OnAir, with Clinical Respiratory News Clinical Respiratory News

The ATS (American Thoracic Society) International Conference is a key event in the global sleep and breathing health calendar. So in this episode of OnAir, we asked Kimberly Sterling and Luciana Rabello – who were there as part of ResMed’s Medical Affairs Team – to share the exciting developments and research findings that caught their attention.
Topics discussed include:
Endotypes: what they are and how they differ to phenotypes – with a look at the role endotyping can play in the management of heterogenous conditions like OSA, and why a collaborative approach to its application may be key.
AI in medicine: how large-language models ‘think’ about complex care cases compared to the reasoning of seasoned clinicians, and the possibility of developing speech-based screening for sleep apnoea.
GLP-1s: could the use of these anti-obesity medications be associated with increased PAP adherence?
Kimberly and Luciana also tell us about connecting with peers to share scientific findings from the 26 abstracts ResMed supported at the event – including evidence that suggests PAP therapy reduces the risks of death and hospitalisation for patients with OSA.*
Guests:
Dr Kimberly Sterling - Vice President, Global Value & Access, Medical Affairs, ResMed
Dr Luciana Rabello - Director of Clinical Advocacy, Medical Affairs, ResMed
References and useful links:
ATS President’s Message
*A. Malhotra, J.-L. Pépin, P.A. Cistulli, A. Wimms, F. Lavergne, F.H. Sert Kuniyoshi, S.H. Munson, B. Schuler, S.R. Badikol, C. Wilson, L. Willes, C. Kelly, T. Kendzerska, D.A. Johnson, R. Heinzer, C.-H. Lee, A.V. Benjafield, and on behalf of the medXcloud group. All-cause Mortality in Obstructive Sleep Apnea: Systematic Literature Review Including Randomised Trials and Confounding Adjusted Non-randomised Controlled Studies and Meta-analysis of Positive Airway Pressure Treatment (abstract). Am J Respir Crit Care Med 2024;209:A4735.
Listen to OnAir with Clinical Respiratory News, the podcast that brings you fresh insights and thought-provoking discussions about hot topics in respiratory care and sleep-disordered breathing.
© ResMed

Funded by a 15 million-euro grant from the EU’s Horizon 2020 programme for health demographic change and wellbeing, the Sleep Revolution project is an ambitious one that aims to shake up current diagnostic methods for sleep-disordered breathing (SBD).
In this episode of OnAir, we talk to the head of the project, Professor Erna Sif Arnardóttir. She tells us how she believes strong collaboration between the project’s partners convinced the EU that the Sleep Revolution project could make real change, including:
Bringing advanced sleep diagnostics from the hospital into patient’s homes
Encouraging patients to participate in their own care with the help of technical solutions
Developing different personalised treatment options for patients with SDB
Creating a new European Sleep Questionnaire to help capture the whole sleep profile of a person for clinical and research purposes
Prof. Arnardóttir also shares her thoughts on topics such as the importance of multi-night diagnostics, whether AHI is sufficient as parameter to classify the severity of OSA, and how digital tools – such as apps and wearables – and cooperation between different entities could transform the future of sleep medicine.
Guest:
Prof. Erna Sif Arnardóttir - Director of the Reykjavik University Sleep Institute; Associate Professor at the Department of Engineering and Department of Computer Science at Reykjavik University, Iceland
References and useful links:
https://sleeprevolution.eu/en
Disclaimers:
This content is intended for health professionals only.
This testimonial is a genuine and documented account of the individual’s response to treatment. Outcomes and results may vary, and this individual’s response does not provide any indication, warranty or guarantee that other people will have the same or a similar experience. This presentation is based on the professional presenter experience, practice and on recent available relevant data which is not intended to be understood as state of the art.
Professor Erna Sif Arnardóttir was provided with a nominal financial incentive for providing the following testimonial. Professor Erna Sif Arnardóttir will not receive any discounts or further incentives as a result of this testimonial.
Listen to OnAir with Clinical Respiratory News, the podcast that brings you fresh insights and thought-provoking discussions about hot topics in respiratory care and sleep-disordered breathing.
© ResMed

In this episode of OnAir, sleep clinician Prof. Dr Manuel Sánchez-de-la-Torre and host Daniela Ehrsam-Tosi discuss the potential benefits of patient phenotyping for obstructive sleep apnoea.
Prof. Dr Sánchez-de-la-Torre explores why patient phenotyping can be relevant during diagnosis, for making effective treatment decisions, and during the follow-up stage. He highlights the role of patient phenotype in predicting responses and understanding neutral effects, with a particular focus on blood pressure and hypoxic burden. He also emphasises the value of telemedicine in promoting engagement and treatment adherence.
Listen to learn why progress in patient phenotyping could affect the way you treat and understand your OSA patients.
Reference:
Sánchez-de-la-Torre M, Gracia-Lavedan E, Benitez ID, et al. Adherence to CPAP Treatment and the Risk of Recurrent Cardiovascular Events: A Meta-Analysis. JAMA. 2023;330(13):1255–1265. https://doi.org/10.1001/jama.2023.17465
Listen to OnAir with Clinical Respiratory News, the podcast that brings you fresh insights and thought-provoking discussions about hot topics in respiratory care and sleep-disordered breathing.
Disclaimers:
This content is intended for health professionals only.
This testimonial is a genuine and documented account of the individual’s response to treatment. Outcomes and results may vary, and this individual’s response does not provide any indication, warranty or guarantee that other people will have the same or a similar experience. This presentation is based on the professional presenter experience, practice and on recent available relevant data which is not intended to be understood as state of the art.
Professor Manuel Sánchez-de-la-Torre was provided with a nominal financial incentive for providing the following testimonial. Professor Manuel Sánchez-de-la-Torre will not receive any discounts or further incentives as a result of this testimonial.
© ResMed

