93 episodes

Throughout my training and practice as a physician I have come to one very disappointing conclusion: Western medicine isn’t helping people lead better lives. Now that I’ve realized this, I’ve become obsessed with understanding what makes us healthy or ill. I want to live the best life I can and I want to be able to share this knowledge with others so that they can do the same. This podcast is the result of my relentless search to understand the roots of chronic disease. If you want to know how to live the most radical life possible I hope you’ll join me on this journey.

Fundamental Health with Paul Saladino, MD Paul Saladino, MD

    • Medicine
    • 4.9 • 121 Ratings

Throughout my training and practice as a physician I have come to one very disappointing conclusion: Western medicine isn’t helping people lead better lives. Now that I’ve realized this, I’ve become obsessed with understanding what makes us healthy or ill. I want to live the best life I can and I want to be able to share this knowledge with others so that they can do the same. This podcast is the result of my relentless search to understand the roots of chronic disease. If you want to know how to live the most radical life possible I hope you’ll join me on this journey.

    Controversial Thoughts: When high cholesterol is GOOD!

    Controversial Thoughts: When high cholesterol is GOOD!

    Is high cholesterol always a bad thing? I say no! Context matters greatly here, as in are you metabolically healthy? Do you know how to assay this? Many people eating an ancestral type diet like carnivore, carnivore-ish, keto, paleo, etc.  (like me!) will see LDL rise, but I don't believe this is a bad thing if we are insulin sensitive/metabolically healthy- this is the importance of context. I discuss the importance of considering context in discussions of LDL, Lp (a), uric acid, and APOE4 in this video. Get ready for a wild ride.  #theremembering 
    Check out heartandsoil.co if you need more nose to tail nutrition in your life. The JRE show notes are there as well.
     

    • 27 min
    What does a mainstream cardiologist think of my cholesterol? With Nadir Ali, MD

    What does a mainstream cardiologist think of my cholesterol? With Nadir Ali, MD

    Dr. Nadir Ali is an interventional cardiologist with over 25 years of experience. He is also the chairman of the Department of Cardiology at Clear Lake Regional Medical Center. Before working as a cardiologist, he served as an assistant professor of medicine for eight years at Baylor College of Medicine in Houston, where he also received his medical training.
     
    Time Stamps:
    0:09:44  Podcast Begins
    0:11:00  Lifestyle change and the power of animal foods
    0:16:38  Is red meat killing us?  
    0:19:32  Humans are not hebivores 
    0:24:31  The problem with mainstream cardiology
    0:31:03  The full story of LDL [and oxidized LDL]
    0:38:22  Changes in Dietary Fat Intake Alter Plasma Levels of Oxidized Low-Density Lipoprotein and Lipoprotein(a)  https://www.ahajournals.org/doi/10.1161/01.ATV.0000118012.64932.f4?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
    0:43:23  Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467319/ 
    0:43:50  Strong increase in hydroxy fatty acids derived from linoleic acid in human low density lipoproteins of atherosclerotic patients  https://www.sciencedirect.com/science/article/abs/pii/S0009308497000959?via%3Dihub
    0:44:44  Linoleic acid is at the root of heart disease  
    0:50:08  LDL and immune health
    0:58:06  Genetic Assessment of Potential Long-Term On-Target Side Effects of PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) Inhibitors  https://www.ahajournals.org/doi/10.1161/CIRCGEN.118.002196
    1:00:11  Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease  https://www.nejm.org/doi/full/10.1056/nejmoa1615664
    1:02:05  Serious adverse events and deaths in PCSK9 inhibitor trials reported on Clinical  Trials.gov: a systematic review  https://www.tandfonline.com/doi/full/10.1080/17512433.2020.1787832
    1:02:56  The dark truth of PCSK9 inhibitors
    1:05:12  Metabolic health is what matters  
    1:07:04  Metabolic health is what matters  
    1:08:07  Let' change the paradigm!
    1:13:21  Dr. Nadir Ali's health optimizaton advice
    1:18:12  Where to find Nadir Ali MD
    1:22:48  Binding and Partial Inactivation of Staphylococcus aureus a-Toxin by Human Plasma Low-Density Lipoproteinhttps://www.jbc.org/content/258/9/5899.long
    1:23:18  Why you should rethink your statin
    1:26:24  The Framingham Study
    1:26:56  High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study  https://www.amjmed.com/article/0002-9343(77)90874-9/pdf
    1:28:51  Mechanisms of HDL lowering in insulin resistant, hypertriglyceridemic states: the combined effect of HDL triglyceride enrichment and elevated hepatic lipase activity  https://pubmed.ncbi.nlm.nih.gov/12951168/
    1:29:44  LDL size matters
    1:31:24  Clinical Effects of Cholesterol Supplementation in Six Patients With the Smith–Lemli–Opitz Syndrome(SLOS)  https://www.researchgate.net/publication/14184407_Clinical_effects_of_cholesterol_supplementation_in_six_patients_with_Smith-Lemli-Opitz_syndrome_SLOS
    1:32:56  Mood, Personality, and Behavior Changes During Treatment with Statins: A Case Series  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005588/
    1:34:19  Determination of lipid oxidation products in vegetable oils and marine omega-3 supplementshttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118035/
    1:34:29  Stop your omega-3 supplement!
     
