165 episodes

Expert insight on health, performance, longevity, critical thinking, and pursuing excellence. Dr. Peter Attia (Stanford/Hopkins/NIH-trained MD) talks with leaders in their fields.

The Peter Attia Drive Peter Attia, MD

    • Medicine
    • 4.8 • 3.9K Ratings

Expert insight on health, performance, longevity, critical thinking, and pursuing excellence. Dr. Peter Attia (Stanford/Hopkins/NIH-trained MD) talks with leaders in their fields.

    Tom Dayspring, M.D.: The latest insights into cardiovascular disease and lipidology

    Tom Dayspring, M.D.: The latest insights into cardiovascular disease and lipidology

    World-renowned lipidologist Tom Dayspring returns to give an update on the current thinking in lipidology as a follow-up to his 2018 five-part podcast series. In this episode, Tom discusses the growing consensus that atherogenic lipoproteins are essential drivers of atherosclerotic vascular disease. Tom further emphasizes apolipoprotein B (apoB) and lipoprotein(a) (Lp(a)). He provides insights into risk assessment, including which lab metrics to use, how to interpret them, and the appropriate therapeutic targets. Additionally, Tom discusses the most recent developments in lipid-lowering drug therapies—from the continued evolution of PCSK9 inhibitors, to the latest understanding of EPA and DHA, and the most recent addition of bempedoic acid to the list of therapeutic agents.
    We discuss:
    The latest in the field of lipidology and cardiovascular disease [3:45]; Apolipoproteins—the key to understanding lipid biology [9:30]; ApoB as a preferred metric over LDL-P [16:30]; Therapeutic goals for apoB concentration [21:45]; Drivers of atherosclerosis [34:15]; Overview and current thinking on high density lipoproteins (HDLs)—Is it a useful metric? [37:00]; Lipoprotein(a)—the most dangerous particle you’ve never heard of [55:00]; Are low density lipoprotein triglycerides (LDL-TGs) a useful metric? [1:13:15]; Tom’s preferred lab measurements [1:17:45]; The latest in lipid-lowering therapies [1:21:30]; The different pathways among various lipid-lowering drugs [1:30:45]; The latest on EPA and DHA [1:38:15]; Fibrates—an underappreciated treatment for hypercholesterolemia [1:49:45] and; More. Learn more: https://peterattiamd.com/

    Show notes page for this episode: https://peterattiamd.com/tomdayspring6 

    Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/

    Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/

    Connect with Peter on Facebook | Twitter | Instagram.

    • 2 hr
    Irene Davis, Ph.D.: The evolution of the foot, running injuries, and minimalist shoes

    Irene Davis, Ph.D.: The evolution of the foot, running injuries, and minimalist shoes

    Irene Davis is the founding Director of the Spaulding National Running Center at the Harvard Medical School. In this episode, Irene describes how her research of biomechanics and clinical work with running injuries, as well as research by others, has shaped her views on maintaining body alignment and foot health. Irene discusses her argument for the role of modern footwear in running-related injuries and how minimalist footwear helps resolve the subsequent biomechanical issues.
    We discuss:
    Irene’s path to her Ph.D., her entry into physical therapy, and her interest in biomechanics [3:20]; How Irene’s thinking about the use of orthotics has changed [7:15]; The evolution of the human foot and the transition from walking to running [10:30]; The evolution of shoes and its impact on running injuries [17:30]; An overview of running injuries [26:00]; Cushioned running shoes, heel striking and impact forces [29:30]; Shin splints [33:45]; How heel strike patterns promotes knee stress through rate of loading [35:30]; The critical importance of exercise [42:15]; Impact forces and injury potential [45:45]; How shoe cushioning alters impact forces despite forefoot striking [49:00]; An overview of minimalist shoes [52:30]; Irene’s protocol for transitioning people out of orthotics [58:45]; Transitioning to minimalist shoes and a forefoot strike [1:05:30]; Foot muscle volume, minimalist shoes, and orthotics [1:07:00]; The recognition of the importance of foot strength in podiatry [1:09:45]; Minimalist shoes across the lifespan—from children to adults [1:12:30]; Why learning to forefoot strike on soft surfaces is not the best approach [1:20:00]; Knee valgus and factors related to knee injury [1:21:45]; IT band syndrome [1:28:30]; Physics and ground reaction forces [1:33:15]; Irene’s approach to retraining a runner’s gait [1:36:00]; Case study—How the transition to minimalist shoes decreased injury and improved performance [1:42:15]; Importance of proper movement patterns and the negative influence of our modern environment [1:45:30]; and More. Learn more: https://peterattiamd.com/

    Show notes page for this episode: https://peterattiamd.com/irenedavis 

    Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/

    Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/

    Connect with Peter on Facebook | Twitter | Instagram.

