HealthTree Podcast for AML HealthTree Podcast for AML

Allogeneic stem cell transplantation is the only curative option for patients battling acute myeloid leukemia. However, a significant number of patients will relapse after transplant. Innovative research and therapies are needed in order to improve outcomes in AML patients. 

The drug Jakafi (ruxolitinib), a kinase inhibitor, is being explored in a current clinical trial as it may help reduce the risk of relapse. Other therapies such as pre-emptive donor lymphocyte infusions, hypomethylating agents and FLT3 inhibitors combined with donor lymphocyte infusions, CAR T-cell and CAR-NK cells are some of the options being explored.

Join us live on Wednesday, October 5th at 1:30 pm EST to hear from Dr. Gabriela Hobbs with Massachusetts General Hospital who will be discussing her clinical trial using Jakafi (ruxolitinib) after allogeneic stem cell transplant as well as other therapies to reduce relapse risk. There will be time at the end of the show to ask Dr. Hobbs your questions directly!

Thank you to our episode sponsor, Bristol Myers Squibb.

The IDH mutation can be found in approximately 20% of adult AML cases. Isocitrate dehydrogenase isoform 1 and 2 or IDH1 and IDH2 mutations are typically found in older AML patients and have an intermediate risk profile, with IDH2 being the more common of the two. There has been the development of targeted therapy drugs, such as IDH inhibitors to address these mutations.

Ivosidenib (Tibsovo) and enasidinib (Idhifa) are IDH inhibitors and were approved for use as monotherapy in relapsed/refractory AML with IDH1 and IDH2 mutations, respectively. Clinical trials have been exploring the use of combinations with other drugs such as azacitidine and venetoclax to improve efficacy and optimize outcomes.

Ivosidenib (Tibsovo) was just recently approved by the FDA in May 2022 for use in combination with azacitidine for newly diagnosed patients age 75 years or older and not fit for intensive chemotherapy.

In this podcast, Dr. Eytan Stein will tell us about IDH mutations, the current treatment options, as well as the recent FDA approval of ivosidenib (Tibsovo) and what that means for the treament landscape.

Thank you to our episode sponsor, Bristol Myers Squibb.

The TP53 mutation in AML is considered to be a high risk mutation and occurs in approximately 5-10% of patients. This genetic mutation has been difficult to treat, often being chemoresistant with a poor prognosis, however, the research indicates progress is being made in this area. 

Join us live on Thursday, July 14th at 11 am EST to hear from Dr. Rory Shallis with Yale New Haven Hospital who will be discussing the TP53 mutation in AML, current treatment options available, and clinical trials using novel investigational agents.

In this podcast, Dr. Shallis will tell us all about the TP53 mutation and the latest research and clinical trials involving investigational agents being used to target this mutation. There will be time at the end of the show to ask Dr. Shallis your questions directly!

Thank you to our episode sponsor, Bristol Myers Squibb.

The FLT3 gene mutation is the most common mutation seen in acute myeloid leukemia patients. It occurs in up to 37% of adult patients with AML. FLT3 mutations have been harder to treat with poor outcomes, however, with combination therapies using targeted drugs such as FLT3 inhibitors, outcomes have greatly improved. The development of FLT3 inhibitors has progressed in recent years and there are currently two FDA-approved options - gilteritinib and midostaurin. There are also many additional FLT3 inhibitors in development such as crenolanib and quizartinib, which leads us to the question of which FLT3 inhibitor should be used for each person and when is the appropriate time to add it to treatment?

Join us live on June 29th at 2 PM EST to hear from Dr. Jane Liesveld from the University of Rochester who will discuss the different FLT3 inhibitor options currently available, as well as the ones in development. She will also share research with us from a clinical trial she is leading comparing midostaurin and crenolanib when given following induction, consolidation and bone marrow transplantation.

During the show, Dr. Liesveld will discuss the differences between FLT3 inhibitor options and what has been learned from previous FLT3 inhibitor trials. Come learn all about the FLT3 mutation, FLT3 inhibitors and have the opportunity to directly ask Dr. Liesveld your questions.

Thank you to our episode sponsor, Abbvie.



 

Immunotherapy continues to be an expanding and evolving area of research for AML with many drugs in development. One drug currently being studied is IMGN632, an antibody drug conjugate, that targets CD123-positive AML cells. IMGN632 has shown promising results in relapsed/refractory patients in previous AML trials. 

Join us live on June 9th at 1 PM EST to learn from Dr. Kendra Sweet, an AML expert from Moffitt Cancer Center in Tampa, Florida, about IMGN632, an exciting new immunotherapy investigational agent.

During the show, Dr. Sweet will discuss what IMGN632 is, how it is helping AML patients and the current trial she is participating in that is testing IMGN632 alone, as monotherapy, or when used in combination with other frontline AML drugs. Learn all about immunotherapy and the role it can play when added to existing AML treatment modalities. There will be time at the end of the show to directly ask Dr. Sweet your questions! 

Thank you to our episode sponsor, Bristol Myers Squibb.

Immunotherapy is one of the most promising areas of cancer research. Drugs like checkpoint inhibitors, monoclonal and bispecific anitbodies, antibody drug conjugates and CAR-T cell therapy are all extensively being studied in AML. 

Join us live on May 26th at 11 AM EST to learn from Dr. Joseph Jurcic, an AML expert from the Herbert Irving Comprehensive Cancer Center at Columbia University, about an exciting new immunotherapy drug in development called magrolimab which is a monoclonal antibody against CD47 and macrophage checkpoint inhibitor. 

During the show, Dr. Jurcic will discuss what magrolimab is, how it is helping AML patients and two upcoming trials he will be participating in that will use magrolimab in combination with other AML drugs. Learn all about the immune system and this emerging therapy with a unique opportunity to directly ask Dr. Jurcic your questions! 

Thank you to our episode sponsor, Abbvie.