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In India, a group of researchers raced to develop a CRISPR-based genome editing therapy to save the life of a young woman with a rare neurodegenerative disease. Despite a valiant effort, the pace of research was ultimately too slow to save her life. While many are convinced that these therapies could offer hope to those with overlooked genetic conditions, it will likely take years to develop the techniques needed to quickly create bespoke treatments, something people in need don't have.
This is an audio version of our Feature: Hope, despair and CRISPR — the race to save one woman’s life

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00:48 A rapid way to identify serious bacterial infectionsA newly-developed method that can rapidly identify the type of bacteria causing a blood-infection, and the correct antibiotics to treat it, could save clinicians time, and patient lives. Blood infections are serious, and can lead to the life-threatening condition sepsis, but conventional diagnostic methods can take days to identify the causes. This new method does away with some of the time-consuming steps, and the researchers behind it say that if it can be fully automated, it could provide results in less than a day.
Research Article: Kim et al.
11:49 Research HighlightsThe discovery of a connection between three star-forming interstellar clouds could help explain how these giant structures form, and evidence of the largest accidental methane leak ever recorded.
Research Highlight: Found: the hidden link between star-forming molecular clouds
Research Highlight: Blowout! Satellites reveal one of the largest methane leaks on record
14:22 AIs fed AI-generated text start to spew nonsenseWhen artificial intelligences are fed data that has itself been AI-generated, these systems quickly begin to spout nonsense responses, according to new research. Typically, large language model (LLM) AI’s are trained on human-produced text found online. However, as an increasing amount of online content is AI-generated, a team wanted to know how these systems would cope. They trained an AI to produce Wikipedia-like entries, then trained new iterations on the model on the text produced by its predecessor. Quickly the outputs descended into gibberish, which highlights the dangers of the Internet becoming increasingly full of AI-generated text.
Research Article: Shumailov et al.
25:49 Briefing ChatHow psilocybin — the hallucinogenic compound found in magic mushrooms — resets communication between brain regions, and the surprise cancellation of a NASA Moon mission.
Nature News: Your brain on shrooms — how psilocybin resets neural networks
Nature News: NASA cancels $450-million mission to drill for ice on the Moon — surprising researchers
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01:04 A gel to safely transport proteinsA gel that encases proteins could be a new way to safely transport medicines without requiring them to be kept cold, according to new research. To test it, the team behind the work posted themselves a protein suspended in this gel, showing that it was perfectly preserved and retained its activity, despite being dropped in transit and exposed to varying temperatures. The researchers hope this gel will help overcome the need to freeze protein-based medicines, which can be expensive to do and difficult to maintain during transportation.
Research Article: Bianco et al.
News and Views: Gel protects therapeutic proteins from deactivation — even in the post
08:51 Research HighlightsHow an abundance of cicadas led to a host of raccoon activity, and how wine-grape harvest records can be used to estimate historical summertime temperatures
Research Highlight: Massive cicada emergence prompted raccoons to run wild
Research Highlight: Wine grapes’ sweetness reveals Europe’s climate history
11:24 Making a plastic biodegradableBy embedding a plastic with an engineered enzyme, researchers have developed a fully biodegradable material that can be broken down in a home compost heap. Plastic production often requires high temperatures, so the team adapted an enzyme to make it more able to withstand heat, while still able to break down a common plastic called PLA. They hope this enzyme-embedded plastic could replace current single-use items, helping to reduce the huge amount of waste produced each year.
Research Article: Guicherd et al.
19:53 Briefing ChatThis time, how to make lab-grown meat taste more meaty, and a subterranean Moon cave that could be a place for humans to shelter.
