibility and high-intensity interval training (HIIT) [1:37:10]; Training versus playing sports, and the best type of activity for kids [1:40:30]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

    • 1 hr 48 min

Customer Reviews

4.1 out of 5
8 Ratings

8 Ratings

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