170 episodes

Welcome to New Frontiers in Functional Medicine, Longevity & Epigenetics™ where I interview the best minds in functional medicine to discuss the science and research behind medicine, longevity, epigenetics, and so much more. Expect thought-provoking ideas, new research, lots of clinical pearls for practitioners, and step-change information for clinicians and patients. Join us! ~DrKF

Copyright © 2023 by KF Education and Consulting, LLC
All Rights Reserved

Dr. Kara Fitzgerald | New Frontiers in Functional Medicine, Longevity, Epigenetics Dr. Kara Fitzgerald

    • Health & Fitness
    • 4.7 • 253 Ratings

Welcome to New Frontiers in Functional Medicine, Longevity & Epigenetics™ where I interview the best minds in functional medicine to discuss the science and research behind medicine, longevity, epigenetics, and so much more. Expect thought-provoking ideas, new research, lots of clinical pearls for practitioners, and step-change information for clinicians and patients. Join us! ~DrKF

Copyright © 2023 by KF Education and Consulting, LLC
All Rights Reserved

    Targeting Cellular Senescence for Healthier, More Youthful Skin With Dr. Alessandra Zonari

    Targeting Cellular Senescence for Healthier, More Youthful Skin With Dr. Alessandra Zonari

    *Save the date! Join me and Dr. Alessandra Zonari for a free webinar on July 25th 2024 and get your questions answered on all things OS-01 peptide and biological aging. Register at https://www.drkarafitzgerald.com/webinars/


    I'm thrilled to be joined by Dr. Alessandra Zonari to take a deep dive into a breakthrough in skincare science that has caught my attention—OneSkin's OS-01 peptide. This episode explores how OS-01 targets cellular senescence, the core of aging, potentially transforming skin health - preserving function, not just aesthetics. I'm particularly impressed by OneSkin's commitment to rigorous research and evidence-based results. Their approach rejuvenates skin function in addition to enhancing its natural radiance, elasticity, and even its microbiome. This could be a significant advancement for individuals managing aging skin or conditions like atopic dermatitis.

    Throughout our discussion, we explore the scientific foundation behind OS-01 and its clinical implications and uncover how this peptide may redefine skincare protocols, offering new possibilities for healthier, more radiant skin. Whether you're a practitioner seeking innovative solutions for patients for ultrasensitive skin or dermatitis, or someone passionate about maintaining skin health, this episode promises insights that could reshape your approach to skincare. And if you’re using OneSkin, I'd be curious to hear from you. You can post a comment wherever you're listening to this or email me directly at DrKaraFitzgerald.com. ~DrKF


    Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources.




    GUEST DETAILS
    Alessandra Zonari, PhD

    OneSkin co-founder and Chief Scientific Officer, Alessandra Zonari, PhD joined the early team in 2017 dedicating her time to understanding the underlying mechanism of the aging process and developing solutions to reverse skin’s biological age. Zonari is the co-inventor of five patents and has published more than 20 peer-reviewed papers in scientific journals.

    Email: alessandra@oneskin.co


    THANKS TO OUR SPONSOR
    OneSkin: Website




    PROMO
    Try OneSkin for yourself with coupon code DRKARA15 to receive 15% off your first purchase at Website






    SHOW NOTES
    Animated science video explaining how OS-01 works Another Study Website
    Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models Study Website
    In vitro and in vivo toxicity assessment of the senotherapeutic Peptide 14 Study Website
    Highly accurate skin-specific methylome analysis algorithm as a platform to screen and validate therapeutics for healthy aging Another Study Website
    MolClock: Estimate DNA methylation age of Skin Tissues Study Website
    Double-blind, vehicle-controlled clinical investigation of peptide OS-01 for skin rejuvenation Another Study Website
    Senotherapeutics, Senolytics, and Senomorphics -- What are they and what is OS-01? Study Website

    • 58 min
    Resolving Chronic Inflammation using SPMs: A Two-Phase Approach with Ashley Koff RD

    Resolving Chronic Inflammation using SPMs: A Two-Phase Approach with Ashley Koff RD

    Practitioners, if specialized pro-resolving lipid mediators (SPMs) aren't already on your radar, you'll be a convert by the end of this New Frontiers episode.

    In functional medicine, we excel at addressing inflammation through nutrition and lifestyle. However, brilliant researchers like Dr. Charles Serhan from Harvard have shown us that resolving inflammation requires a two-phase approach. We need to shift gears, rally the cleanup crew, start the repair process, and turn down the volume on the immune system. This transition from inflammation to resolution is exactly what our guest, Ashley Koff, RD, will discuss.