In this episode of OnAir, clinical expert Professor Christoph Schöbel and host Daniela Ehrsam-Tosi discuss sleep quality and sleep disorders.
There’s a growing awareness of the importance of sleep for our cardiovascular system and our general health and wellbeing. At the same time, our ability to get good sleep is increasingly challenged by everything from late-night scrolling to irregular work schedules, stress and anxiety. It’s thought that 10-30% of people worldwide suffer from insomnia1, not to mention other sleep disorders like OSA and restless leg syndrome.
In this context, which diagnostic and treatment pathways should we be prioritising? Should primary care screening programmes focus on sleep as well as diet and exercise? What benefits might digital technology have to offer? Professor Schöbel shares his thoughts on these points, as well as discussing the new European Insomnia Guideline2 and the challenges of treating COMISA (co-morbid insomnia and sleep apnoea).
References and useful links:
1. Bhaskar S, Hemavathy D, Prasad S. Prevalence of chronic insomnia in adult patients and its correlation with medical comorbidities. J Family Med Prim Care. 2016 Oct-Dec;5(4):780-784. https://10.4103/2249-4863.201153. PMID: 28348990; PMCID: PMC5353813.
2. Riemann, D., Espie, C. A., Altena, E., Arnardottir, E. S., Baglioni, C., Bassetti, C. L. A., Bastien, C., Berzina, N., Bjorvatn, B., Dikeos, D., Dolenc Groselj, L., Ellis, J. G., Garcia-Borreguero, D., Geoffroy, P. A., Gjerstad, M., Gonçalves, M., Hertenstein, E., Hoedlmoser, K., Hion, T., … Spiegelhalder, K. (2023). The European Insomnia Guideline: An update on the diagnosis and treatment of insomnia 2023. Journal of Sleep Research, 32(6), e14035. https://doi.org/10.1111/jsr.14035
Listen to OnAir with Clinical Respiratory News, the podcast that brings you fresh insights and thought-provoking discussions about hot topics in respiratory care and sleep-disordered breathing.
Disclaimers:
This content is intended for health professionals only.
This testimonial is a genuine and documented account of the individual’s response to treatment. Outcomes and results may vary, and this individual’s response does not provide any indication, warranty or guarantee that other people will have the same or a similar experience. This presentation is based on the professional presenter experience, practice and on recent available relevant data which is not intended to be understood as state of the art.
Professor Christoph Schöbel was provided with a nominal financial incentive for providing the following testimonial. Professor Christoph Schöbel will not receive any discounts or further incentives as a result of this testimonial.
© ResMed

In this episode of OnAir, we ask whether treatment-adherent OSA patients could be lowering their cardiovascular risk while they sleep. Professor Frédéric Gagnadoux and host Nina Wiklund explore the design, results and implications of his recent 5,000-patient cohort study, which indicates that CPAP can deliver a significant reduction in major adverse cardiovascular events. They ask which patients are likely to benefit, discuss the importance of hours of usage, and consider the tools that clinicians can use to support therapy adherence. Listen to learn about the potential impact of CPAP therapy on the cardiovascular health of your OSA patients.
References and useful links:
Gerves-Pinquie C, Bailly S, Goupil F, Pigeanne T, Launois S, Leclair-Visonneau L, et al.; Pays de la Loire Sleep Cohort Study Group. (2022). Positive airway pressure adherence, mortality and cardiovascular events in sleep apnea patients. Am J Respir Crit Care Med, 206, pp. 1393–1404. DOI: 1164/rccm.202202-0366OC
Sánchez-de-la-Torre M, Gracia-Lavedan E, Benitez ID, et al. Adherence to CPAP Treatment and the Risk of Recurrent Cardiovascular Events: A Meta-Analysis. 2023;330(13):1255–1265. doi:10.1001/jama.2023.17465
ERS 2023 Workshop: CPAP therapy and cardiovascular outcomes – what have we learned from real-life cohorts?
Listen to OnAir with Clinical Respiratory News, the podcast that brings you fresh insights and thought-provoking discussions about hot topics in respiratory care and sleep-disordered breathing.
Disclaimers:
This content is intended for health professionals only.
This testimonial is a genuine and documented account of the individual’s response to treatment. Outcomes and results may vary, and this individual’s response does not provide any indication, warranty or guarantee that other people will have the same or a similar experience. This presentation is based on the professional presenter experience, practice and on recent available relevant data which is not intended to be understood as state of the art.
Professor Frédéric Gagnadoux was provided with a nominal financial incentive for providing the following testimonial. Professor Frédéric Gagnadoux will not receive any discounts or further incentives as a result of this testimonial.
© ResMed

The world has changed profoundly in the 25 years since the internet became mainstream. Is it finally healthcare’s turn to experience a dramatic data-driven transformation? Daniela Ehrsam-Tosi and ResMed’s Chief Medical Officer Carlos Nunez explore the risks, realities and research potential of real-world data and deep machine learning. Their discussion starts with the perennial challenges of rising healthcare costs and ageing populations and invites us to look to a future where our data isn’t just used to serve us relevant advertising, but can also provide us with personalised healthcare in almost real time.
Listen to OnAir with Clinical Respiratory News, the podcast that brings you fresh insights and thought-provoking discussions about hot topics in respiratory care and sleep-disordered breathing.
Disclaimers:
This content is intended for health professionals only.
This testimonial is a genuine and documented account of the individual’s response to treatment. Outcomes and results may vary, and this individual’s response does not provide any indication, warranty or guarantee that other people will have the same or a similar experience. This presentation is based on the professional presenter experience, practice and on recent available relevant data which is not intended to be understood as state of the art.
© ResMed