The Incubator The Incubator

In this episode of The Incubator Journal Club, Ben and Daphna discuss several recent neonatology papers. They review a NEJM trial on nutritional support strategies for moderate to late preterm infants, finding no effects on time to full feeds or body composition at 4 months. Next, they discuss a study on umbilical cord blood cultures for early onset sepsis, noting good concordance with neonatal blood cultures. A Japanese retrospective study found erythropoietin use was associated with increased ROP risk but decreased NEC and mortality. However, the hosts caution about limitations in EPO dosage data and variation between centers. They then discuss a trial showing breast milk enemas reduce time to meconium evacuation and full feeds compared to saline enemas in preterm infants. A paper from Nationwide Children's reports good outcomes managing BPD without routine blood gases, potentially saving costs. Lastly, a study suggests transcutaneous bilirubinometry may safely monitor rebound hyperbilirubinemia after phototherapy. Throughout the discussion, Ben and Daphna provide insightful analysis of each study's strengths, limitations, and implications for practice. They also highlight their upcoming 3-year podcast anniversary, announcing a special giveaway and listener survey. 


As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.
Enjoy!

Breast Milk Enema and Meconium Evacuation Among Preterm Infants: A Randomized Clinical Trial. Zheng L, Gai L, Wu Y, Kong C, Sun F, Gao J, Yuan W, Liu M, Jiang H, Tuo N, Yang F.JAMA Netw Open. 2024 Apr 1;7(4):e247145. doi: 10.1001/jamanetworkopen.2024.7145.PMID: 38648060 Free article. Clinical Trial.
As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.
Enjoy!

EBNEO commentary: Patent ductus arteriosus (PDA)-To treat early or not with ibuprofen? Javed R, Gowda H.Acta Paediatr. 2024 Apr 30. doi: 10.1111/apa.17259. Online ahead of print.PMID: 38687140 No abstract available.
As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.
Enjoy!

Nutritional Support for Moderate-to-Late-Preterm Infants - A Randomized Trial. Alexander T, Asadi S, Meyer M, Harding JE, Jiang Y, Alsweiler JM, Muelbert M, Bloomfield FH; DIAMOND Trial Group.N Engl J Med. 2024 Apr 25;390(16):1493-1504. doi: 10.1056/NEJMoa2313942.PMID: 38657245 Clinical Trial.
 
As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.
Enjoy!

In this intimate chat with Leah, Isabella shares her experience of her baby Lily being born prematurely at 27 weeks and being admitted to the NICU. She talks about the initial shock and the unexpected journey of having a baby in the NICU. Isabella shares her daughter Lily's journey in the NICU, from surgery to feeding challenges and extended hospital stays. She emphasizes the importance of trusting your instincts as a parent. Isabella expresses gratitude for the medical staff and the lessons she learned about patience and acceptance. She shares her hope for other NICU families and offers words of wisdom for those currently in the NICU.
As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.
Enjoy!

In this episode of “At the Bench” in the Incubator podcast family, Dr. Donna Ferrero discusses her work on therapeutic hypothermia and neonatal brain injuries. She explains the development and implementation of therapeutic hypothermia as a treatment for brain injuries in newborns. Dr. Ferrero also explores the signaling pathways and early markers that can help identify patients who will respond well to hypothermia. She discusses the use of erythropoietin (EPO) and the results of the HEAL trial. Additionally, Dr. Ferrero highlights the importance of genetic variants and sex-specific differences in understanding and treating brain injuries. She also emphasizes the need for a multi-omics approach to better comprehend the complexity of brain injuries and develop personalized interventions. We also delve into the future of care for hypoxia ischemia and the importance of collaboration and career development for physician scientists. The value of collaboration with international researchers and the benefits of visiting other institutions and labs are highlighted. Tips for effective collaboration and overcoming challenges in career development are provided, along with insights into the role of leadership in advancing the field.
As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.
Enjoy!