    Heart & Soil is my passion based company founded to help a few million more people reclaim their ancestral birthright to radical health through nose to tail nutrition. We are making grass fed, grass finished desiccated organ capsules from regenerative farms in New Zealand and developing a US based supply chain. Check us out at: www.heartandsoil.co, @heartandsoilsupplements on Instagram 



    Belcampo: www.b

    • 1 hr 40 min
    Controversial Thoughts: Do organ meats cause Gout? What does?

    Controversial Thoughts: Do organ meats cause Gout? What does?

    Meat and Organs cause gout, right? Not so fast sea bass! In this controversial thoughts video, I break it all down and discuss how CONTEXT is again critical here and how Western Medicine is myopic in its view of gout. Hint: it's all about metabolic dysfunction, like so many other things!
    Check us out at Heart & Soil (www.heartandsoil.co) if you need more nose to tail nutrition in your life! Send me an email at drpaul@heartandsoil.co if you have questions about diet/organs!
     

    • 22 min
    Is it saturated fat or polyunsaturated fat that’s killing you? With Peter Dobromylskyj from Hyperlipid.

    Is it saturated fat or polyunsaturated fat that’s killing you? With Peter Dobromylskyj from Hyperlipid.

    Petro Dobromylskyj is a veterinarian, trained at the RVC, London University. He was fortunate enough to intercalate a BSc degree in physiology into his veterinary degree. He was even more fortunate to study under Patrick Wall at UCH, who set me on course to become a veterinary anaesthetist, mostly working on acute pain control. That led to the Certificate then Diploma in Veterinary Anaesthesia and enough publications to allow him to enter the European College of Veterinary Anaesthesia and Analgesia as a de facto founding member. Anaesthesia teaches you a lot. Basic science is combined with the occasional need to act rapidly. Wrong decisions can reward you with catastrophe in seconds. Thinking is mandatory. He stumbled onto nutrition completely by accident. Once you have been taught to think, it's hard to stop.
     
    Time Stamps:
     