    We'll explore why SPMs, discovered by Dr. Serhan, are crucial for healthy inflammation resolution and how Metagenics has developed a product using the patented Serhan method that has numerous clinical applications, from managing inflammation and pain to addressing neurodegenerative conditions, autoimmunity, and even infertility. We'll also delve into factors that influence our ability to convert omega-3 and -6 fatty acids into these superstar molecules, such as diet, genetics, inflammatory bias, and poor vagal tone. This conversation is packed with clinical pearls for your practice and personal use. Enjoy. ~DrKF


    Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources.





    GUEST INFORMATION
    Ashley Koff, RD is a 25+ year award-winning practitioner, founder of The Better Nutrition Program (est. 2019), and fractional Chief Nutrition Officer for entities like Vitaboom.

    Ashley Koff, RD | The Better Nutrition Program

    Phone: 323-251-7537 | Email: ashley@thebetternutritionprogram.com





    GUEST DETAILS
    Ashley Koff, RD: https://tinyurl.com/2drp29ky

    Founder - The Better Nutrition Program: https://thebetternutritionprogram.com/

    Phone: 323-251-7537

    Email: ashley@thebetternutritionprogram.com




    THANKS TO OUR SPONSOR: Metagenics: Website




    PROMO
    Get 15% off Metagenics SPM Active Supplement with Code SPMW624US (US) or SPMW624CAN (Canada) at checkout. https://tinyurl.com/4jc9np3y (Offer expires 7/15/24. Max order value $500. For consumer purchases only.)




    SHOW NOTES
    Metagenics Institute Study Website
    NFFM Podcast: Specialized Pro-Resolving Mediators (SPMs): As Close to a Panpharmacon as We Can Get? Another Study Website
    Latest Updates on Specialized Pro-Resolving Mediator (SPM) Science by Charles Serhan, PhD, DSc Another Study Website




    CONNECT WITH DrKF on:

    YouTube: https://tinyurl.com/hjpc8daz

    Instagram: https://www.instagram.com/drkarafitzgerald/

    • 59 min
    Towards Predicting Autism in Utero with Dr. Janine LaSalle

    Towards Predicting Autism in Utero with Dr. Janine LaSalle

    What if we could actually identify and even correct significant autism risk factors in utero, before a baby is born?

    This is the promise of the game-changing research of Dr. Janine LaSalle, epigeneticist extraordinaire from UC Davis. With autism rates continuing to increase at alarming rates (the latest data from the CDC, released in 2023, is 1 in 36 children in the US, an increase from the prior 1 in 44), new ways to prevent and treat this condition are of utmost importance. Dr. LaSalle is on a mission to change that, by investigating something you probably haven't heard much about yet - the placental methylome. Methylation signatures in the maternal placenta are yielding information both for predicting autism in children and for intervention targets to prevent the development of the disease. It's just incredibly exciting.

    In our conversation, you'll also learn how placental methylation behaves differently to DNA methylation in other tissues, and how the placental methylome may also help us better understand cancer as well as mechanisms that restore more youthful epigenetic patterns. Hold onto your hats folks - yes this is deep science, but it's also actionable even now. You'll hear how methylation support specifically in the early pregnancy window is key and how it's also protective against insults from environmental toxicants. You’re in for a treat with this fascinating conversation that has far-reaching implications for you and your patients. ~DrKF

    Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources.


    Guest Information
    Janine LaSalle, Ph.D.
    Professor, Medical Microbiology and Immunology, School of Medicine
    University of California, Davis
    jmlasalle@ucdavis.edu
    The LaSalle Lab at University of California, Davis


    Thank you to our sponsors
    Diamond
    Rupa Health: https://tinyurl.com/4anbz7b3

    Biotics Research: https://www.bioticsresearch.com/

    Integrative Therapeutics: https://tinyurl.com/4emwj48z


    Gold
    TimeLine Nutrition: https://tinyurl.com/bdzx2xms

    OneSkin: https://tinyurl.com/ycxtw4zt
    Try OneSkin for yourself with coupon code DRKARA15 to receive 15% off your first purchase.


    Midroll
    Practice Better: https://tinyurl.com/28mmab99
    Start your free trial and save 20% for 4 months on any paid plan with code KF20


    Show Notes
    Perinatal Origins of Disparities Center: https://pod.ucdavis.edu/

    Environmental Health Sciences Center: https://environmentalhealth.ucdavis.edu/

    MIND Institute: https://health.ucdavis.edu/mindinstitute/

    Article: Too Much Folate in Pregnant Women Increases Risk for Autism, Study Suggests: https://tinyurl.com/bdf9ez6k

    The human placental methylome: https://tinyurl.com/7zz8dz55

    Markers of Autism Risk in Babies (MARBLES): https://tinyurl.com/49phe22r

    • 1 hr 5 min
    Challenging Food Reactions? Addressing the Gut Microbiome and More with Dr. Thomas Fabian

    Challenging Food Reactions? Addressing the Gut Microbiome and More with Dr. Thomas Fabian

    Addressing adverse food reactions goes way beyond simply cutting out the culprits, so I’m thrilled to have Dr. Tom Fabian join us again on New Frontiers to highlight the interventions that will move the needle for our patients. We explore the mechanisms through which specific strains can either exacerbate or alleviate both immune-mediated and non-immune-mediated food reactions, and discuss the fascinating connection between circadian rhythms of mast cells and intestinal permeability, feeding times and increased susceptibility to food reactivity. We look at why some patients may be more sensitive to symptoms and how histamine-producing microbes may lead to visceral hypersensitivity.

