The Chain: Protein Engineering Podcast

Cambridge Healthtech Institute
  • 4.8 (25)
  • LIFE SCIENCES
  • UPDATED MONTHLY
The Chain: Protein Engineering Podcast

The Chain explores the lives, careers, research, and discoveries of protein engineers and scientists, the impact their work is having on the field, and where the industry is headed. Tune in to stay up-to-date on the newest advancements and to hear the stories that are impacting the world of biologics.

  1. Episode: 68 - Changing the Game of Protein-Protein Interactions With Randolph Lopez

    12/10/2024

    Episode: 68 - Changing the Game of Protein-Protein Interactions With Randolph Lopez

    In this episode of The Chain, host Andrew Bradbury, CSO of Specifica, an IQVIA business, speaks with Randolph Lopez, CTO and co-founder of A-Alpha Bio, about how A-Alpha Bio is changing the game of protein-protein interactions with their platform AlphaSeq. Lopez delves into the origins, the process, the successes, and the possibilities of the company’s platform and how it can help with epitope mapping, affinity predictions, and off-target binding. With the data the platform generates, Lopez a...

    46 min
  2. Episode: 67 - Anthony Tolcher Discusses Oncology, Dual-Payload Technology, and the ADC Field

    11/12/2024

    Episode: 67 - Anthony Tolcher Discusses Oncology, Dual-Payload Technology, and the ADC Field

    November 12, 2024 | In this episode of The Chain, host Rakesh Dixit, PhD, DABT, president and founder of Bionavigen Oncology and Regio Biosciences, speaks with Anthony Tolcher, M.D., FRCPC, cofounder of NEXT Oncology, about antibody drug conjugates (ADCs) including the role of the bystander effect, approaching targets in oncology, dual-payload technologies, the potency of new payloads, and bispecific targeting. Tolcher also shares what inspired him to pursue oncology, how he came across ADCs,...

    43 min
  3. Episode: 66 - John Lambert on Antibody Drug Conjugates Then, Now, & Beyond

    10/16/2024

    Episode: 66 - John Lambert on Antibody Drug Conjugates Then, Now, & Beyond

    October 15, 2024 | In this month’s episode of The Chain, host Rakesh Dixit, PhD, DABT, president and founder of Bionavigen Oncology and Regio Biosciences, and John Lambert, PhD, consultant, about antibody drug conjugates (ADCs) then, now, and beyond. Lambert shares his experiences from his decades-long career at ImmunoGen, why ADCs are more successful now compared to in the past, and where he sees ADCs going forward. He also discusses his thoughts on the half-life of diffusible payloads, the ...

    40 min
  4. Episode 65- Tariq Ghayur on the Renaissance of Bispecifics and ADCs, AI, and More

    09/10/2024

    Episode 65- Tariq Ghayur on the Renaissance of Bispecifics and ADCs, AI, and More

    September 10, 2024 | In this episode of The Chain, host Nimish Gera speaks with Tariq Ghayur, founder of FairJourney Biologics (and a fellow host of the podcast), about the current renaissance of bispecifics and ADCs, the impact of AI in pharmaceuticals, and what to watch out for in the biopharma space in the next few years. Ghayur also shares his journey from BASF Pharma to AbbVie, what it was like when the industry shifted its focus from small molecules to biologics, and the major differenc...

    32 min
  5. Episode: 64 - Peyton Greenside on AI’s Role in Antibody Engineering, Optimization, and More

    08/13/2024

    Episode: 64 - Peyton Greenside on AI’s Role in Antibody Engineering, Optimization, and More

    In this episode of The Chain, host Nimish Gera, Ph.D., vice president of biologics at Mythic Therapeutics, speaks with Peyton Greenside, CSO and co-founder of BigHat Biosciences, about the role of AI and machine learning in antibody engineering and targeting complex modalities, including bispecifics and ADCs. Greenside also discusses the work her organization does, what BigHat is doing to ensure the quality of data to train their AI models with, the methods of approaching harder targets such ...

    33 min
  6. Episode: 63 - Discussing Protein Signaling and Structural Biology With Andrew Kruse

    07/16/2024

    Episode: 63 - Discussing Protein Signaling and Structural Biology With Andrew Kruse

    In this episode of The Chain, host Brandon DeKosky, associate professor at MIT, speaks with Andrew Kruse, PhD, professor of biological chemistry and molecular pharmacology at Harvard University, about protein signaling and structural biology. Kruse explains what exactly bias signaling is and discusses the problems he and his team are working to resolve, as well as the tools they use to work out the dynamics of structures. He also shares the findings in signaling receptors and biology that he’...

    38 min
  7. Episode: 62 - AI/ML in Antibody Discovery and Engineering: Reality, Hope, Future, and Hype

    06/11/2024

    Episode: 62 - AI/ML in Antibody Discovery and Engineering: Reality, Hope, Future, and Hype

    his special episode of The Chain features a panel of industry experts who discussed AI and ML in antibody discovery and engineering at this year’s PEGS Boston event. Peter Tessier, professor at the University of Michigan; Andrew Bradbury, CSO at Specifica; Andrew Waight, Senior Director of Machine Learning, Discovery Biologics & Protein Sciences at Merck Research Labs; Peyton Greenside, Co-Founder & CSO of BigHat Biosciences; and Paolo Marcatili, Director of Antibody Design at Novo No...

    1h 4m
  8. Episode: 61 - Tomoyuki Igawa Discusses Leadership and His Experiences in Discovery and Development

    05/14/2024

    Episode: 61 - Tomoyuki Igawa Discusses Leadership and His Experiences in Discovery and Development

    In this episode of The Chain, host Tariq Ghayur, PhD, consultant and entrepreneur in residence, FairJourney Biologics, speaks with Tomoyuki Igawa, PhD, chief executive officer, Chugai Pharmabody Research in Singapore, about his 20+ years of experience in drug discovery and development. Igawa possesses a unique perspective that has allowed him and his team to develop innovative concepts, such as recycling sweeping antibodies and bispecific platforms. He discusses how the discovery and developm...

    55 min
See All (71)

4.8
out of 5
25 Ratings

About

The Chain explores the lives, careers, research, and discoveries of protein engineers and scientists, the impact their work is having on the field, and where the industry is headed. Tune in to stay up-to-date on the newest advancements and to hear the stories that are impacting the world of biologics.

Information

You Might Also Like

To listen to explicit episodes, sign in.

Stay up to date with this show

Sign in or sign up to follow shows, save episodes, and get the latest updates.
Select a country or region

Africa, Middle East, and India

Asia Pacific

Europe

Latin America and the Caribbean

The United States and Canada