    0:08:42  Podcast Begins
    0:09:52  Peter's Background
    0:16:36  The Electron Transport Chain
    0:45:30  Insulin resistance is a cellular antioxidant defense mechanism   https://www.pnas.org/content/106/42/17787
    0:47:50 High rates of superoxide production in skeletal-muscle mitochondria respiring on both complex I- and complex II-linked substrates   https://www.researchgate.net/publication/5929069_High_rates_of_superoxide_production_in_skeletal-muscle_mitochondria_respiring_on_both_complex_I-_and_complex_II-linked_substrates
    0:49:50  We need insulin resistance
    0:54:53  All about a1a
    1:00:37  How PUFAs affect mitochondria
    1:02:40  PUFAs and cellular lipid accumulation
    1:05:34  Pathological insulin sensitivity  
    1:07:52  Insulin-induced translocation of CD36 to the plasma membrane is reversible and shows similarity to that of GLUT4  https://www.sciencedirect.com/science/article/abs/pii/S1388198107002296?via%3Dihub
    1:12:34  The center of metabolic health: the adipocytes 
    1:14:08  PUFAs and tumor growth
    1:15:52  Eating the perfect ratio of fatty acids
    1:20:18  Differential Metabolic Effects of Saturated Versus Polyunsaturated Fats in Ketogenic Diets  https://academic.oup.com/jcem/article/89/4/1641/2844241
    1:20:18  How PUFAs break your metabolism
    1:23:20  Premature Atherosclerosis Associated With Monogenic Insulin Resistance  https://www.ahajournals.org/doi/10.1161/01.cir.103.18.2225?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
    1:25:21  Role of Physiological Levels of 4-Hydroxynonenal on Adipocyte Biology: Implications for Obesity and Metabolic Syndrome  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038367/
    1:30:16  Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467319/
    1:30:53  Context matters in interpreting lipids
    1:36:49  You might want to rethink your avocado and olive oil
    1:40:17  Plant are not benevolent
    1:47:55  How to find Peter Dobromylskyj
    1:51:01  Peter's radical running habits
    1:53:54  Green tea extract only affects markers of oxidative status postprandially: lasting antioxidant effect of flavonoid-free diet   https://www.cambridge.org/core/product/identifier/S0007114502000673/type/journal_article
    1:55:42  The roots of the chronic disease epidemic
    1:58:23  Diet Fat Composition Alters Membrane Phospholipid Composition, Insulin Binding, and Glucose Metabolism in Adipocytes from Control and Diabetic Animals  jbc.org/content/265/19/11143.long
    1:59:29 Insulin-sensitive obesity   https://journals.physiology.org/doi/full/10.1152/ajpendo.00586.2009?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org




    Heart & Soil is my passion based company founded to help a few million more people reclaim their ancestral birthright to radical health through nose to tail nutrition. We are making grass fed, grass finished desiccated organ capsules from regenerative farms in New Zealand and developi

    • 2 hrs 5 min
    Controversial Thoughts: How does bloodwork look on a nose to tail carnivore diet?

    Controversial Thoughts: How does bloodwork look on a nose to tail carnivore diet?

    What does bloodwork look like on a Nose to Tail Carnivore diet? Find out in this detailed video in which I review @KarnivoreKurt 's bloodwork with him and add detailed commentary. Spoiler alert: It looks amazingly good because animal-based diets are what humans are designed to eat! Check us out at www.heartandsoil.co if you need more nose to tail nourishment in your life! Welcome to The Remembering... 
     
    Firestarter and Gut & Digestion are out now in addition to Beef Organs and Bone Marrow & Liver. Blood Builder and Histamine & Immune are out now as well!  Yeehaw!
     

    • 33 min
    How High Cholesterol Can Be Healthy, and Low Cholesterol Could be Harmful, with Dave Feldman.

    How High Cholesterol Can Be Healthy, and Low Cholesterol Could be Harmful, with Dave Feldman.

    If you are interested in lipids, you’ve probably heard of Dave Feldman and his work. If not,  you’ve got some homework to do, and I think you’ll be  amazed at what you find. Dave’s work can be found at cholesterolcode.com where he details his multiple, meticulous self-experimental projects. Prior to cholesterol adventures Dave was a senior software scientist and an engineer. He brings this “out of the box” thinking to the world of medicine and we are all better off for it. 
     
    He began a low-carb, high-fat diet in April 2015 and has since learned everything he could about it with special emphasis on cholesterol. He saw his own lipid numbers spike substantially after going on the diet and spotted a pattern in the lipid system that’s very similar to distributed objects in networks.
     