Nature News: This lab-grown meat probably tastes like real beef
The Guardian: Underground cave found on moon could be ideal base for explorers
Nature hits the books: Living on Mars would probably suck — here's why
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00:45 In situ editing of the gut microbiomeResearchers have developed a method to directly edit the genes of specific bacteria in the guts of live mice, something that has previously been difficult to accomplish due to the complexity of this environment. The tool was able to edit over 90% of an E. coli strain colonising mice guts, with other work showing the tool could be used to edit genes in pathogenic bacterial species and strains. It is hoped that with further research this technique could be adapted to work in humans, potentially altering bacteria associated with disease.
Nature News: This gene-editing tool alters bacteria in the gut of living mice
Research Article: Brödel et al.
06:56 Research HighlightsThe ants that perform life-saving surgery on their nest-mates, and why amber’s scarcity led ancient artisans to make imitation jewellery.
Research Highlight: Ants amputate their nest-mates’ legs to save lives
Research Highlight: Fake jewellery from the Stone Age looks like the real deal
08:46 How is bone health maintained during breastfeeding?During breastfeeding bones are stripped of calcium, while levels of oestrogen — which normally helps keep them healthy — drop off precipitously. This puts bones under tremendous stress, but why they don’t break down at this time has proved a mystery. Now, a team has identified a hormone produced in lactating mice that promotes the build up of bones, keeping them strong during milk production. Injecting this hormone into injured mice helped their bones heal faster, and the team hopes that their finding could ultimately help treat bone-weakening conditions like osteoporosis in humans.
Research Article: Babey et al.
17:55 Briefing ChatThis time, new clues about the neurological events that spark migraines, and a quick chemical method to recycle old clothes.
Nature News: What causes migraines? Study of ‘brain blackout’ offers clues
Nature News: Chemical recycling’: 15-minute reaction turns old clothes into useful molecules
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00:47 Searching for dark matter in black holesResearchers have been scanning the skies looking for black holes that formed at the very beginning of the Universe — one place where elusive and mysterious dark matter is thought to be located. If these black holes did contain dark matter, they would be especially massive and so researchers would be able to see the bending of light as they pass in front of stars. Such events would be rare, so to find them researchers trawled through a decades-long dataset. However, despite the large number of observations, the researchers didn't find many examples of these events and none that were long enough to show signs of much dark matter. So, the hunt for enigmatic material goes on.
Research Article: Mróz et al.
09:42 Research HighlightsHow some comb jellies survive the crushing ocean depths, and how giving cash to mothers in low-income households can boost time and money spent on children.
Research Highlight: Deep-sea creatures survive crushing pressures with just the right fats
Research Highlight: Families given cash with no strings spend more money on kids
12:39 A simple, solution to tackle a deadly frog diseaseA simple ‘sauna’ built of bricks and a supermarket-bought greenhouse, can help frogs rid themselves of a devastating fungal disease, new research has shown. While options to prevent or treat infection are limited, the fungus that causes the disease chytridiomycosis has an achilles heel: it can’t survive at warm temperatures. A team in Australia used this knowledge to their advantage to develop saunas where frogs can warm themselves to clear an infection. Frogs who spent time in these hot environments were able to shake the fungus, and gained some immunity to subsequent infections. While this research only involved one type of frog, it offers some hope in tackling a deadly disease that has driven multiple species to extinction.
Research Article: Waddle et al.
News and Views: Mini saunas save endangered frogs from fungal disease
20:06 Briefing ChatThis time, we discuss what the upcoming UK election could mean for science, and the return of rock samples from the Moon’s far side.
Nature News: UK general election: five reasons it matters for science
Nature News: First ever rocks from the Moon’s far side have landed on Earth
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In 2026, NASA aims to send humans back to the Moon's surface, as part of the Artemis III mission. In preparation, astronauts have been performing moonwalking simulations to ensure that they are able to make the most of their precious time on the lunar surface. In one dress rehearsal, a pair of astronauts took part in a training exercise in an Arizona volcanic field, working with a science team to practice doing geology work in difficult conditions designed to mimic some that will be experienced at the lunar south pole.
This is an audio version of our Feature: How NASA astronauts are training to walk on the Moon in 2026
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