High Intensity Health with Mike Mutzel, MS Author Mike Mutzel interviews Jeff Bland, Datis Kharrazian, Ben Greenfield, Abel James, Dave Asprey, Ben Lynch, Jade Teta and Corey chuler

Deaths in children have increased 20% as a result of lockdowns and so called safety measures 'to flatten the curve.

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References:
Woolf SH, Wolf ER, Rivara FP. The New Crisis of Increasing All-Cause Mortality in US Children and Adolescents. JAMA. Published online March 13, 2023. doi:10.1001/jama.2023.3517
Time Stamps:
00:21 There has been a dramatic increase in the death rate of children and adolescents.
01:45 COVID had little to do with the surge in death rates.
02:30 An increase of nearly 20% in all-cause mortality for children ages 1 to 19 years old between has taken place between 2019 and 2022.
03:30 All cause mortality for children 9 and under increased in 2021 by 8.4%.
04:10 Significantly more children died from suicide, homicide, overdoses, and injuries, than died from COVID.
06:45 Injury mortality for ages 10 to 19 rose 22.6% between 2019 and 2020.
06:55 Homicides for ages 10 to 19 rose 39.1% and drug overdose deaths increased by 113.5%.
07:45 Transportation-related deaths increased by 15.6%.

A new study found daily intermittent fasting for ~ 17-19 hours was sufficient to enhance fat loss, metabolic health and bio-markers linked longevity as well as cancer prevention. 
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Time Stamps:
 
00:00 Fasting 17 to 19 hours per day for 30 days increased autophagy and increased tumor suppressor P53.
02:10 Autophagy increased, favorable changes were made in the inflammasome hub, and there was a decrease in senescence-associated-signaling molecules.
03:00 P53 helps repair DNA damage, prevents senescence, and contributes to reduced atherogenic risk.
06:05 Autophagy has tissue-specific benefits, especially in the liver and brain.
07:35 Regular exercisers have a great increase in fasted-associated autophagy initiation proteins.
08:35 Long duration fasts can catabolize lean mass, possibly increasing risk for cardiovascular disease.

After years of demonizing dietary cholesterol, the consensus in the medical community is finally shifting: cholesterol-rich foods have a minimal impact on serum LDL or total cholesterol.
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---------------------------Show Notes-----------------------
0:00 Intro
1:10 Insulin regulates the enzyme that synthesizes endogenous cholesterol. 
1:50 Dietary cholesterol does not have a significant impact on serum cholesterol. 
2:45 Carbohydrates increase LDL and total cholesterol and insulin.
3:30 Cholesterol has powerful benefits. 
5:00 Low cholesterol diets can increase endogenous production of cholesterol and the expression of LDL receptors. 
5:40 High cholesterol diet expresses fewer LDL receptors. 
8:00 Eggs and meat consumption has a minimal impact on serum cholesterol. 
8:53 Increased LDL cholesterol may be from of increased fat metabolism.
10:30 Type 2 diabetes and insulin resistance modifies LDL particles to be smaller and denser and more likely to become atherogenic. 
13:50 Diabetes can be a side effect of Statin drugs.
14:20 Cholesterol is used to make bile.
16:20 A diet rich in seed oils may foster the modification of LDL cholesterol that can make the atherogenic.
17:45 LDL cholesterol has antiviral properties.
19:30 Insulin resistance and physical inactivity increase triglyceride production, leading to the formation of fats in the liver and elevated triglycerides and elevated vLDL cholesterol.

Let's discuss how how different macronutrients and blood sugar issues can regulate aging and the induction of cellular senescence. We also discuss how various dietary interventions can achieve prevention of disease and extension of lifespan by modulating senescence.

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Show Notes:
00:25 Cellular senescence accelerates biologic ageing.
02:00 Senescent cells are enlarged, have dysfunctional mitochondria, and release pro-inflammatory signaling molecules.
02:30 Senescence manifests as wrinkles, memory loss, muscle loss, gray hair, fatty liver, excessive visceral adipose tissue.
03:45 Senescence occurs in response to stressors or developmental signals and behave similar to cancer cells.
05:45 Dysfunctional mitochondria influences glycolysis in cells.
06:15 Give your cells less fuel, glucose, for the proliferation of inflammation.
07:45 Hyperglycemia decreases nitric oxide, which helps prevent cellular senescence.
08:00 Sirtuins can inhibit the formation of senescent cells.
08:55  Berberine, Metformin, and low dose rapamycin, have been used to mitigate hyperglycemia.
10:30 Hyperglycemia also impacts your cardiovascular system and endothelial cells.
12:00 Fat cells can become senescent.
13:00 Ketones (BHB) can help inhibit cellular senescence.
13:25 Optimized omega 3 to omega 6 ratio can help.
14:00 Exercise counters age-related accumulation of senescent cells.
14:40 Senescence within your immune cells is linked with cancer and poor response to infection.

Several new studies find NAC and Glycine combinations can support biologic aging and more. Let's dive into these details.

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Episode Time Stamps

00:00 Glutathione is one of your body’s most important antioxidant and detox molecules.
00:30 Supplement with raw materials, instead of directly supplementing with glutathione.
01:00 N-acetylcysteine and glycine are rate limiting amino acids in glutathione production.
01:00 Glutathione is comprised of glutamine, cystine, and glycine.
02:40 Glycine-NAC supplementation improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, ageing hallmarks, metabolic defects, muscle strength, cognitive decline and body composition.
05:20 Taking direct antioxidants has conflicting evidence.
07:30 GGT liver enzyme is a marker of glutathione turnover.
11:00 Take antioxidant supplements in the evening.

According to the media, erythritol purportedly causes heart attacks. In actuality, metabolically unhealthy people convert glucose to erythritol. Here's the details about high blood levels of erythritol and heart disease. 
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Link to Studies Mentioned: https://bit.ly/Erythritol-study-breakdown