144 episodes

Huberman Lab discusses neuroscience: how our brain and its connections with the organs of our body control our perceptions, our behaviors, and our health. We also discuss existing and emerging tools for measuring and changing how our nervous system works. Dr. Andrew Huberman is a tenured professor of neurobiology and ophthalmology at Stanford School of Medicine. His laboratory studies neural regeneration, neuroplasticity, and brain states such as stress, focus, fear, and optimal performance. For more than 20 years, Dr. Huberman has consistently published original research findings and review articles in top-level peer-reviewed journals, including Nature, Science, Cell, Neuron, and Current Biology. He is a regular member of several National Institutes of Health review panels and a Fellow of the McKnight Foundation and the Pew Charitable Trusts. Dr. Huberman regularly consults for technology development companies, professional athletic organizations, and various units of U.S. and Canadian Special Operations.

Huberman Lab Scicomm Media

    • Health & Fitness
    • 4.9 • 16K Ratings

Huberman Lab discusses neuroscience: how our brain and its connections with the organs of our body control our perceptions, our behaviors, and our health. We also discuss existing and emerging tools for measuring and changing how our nervous system works. Dr. Andrew Huberman is a tenured professor of neurobiology and ophthalmology at Stanford School of Medicine. His laboratory studies neural regeneration, neuroplasticity, and brain states such as stress, focus, fear, and optimal performance. For more than 20 years, Dr. Huberman has consistently published original research findings and review articles in top-level peer-reviewed journals, including Nature, Science, Cell, Neuron, and Current Biology. He is a regular member of several National Institutes of Health review panels and a Fellow of the McKnight Foundation and the Pew Charitable Trusts. Dr. Huberman regularly consults for technology development companies, professional athletic organizations, and various units of U.S. and Canadian Special Operations.

    AMA #7: Cold Exposure, Maximizing REM Sleep & My Next Scientific Studies

    AMA #7: Cold Exposure, Maximizing REM Sleep & My Next Scientific Studies

    Welcome to a preview of the seventh Ask Me Anything (AMA) episode, part of the Huberman Lab Premium subscription.
    The Huberman Lab Premium subscription was launched for two main reasons. First, it was launched in order to raise support for the standard Huberman Lab podcast channel — which will continue to come out every Monday at zero-cost. Second, it was launched as a means to raise funds for important scientific research. A significant portion of proceeds from the Huberman Lab Premium subscription will fund human research (not animal models) selected by Dr. Huberman, with a dollar-for-dollar match from the Tiny Foundation.
    Subscribe to Huberman Lab Premium at https://hubermanlab.com/premium.
    Timestamps
    (00:00:00) Introduction
    (00:01:45) Is It Possible to Get a Cold or Sick From Deliberate Cold Exposure?
    (00:20:02) Huberman Lab Premium

    In the full AMA episode, we discuss:

    How Can You Increase Rapid Eye Movement (REM) Sleep?

    What Experiment(s) Would You Like to Undertake in Regard to Physical or Mental Performance?

    Articles

    Immune system of cold-exposed and cold-adapted humans

    Voluntary activation of the sympathetic nervous system and attenuation of the innate immune response in humans

    The Effects of Sleep Extension on the Athletic Performance of Collegiate Basketball Players

    Sleep extension improves serving accuracy: A study with college varsity tennis players

    The impact of extended sleep on daytime alertness, vigilance, and mood


    Title Card Photo Credit: Mike Blabac
    Disclaimer

    • 22 min
    Adderall, Stimulants & Modafinil for ADHD: Short- & Long-Term Effects

