New Books in Medicine Marshall Poe

If you're interested in memory, you'll find a lot in Memory Makes the Brain: The Biological Machinery That Uses Experiences To Shape Individual Brains (World Scientific, 2021), from cellular processes to unique and interesting perspectives on autism.

Detailed descriptions of cellular processes involved in forming a memory.

Connecting those cellular processes to everyday experiences - like the memorable image of a butterfly seen during a hike decades ago.

Comparisons of plasticity in different brain areas, like cortex, hippocampus, cerebellum.

Comparisons of plasticity and learning in different phases of the human life.

Important milestones in the history of neuroscience. Like Wiesel and Hubel's work identifying the critical period for plasticity, or Huttenlocher's discovery of synaptic pruning.

Up-to-date science and open questions about autism, a wide range of phenomena that seems to be connected both to synaptic pruning and to the funtion of the cerebellum.

An outlook on non-synaptic plasticity.


Professor Christian Hansel starts both the book and the conversation with establishing a very broad definition of memory. Traditionally, a lot of research focused on the "observable outcome" of learning: acquiring new skills, changing behavior. Instead, he defines memory as any event that changes the brain.
The first 2 chapters introduce major discoveries from the 1960s and 1970s. David Hubel and Thorsten Wiesel examined the visual system of kittens. They recognized that it's much more adaptive in a "critical period", ca. 4-8 weeks after birth. Peter Huttenlocher discovered another fascinating phenomena during childhood: synaptic pruning. In the years 2-12, a lot of synapses (connections between neurons) disappear.
Chapter 3 describes the molecular machinery behind all these observations. We'll get to know the terms LTP (long-term potentiation) and LTD (long-term depression), which mean the long-term strengthening and weakening of synaptic connections respectively. We find a detailed description of these processes, incl. the enzymes, neurotransmitters and receptors contributing to them.
Chapter 4 continues examining these processes across the human life span. The (perhaps surprising) conclusion: The machinery for synaptic plasticity is quite similar in a small child an in an adult. What's different is the magnitude of these processes.
Autism is a central topic both in the book and in the Hansel Lab's work. Chapter 5 starts with describing the difficulties of a definition. ASD (autism spectrum disorder) is an umbrella term encompassing several symptoms and intensities. In the last years, it has turned out that low degree of synaptic pruning plays a significant role in multiple forms of autism. We'll see in the next years how the research about synaptic pruning and learning can be used for clinical purposes. Understanding the biological mechanism can also make it easier to relate to some peculiar-sounding symptoms. If we consider that an individual's brain contains an unusually high number of synapses, their reports about unusually intense perceptions suddenly become more understandable.
A thought-provoking chapter is number 6. It describes various experiments with mouse models to study autism-like symptoms. The chapter might also make you reflect about the merits and shortcomings of animal models generally.
The cerebellum was long considered to be the brain area for finetuning movements. Now, it's clear that its repertoire is much bigger. In the interview, Christian describes a hypothesis that the cerebellum has a capability of timing. This in turn makes it a crucial factor in several behaviors beyond sophisticated movements, including speech.
We know a lot about synaptic plasticity and its significance in learning. Chapter 8 tackles the big, open question, what else? Which other processes contribute to memory formation? It presents some hypotheses about intrinsic plasticity.
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As the U.S. population ages and as health care needs become more complex, demand for paid care workers in home and institutional settings has increased. This book draws attention to the reserve of immigrant labour that is called on to meet this need. 
Migrants Who Care: West Africans Working and Building Lives in U.S. Health Care (Rutgers University Press, 2023) by Dr. Fumilayo Showers tells the little-known story of a group of English-speaking West African immigrants who have become central to the U.S. health and long-term care systems. With high human capital and middle-class pre-migration backgrounds, these immigrants - hailing from countries as diverse as Cameroon, Sierra Leone, Ghana, Nigeria, and Liberia - encounter blocked opportunities in the U.S. labour market. They then work in the United States, as home health aides, certified nursing assistants, qualified disability support professionals, and licensed practical and registered nurses.
This book reveals the global, political, social, and economic factors that have facilitated the entry of West African women and men into the health care labour force (home and institutional care for older adults and individuals with physical and intellectual disabilities; and skilled nursing). It highlights these immigrants’ role as labour brokers who tap into their local ethnic and immigrant communities to channel co-ethnics to meet this labour demand. It illustrates how West African care workers understand their work across various occupational settings and segments in the healthcare industry. This book reveals the transformative processes migrants undergo as they become produced, repackaged, and deployed as health care workers after migration.
Ultimately, this book tells the very real and human story of an immigrant group surmounting tremendous obstacles to carve out a labour market niche in health care, providing some of the most essential and intimate aspects of care labour to the most vulnerable members of society.

