Möglichkeiten der Frühdiagnostik der Osteomyelitis durch Magnetresonanz-Tomographie - Experimentelle Untersuchungen am Kaninchen Tierärztliche Fakultät - Digitale Hochschulschriften der LMU - Teil 01/07
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Possibilities of early diagnosis of osteomyelitis by magnetic resonance tomography - experimental studies in rabbits
Correlation of MR-images and macroscopic sections demonstrates, that anatomical structures
of rabbits can be excellently visualized by MRT. Clinically used MR-systems are able to provide
satisfactory resolution. Following experimentally induced osteomyelitis infected bone
marrow can be detected by decreased signal on native T1-weighted and increased signal on
T2-weighted images. After administration of gadolinium-DTPA marked enhancement can be
observed. Detection of soft-tissue infection is superior on T2-wheigted scans showing high
signal intensity. After administration of gadolinium DTPA rim enhacement provides good
differentiation of abscessmembrane.
Especially in earlier stages of disease (3 to 5, 8 to 12 and 12 to 19 days post infection) the
sensitivity of native MRT (80%, 100%, about 67%) is superior compared to other diagnostic
modalities, e.g. radiography (about 29%, about 46%, 50%), CT-scan (about 29%, about 13%,
about 17%) and scintigraphy (60%, about 78%, 100%). Gadolinium-DTPA increases sensitivity
(100%, 100%, 100%). At the end of the observation period bone scintigraphy provides
the same sensitivity. MRT, however, is superior in detecting involvement of bone marrow and
soft-tissue infection. Compared to scintigraphy and MRT radiography and CT-scan shows
lower sensitivity during the whole observation period.
Regional differences in detecting osteomyelitis can be recognized unsing MRT, less using
other modalities. In early stages of the disease most infectious lesions are detected in the
proximal femur. Explanation can be a different involvement of the femur, but also a different
diagnostic potential of MRT concerning different anatomical regions.
All in all MRT is an excellent tool in the diagnosis of osteomyelitis and is superior to other
imaging modalities. Application of contrast material provides further improvement in sensitivity.
In the clinical use fat suppression and STIR-sequence have provided further improvement.
The role of MRT as a diagnostic instrument in osteomyelitis is established in clinical
medicine and seems promising in veterinary medicine.
Possibilities of early diagnosis of osteomyelitis by magnetic resonance tomography - experimental studies in rabbits
Correlation of MR-images and macroscopic sections demonstrates, that anatomical structures
of rabbits can be excellently visualized by MRT. Clinically used MR-systems are able to provide
satisfactory resolution. Following experimentally induced osteomyelitis infected bone
marrow can be detected by decreased signal on native T1-weighted and increased signal on
T2-weighted images. After administration of gadolinium-DTPA marked enhancement can be
observed. Detection of soft-tissue infection is superior on T2-wheigted scans showing high
signal intensity. After administration of gadolinium DTPA rim enhacement provides good
differentiation of abscessmembrane.
Especially in earlier stages of disease (3 to 5, 8 to 12 and 12 to 19 days post infection) the
sensitivity of native MRT (80%, 100%, about 67%) is superior compared to other diagnostic
modalities, e.g. radiography (about 29%, about 46%, 50%), CT-scan (about 29%, about 13%,
about 17%) and scintigraphy (60%, about 78%, 100%). Gadolinium-DTPA increases sensitivity
(100%, 100%, 100%). At the end of the observation period bone scintigraphy provides
the same sensitivity. MRT, however, is superior in detecting involvement of bone marrow and
soft-tissue infection. Compared to scintigraphy and MRT radiography and CT-scan shows
lower sensitivity during the whole observation period.
Regional differences in detecting osteomyelitis can be recognized unsing MRT, less using
other modalities. In early stages of the disease most infectious lesions are detected in the
proximal femur. Explanation can be a different involvement of the femur, but also a different
diagnostic potential of MRT concerning different anatomical regions.
All in all MRT is an excellent tool in the diagnosis of osteomyelitis and is superior to other
imaging modalities. Application of contrast material provides further improvement in sensitivity.
In the clinical use fat suppression and STIR-sequence have provided further improvement.
The role of MRT as a diagnostic instrument in osteomyelitis is established in clinical
medicine and seems promising in veterinary medicine.
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