    But we also talk strategy, with one pearl after another, such as the potential of Lactobacillus reuteri in attenuating immune-mediated food reactions, the role of butyrate and indole in stabilizing mast cells, and using specific polyphenols to calm the immune system and promote a health microbiome. For any practitioner or health-savvy individual grappling with these issues, this is an episode you won’t want to miss. ~DrKF

    Head over to https://www.drkarafitzgerald.com/fxmed-podcast/ for the transcript, a COMPLETE LIST OF SHOW NOTES and all the FxMed resources.

    GUEST INFORMATION
    Thomas Fabian, PhD, CNTP https://tinyurl.com/5ehysjp7
    Dr. Fabian serves as a translational science consultant and science advisor with Diagnostic Solutions Laboratory and is a leading expert on the role of the microbiome in health, immune function, chronic disease, and aging.


    THANK YOU TO OUR SPONSOR
    Diagnostic Solutions Laboratory https://bit.ly/2IEhVrS


    *SPECIAL OFFER FOR FxMED LISTENERS*
    Download the GI-MAP Interpretive Guide at https://tinyurl.com/5ehysjp7 and use it to follow along with the episode. This practical guide from Diagnostic Solutions Laboratory can help you better understand and interpret test results for your patients.


    SHOW NOTES
    Understanding food allergy through neuroimmune interactions in the gastrointestinal tract https://tinyurl.com/2kstjrzp

    The intestinal neuro-immune axis: crosstalk between neurons, immune cells, and microbes https://tinyurl.com/5n7ymaj4

    DSL Webinar: Neuroinflammation and the Gut-Brain Connection https://tinyurl.com/ykeeehnk

    Mechanisms Underlying Food-Triggered Symptoms in Disorders of Gut-Brain Interactions https://tinyurl.com/yhb5ddyc


    FxMED RESOURCES
    Gut Healing in Aging & Disease: Emerging Roles of the Microbiome and Diet in Intestinal Barrier Regeneration with Tom Fabian, PhD, CNTP https://tinyurl.com/h3rtumbs

    Hydrogen Sulfide in Health, Disease & Longevity with Dr. Tom Fabian https://tinyurl.com/25fmk83n

    Latest Insights into the Role of the Gut Microbiome in Healthy Aging with Dr. Tom Fabian https://tinyurl.com/bdz5u7vz


    CONNECT WITH DrKF
    Facebook: https://www.facebook.com/DrKaraFitzgerald/

    YouTube: https://tinyurl.com/hjpc8daz

    Instagram: https://www.instagram.com/drkarafitzgerald/

    DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb

    Bio Age Lab Test: https://tinyurl.com/b7bjmfj9

    Bio Age Self Assessment Quiz: https://tinyurl.com/4z8f7ucc

    • 1 hr 10 min
    Smart, Actionable Strategies for Childhood Resilience, with Dr. Elisa Song

    Smart, Actionable Strategies for Childhood Resilience, with Dr. Elisa Song

    Dr. Elisa Song is one of those clinicians that I could just keep talking to! She's a respected colleague and pioneer in pediatric functional medicine with so many practical tips for navigating childhood illness and health. Need to get your kiddo/patient through a blood draw they don't want to do? Or get your picky eater to take their supplement? Dr. Song has the answers. I appreciate her candor as she talks about how and why her practice has evolved in certain areas (such as in the use of targeted probiotics and even "psychobiotics" for autism, ADHD, anxiety, OCD and more) and in spelling out which supplement brands and doses she uses and why. Dr. Song tackles the immense challenges impacting the health of our kids and teens head on with positivity and smart, doable strategies for lasting success. This is a fascinating and empowering discussion with many clinical pearls that I will be implementing both in practice and for my own daughter going forwards. I hope you enjoy it too! ~DrKF


    Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for all the relevant links and resources.