This interview was conducted by Dr. Miranda Melcher whose new book focuses on post-conflict military integration, understanding treaty negotiation and implementation in civil war contexts, with qualitative analysis of the Angolan and Mozambican civil wars.
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Dr. Susan Partovi first experienced poverty medicine volunteering at a dump site in Tijuana during high school. There, she recognized the need for all people to have access to quality medical care. Over the years, she has worked in various facilities around Los Angeles County, incorporating her renegade method of going the extra mile for her patients. As Medical Director of Homeless Health Care Los Angeles, she works to provide a safety net of care for the underserved skid row community and surrounding neighborhoods.
Recognized internationally as a leader in street medicine, Dr. Partovi started documenting her patients' stories so that others could hear their voices. By addressing the practical and moral considerations when treating each patient, Dr. Partovi developed her philosophies about what it means to be a "good doctor." Along the way, she began to understand how her personal ethics evolved--from a challenging childhood and complicated relationships with her parents, through professional hurdles--often, she had to push against a system that doesn't always put the patient first.
Renegade M.D.: A Doctor's Stories from the Streets (Bookbaby, 2024) is a powerful and inspiring memoir by Dr. Susan Partovi, a renowned street doctor who has dedicated her life to treating the impoverished around the world and people experiencing homelessness on LA's skid row. Through her stories, Dr. Partovi takes us on a journey to the heart of the challenges faced by those living on the streets, and shines a light on her unwavering commitment to advocate for social justice and to provide compassionate care to some of the most vulnerable people in our society.
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Covering a fascinating period of population growth, high infant mortality and deep social inequality, rapid medical advances and pseudoscientific quackery, Confinement: The Hidden History of Maternal Bodies in Nineteenth-Century Britain (The History Press, 2023) by Dr. Jessica Cox is the untold history of pregnancy and childbirth in Victorian Britain.
During the nineteenth century, having children was frequently viewed as a woman’s central function and destiny – and yet the pregnant and postnatal body, as well as the birthing room, are almost entirely absent from the public conversation and written histories of the period. Confinement corrects this omission by exploring stories of pregnancy and motherhood across this period. Drawing on a range of contemporary sources, Dr. Cox charts the maternal experiences of women, examining fertility, pregnancy, miscarriage, childbirth, maternal mortality, unwanted pregnancies, infant loss, breastfeeding, and postnatal bodies and minds.
From the royal family to inhabitants of the workhouse, this absorbing history reveals what motherhood was truly like for the women of nineteenth-century Britain.

This interview was conducted by Dr. Miranda Melcher whose new book focuses on post-conflict military integration, understanding treaty negotiation and implementation in civil war contexts, with qualitative analysis of the Angolan and Mozambican civil wars.
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Measurements, and their manipulation, have been underestimated as crucial historical forces motivating and guiding the way we think about disability.
Using measurement technology as a lens, and examining in particular the measurement of hearing and breathing, Coreen McGuire's book Measuring Difference, Numbering Normal: Setting the Standards for Disability in the Interwar Period (Manchester UP, 2020) draws together several existing discussions on disability, phenomenology, healthcare, medical practice, big data, embodiment, and emerging medical and scientific technologies around the turn of the twentieth century. These are popular topics of scholarly attention but have not, until now, been considered as interconnected topics within a single book. As such, this work connects several important, and usually separate academic subject areas and historical specialisms. The standards embedded in instrumentation created strict, but, ultimately arbitrary thresholds of what is categorised as normal and abnormal. Considering these standards from a long historical perspective reveals how these dividing lines shifted when pushed.
This book is available open access here. 
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Most of us appreciate the importance of the immune system yet have very little knowledge about how it actually works. If you fall into this camp and are curious to learn more about this intricate system, Bobby Cherayil's book is an excellent resource.
The Logic of Immunity: Deciphering an Enigma was published in January 2024 by John Hopkins University Press. It gives a great overview of this complex system, including several findings from the recent years. It also points out the many areas of ongoing research and open questions.
The book introduces the actors of the system and the many interactions between them:

the various types of immune cells,

the pathogens and pathogen-associated patterns they recognize,

the cascade of events that ultimately leads to an immune response.

The opening chapter explains (and visualizes!) where these cells are located. It explains how they contribute to the immune response, and how we broadly categorize them into innate and adaptive immunity.
Chapters 2 and 3 discuss the innate immune system. We get to know the general concepts, like molecular patterns and receptors recognizing them. They describe in detail some well-studied mechanisms, like the LPS-TLR4 interaction. And we also learn the story of their research spanning multiple years and multiple discoveries building upon each other.
Chapters 4-6 delve into the mechanisms of adaptive immunity and their main cell types: B- and T-lymphocytes. Have you ever wondered how the immune system is able to "remember" earlier infections? You'll find here both an overview of "immune memory" and a detailed description how B and T cell proliferate and specialize.
Chapter 7 shows how these immune reactions are sometimes provoked by harmless substances - that's what we call allergy. Or even by human cells - that's what we call autoimmune diseases.
The next chapters put the immune system into a bigger context. They discuss the variability of immunity across different individuals and the many reasons behind it. Genes, environment, past infections, life style. A particularly fascinating part of "the human ecosystem" is the microbiota. Its importance has been recognized only in the last two decades. Chapter 8 introduces really well this emerging field of study.
Chapter 11 is dedicated to an immunology topic that affects all of us: vaccines. Building upon the knowledge from previous chapters, it explains how vaccines work.
Throughout the book, we learn a lot both about the exciting developments and the open questions in the field of immunology. Chapter 12 gives a summary of some trends of the last decades and an outlook for the next big puzzles to tackle.
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