Root of the Cause Radio Root of the Cause Radio

Dov is once again joined by Dr. Brian Cornblatt, Chief Medical Officer at BioHarvest Sciences, for a spirited and in-depth conversation. They take a deep dive into the detox process and discuss the science behind VINIA, a revolutionary supplement that leverages the power of technology to deliver unparalleled bioavailability of detoxifying phytochemical compounds. Dr. Cornblatt is a Johns Hopkins University School of Medicine Graduate with a Ph.D. in Pharmacology and Molecular Sciences and a postdoctoral fellowship from the Johns Hopkins Bloomberg School of Public Health, Environmental Health Sciences Division of Toxicology. He is also the inventor of 3 issued patents and 4 pending provisional patents focused on plant-based bioactive compounds and health promotion. 
RESOURCES
The Science of VINIA
VINIA’s Solubility Advantage
VINIA’s Bioavailability Advantage      
Research Article
Got a question, comment or suggestion for a future topic? Email ROTC@rootofthecause.net.
SHOW NOTES
5:15 – Dr. Cornblatt explains why he likes discussing the chemical compounds heterocyclic amines and benzene9:05 – Testing for benzene levels in the body10:30 – Objective methods Dr. Cornblatt implements to determine one’s ability to detox benzene using phytochemicals; Lab report measuring benzene levels (see page 4). 11:34 – Phase 2 enzymes and how they work like a dimmer switch; how plant-based bioactive compounds can modulate the switch 17:27 – Glutathione S Transferase: how these enzymes work and the many redundancies at the cellular level19:30 – How Glutathione is made and how plant phytochemicals can upregulate it21:40 – Are plant phytonutrients antioxidants, pro-oxidants or “indirect” antioxidants? 24:14 – The evolutionary principle behind how and why these plant compounds produce phytochemicals 26:32 – Benefits of taking phytochemicals; stimulation of NRF2, ET1 (impacts vasoconstriction) and eNOS (impacts vasodilation); how VINIA stimulates all 3 pathways, helping to modulate blood pressure and oxygenate the blood, aiding in the reversal of chronic fatigue31:40 – How the piceid form of resveratrol in VINIA is vastly different from standard resveratrol (cis and trans form); unparalleled absorbability and bioavailability and the innovative ways Dr. Cornblatt’s team achieves this41:00 – New innovations coming soon from BioHarvest 44:00 – VINIA’s impact on insulin sensitivity; VINIA's wide-ranging polyphenolic content versus standard resveratrol's limited polyphenolic content 48:55 – LDL cholesterol vs oxidized LDL and how VINIA upregulates a phase 2 enzyme called PON1, preventing oxidation of LDL cholesterol59:37 – The value of genetic testing when applying nutraceuticals and pharmaceuticals in a customized way 1:04 – Does the body recognize the difference between human-made...

In this solo episode, I present a foundational primer on the very misunderstood topic of detoxification. I deconstruct all the phases of detox, including the very overlooked and unspoken phase zero. I also include the often forgotten (yet what I feel to be the most important) part of detox: the elimination phase. I, of course, cover phases 1, 2 and 3 as well, explaining how detox conjugation works, what the 6 conjugation pathways are and how we can leverage these pathways when embarking on a detox. Listen for a fun analogy I use to simplify this very complex topic and help you understand just how practical, as well as critical, detoxification is in today’s unavoidably toxic world.
For questions or to suggest future topics, email ROTC@rootofthecause.net.

Part 2 of my discussion with Roxanne Grobbel, leading expert in EMDR (Eye Movement Desensitization and Reprocessing). Listen as Roxanne demystifies EMDR and teaches us just how effective and well researched this treatment is.
Roxanne is a certified EMDR therapist and consultant. With a career focused on trauma-related issues, she is widely considered one of the leading experts on EMDR today. Roxanne is also an EMDRIA-approved EMDR instructor, teaching clinicians both basic and advanced EMDR courses and traveling around the country conducting workshops and lectures. Roxanne currently provides intensive trauma treatment at the 11th Hour Trauma Retreat in Denver, Colorado.
emdria.org
www.insightcounselingandeducation.com or www.Center4emdr.com
EMDRrox@gmail.com
For questions or to request future show topics, email ROTC@rootofthecause.net.

