75 episodes

ASCP's podcast for all things laboratory--if it's happening inside the lab, we're talking about it.

Inside the Lab American Society for Clinical Pathology

    • Health & Fitness
    • 4.6 • 38 Ratings

ASCP's podcast for all things laboratory--if it's happening inside the lab, we're talking about it.

    Special Episode: Emerging Biomarkers for the Assessment of Alzheimer's Disease

    Special Episode: Emerging Biomarkers for the Assessment of Alzheimer's Disease

    Recent developments in disease modifying therapies have been proven to slow the progression of cognitive decline associated with Alzheimer’s disease. 
    And yet, we can only confirm a diagnosis of AD after a patient’s death. 
    But what if we could use biomarkers to identify preclinical stage Alzheimer’s and step in long before a patient exhibits dementia? 
    On this episode of Inside the Lab, your host, Ms. Kelly Swails, MT(ASCP) introduces us to Dr. Shih-Hsiu Jerry Wang, MD, PhD, Assistant Professor of Pathology and Assistant Professor of Neurology at the Duke University School of Medicine, and shares his talk on emerging biomarkers for the assessment of Alzheimer’s disease from the ASCP 2023 Annual Meeting. 
    Dr. Wang explains how we measure AD right now and why there’s discordance between the clinical presentation and pathology of Alzheimer’s. 
    Dr. Wang walks us through the core biomarkers for identifying AD per the AT(N) framework, describing the pros and cons of current detection methodologies and offering recommendations around when to use blood biomarkers versus PET imaging or CSF. 
    Listen in for insight into the ongoing search for better AD biomarkers and learn what we are doing to diagnose Alzheimer’s in its early stages and intervene accordingly. 
    Topics Covered  
    · The clinical definition of Alzheimer’s disease and how it impacts cognitive function
    · How we measure Alzheimer’s in pathology by amyloid plaques and neurofibrillary tangles
    · Why there’s discordance between the clinical presentation and pathology of AD
    · The core biomarkers for identifying Alzheimer’s disease per the AT(N) framework
    · Identifying the stages of AD based on amyloid plaque, pathologic tau and neurodegeneration
    · Examples of PET imaging for the different stages of AD and how imaging biomarkers predict cognitive decline
    · The limitations of fluid biomarkers vs. imaging biomarkers to detect Alzheimer's disease
    · Some of the emerging ultrasensitive biomarker detection methods in development for AD
    · Using cerebral spinal fluids (CSF) vs. plasma biomarkers to identify Alzheimer's disease
    · A comparison of the mass spectrometry vs. SIMOA methods of analyzing p-tau biomarkers
    · Why Dr. Wang suggests blood biomarkers for AD screening (with confirmation by PET or CSF)
    · Why SNAP-25, NfL and GFAP are not considered core biomarkers for Alzheimer’s disease
    · The ongoing search for better biomarkers and ultrasensitive detection methods for AD 
    Connect with ASCP
    ASCP
    ASCP on Facebook
    ASCP on Instagram
    ASCP on Twitter 
    Connect with Dr. Wang
    Dr. Wang at Duke University 
    Connect with Ms. Swails
    Ms. Swails on Twitter

    Resources
    Dr. Wang’s Slides from the ASCP Annual Meeting 2023
    ‘NIA-AA Research Framework: Toward a Biological Definition of Alzheimer’s Disease’ in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association
    Inside the Lab in the ASCP Store 

    • 37 min
    Special Episode:How Advances in Treatment for NSCLC and Melanoma Impact the Laboratory

    Special Episode:How Advances in Treatment for NSCLC and Melanoma Impact the Laboratory

    The availability of targeted therapies has changed the landscape of cancer treatment in the last few years.  And two types of cancer particularly affected by these advances are melanoma and non-small cell lung carcinoma or NSCLC. What role does the laboratory play in the diagnosis and treatment of these cancers? How can pathologists and lab professionals work with oncologists to optimize biomarker testing and improve patient outcomes?  

    On this episode of Inside the Lab, your hosts, Ms. Kelly Swails, MT(ASCP), and Dr. Ali Brown, MD, FASCP, are joined by Dr. Sanjay Mukhopadhyay, MD, Director of the Lung Pathology Service at the Cleveland Clinic, Ms. Lynnette Pineault, MBA, SCT(ASCP), Operations Manager for Laboratory and Genetic Services for Health Partners, and Mr. Jim Ondick, ASCP Patient Champion and IT Associate at The University of Kansas Health System, to discuss advancements in biomarker testing to improve NSCLC and melanoma cancer care.  