    • 1 hr 53 min
    AMA #3 with sleep expert, Matthew Walker, Ph.D.: Fasting, gut health, blue light, caffeine, REM sleep, and more

    AMA #3 with sleep expert, Matthew Walker, Ph.D.: Fasting, gut health, blue light, caffeine, REM sleep, and more

    In this special episode, Matthew Walker returns for his third AMA episode to provide his expert insight into numerous sleep-related questions directly from listeners. He explains how he adjusted his hypotheses on topics like blue light and caffeine, and why he is more bullish on the importance of REM sleep. Matt also answers questions about sleep wearables, how fasting affects sleep, how sleep deprivation impacts gut health, and magnesium as a sleep aid. Finally, Matt reveals what he believes is the next evolution in sleep science and technology. If you’re a subscriber, you can now listen to this full episode on your private RSS feed or on our website on the show notes page.
    We discuss:

    Matt’s framework for changing his mind when faced with new information [1:30]; Blue light—How Matt shifted his thinking [5:45]; Caffeine—How Matt has adjusted his hypothesis [12:00]; REM sleep—Why Matt is more bullish on the importance of dream sleep [16:30]; How to increase REM sleep [27:30]; Sleep tracking wearables—criteria for evaluation, and why Matthew favors Oura [35:00]; Does the electromagnetic force of devices have any impact on sleep? [40:15]; The relationship between fasting and sleep [46:15]; Restless leg syndrome [58:10]; Magnesium supplementation as a sleep aid [1:03:00]; The relationship between sleep deprivation and gut health [1:08:30]; The next evolution in sleep science and technology [1:16:30]; Questions Matt would like to explore if money was no issue [1:24:15]; and More. Learn more: https://peterattiamd.com/

    Show notes page for this episode: https://peterattiamd.com/matthewwalkerama3

    Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/

    Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/

    Connect with Peter on Facebook | Twitter | Instagram.

    • 15 min
    Matthew Walker, Ph.D.: Sleep and immune function, chronotypes, hygiene tips, and addressing questions about his book

    Matthew Walker, Ph.D.: Sleep and immune function, chronotypes, hygiene tips, and addressing questions about his book

    In this episode, sleep expert Matthew Walker returns by popular demand to dive deeper into many sleep-related topics, starting with what we’ve learned about sleep through the lens of the COVID-19 pandemic and how sleep impacts the immune system. He then covers topics such as how dreaming affects emotional health, the different sleep chronotypes, the best sleep hygiene tips, and the pros and cons of napping. Matthew finishes by addressing several of the errors that readers have pointed out in his book, Why We Sleep.

    We discuss:

    Three ways the coronavirus pandemic impacts sleep [3:30]; The importance of dreaming for emotional health, and how the coronavirus pandemic increases dreaming [11:45]; The impact of alcohol consumption on sleep quality and stress levels [20:00]; Sleep’s impact on the immune system and implications for a future COVID-19 vaccine [27:45]; What determines how much deep sleep and REM sleep you need? [36:30]; Pros and cons of napping, and insights from the sleep habits of hunter-gatherer tribes [42:15]; Sleep hygiene, wind-down routine, and tips for better sleep [56:45]; Understanding sleep chronotypes and how knowing yours can help you [1:06:00]; Night terrors in kids—what they are and why they happen [1:16:30]; Addressing errors found in Matt’s book, Why We Sleep [1:20:45]; and More.
    Learn more: https://peterattiamd.com/

    Show notes page for this episode: https://peterattiamd.com/matthewwalker4

    Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/

    Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/

    Connect with Peter on Facebook | Twitter | Instagram.

    • 1 hr 41 min
    John Arnold: The most prolific philanthropist you may not have heard of

    John Arnold: The most prolific philanthropist you may not have heard of

    John Arnold is widely regarded as the greatest natural gas trader of all time, but in his late 30’s he walked away from it all and turned full-time philanthropist. He and his wife have committed to strategically give away most of their vast fortune in their lifetime and are already doing so at a staggering pace of nearly a half billion dollars a year. In this episode, John explains his quest to address the most challenging social programs plaguing the country, including criminal justice, health care policy, and K-12 education. John also shares self-identified attributes that contributed to his success in natural gas trading and how those same traits have translated to his philanthropic aspirations.
    We discuss:
    John’s background, upbringing, and early entrepreneurial tendencies [3:50]; John’s time and rise at Enron [16:45]; Characteristics that made John an exceptional natural gas trader and how they translate to his philanthropic work [27:30]; The collapse of Enron [35:00]; The success of John’s hedge fund, and his early interest in philanthropy [40:30]; The infamous 2006 trade that brought down Amaranth Advisors [55:45]; John’s analytical prowess and emphasis on fundamentals [1:02:15]; The decision to become a full-time philanthropist and the founding of Arnold Ventures [1:09:00]; Education—John’s quest to fundamentally change K-12 education [1:18:45]; Strategic philanthropy—preventing problems by attacking root causes and creating structural change [1:24:30]; The criminal justice system—structural changes needed to address mass incarceration, policing practices, and recidivism [1:31:45]; Re-imagining prisons to reduce recidivism [1:49:00]; US health care policy—John’s focus on drug prices, and the severe consequences of not making system changes [1:56:15]; Climate change—the bipartisan role of John’s foundation [2:13:45]; Advice for young adults interested in philanthropy [2:17:45]; and More Learn more: https://peterattiamd.com/