My guest this episode is Roxanne Grobbel, leading expert in EMDR (Eye Movement Desensitization and Reprocessing). Listen as Roxanne demystifies EMDR and teaches us just how effective and well researched this treatment is.
Roxanne is a certified EMDR therapist and consultant. With a career focused on trauma-related issues, she is widely considered one of the leading experts on EMDR today. Roxanne is also an EMDRIA-approved EMDR instructor, teaching clinicians both basic and advanced EMDR courses and traveling around the country conducting workshops and lectures. Roxanne currently provides intensive trauma treatment at the 11th Hour Trauma Retreat in Denver, Colorado.
emdria.org
www.insightcounselingandeducation.com or www.Center4emdr.com
EMDRrox@gmail.com
2:49-What is EMDR?
5:40-The connection between R.E.M. and EMDR
8:33-Taxation of working memory while doing a secondary task. https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC4325664/#S1title
10:38-What to expect from your first EMDR session
14:44-How does an EMDR practitioner extract repressed traumas that are driving a fear, phobia or anxiety?
23:37-Is EMDR effective for everyone? Is there an efficacy spectrum?
26:12-Reasons for non-responders
29:55-Is EMDR for trauma-related struggles only?
36:25-The impact environment has on children aged 0-3 and how the practitioner taps into a trauma their patient was too young to remember (as opposed to a repressed memory)
For questions or to request future show topics, email ROTC@rootofthecause.net.

In this episode of Root of the Cause Radio, I’ll be covering the good, the bad and the ugly of estrogen metabolites: the more benign 2-Hydroxyestrone, the duality of the 16-Hydroxyestrone and the dreaded 4-Hydroxyestrone.
1:53 - Phase 1 estrogen detoxification and estrogen metabolites
2:47 - 16-Hydroxyestrone, the impact, risk and reasons for high levels and the possible downsides of very low levels
4:06 - Can Estriol convert into anything harmful or helpful?
5:40 - The bad and ugly of the 4-Hydroxyestrone and how methylation plays a critical role
7:42 - Phosphatidylcholine and how it can indirectly help to neutralize the 4-Hydroxyestrone metabolite
9:23 - What happens to the 4-Hydroxyestrones that don’t get methylated? Hint: DNA damage
9:42 - How sulforaphane stimulates glutathione S transferase and quinone reductase to mop up DNA damaging quinones
11:12 - Can you measure quinone levels? Can you measure DNA damage from oxidative stress (8-hydroxy-2-deoxyguanosine)?
12:00 - How glutathione is made and the critical nutrients necessary
13:49 - How glutathione and sulforaphane impact estrogen metabolites that don’t get methylated

Today’s episode is part 2 of my 3-part series on estrogen, where I’ll be covering the nuts and bolts of how we properly eliminate estrogen from the body, what’s needed to do so and some reasons for why that process may become suboptimal. I also discuss the timing of testing as well as how and why that detail can render greater value for some people.
2:58 - Does the day of the month you test for estrogen matter? If so, when should you test and why
4:52 - Mid-luteal phase of the menstrual cycle and its importance with estrogen testing
6:24 - Estrogen clearance 101
6:52 - The gallbladder’s, liver’s and bile’s impact on estrogen clearance
7:53 - Bile production, bile flow, bile acids vs. bile salts and glycine/taurine and how they all impact estrogen clearance
9:50 - Phosphatidylcholine, PEMT gene and their impact on bile and the gallbladder
11:13 - Gut dysbiosis
14:11 - Calcium D-glucarate
15:29 - Some potential reasons for high estrogen in men