    Listen in for insight on ensuring equitable patient access to biomarker testing and learn how to register for ASCP’s Immuno-Oncology Microlearning Courses for pathologists and laboratory professionals.  
    Topics Covered   
    How targeted therapies and immunotherapies have improved treatment for melanoma and lung cancer in the past few years Mr. Ondick’s success story of being treated with immunotherapy for metastatic melanoma and why he had little interaction with laboratory professionals during his diagnosis and treatmentHow pathologists can work with oncologists and surgeons to improve care for patients with cancer The obstacles to providing laboratory services or support for biomarker testing Dr. Mukhopadhyay and Ms. Pineault’s advice on designing workflows to optimize biomarker testing and ensuring equitable access for patients Mr. Ondick’s take on what cancer patients should know about the laboratory team  Connect with ASCP
    ASCP
    ASCP on Facebook 
    ASCP on Instagram
    ASCP on Twitter   
    Connect with Dr. Mukhopadhyay 
    Dr. Mukhopadhyay at Cleveland Clinic
    Dr. Mukhopadhyay on LinkedIn  
    Connect with Ms. Pineault
    Ms. Pineault on ResearchGate
    Ms. Pineault on LinkedIn  
    Connect with Mr. Ondick
    Mr. Ondick on LinkedIn
    Mr. Ondick’s Story on ASCP Patient Champions  
    Connect with Ms. Swails & Dr. Brown
    Ms. Swails on Twitter
    Dr. Brown on Twitter  
    Resources
    ASCP Patient Champions
    ASCP Immuno-Oncology Microlearning Courses
    Inside the Lab in the ASCP Store   
    Sponsor
    Bristol Myers Squibb 

    • 47 min
    S4Ep2: The FDA’s Proposed Rule on Laboratory Developed Tests

    S4Ep2: The FDA’s Proposed Rule on Laboratory Developed Tests

    Tests that are designed in-house to fulfill a clinical need (but aren’t FDA approved) qualify as laboratory developed tests. And these LDTs are currently regulated by CLIA. But the FDA is proposing a new rule that would give them oversight of the design and development of laboratory developed tests. So, what does that mean for us? How would this new legislation impact everyday practice inside the lab? 
    On this episode of the podcast, your hosts, Ms. Kelly Swails, MLS(ASCP), and Dr. Ali Brown, MD, FASCP, are joined by Dr. Gregory Sossaman, MD, Clinical Pathologist and Service Line Lead for Pathology and Lab Medicine at Ochsner Health, Dr. Jonathan Genzen, MD, Clinical Pathology Professor at the University of Utah and Chief Medical Officer and Senior Director of Government Affairs at ARUP Laboratories, and Mr. Matthew Schulze, Senior Director for the Center for Public Policy at ASCP, to discuss the implications of the proposed FDA regulations for LDTs. 
    Our panelists share their anxiety around the labor and costs involved in complying with the new rule and describe how lab professionals might be forced into situations where we deny care due to regulations. Listen in to understand why public opinion favors the proposed rule and learn how to share your concerns with the FDA during the public comment period from October 3rd to December 4th, 2023. 
    Topics Covered  
    · How tests that are not FDA approved but designed in-house to fulfill a clinical need fall into the category of laboratory developed tests
    · Examples of common LDTs used in academic medical centers + large community health systems
    · The current regulations re: performance standards for LDTs under CLIA
    · Dr. Sossaman, Dr. Genzen & Mr. Schulze’s concerns around the labor and costs involved in complying with the proposed FDA rule
    · The lack of clarity re: what modifications to FDA approved tests would be allowed under the proposed regulations
    · How direct-to-consumer testing, the pandemic and technological advances influenced the proposed FDA rule and why the general public is in favor of it
    · How the proposed FDA regulations would affect our ability to respond in future pandemics

    Connect with ASCP
    ASCP
    ASCP on Facebook
    ASCP on Instagram
    ASCP on Twitter 
    Connect with Dr. Sossaman
    Dr. Sossaman on LinkedIn 
    Connect with Dr. Genzen
    Dr. Genzen on LinkedIn 
    Connect with Mr. Schulze
    Mr. Schulze on LinkedIn 
    Connect with Ms. Swails & Dr. Brown
    Ms. Swails on Twitter
    Dr. Brown on Twitter 
    Resources
    ASCP Membership 2024
    Proposed FDA Regulation of Laboratory Developed Tests
    Public Comment on the FDA’s Proposed Rule
    Inside the Lab in the ASCP Store 