    Adderall, Stimulants & Modafinil for ADHD: Short- & Long-Term Effects

    In this episode, I explain how medications such as Adderall, Ritalin, Vyvanse and other stimulants work to increase focus and treat attention-deficit/hyperactivity disorder (ADHD). I explain the brain circuits involved in focus and the key roles dopamine and norepinephrine play in their regulation. Then I explain how stimulants such as Adderall and Vyvanse can increase focus and reduce hyperactivity in kids or adults with ADHD, and how and why Ritalin and other medications (e.g., Modafinil, Guanfacine) may work better for some. I explain the long-term effects of ADHD medications on height, cardiovascular health, hormones, predisposition to addiction and psychosis, and whether these treatments can be used and then stopped. I also discuss the immense individual variation in dosage sensitivity for these medications and the negative side-effects that occur from recreational use. This episode ought to benefit anyone with ADHD, their parents, those on ADHD medications or anyone curious about how these medications work.
    For the full show notes, visit hubermanlab.com.
    Thank you to our sponsors
    AG1: https://athleticgreens.com/huberman
    Maui Nui Venison: https://mauinuivenison.com/huberman
    ROKA: https://roka.com/huberman
    HVMN: https://hvmn.com/huberman
    InsideTracker: https://insidetracker.com/huberman
    Momentous: https://www.livemomentous.com/huberman
    The Brain Body Contract
    https://hubermanlab.com/tour
    Timestamps
    (00:00:00) Stimulants & Attention-Deficient/Hyperactivity Disorder (ADHD)
    (00:03:21) Sponsors: Maui Nui, ROKA, HVMN
    (00:06:35) The Brain-Body Contract
    (00:07:22) Attention, Prefrontal Cortex & ADHD
    (00:16:27) Stimulants “Sympathomimetics”
    (00:21:29) Adderall, Dopamine & Norepinephrine
    (00:25:58) Sympathomimetics, Dopamine & Norepinephrine
    (00:31:05) Sponsor: AG1
    (00:32:20) Vyvanse is Timed-Release D-Amp
    (00:36:36) Ritalin, Concerta
    (00:40:10) Dopamine & “Noise Reduction”; Norepinephrine & “Signal Amplification”
    (00:45:28) ADHD: Focus, Hyperactivity & Impulsivity; Drug Selection & Dose
    (00:50:57) How do Stimulants ‘Calm’ ADHD?
    (00:54:480 Neuroplasticity & Neuromodulators
    (00:58:06) Kids, ADHD Diagnosis & Treatment; Predispose Addiction?
    (01:04:02) Sponsor: InsideTracker
    (01:05:12) ADHD Medications: Individuality, Doses, Tapering & Long-Term Use
    (01:13:28) Medication & Long-Term Effects: Height, Cardiovascular Risk, Alcohol
    (01:19:32) Cortisol & Hormones
    (01:27:45) Psychosis & Addiction; Methamphetamine
    (01:38:20) Recreational Use, Addiction & Psychosis; Habituation
    (01:42:30) Drug Holidays; Ritalin & Long-Term Effects
    (01:45:35) Modafinil, Armodafinil; Side-Effects
    (01:53:03) Guanfacine, Alcohol
    (01:58:03) ADHD Medications
    (02:00:26) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Social Media, Neural Network Newsletter
    Title Card Photo Credit: Mike Blabac
    Disclaimer

    • 2 hr 2 min
    Dr. Robin Carhart-Harris: The Science of Psychedelics for Mental Health

    Dr. Robin Carhart-Harris: The Science of Psychedelics for Mental Health

    In this episode, my guest is Robin Carhart-Harris, PhD, distinguished professor of neurology and psychiatry at the University of California, San Francisco. He is one of leading researchers in the study of how psychedelics such as psilocybin, LSD and DMT can change the human brain and in doing so, be used to successfully treat various mental health challenges such as major depression, anorexia, obsessive-compulsive disorder (OCD) and addiction. He explains how psilocybin induces sustained changes in adaptive brain wiring and cognition. We discuss the key components of safe and effective psychedelic journeys, the role of hallucinations, the use of eye-masks to encourage people to “go internal,” and music, as well as what effective therapist support consists of before, during and after the session (also known as integration). We discuss micodosing vs. macrodosing and how researchers control for placebo effects in psychedelic research. We also discuss the current legal landscape around psychedelic therapies. Psychedelic therapies are fast emerging as powerful and soon-to-be mainstream treatments for medical health disorders, but they are not without their risks. As such, this episode ought to be of use to anyone interested in brain plasticity, mental health, psychology or neuroscience.
    For the full show notes, visit hubermanlab.com.
    Thank you to our sponsors
    AG1 (Athletic Greens): https://athleticgreens.com/huberman
    Eight Sleep: https://eightsleep.com/huberman
    Levels: https://levels.link/huberman
    HVMN: https://hvmn.com/huberman
    LMNT: https://drinklmnt.com/huberman
    Momentous: https://www.livemomentous.com/huberman
    The Brain Body Contract
    https://hubermanlab.com/tour
    Timestamps
    (00:00:00) Dr. Robin Carhart-Harris
    (00:02:12) Sponsors: Eight Sleep, Levels, HVMN
    (00:05:41) The Brain-Body Contract
    (00:06:31) Origin of the Word: “Psychedelics”; Pharmacology
    (00:12:05) Psychedelics & Revealing the Unconscious Mind, Psychotherapy
    (00:17:32) Microdosing
    (00:26:08) Psilocybin vs. Magic Mushroom Doses
    (00:28:28) “Psychedelic-Therapy”, Music
    (00:35:12) Sponsor: AG1 (Athletic Greens)
    (00:36:26) Psychedelic Journey: “Trust, Let Go, Be Open”
    (00:43:01) Negative Emotions, Fear & Psychedelics
    (00:46:21) Global Functional Connectivity, Serotonin 2A Receptor; Subjective Experiences
    (00:52:33) Pharmacology: Therapeutics without Psychedelic Effects; SSRIs
    (00:58:45) Psilocybin & Depression; Long-Term Effects: Connectivity & Neuroplasticity
    (01:09:14) Sponsor: LMNT
    (01:10:26) Psilocybin Therapy & Anorexia
    (01:12:56) Integration Phase & Psychedelic-Therapy; Meditation
    (01:19:50) First-Time Psychedelic Use, “Entropic Brain Effect”, Neuroplasticity, Cognition
    (01:30:16) Fibromyalgia & Psychedelic Treatment; MDMA Therapy & “Inner Healer”
    (01:38:55) Placebo Response & Psychedelic Therapy
    (01:41:39) LSD & Psychedelic-Therapy, Micro-Dose
    (01:48:19) Combination Psilocybin-MDMA Therapy
    (01:56:06) DMT “Rocketship” & Serotonin 2A Receptors; Ibogaine
    (02:01:04) “Ego Dissolution”, Cocaine vs. Psychedelics; Relapses
    (02:12:26) Psychedelics & Legal Landscape; Decriminalization
    (02:17:54) MDMA, Trauma & Clinical Trials; Future Regulatory (FDA) Approval?
    (02:23:25) Psilocybin & Current Clinical Trials
    (02:28:41) Mental Health & Psychedelic Treatment, Safeguards, Paradigm Shift
    (02:34:39) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Social Media, Neural Network Newsletter
    Title Card Photo Credit: Mike Blabac
    Disclaimer

