Pharmacy to Dose: The Critical Care Podcast Nick Peters
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- Health & Fitness
Pharmacy to Dose: The Critical Care Podcast discusses critical care and its pharmacotherapy in a fun and entertaining manner. Each episode features a special guest, a subject matter expert, talking with host Nick Peters.
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Trial of the Week: ESETT
Trial of the Week: ESETT
Special Guest: Ashley McCormick, PharmD, BCPS, BCCCP
Ashley McCormick joins to discuss the April Trial of the Week “Randomized Trial of Three Anticonvulsant Medications for Status Epilepticus” the ESETT study, published in NEJM in 2019.
We set the scene by reviewing ASM PK/PD properties and discussing if there was a standard of care first-line treatment. Then we do a deep dive into the ESETT trial of the week. Did the 75kg dose cap influence results? How appropriate was the BZD dosing? How does this % of seizure cessation compare to other studies? Where did this dosing scheme come from? Trial fun facts, medication safety considerations, and much, much more.
Reference list: https://pharmacytodose.files.wordpress.com/2024/04/esett-trial-of-the-week-references.pdf
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Thrombolytic Dosing in PE: Versus Series
Thrombolytic Dosing in PE: Versus Series
Special Guest: Lauren Igneri, PharmD, BCPS, BCCCP, FCCM
05:20 – High-risk PE
23:00 – Intermediate-risk
37:10 – Cardiac arrest
52:30 – Closing arguments
57:15 – Bonus: TNK v. tPA
Reference List: https://pharmacytodose.files.wordpress.com/2024/04/thrombolytic-dosing-in-pe-references.pdf
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Trial of the Week: SEPSISPAM
Trial of the Week: SEPSISPAM
Special Guest: Katherine Spezzano, PharmD, MBA, BCCCP @KatSpazPharmD
Katherine Spezzano joins to discuss the April Trial of the Week “High versus Low Blood-Pressure Target in Patients with Septic Shock” the SEPSISPAM study, published in NEJM in 2014.
We set the scene by reviewing the concept of autoregulation, guideline recommendations, and pre-SEPSISPAM research assessing BP goals in sepsis. Then we do a deep dive into the SEPSISPAM trial of the week. Would we see these same results with other vasopressors? Did each group meet their BP goal range? How do we balance AKI prevention and longer ICU LOS? What do our guidelines recommend now? Trial fun facts, alternate trial acronym ideas, and much more!
Reference list: https://pharmacytodose.files.wordpress.com/2024/04/sepsispam-trial-of-the-week-references.pdf
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Glycemic Control in the Critically Ill: Part II
Glycemic Control in the Critically Ill: Part II
Special Guests: Judi Jacobi, PharmD, FCCP, MCCM, BCCCP @JudiJacobi
Michael Sirimaturos, PharmD, BCNSP, BCCCP, FCCM @MSirimaturos
04:10 – Becoming panel members
11:50 – Guideline scope and PICO questions
21:35 – 2012 v. 2024 guidelines
28:05 – Effect of TGC-FAST
30:40 – 2024 guideline deep-dive
42:00 – Clinical decision support tools
50:00 – Pediatric recommendations
54:40 – Important future research topics
66:05 – Guideline manuscript writing
76:10 – Take-home points
Reference List: https://pharmacytodose.files.wordpress.com/2024/04/glycemic-control-in-the-icu-part-ii-references.pdf
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November 2023 Literature Review Series
Literature Review Series
November 2023
Special Guests: Arjay Mendoza, PharmD, BCPS, AAHIVP
Brock Townsend, PharmD @Townsend_PharmD
04:30 – Featured Articles
35:25 – Cardiology
48:05 – Precision-based medicine potpourri
58:50 – Infectious Diseases
69:10 – PharmD
Reference List: https://pharmacytodose.files.wordpress.com/2024/04/november-lrs-2023-references.pdf
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Trial of the Week: SOAP II
Trial of the Week: SOAP II
Special Guest: Jessica Casey, PharmD, BCPS, BCCP @jmc_cardspharmd
Jessica Casey joins to discuss the April Trial of the Week “Comparison of Dopamine and Norepinephrine in the Treatment of Shock,” the SOAP II study, published in NEJM in 2010.
We set the scene by reviewing catecholamine vasopressor receptor physiology, guideline recommendations, and pre-SOAP II research. Then we do a deep dive into the SOAP II trial of the week. Did including all forms of shock help or hurt? How does the mortality in this study compare with others? Would this have been as positive of a study in 2024? What do the guidelines recommend now? Is dopamine dead? Will anyone take norepinephrine’s throne? Jessica and I review trial fun facts, stand-out supplementary materials, and much, much more.
Reference list: https://pharmacytodose.files.wordpress.com/2024/04/soap-ii-trial-of-the-week-references.pdf
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