    • 42 min
    S4Ep1: Patient-Centered Care from a Laboratory Perspective

    S4Ep1: Patient-Centered Care from a Laboratory Perspective

    Working on the bench can feel like being in a black box. And as important as it is to advocate for patients, pathologists and laboratory professionals rarely have direct access to them. 
    So, what can we do to encourage patient-centered care in the medical laboratory? 
    On this episode of Inside the Lab, your hosts, Ms. Kelly Swails, MLS(ASCP), and Dr. Lotte Mulder, PhD, are joined by three members of the laboratory staff at University Hospital in San Antonio, Ms. Carrie Bartosh, MLS(ASCP), SV, Laboratory Supervisor in the Microbiology Department, Ms. Claudia Courtright, MLS(ASCP), Technical Supervisor in Microbiology Services, and Mr. Scott Bowman, MLS(ASCP), Bench Technologist, to discuss patient advocacy in the laboratory. 
    Our panelists describe what laboratories can do to promote a culture of patient-centered care, sharing examples of situations when they advocated for patients from the bench and what they wish people knew about the value of the work done in the medical laboratory.  
    Listen in for Ms. Bartosh, Ms. Courtright, and Mr. Bowman’s advice for laboratory professionals on avoiding burnout and learn how your laboratory can establish processes that support patient-centered care.  
    Topics Covered 
    · How frontline laboratory professionals can advocate for patients from the bench
    · Instances of advocating for patients and how working in a culture of safety empowered those situations
    · What the University Health laboratory does to continuously evaluate and improve its patient-centered care practices
    · What laboratories can do to promote a culture of patient-centered care
    · Why a punitive culture in the laboratory is not conducive to patient-centered care
    · Examples of processes that support patient-centered care
    · Advice to laboratory professionals on how to avoid burnout
    · How Ms. Bartosh, Ms. Courtright, and Mr. Bowmanstay motivated to focus on advocacy
    · Why laboratory professionals rarely have an opportunity to involve patients in the decision-making process around laboratory testing and results interpretation (and how impactful it is when they do)
    · What our panelists wish patients knew about the value of the work we do in the medical laboratory 
    Connect with ASCP
    ASCP
    ASCP on Facebook
    ASCP on Instagram
    ASCP on Twitter

    Connect with Ms. Bartosh, Ms. Courtright & Mr. Bowman
    University Health Laboratory Services
    Ms. Bartosh on LinkedIn 
    Connect with Ms. Swails & Dr. Brown
    Ms. Swails on Twitter
    Dr. Mulder on Twitter
    Resources
    CAP Inspection Checklists
    ASCP Patient Champions Program
    Inside the Lab in the ASCP Store 

    • 39 min
    S3Ep15: Strategies for Promoting DEI in the Lab

    S3Ep15: Strategies for Promoting DEI in the Lab

    We know that diverse teams perform better. In laboratory medicine, diversity, equity, and inclusion in leadership not only inspires young professionals, it also promotes retention in a profession that struggles with staffing shortages. 
    So, what’s stopping us from increasing representation and equity in laboratory leadership?  
    What can we do to recruit a more diverse pool of job applicants and then support them in growing into lab leadership and management roles? 
    On this episode of Inside the Lab, your hosts, Ms. Kelly Swails, MLS(ASCP), and Dr. Lotte Mulder, PhD, are joined by Ms. Lona Gordon Small, MLS(ASCP), MBA, Quality Specialist at the Johns Hopkins Hospital Core Lab and coach and Founder of LabOPEX Training and Consulting, Dr. Marissa J. White, MD, FASCP, Surgical Pathologist and Deputy Director for Diversity, Equity and Inclusion at Johns Hopkins, and Mr. Mohamed Abdelmonem, MBA-HCM, MSc, MLS(ASCP)SBB, Blood Bank Specialist and Transfusion and Reference Lab Supervisor at STEM Healthcare, to discuss diversity, equity and inclusion strategies for the medical lab. 
    Our panelists explain the common barriers to expanding representation among laboratory leadership and explore effective strategies for mentoring underrepresented groups in management roles. 
    Listen in for Ms. Small, Dr. White, and Mr. Abdelmonem’s insight on establishing equity around pay and promotion and learn what educational institutions and professional organizations can do to promote representation at all levels of the laboratory workforce! 
    Topics Covered 
    · The crucial need to increase representation in laboratory leadership and management positions
    · Common barriers to expanding representation and equity in laboratory leadership
    · What educational institutions and professional organizations can do to promote representation and equity in the laboratory workforce
    · The benefits of equity around pay and promotion in the medical lab
    · Effective strategies for mentoring and supporting underrepresented groups in laboratory leadership roles
    · Strategies to identify and recruit a more diverse pool of job applicants for roles in the medical laboratory  
    Connect with ASCP
    ASCP
    ASCP on Facebook
    ASCP on Instagram
    ASCP on Twitter 
    Connect with Ms. Small
    Ms. Small on LinkedIn
    Connect with Dr. White
    Dr. White at Johns Hopkins 
    Connect with Mr. Abdelmonem
    Mr. Abdelmonem on LinkedIn