    • 2 hr 37 min
    Dr. Susanna Søberg: How to Use Cold & Heat Exposure to Improve Your Health

    Dr. Susanna Søberg: How to Use Cold & Heat Exposure to Improve Your Health

    In this episode, my guest is Susanna Søberg, PhD. She earned her doctoral degree at the University of Copenhagen in Denmark, researching the effects of deliberate cold and deliberate heat exposure on metabolism and other aspects of human physiology. We discuss how cold or sauna can improve metabolism, cardiovascular and brain health, balance hormones, and decrease inflammation. Dr. Søberg discusses how deliberate cold protocols can improve glucose metabolism and insulin sensitivity and trigger release of neurotransmitters like dopamine and norepinephrine which enhance energy, mood, and focus. We compare cold showers and cold immersion, traditional and infrared saunas, and other variables. This episode provides actionable tools and answers to common questions about the use of deliberate cold and heat to improve health.
    For the full show notes, visit hubermanlab.com.
    Thank you to our sponsors
    AG1 (Athletic Greens): https://athleticgreens.com/huberman
    Plunge: https://plunge.com/huberman
    Maui Nui: https://mauinuivenison.com/huberman
    Thesis: https://takethesis.com/huberman
    InsideTracker: https://insidetracker.com/huberman
    Momentous: https://www.livemomentous.com/huberman
    The Brain Body Contract
    Tickets: https://hubermanlab.com/tour
    Presale code: HUBERMAN
    Timestamps
    (00:00:00) Dr. Susanna Søberg
    (00:03:23) Sponsors: Plunge, Maui Nui, Thesis
    (00:06:49) The Brain-Body Contract
    (00:07:40) Physiology in Uncomfortably Cold Environments
    (00:12:05) Tool: Water Temperature, “Cold Shock” & Discomfort
    (00:17:37) Cold Showers vs. Immersion in Water, Brown Fat
    (00:22:11) Cold Receptors, Brown Fat & Temperature Homeostasis
    (00:25:22) Shiver, “After Drop”, Healthy Stress
    (00:31:08) Long-Term Health Benefits of Deliberate Cold Exposure
    (00:35:48) Sponsor: AG1 (Athletic Greens)
    (00:37:02) Blood Pressure & Heath
    (00:38:26) Brown Fat, Insulin Sensitivity & Metabolism
    (00:45:07) Temperature Regulation, Brown Fat vs. White Fat
    (00:52:26) Cold Resilience, Scandinavia
    (00:59:07) Sponsor: InsideTracker
    (01:00:16) Winter Swimmers & Brown Fat; Discomfort
    (01:10:28) Sex differences & Brown Fat, Cold-Adapted
    (01:15:21) Diving Reflex & Parasympathetic Activation
    (01:18:44) Tool: Deliberate Cold & Sauna Protocol
    (01:23:11) Winter Swimmers, Shiver; Circadian Rhythm & Brown Fat
    (01:31:14) Tool: Minimum Threshold for Cold & Heat; Sauna & Cardiovascular Health
    (01:35:19) Tool: Maintaining Stimulus when Cold-Adapted; Shorter Sessions
    (01:38:09) Cold Exposure, Sleep Quality, Clothing
    (01:47:37) “Brown Fat Negative” & Shiver
    (01:52:13) Cold & Heat, Inflammation Reduction
    (01:55:40) Tool: “Soberg Principle”: End on Cold, Metabolism
    (01:59:39) Cold Exposure: Fed or Fasted?
    (02:00:32) Raynaud’s Syndrome; Hand/Feet Protection in Cold
    (02:05:21) Tool: Headache & Cold Exposure; Head Submersion & Head Coverings
    (02:11:29) Children & Hypothermia Risk
    (02:17:16) Gender Differences & Cold Exposure
    (02:19:57) Tool: Brief, Repeated Temperature Changes; Circadian Rhythm & Temperature
    (2:27:53) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Social Media, Neural Network Newsletter
    Title Card Photo Credit: Mike Blabac
    Disclaimer