    Show notes page for this episode: https://peterattiamd.com/JohnArnold

    Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/

    Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/

    Connect with Peter on Facebook | Twitter | Instagram.

    • 2 hr 28 min
    AMA #15: Real-world case studies—metabolic dysregulation, low testosterone, menopause, and more

    AMA #15: Real-world case studies—metabolic dysregulation, low testosterone, menopause, and more

    As a follow up to AMA #14 where Peter explained his framework for analyzing labs, this “Ask Me Anything” (AMA) episode focuses on a number of real-world case studies exploring metabolic dysregulation, low testosterone, menopause, hypothyroidism, elevated uric acid, and more. From the examples discussed, you can follow along how our clinical team goes about interpreting diagnostic measures and applying relevant research findings. Once again, Bob Kaplan, Peter’s head of research, will be asking the questions. If you’re a subscriber, you can now listen to this full episode on your private RSS feed or on our website at the AMA #15 show notes page.
    We discuss:
    Should you stop taking supplements before getting a lab test? [2:45]; Family history—Questions to ask and what to look for [5:30]; The purpose of an oral glucose tolerance test (OGTT) [12:15]; Case study—Insufficient muscle mass for proper glucose disposal [17:15]; Why hemoglobin A1c is a relatively unhelpful metric [24:00]; Case study—Exceeding carbohydrate tolerance [26:30]; Case study—Metabolic dysfunction and a framework for metabolic health [33:30]; Peter’s ideal tracking of metabolic health for all his patients [43:30]; Contrasting presentations of hypogonadism—Low free testosterone [45:00]; How sleep, exercise, and alcohol affect testosterone levels? [56:20]; Case study—Surprisingly fast onset of menopause [59:25]; Case study—Hypothyroidism and high cholesterol [1:07:00]; Case study—Elevated uric acid and hypertension [1:10:55]; and More. Learn more: https://peterattiamd.com/

    Show notes page for this episode: https://peterattiamd.com/ama15

    Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/

    Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/

    Connect with Peter on Facebook | Twitter | Instagram.

    • 16 min

Customer Reviews

4.8 out of 5
3.9K Ratings

3.9K Ratings

caseyjayner ,

An Author of Words & a Lover of Science

Peter Attia is absolutely committed to excellence and his podcast shows it. He is not only always striving to better himself but bringing us along for the ride. Please put away your bro doctors and learn truly high quality, nuanced, ethical, and thoughtful medical science with Dr. Attia. He has become a personal hero of mine, from the days of Nerd Safari until today, his thoughts and efforts expand my mind.

Further, he is a huge part of the reason I am so proud to go to Hopkins & that I fell in love with mathematics as a field. I hope one day to meet this brilliant human and I will not hold back thanking him for his impact on my life.

RTC-Edmond ,

Excellent show Peter.

Excellent interview, with explaining how to put into effect immediately. Thanks.

pattywithawhy ,

Five Star+ Gratitude

I’m a second (or third, fourth?) career ICU nurse with multiple other interests and lifelong side projects and ideas. I have to say, the show is a key part of what’s getting me through Covid-19 times. I was already doing fasting and listening to Dr. Rhonda Patrick and Tim Ferriss regularly prior to all this, but Peter’s (Dr. Attia’s?) stuff really spoke to me at the beginning of this time when so much was uncertain and so terrifying. I remember back in March or April 2020 listening to the conversation with the stoic guy, I’d be out on a run listening, feeling empowered, thinking about how Winston Churchill and Anne Frank (and Peter) managed to get through each day.

Anyway, I’m finally getting around to paying for my subscription so that my husband can listen to the complete version of the Matthew Walker sleep episode. Incidentally he’s also a huge Ayrton Senna fan.

Not trying to sound like too much of a fangirl, but five stars feels like not enough for me.

Highly recommended.

Top Podcasts In Medicine

Listeners Also Subscribed To