    Connect with Ms. Swails & Dr. Mulder
    Ms. Swails on Twitter
    Dr. Mulder on Twitter 
    Resources
    eLABorate Topics Podcast
    Mass General Brigham’s Mentoring Across Differences
    Positive Intelligence by Shirzad Chamine
    ASCP Mentorship Program
    Inside the Lab in the ASCP Store 

    • 45 min
    S3Ep14: Mentorship in the Medical Laboratory

    S3Ep14: Mentorship in the Medical Laboratory

    Would you benefit from having a mentor to help you grow as a pathologist or laboratory professional? How might you benefit from becoming a mentor yourself? 
    We get further, faster, with support, and having the right mentor accelerates your personal and professional development. 
    But how do you find a good mentor? And what can you do to make the mentor-mentee relationship successful?  
    On this episode of Inside the Lab, your hosts, Ms. Kelly Swails, MT(ASCP), and Dr. Lotte Mulder, PhD, are joined by Dr. Nathan Johnson, PhD, FACHE, MASCP, DLM(ASCP), Chair of Laboratory Sciences at the University of Arkansas for Medical Sciences in Little Rock, Arkansas,Ms. Tywauna Wilson, MBA, MLS(ASCP)CM, System Technical Director of Chemistry for CompuNet Clinical Laboratories and President of Trendy Elite Coaching, and Dr. Russell Broaddus, MD, PhD, Chair of Pathology and Laboratory Medicine at the University of North Carolina School of Medicine at Chapel Hill, to discuss mentorship in the laboratory. 
    Our panelists explore the characteristics of a good mentor, explaining why mentorship is important at ALL levels of your career and where to look for mentorship as a pathologist or laboratory professional. 
    Listen in for examples of how Dr. Johnson, Ms. Wilson, and Dr. Broaddus have benefitted from serving as mentors and learn how to maximize the benefits of a mentor-mentee relationship in the medical lab. 
    Topics Covered
    · What inspired Dr. Johnson, Ms. Wilson, and  Dr. Broaddus to become mentors
    · Why our panelists look to mentor in the areas of leadership and career development
    · How experienced laboratory professionals can learn from their younger colleagues
    · The characteristics of a good mentor
    · What makes the mentor-mentee relationship work
    · What questions you should ask yourself before saying YES to mentoring someone
    · Insight on where to look for a mentor
    · Common  mistakes people make in looking for a mentor
    · Why mentorship is important at ALL levels of your laboratory career
    · How our panelists have benefited from serving as mentors
    · What you can do to maximize your mentor-mentee relationships in the lab

    Connect with ASCP
    ASCP
    ASCP on Facebook
    ASCP on Instagram
    ASCP on Twitter 
    Connect with Dr. Johnson
    Dr. Johnson at the University of Arkansas
    Dr. Johnson on LinkedIn
    Connect with Ms. Wilson
    Trendy Elite Coaching
    Ms. Wilson on Twitter
    Ms. Wilson on LinkedIn

    Connect with Dr. Broaddus
    Dr. Broaddus at UNC School of Medicine
    Dr. Broaddus on LinkedIn 
    Connect with Ms. Swails & Dr. Mulder
    Ms. Swails on Twitter
    Dr. Mulder on Twitter 
    Resources
    Inside the Lab in the ASCP Store 

    • 45 min

Customer Reviews

4.6 out of 5
38 Ratings

38 Ratings

KMC4406 ,

Love this platform as a CEU pathway

Thank you ASCP for making a free resource to gain CEUs! This is helpful and informative.

ACT_88 ,

Urgently important & Very informative!

I consume a lot of mainstream media; I’m amazed how the perspectives of the lab professionals, who are a critical part of the front line worriers against COVID-19, have largely been missing in the national conversation!!
This podcast is a great first step in raising awareness of the issues that lab professionals and pathologists have been facing during this pandemic and the crucial contributions they continue to make in this fight!
Keep up the great work, and thank you for giving a voice to this untold story!

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