    Guest Information

    Dr. Elisa Song, MD
    Healthy Kids, Happy Kids: An Integrative Pediatrician’s Guide to Whole Child Resilience: https://www.healthykidshappykids.com/book/
    Healthy Kids, Happy Kids: https://healthykidshappykids.com/
    IG: @healthykids_happykids
    FB: https://www.facebook.com/DrElisaSongMD/


    Thank you to our sponsors
    Diamond
    Rupa Health: https://tinyurl.com/4anbz7b3
    Biotics Research: https://www.bioticsresearch.com/
    Integrative Therapeutics: https://tinyurl.com/4emwj48z


    Gold
    OneSkin: https://tinyurl.com/ycxtw4zt
    TimeLine Nutrition: https://tinyurl.com/bdzx2xms


    Midroll
    Practice Better: https://tinyurl.com/28mmab99
    Start your free trial and save 20% for 4 months on any paid plan with code KF20


    Show Notes

    A Potential Decline in Life Expectancy in the United States…https://tinyurl.com/3frr8z6d
    Lost microbes of COVID-19: Bifidobacterium… https://tinyurl.com/r348tm78
    Increasing Prevalence of Antinuclear Antibodies… https://tinyurl.com/7why9yrv
    Role of Bifidobacteria on Infant Health: https://tinyurl.com/4sk5u9ds
    Protective effect of Bifidobacterium infantis CGMCC313-2 on… https://tinyurl.com/2kn2vjnw
    Trends in Consumption of Ultraprocessed Foods Among US Youths… https://tinyurl.com/5fn5sce7
    Dietary patterns, brain morphology and cognitive performance in children…https://tinyurl.com/mp5ekp26

    • 1 hr 8 min
    Mitigating Muscle Loss from GLP-1 Agonists, with Dr. Anurag Singh

    Mitigating Muscle Loss from GLP-1 Agonists, with Dr. Anurag Singh

    Even as we prioritize natural interventions in functional medicine, GLP-1 agonist drugs such as Wegovy and Ozempic offer sometimes life-changing support for those who have long struggled with resistant overweight/obesity and high blood sugar. However, there are side effects, including the risk of substantial muscle loss and sagging, aged skin ("Ozempic face" as it's indelicately known). It's a concern that hits home for me, considering the pivotal role we know that muscle plays in overall health and longevity.


    In this New Frontiers podcast episode I welcome back Dr. Anurag Singh to unravel the complexities of these issues. We explore the interplay between metabolic health and muscle preservation, touching on everything from the mechanisms of GLP-1 agonists and their long-term effects on aging and sarcopenia, to the promising potential of dietary and lifestyle interventions to counteract negative effects. We consider the potential for one of my all-time fave postbiotic epinutrients - Urolithin A - to assist by supporting mitochondrial health and preserving/enhancing muscle quality. This timely conversation is one you won't want to miss. Tune in and please leave us a review wherever you listen to New Frontiers. – DrKF


    Check out our show notes https://www.drkarafitzgerald.com/fxmed-podcast/


    Guest information
    Anurag Singh, MD, PhDChief Medical Officer at Timeline


    Thank you to our sponsor

    Timeline
    Mitopure
    Research from Timeline
    care@timeline.com

    Timeline Discount for New Frontiers Listeners
    Timeline is offering DrKFs readers a 10% discount on Timeline products. Head over to Timeline and use the code KARA10 at checkout.


    Show Notes

    Study: Once-Weekly Semaglutide in Adults with Overweight or Obesity https://tinyurl.com/y3c2ypkw

    Pre-clinical trial (Recruiting): Effects of Urolithin A Supplementation on Glucose Metabolism in Healthy Adults 55>= Years Old...https://tinyurl.com/bdzfccr8

    Study: Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults https://tinyurl.com/2p9pjpxc

    Study: Antidiabetic Effect of Urolithin A in Cultured L6 Myotubes and Type 2 Diabetic Model KK-Ay/Ta Mice with Glucose Intolerance https://tinyurl.com/2jkhmu9w

    Study: Urolithin A, a Gut Metabolite, Improves Insulin Sensitivity Through Augmentation of Mitochondrial Function and Biogenesis https://tinyurl.com/mvrjxxsm

    Study: Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults A Randomized Clinical Trial https://tinyurl.com/fscfdd85

    Study: Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population https://tinyurl.com/e6npdvyp

    Preprint article: Topical application of Urolithin A slows intrinsic skin aging and protects from UVB-mediated photodamage: Findings from Randomized Clinical Trials https://tinyurl.com/2m2nzd56

    • 31 min

Customer Reviews

4.7 out of 5
253 Ratings

253 Ratings

grgryk ,

Simply Brilliant!

This is a must listen podcast for staying on the forefront of what’s happening in longevity and functional medicine.

Terrify04 ,

Amazing resource!

Dr Kara has such great episodes. Her personality is so fun and engaging. Thank you for talking about such important topics!

MegPR7 ,

Great Podcast!

Informative and useful health information that is easy to understand.

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