    • 2 hr 30 min
    How Psilocybin Can Rewire Our Brain, Its Therapeutic Benefits & Its Risks

    How Psilocybin Can Rewire Our Brain, Its Therapeutic Benefits & Its Risks

    In this episode, I discuss what psilocybin is (chemically) and how it works at the cellular and neural circuit level to trigger neuroplasticity, which is our brain’s ability to rewire itself in ways that lead to long-lasting shifts in our emotional, cognitive and behavioral patterns and abilities. I discuss the emerging clinical trial evidence for the use of psilocybin in the treatment of depression, addictions and other psychiatric challenges. I explain the typical duration and phases of a psilocybin journey, the different categories of dosages often used and I explain the importance of set, setting and support when using psychedelics. I explain which groups of people place themselves at great risk by taking psilocybin as well as groups that could benefit, and I highlight the rapidly changing legal and medical landscape around psilocybin. This episode is a thorough exploration of psilocybin from the scientific and clinical literature perspective and ought to be of interest to anyone curious about psilocybin, mental health, neuroplasticity and/or psychedelics more generally.
    For the full show notes, visit hubermanlab.com.
    Thank you to our sponsors
    AG1 (Athletic Greens): https://athleticgreens.com/huberman
    Eight Sleep: https://eightsleep.com/huberman
    ROKA: https://roka.com/huberman
    HVMN: https://hvmn.com/huberman
    LMNT: https://drinklmnt.com/huberman
    Supplements from Momentous
    https://www.livemomentous.com/huberman
    Timestamps
    (00:00:00) Psilocybin, Legal Considerations
    (00:08:32) Sponsors: Eight Sleep, ROKA, HVMN
    (00:12:00) Psilocybin Becomes Psilocin in the Gut, Serotonin
    (00:17:00) The Serotonin 2A Receptor, Therapeutic Outcomes SSRIs vs. Psilocybin
    (00:21:40) Serotonin Receptor Expression; Visual Hallucinations & Eyes Closed
    (00:27:21) Safety & Cautions for Specific Patient Populations
    (00:29:13) Sponsor: AG1 (Athletic Greens)
    (00:30:28) Psilocybin, “Magic Mushrooms” Dosing, Micro-Dosing, “Heroic Doses”
    (00:36:21) Psychedelic Journey: Set, Setting & Support
    (00:43:43) Music & the Psilocybin Journey; Duration of Effects
    (00:48:58) Psilocybin & the Brain: Subjective Experiences, Perception
    (00:58:36) Sponsor: LMNT
    (00:59:48) Brain Networks & Therapeutic Outcomes
    (01:05:23) Creativity; Music, Emotionality & Psychedelic Journeys
    (01:12:39) Depression & Psychedelics as Neuroplasticity “Wedge”
    (01:16:53) Positive Psychedelic Journeys, Unity, “Oceanic Boundlessness”
    (01:25:23) “Bad Trips”, Anxiety & Physiological Sighs
    (01:32:57) Therapeutic Use of Psilocybin
    (01:36:11) Neuroplasticity, Structural Brain Changes & Psilocybin
    (01:48:08) Psychedelics: Therapeutic Breakthroughs & Depression
    (01:56:37) Combining Psilocybin Therapy & Talk Therapy, Antidepressant Effects
    (02:03:11) Psilocybin Experience & Mental Health
    (2:06:42) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Neural Network Newsletter, Social Media
    Title Card Photo Credit: Mike Blabac
    Disclaimer