    Time Stamps:
     
    0:08:46  Podcast Begins
    0:14:21  The Bradford Hill Criteria
    0:15:29  Context matters in lipids
    0:19:44  Carnivore MD's Lipid Panel
    0:30:15  Why LDL can't be the root cause of CVD
    0:35:57  Testing the Lipid Hypothesis 
    0:41:20  Why you can't look at LDL in a vacuum
    0:47:38 High-density lipoprotein as a protective factor against coronary heart disease The Framingham study - The Framingham Study  https://www.amjmed.com/article/0002-9343(77)90874-9/pdf
    0:49:19  Metabolic health is what really matters
    0:52:01  Premature Atherosclerosis Associated With Monogenic Insulin Resistance  https://www.ahajournals.org/doi/10.1161/01.cir.103.18.2225?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed&
    0:54:19  LDL quality is what actually matters
    1:00:39  What's the root cause of oxidized LDL?  
    1:06:20  Why most LDL lab tests are bonk!
    1:07:41  Dave's latest experiment results
    1:16:12  Summary of Dave's Energy Model
    1:21:21  The body holds onto and reuses cholesterol.
    1:24:28  The vital importance of ample cholesterol
    1:25:40  Fasting Increases Serum Total Cholesterol, LDL Cholesterol and Apolipoprotein B in Healthy, Nonobese Humans  https://academic.oup.com/jn/article/129/11/2005/4721856
    1:26:19  Brown Bears (Ursus arctos) Seem Resistant to Atherosclerosis ­Despite Highly Elevated Plasma Lipids during Hibernation and Active State  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439871/
    1:28:40  Strong increase in hydroxy fatty acids derived from linoleic acid in human low-density lipoproteins of atherosclerotic patients  https://pubmed.ncbi.nlm.nih.gov/9488997/
    1:30:45  Why PUFAs lower LDL and why this is a bad thing
    1:32:56  Changes in Dietary Fat Intake Alter Plasma Levels of Oxidized Low-Density Lipoprotein and Lipoprotein(a)  https://www.ahajournals.org/doi/10.1161/01.ATV.0000118012.64932.f4?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
    1:32:56  Variables beyond LDL-- Lp(a)
    1:37:50  Quantification of apo[a] and apoB in human atherosclerotic lesions   https://www.jlr.org/content/32/2/317.long
    1:42:51  Metabolic health   greatly influences lipids
    1:45:18  Citizen Science Foundation  https://citizensciencefoundation.org/
    1:47:58  Dave, the Radical human test tube!
     
     
    Heart & Soil is my passion based company founded to help a few million more people reclaim their ancestral birthright to radical health through nose to tail nutrition. We are making grass fed, grass finished desiccated organ capsules from regenerative farms in New Zealand and developing a US based supply chain. Check us out at: www.heartandsoil.co, @heartandsoilsupplements on Instagram 



    Belcampo: www.belcampo.com Use the code “carnivoremd” for 20% off your order! 



    Nutrisense (Continuous Glucose Monitor- CGM): www.Nutrisense.io, 
     
    BluBlox: www.blublox.com use the code CarnivoreMD for 15% off your order
     
    White Oak Pastures: Use the code CARNIVOREMD at www.whiteoakpastures.com for 10% off your first order!

    • 1 hr 50 min

Customer Reviews

4.9 out of 5
121 Ratings

121 Ratings

LahCD00 ,

Radical podcast

This podcast is one of the most evidence based and sincere nutrition podcast I’ve listed too. Dr Saladino is so passionate about providing evidence based nutritional, diet and lifestyle information to allow people to make decisions to live their best that it’s hard not to get caught up in his enthusiasm. The podcast not only informs on nutrition but promotes community and living in nature in the way our ancestors did, both of which are often overlooked when working towards optimism health. This is a truly radical podcast. Thank you Dr Saladino.

Aussie895 ,

Life changing

I’m so glad I came across your podcast! After looking into new lifestyle choices I started on the keto diet to take control of my health. Now that I am learning more, I have moved to a carnivore diet and this podcast discusses all the recent information, body changes, concerns, research and gives such great advice from Paul and the guest he has on the show. It has been so informative my partner now listens regularly and enjoys how clearly the advice is passed on and follows you on instagram. Thanks for all that you have posted so far, and keep all that good juicy information coming!

Crashiscool ,

A breath of fresh air amongst the clutter !

Paul’s approach is not only the best scientific research but is helpful, informative, diverse and a solid path to optimum health. Thanks Paul !

Top Podcasts In Medicine

Listeners Also Subscribed To