    • 2 hr 9 min
    Dr. Noam Sobel: How Smells Influence Our Hormones, Health & Behavior

    Dr. Noam Sobel: How Smells Influence Our Hormones, Health & Behavior

    In this episode, my guest is Noam Sobel, PhD, professor of neurobiology in the department of brain sciences at the Weizmann Institute of Science. Dr. Sobel explains his lab’s research on the biological mechanisms of smell (“olfaction”) and how sensing odorants and chemicals in our environment impacts human behavior, cognition, social connections, and hormones. He explains how smell is a crucial component of “social sensing” and how we use olfaction when meeting new people to determine things about their physiology and psychology, and he explains how this impacts friendships and romantic partners. He explains how smell influences emotions, hormone levels, memories and the relationship between breathing and autonomic homeostasis. He describes how smell-based screening tests can aid disease diagnosis and explains his lab’s work on digitization of smell — which may soon allow online communication to include “sending of odors” via the internet. Dr. Sobel’s work illustrates how sensitive human olfaction is and how it drives much of our biology and behavior.
    For the full show notes, visit hubermanlab.com.
    Thank you to our sponsors
    AG1 (Athletic Greens): https://athleticgreens.com/huberman
    ROKA: https://roka.com/huberman
    Thesis: https://takethesis.com/huberman
    Helix Sleep: https://helixsleep.com/huberman
    InsideTracker: https://insidetracker.com/huberman
    Supplements from Momentous
    https://www.livemomentous.com/huberman
    Timestamps
    (00:00:00) Dr. Noam Sobel
    (00:03:46) Sponsors: ROKA, Thesis, Helix Sleep
    (00:06:46) Olfaction Circuits (Smell)
    (00:14:49) Loss & Regeneration of Smell, Illness
    (00:21:39) Brain Processing of Smell
    (00:24:40) Smell & Memories
    (00:27:52) Sponsor: AG1 (Athletic Greens)
    (00:29:07) Humans & Odor Tracking
    (00:39:25) The Alternating Nasal Cycle & Autonomic Nervous System
    (00:48:18) Cognitive Processing & Breathing
    (00:54:47) Neurodegenerative Diseases & Olfaction
    (01:00:12) Congenital Anosmia
    (01:05:01) Sponsor: InsideTracker
    (01:06:19) Handshaking, Sharing Chemicals & Social Sensing
    (01:15:07) Smelling Ourselves & Smelling Others
    (01:22:02) Odors & Romantic Attraction
    (01:24:58) Vomeronasal Organ, “Bruce Effect” & Miscarriage
    (01:40:20) Social Chemo-Signals, Fear
    (01:50:26) Chemo-Signaling, Aggression & Offspring
    (02:03:57) Menstrual Cycle Synchronization
    (02:12:11) Sweat, Tears, Emotions & Testosterone
    (02:27:46) Science Politics
    (02:37:54) Food Odors & Nutritional Value
    (02:45:34) Human Perception & Odorant Similarity
    (02:52:12) Digitizing Smell, COVID-19 & Smell
    (03:05:50) Medical Diagnostic Future & Olfaction Digitization
    (03:10:55) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Social Media, Neural Network Newsletter
    Title Card Photo Credit: Mike Blabac
    Disclaimer

    • 3 hr 13 min

Customer Reviews

4.9 out of 5
16K Ratings

16K Ratings

C8D615 ,

Straight Amphetamine

Around the 22 minute mark of the recent ADHD episode, you discuss the difference between L-amphetamine, and D-amphetamine. I finally found a medication that doesn’t give me terrible anxious side effects, and it’s straight amphetamine without the salts. It’s called Adenzys and it’s absorbed through the gums-it dissolves in the mouth. Can you by chance explain straight amphetamine without the salts and the effects on the body? I now believe it was the salts that was giving me the anxious feelings and not the amphetamine itself.

Listener0602 ,

Question about protein intake requirement?

Is there an episode where you discuss daily protein requirements? In the Maui Nui venison ad, you claim we need 1g per 1lb of body weight, but I understand it largely varies by sex, activity level, weight goals etc. 1g per 1lb of body weight also seems very high for most people (thinking about kidneys!). Thanks so much.

zerowastelife ,

Love it!

It’s so nice to have this resource so we don’t have to all become scientists to dig deeper into these topics. Thank you for making it accessible.

Do you have a breakdown of collagen supplements? I have friends recommending these and marketing targeting me, so just wondering if they’re actually effective for the cost. Thanks!

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